The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Inhibition of the Serotonin (5-Hydroxytryptamine) Transporter Reduces Bone Accrual during Growth
Open accessAbstract
Selective serotonin-reuptake inhibitors (SSRIs) antagonize the serotonin (5-hydroxytryptamine) transporter (5-HTT), and are frequently prescribed to children and adolescents to treat depression. However, recent findings of functional serotonergic pathways in bone cells and preliminary clinical evidence demonstrating detrimental effects of SSRIs on bone growth have raised questions regarding the effects of these drugs on the growing skeleton. The current work investigated the impact of 5-HTT inhibition on the skeleton in: 1) mice with a null mutation in the gene encoding for the 5-HTT; and 2) growing mice treated with a SSRI. In both models, 5-HTT inhibition had significant detrimental effects on bone mineral accrual. 5-HTT null mutant mice had a consistent skeletal phenotype of reduced mass, altered architecture, and inferior mechanical properties, whereas bone mineral accrual was impaired in growing mice treated with a SSRI. These phenotypes resulted from a reduction in bone formation without an increase in bone resorption and were not influenced by effects on skeletal mechanosensitivity or serum biochemistries. These findings indicate a role for the 5-HTT in the regulation of bone accrual in the growing skeleton and point to a need for further research into the prescription of SSRIs to children and adolescents.
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Cites
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Lrp5 Controls Bone Formation by Inhibiting Serotonin Synthesis in the Duodenum
Yadav, V. K., Ryu, J.-H., Suda, N., Tanaka, K. F., Gingrich, J. A., Schütz, G., Glorieux, F. H., Chiang, C. Y., Zajac, J. D., Insogna, K. L., et al. (2008) · Cell · doi:10.1016/j.cell.2008.09.059 · Cited by 834
Yadav, V. K., Oury, F., Suda, N., Liu, Z.-W., Gao, X.-B., Confavreux, C., Klemenhagen, K. C., Tanaka, K. F., Gingrich, J. A., Guo, X. E., et al. (2009) · Cell · doi:10.1016/j.cell.2009.06.051 · Cited by 661
Targeting the murine serotonin transporter: insights into human neurobiology
Murphy, D. L., & Lesch, K.-P. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2284 · Cited by 478
Effect of Selective Serotonin Reuptake Inhibitors on the Risk of Fracture
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Diem, S. J. (2007) · Archives of Internal Medicine · doi:10.1001/archinte.167.12.1240 · Cited by 326
Metadata
- Authors
- Warden, S. J., Robling, A. G., Sanders, M. S., Bliziotes, M. M., & Turner, C. H.
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2005-02-01
- Volume
- 146
- Issue
- 2
- Pages
- 685-693
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2162816738
- Cited by
- 221
- References
- 6
- FWCI
- 3.06
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Warden, S. J., Robling, A. G., Sanders, M. S., Bliziotes, M. M., & Turner, C. H. (2005). Inhibition of the Serotonin (5-Hydroxytryptamine) Transporter Reduces Bone Accrual during Growth. Endocrinology. https://doi.org/10.1210/en.2004-1259
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
