Cited by 433Regulation of Appetite and ObesityNeuropeptides and Animal PhysiologyVagus Nerve Stimulation Research

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The role of the vagal nerve in peripheral PYY3-36-induced feeding reduction in rats

Koda, Shuichi, Date, Yukari, Murakami, Noboru, Shimbara, Takuya, Hanada, Takeshi, Toshinai, Koji, Niijima, Akira, Furuya, Mayumi, Inomata, Norio, Osuye, Kazuhiro, Nakazato, Masamitsu·2005·Endocrinology

DOI 10.1210/en.2004-1266

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Abstract

Peptide YY (PYY), an anorectic peptide, is secreted postprandially from the distal gastrointestinal tract. PYY(3-36), the major form of circulating PYY, binds to the hypothalamic neuropeptide Y Y2 receptor (Y2-R) with a high-affinity, reducing food intake in rodents and humans. Additional gastrointestinal hormones involved in feeding, including cholecystokinin, glucagon-like peptide 1, and ghrelin, transmit satiety or hunger signals to the brain via the vagal afferent nerve and/or the blood stream. Here we determined the role of the afferent vagus nerve in PYY function. Abdominal vagotomy abolished the anorectic effect of PYY(3-36) in rats. Peripheral administration of PYY(3-36) induced Fos expression in the arcuate nucleus of sham-operated rats but not vagotomized rats. We showed that Y2-R is synthesized in the rat nodose ganglion and transported to the vagal afferent terminals. PYY(3-36) stimulated firing of the gastric vagal afferent nerve when administered iv. Considering that Y2-R is present in the vagal afferent fibers, PYY(3-36) could directly alter the firing rate of the vagal afferent nerve via Y2-R. We also investigated the effect of ascending fibers from the nucleus of the solitary tract on the transmission of PYY(3-36)-mediated satiety signals. In rats, bilateral midbrain transections rostral to the nucleus of the solitary tract also abolished PYY(3-36)-induced reductions in feeding. This study indicates that peripheral PYY(3-36) may transmit satiety signals to the brain in part via the vagal afferent pathway.

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Authors: Koda, S., Date, Y., Murakami, N., Shimbara, T., Hanada, T., Toshinai, K., Niijima, A., Furuya, M., Inomata, N., Osuye, K., & Nakazato, M.
Affiliations: University of Miyazaki (JP)
Niigata University (JP)
Suntory (Japan) (JP)
Corresponding author: Nakazato, Masamitsu
ORCID: Date, Yukari
Toshinai, Koji
Inomata, Norio
Nakazato, Masamitsu
Venue: Endocrinology
Publisher: The Endocrine Society
Published: 2005-05-01
Volume: 146
Issue: 5
Pages: 2369-2375
ISSN: 0013-7227 (ISSN-L)
1945-7170
DOI: 10.1210/en.2004-1266
OpenAlex: W2099688918
Cited by: 431
References: 38
Citations by year: 2026: 6 · 2025: 15 · 2024: 15 · 2023: 10 · 2022: 14 · 2021: 25 · 2020: 8 · 2019: 9 · 2018: 21 · 2017: 26 · 2016: 18 · 2015: 15 · 2014: 26 · 2013: 32 · 2012: 32
FWCI: 11.85
Type: journal article
Language: en
Open access: closed
Locations: Endocrinology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
Keywords: peptide YY, PYY3-36, vagal afferent nerves, vagotomy, Y2 receptor, satiety signals, arcuate nucleus, nodose ganglion, nucleus tractus solitarius, anorectic peptides, gastrointestinal hormones
MeSH terms: Afferent Pathways, Animals, Arcuate Nucleus of Hypothalamus, Eating, Electrophysiology, Fluorescent Antibody Technique, Male, Nodose Ganglion, Peptide Fragments, Satiation, Vagotomy, Vagus Nerve, Proto-Oncogene Proteins c-fos, Rats, Wistar, Receptors, Neuropeptide Y, Peptide YY, Rats

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The role of the vagal nerve in peripheral PYY3-36-induced feeding reduction in rats

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