Palmitate-Induced Interleukin 6 Production Is Mediated by Protein Kinase C and Nuclear-Factor κB Activation and Leads to Glucose Transporter 4 Down-Regulation in Skeletal Muscle Cells

Insulin Resistance: A Multifaceted Syndrome Responsible for NIDDM, Obesity, Hypertension, Dyslipidemia, and Atherosclerotic Cardiovascular Disease

DeFronzo, R. A., & Ferrannini, E. (1991) · Diabetes Care · doi:10.2337/diacare.14.3.173 · Cited by 4,555

C-Reactive Protein, Interleukin 6, and Risk of Developing Type 2 Diabetes Mellitus

Pradhan, A. D. (2001) · JAMA · doi:10.1001/jama.286.3.327 · Cited by 4,433

Protein kinase C and lipid signaling for sustained cellular responses

Nishizuka, Y. (1995) · The FASEB Journal · doi:10.1096/fasebj.9.7.7737456 · Cited by 2,499

A rapid micrqpreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells

Andrews, N. C., & Faller, D. V. (1991) · Nucleic Acids Research · doi:10.1093/nar/19.9.2499 · Cited by 2,337

Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance

Kern, P. A., Ranganathan, S., Li, C., Wood, L., & Ranganathan, G. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.280.5.e745 · Cited by 1,883

Role of Fatty Acids in the Pathogenesis of Insulin Resistance and NIDDM

Boden, G. (1997) · Diabetes · doi:10.2337/diab.46.1.3 · Cited by 1,728

Mechanism of free fatty acid-induced insulin resistance in humans.

Roden, M., Price, T. B., Perseghin, G., Petersen, K. F., Rothman, D. L., Cline, G. W., & Shulman, G. I. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118742 · Cited by 1,539

Lipid-Induced Insulin Resistance in Human Muscle Is Associated With Changes in Diacylglycerol, Protein Kinase C, and IκB-α

Itani, S. I., Ruderman, N. B., Schmieder, F., & Boden, G. (2002) · Diabetes · doi:10.2337/diabetes.51.7.2005 · Cited by 1,390

Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade.

Griffin, M. E., Marcucci, M. J., Cline, G. W., Bell, K., Barucci, N., Lee, D., Goodyear, L. J., Kraegen, E. W., White, M. F., & Shulman, G. I. (1999) · Diabetes · doi:10.2337/diabetes.48.6.1270 · Cited by 1,267

NIDDM as a disease of the innate immune system: association of acute-phase reactants and interleukin-6 with metabolic syndrome X

Pickup, J. C., Mattock, M. B., Chusney, G. D., & Burt, D. J. (1997) · Diabetologia · doi:10.1007/s001250050822 · Cited by 1,246

Association of PTP1B with Outcomes of Breast Cancer Patients who Underwent Neoadjuvant Chemotherapy

Rivera‐Franco, M. M., Rodríguez, E. L., Martínez‐Benítez, B., Rodriguez, L. G. V., González, M. D. L. L. S., & Alonso, A. A. (2016) · Breast Cancer Basic and Clinical Research · doi:10.4137/bcbcr.s40934 · Cited by 7

Pollen Typhae total flavones inhibit expression of interleukin-6 in C2C12 skeletal muscle cells cultured with palmitate

Lou, S. (2008) · Journal of Chinese Integrative Medicine · doi:10.3736/jcim20080511 · Cited by 7

Bisphenols and the Development of Type 2 Diabetes: The Role of the Skeletal Muscle and Adipose Tissue

Ahmed, F., Pereira, M. J., & Aguer, C. (2021) · Environments · doi:10.3390/environments8040035 · Cited by 7

Obesity-induced TRB3 negatively regulates Brown adipose tissue function in mice

Jeong, H., Choi, R. H., & Koh, H. (2021) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2021.01.103 · Cited by 5

Elevated metabolic rate and skeletal muscle oxidative metabolism contribute to the reduced susceptibility of NF-κB p50 null mice to obesity

Bhatt, B. A., Dedousis, N. L., SIPULA, I. J., & O'Doherty, R. M. (2018) · Physiological Reports · doi:10.14814/phy2.13836 · Cited by 5

A Systematic Review of Palmitate-Mediated Insulin Resistance in C2C12 Myotubes

Zimmerman, J. M., Klein, A. J., Travis, K. B., & Vaughan, R. A. (2025) · Nutrients · doi:10.3390/nu17223619 · Cited by 6

Inflammatory Effects of Very low-density Lipoprotein and Fatty Acids

Ares, M. P. S., & Stollenwerk, M. M. (2006) · Future Cardiology · doi:10.2217/14796678.2.3.315 · Cited by 5

Association of plasma fatty acids pattern with omentin gene expression in human adipose tissues: A cross-sectional study

Nosrati‐Oskouie, M., Yuzbashian, E., Zarkesh, M., Aghili‐Moghaddam, N. S., Hedayati, M., Safarian, M., Asghari, G., Khalaj, A., & Mirmiran, P. (2020) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2020.11.019 · Cited by 5

Chapter 14 Insulin resistance, inflammation, and the IKK/IκB/NF-κB pathway

Bhatt, B. A., & O'Doherty, R. M. (2006) · Advances in molecular and cellular endocrinology · doi:10.1016/s1569-2566(06)05014-9 · Cited by 4

A common polymorphism near the interleukin-6 gene modifies the association between dietary fat intake and insulin sensitivity

Badawi, A. F., Cuda, Garcia-Bailo, Karmali, M. A., & El‐Sohemy, A. (2012) · Journal of Inflammation Research · doi:10.2147/jir.s27911 · Cited by 4

Insulin Resistance and Erectile Dysfunction

Kim, S.-C. (2006) · Korean journal of urology · doi:10.4111/kju.2006.47.9.917 · Cited by 4

Immortalization and Characterization of GFAP-expressing Glial Cells from the Adult Mouse Hypothalamus, Cortex, and Brain Stem

Loganathan, N., Lieu, C. V., & Belsham, D. D. (2024) · Neuroscience · doi:10.1016/j.neuroscience.2024.05.022 · Cited by 2

Fatty Acid Levels in Striated Muscles of Chronic Alcohol-Fed Rats

Kulagina, T. P., Gritsyna, Y. V., Aripovsky, A. V., Zhalimov, V. K., & Vikhlyantsev, I. M. (2018) · BIOPHYSICS · doi:10.1134/s0006350918050135 · Cited by 2

Nutritional risk factors for the metabolic syndrome in overweight children

Herter‐Aeberli, I. (2008) · doi:10.3929/ethz-a-005633355 · Cited by 2

ChaiQi Decoction Alleviates Vascular Endothelial Injury by Downregulating the Inflammatory Response in ApoE-Model Mice

Wang, B., Zhang, J., Lu, Y., Peng, L., Yuan, W., Zhao, Y., & Zhang, L. (2021) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2021/9415819 · Cited by 1

Reactive Oxygen Species and p38 Mitogen-activated Protein Kinase Mediate Exercise-induced Skeletal Muscle-derived Interleukin-6 Expression

Zhang, X., Xie, M., Yan, Y., Wu, Y., & Xu, J. (2011) · Journal of Exercise Science & Fitness · doi:10.1016/s1728-869x(12)60008-2 · Cited by 1

Controle da produção muscular de espécies reativas e citocinas por ácido palmítico e eletroestimulação: possíveis implicações no envelhecimento.

Lambertucci, R. H. (2009) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.42.2009.tde-01072009-120056 · Cited by 1

Development of obesity-induced inflammation and insulin resistance: The role of adipose tissue, fatty acids, and toll-like receptors

Davis, J. E. (2008) · Iowa State University Digital Repository (Iowa State University) · doi:10.31274/etd-180810-1101 · Cited by 1

Determinants and clinical implications of circulating fatty acids in individuals with chronic kidney disease

Huang, X. (2013) · Figshare

The Effects of a High Fat Diet on Mitochondrial Biogenesis and Inflammation in the Brain

Vervaecke, L. S., Davis, J. M., Carson, J., Murphy, A., & Thompson, R. (2014) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000495380.12776.95

Fatty acid metabolism, impaired glucose tolerance and the effects of lifestyle

Corpeleijn, E. (2006) · Research Publications (Maastricht University) · doi:10.26481/dis.20061110ec

Ácidos graxos insaturados oléico e linoléico reprimem o gene Slc2a4 via NF-kB e SREBP-1.

Poletto, A. C. (2011) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.42.2011.tde-19032012-131059

The impact of dialysis therapy on metabolic syndrome traits at the Groote Schuur Hospital

Maree, M. J. (2015) · DUT Open Scholar (Durban University of Technology) · doi:10.51415/10321/1246

Non-Invasive Determination of Pre-Clinical Markers of Cardiovascular Diseases in Low Birth Weight and Maternal Western Diet Guinea Pig Offspring Exposed to a Postnatal Western Diet

Chiu, J. S. S. (2015) · Scholarship@Western (Western University)

Participação do canal de potássio dependente de ATP (KATP) na resistência à insulina em músculo esquelético: correlação com o gene do GLUT4.

Marques, M. F. D. S. F. (2013) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.42.2013.tde-26092013-090548

PPAR β/δ, inflamació i resistència a la insulina en adipòcits

Marco, L. S. (2011) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)

PARTICIPAÇÃO DO CANAL DE POTÁSSIO DEPENDENTE DE ATP (KATP) NA RESISTÊNCIA À INSULINA EM MÚSCULO ESQUELÉTICO: CORRELAÇÃO COM O GENE DO GLUT4

Humana, F. (2013)

Effects of IL-6 and IL-8 on respiratory and peripheral skeletal muscle function: consequences for systemic inflammation in COPD.

Janssen, S. P. M. (2006)

Redução da expressão do GLUT4 induzida por palmitato não envolve estresse de retículo endoplasmático em células musculares L6.

Silva, P. E. (2013) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.42.2013.tde-24062014-100122

Myokine secretion in cultured human skeletal muscle cells

Stray, K. (2008) · NORA - Norwegian Open Research Archives

Targeting PPARs in metabolic risk management: A pharmacological and nutritional approach

Bragt, M. C. E. (2011) · Research Publications (Maastricht University) · doi:10.26481/dis.20111214mb

Genetic Variation in Innate Immunity, Diet and Biomarkers of the Metabolic Syndrome

Cuda, C. (2010) · TSpace (University of Toronto)

The pathological effects of Leishmania mexicana infection on macrophage cell signalling and immune responses

Shweash, M. A. M. (2010) · OpenGrey (Institut de l'Information Scientifique et Technique) · doi:10.48730/je69-5959

El ácido palmítico estimula la producción de interleucina 6 en células musculares esqueléticas por activación de la proteincinasa C y el factor nuclear κB

Jové, M., Planavila, A., & Vázquez‐Carrera, M. (2005) · Clínica e Investigación en Arteriosclerosis · doi:10.1016/s0214-9168(05)73353-2 · Cited by 1

Palmitate induces tumor necrosis factor-α expression in C2C12 skeletal muscle cells by a mechanism involving protein kinase C and nuclear factor-κB activation

Jové, M., Planavila, A., Sánchez, R. M., Merlos, M., Laguna, J. C., & Vázquez-Carrera, M. (2006) · Endocrinology · doi:10.1210/en.2005-0440 · Cited by 172

Palmitate, but Not Unsaturated Fatty Acids, Induces the Expression of Interleukin-6 in Human Myotubes through Proteasome-dependent Activation of Nuclear Factor-κB

Weigert, C., Brodbeck, K., Staiger, H., Kausch, C., Machicao, F., Häring, H. U., & Schleicher, E. D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312692200 · Cited by 269

Lipid induced overexpression of NF-κB in skeletal muscle cells is linked to insulin resistance

Barma, P., Bhattacharya, S., Bhattacharya, A., Kundu, R., Dasgupta, S., Biswas, A., Bhattacharya, S., Roy, S. S., & Bhattacharya, S. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2008.11.014 · Cited by 59

Agonist-induced activation releases peroxisome proliferator-activated receptor β/δ from its inhibition by palmitate-induced nuclear factor-κB in skeletal muscle cells

Jové, M., Laguna, J. C., & Vázquez‐Carrera, M. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2005.02.002 · Cited by 24