The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
The role of the vagal nerve in peripheral PYY3-36-induced feeding reduction in rats
Abstract
Peptide YY (PYY), an anorectic peptide, is secreted postprandially from the distal gastrointestinal tract. PYY(3-36), the major form of circulating PYY, binds to the hypothalamic neuropeptide Y Y2 receptor (Y2-R) with a high-affinity, reducing food intake in rodents and humans. Additional gastrointestinal hormones involved in feeding, including cholecystokinin, glucagon-like peptide 1, and ghrelin, transmit satiety or hunger signals to the brain via the vagal afferent nerve and/or the blood stream. Here we determined the role of the afferent vagus nerve in PYY function. Abdominal vagotomy abolished the anorectic effect of PYY(3-36) in rats. Peripheral administration of PYY(3-36) induced Fos expression in the arcuate nucleus of sham-operated rats but not vagotomized rats. We showed that Y2-R is synthesized in the rat nodose ganglion and transported to the vagal afferent terminals. PYY(3-36) stimulated firing of the gastric vagal afferent nerve when administered iv. Considering that Y2-R is present in the vagal afferent fibers, PYY(3-36) could directly alter the firing rate of the vagal afferent nerve via Y2-R. We also investigated the effect of ascending fibers from the nucleus of the solitary tract on the transmission of PYY(3-36)-mediated satiety signals. In rats, bilateral midbrain transections rostral to the nucleus of the solitary tract also abolished PYY(3-36)-induced reductions in feeding. This study indicates that peripheral PYY(3-36) may transmit satiety signals to the brain in part via the vagal afferent pathway.
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“Moreover, these gut peptides can activate their cognate receptors located in vagal afferents to signal to the brainstem [179,180].”
From Anxiety, depression, and the microbiome: A role for gut peptides (2018) · cites this paper as [179]
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Abdominal Vagotomy Blocks the Satiety Effect of Cholecystokinin in the Rat
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Metadata
- Authors
- Koda, S., Date, Y., Murakami, N., Shimbara, T., Hanada, T., Toshinai, K., Niijima, A., Furuya, M., Inomata, N., Osuye, K., & Nakazato, M.
- Affiliations
- University of Miyazaki (JP)
- Niigata University (JP)
- Suntory (Japan) (JP)
- Corresponding author
- Nakazato, Masamitsu
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2005-05-01
- Volume
- 146
- Issue
- 5
- Pages
- 2369-2375
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2099688918
- Cited by
- 431
- References
- 38
- Citations by year
- 2026: 6 · 2025: 15 · 2024: 15 · 2023: 10 · 2022: 14 · 2021: 25 · 2020: 8 · 2019: 9 · 2018: 21 · 2017: 26 · 2016: 18 · 2015: 15 · 2014: 26 · 2013: 32 · 2012: 32
- FWCI
- 11.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Keywords
- peptide YY, PYY3-36, vagal afferent nerves, vagotomy, Y2 receptor, satiety signals, arcuate nucleus, nodose ganglion, nucleus tractus solitarius, anorectic peptides, gastrointestinal hormones
- MeSH terms
- Afferent Pathways, Animals, Arcuate Nucleus of Hypothalamus, Eating, Electrophysiology, Fluorescent Antibody Technique, Male, Nodose Ganglion, Peptide Fragments, Satiation, Vagotomy, Vagus Nerve, Proto-Oncogene Proteins c-fos, Rats, Wistar, Receptors, Neuropeptide Y, Peptide YY, Rats
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