Palmitate-Induced Interleukin 6 Production Is Mediated by Protein Kinase C and Nuclear-Factor κB Activation and Leads to Glucose Transporter 4 Down-Regulation in Skeletal Muscle Cells

Insulin Resistance: A Multifaceted Syndrome Responsible for NIDDM, Obesity, Hypertension, Dyslipidemia, and Atherosclerotic Cardiovascular Disease

DeFronzo, R. A., & Ferrannini, E. (1991) · Diabetes Care · doi:10.2337/diacare.14.3.173 · Cited by 4,555

C-Reactive Protein, Interleukin 6, and Risk of Developing Type 2 Diabetes Mellitus

Pradhan, A. D. (2001) · JAMA · doi:10.1001/jama.286.3.327 · Cited by 4,433

Protein kinase C and lipid signaling for sustained cellular responses

Nishizuka, Y. (1995) · The FASEB Journal · doi:10.1096/fasebj.9.7.7737456 · Cited by 2,499

A rapid micrqpreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells

Andrews, N. C., & Faller, D. V. (1991) · Nucleic Acids Research · doi:10.1093/nar/19.9.2499 · Cited by 2,337

Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance

Kern, P. A., Ranganathan, S., Li, C., Wood, L., & Ranganathan, G. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.280.5.e745 · Cited by 1,883

Role of Fatty Acids in the Pathogenesis of Insulin Resistance and NIDDM

Boden, G. (1997) · Diabetes · doi:10.2337/diab.46.1.3 · Cited by 1,728

Mechanism of free fatty acid-induced insulin resistance in humans.

Roden, M., Price, T. B., Perseghin, G., Petersen, K. F., Rothman, D. L., Cline, G. W., & Shulman, G. I. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118742 · Cited by 1,539

Lipid-Induced Insulin Resistance in Human Muscle Is Associated With Changes in Diacylglycerol, Protein Kinase C, and IκB-α

Itani, S. I., Ruderman, N. B., Schmieder, F., & Boden, G. (2002) · Diabetes · doi:10.2337/diabetes.51.7.2005 · Cited by 1,390

Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade.

Griffin, M. E., Marcucci, M. J., Cline, G. W., Bell, K., Barucci, N., Lee, D., Goodyear, L. J., Kraegen, E. W., White, M. F., & Shulman, G. I. (1999) · Diabetes · doi:10.2337/diabetes.48.6.1270 · Cited by 1,267

NIDDM as a disease of the innate immune system: association of acute-phase reactants and interleukin-6 with metabolic syndrome X

Pickup, J. C., Mattock, M. B., Chusney, G. D., & Burt, D. J. (1997) · Diabetologia · doi:10.1007/s001250050822 · Cited by 1,246

Reciprocal Relationships Between Insulin Resistance and Endothelial Dysfunction: Molecular and Pathophysiological Mechanisms

Kim, J.-A., Montagnani, M., Koh, K. K., & Quon, M. J. (2006) · Circulation · doi:10.1161/circulationaha.105.563213 · Cited by 1,652

Cardiovascular Actions of Insulin

Muniyappa, R., Montagnani, M., Koh, K. K., & Quon, M. J. (2007) · Endocrine Reviews · doi:10.1210/er.2007-0006 · Cited by 888

Saturated Fatty Acid-Mediated Inflammation and Insulin Resistance in Adipose Tissue: Mechanisms of Action and Implications

Kennedy, A. J., Martinez, K., Chuang, C., LaPoint, K., & McIntosh, M. (2008) · Journal of Nutrition · doi:10.3945/jn.108.098269 · Cited by 579

Oleate Reverses Palmitate-induced Insulin Resistance and Inflammation in Skeletal Muscle Cells

Coll, T., Eyre, E., Rodríguez-Calvo, R., Palomer, X., Sánchez, R. M., Merlos, M., Laguna, J. C., & Vázquez-Carrera, M. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m708700200 · Cited by 347

Renin-angiotensin-aldosterone system and oxidative stress in cardiovascular insulin resistance

Cooper, S. A., Whaley-Connell, A., Habibi, J., Wei, Y., Lastra, G., Manrique, C., Stas, S., & Sowers, J. R. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00522.2007 · Cited by 317

The Influence of Dietary Fatty Acids on Immune Responses

Radzikowska, U., Rinaldi, A. O., Çelebi Sözener, Z., Karaguzel, D., Wojcik, M., Cypryk, K., Akdis, M., Akdis, C. A., & Sokolowska, M. (2019) · Nutrients · doi:10.3390/nu11122990 · Cited by 306

Cross-talk between skeletal muscle and immune cells: muscle-derived mediators and metabolic implications

Pillon, N. J., Bilan, P. J., Fink, L. N., & Klip, A. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00553.2012 · Cited by 299

Macrophage polarization: the link between inflammation and related diseases

Bashir, S., Sharma, Y., Elahi, A., & Khan, F. (2015) · Inflammation Research · doi:10.1007/s00011-015-0874-1 · Cited by 279

Toll-like receptor-2 is essential for the development of palmitate-induced insulin resistance in myotubes

Senn, J. J. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.a109.513304 · Cited by 8

Induction of proinflammatory cytokines by long-chain saturated fatty acids in human macrophages

Håversen, L., Danielsson, K. N., Fogelstrand, L., & Wiklund, O. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2008.05.033 · Cited by 248

Dietary Fatty Acids Differentially Regulate Production of TNF‐α and IL‐10 by Murine 3T3‐L1 Adipocytes

Bradley, R. L., Fisher, F. M., & Maratos–Flier, E. (2008) · Obesity · doi:10.1038/oby.2008.39 · Cited by 163

Conjugated Linoleic Acid Promotes Human Adipocyte Insulin Resistance through NFκB-dependent Cytokine Production

Chung, S., Brown, J. M., Provo, J. N., Hopkins, R. G., & McIntosh, M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508159200 · Cited by 160

Obesity-associated insulin resistance in skeletal muscle: Role of lipid accumulation and physical inactivity

Eckardt, K., Taube, A., & Eckel, J. (2011) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-011-9168-2 · Cited by 160

Molecular Mechanism of Lipotoxicity as an Interesting Aspect in the Development of Pathological States—Current View of Knowledge

Lipke, K., Kubis-Kubiak, A., & Piwowar, A. (2022) · Cells · doi:10.3390/cells11050844 · Cited by 164

Palmitate-Mediated Downregulation of Peroxisome Proliferator–Activated Receptor-γ Coactivator 1α in Skeletal Muscle Cells Involves MEK1/2 and Nuclear Factor-κB Activation

Coll, T., Jové, M., Rodríguez‐Calvo, R., Eyre, E., Palomer, X., Sánchez, R. M., Merlos, M., Laguna, J. C., & Vázquez‐Carrera, M. (2006) · Diabetes · doi:10.2337/db05-1494 · Cited by 152

Diabetes and Periodontal Infection: Making the Connection

Southerland, J. H., Taylor, G. W., & Offenbacher, S. (2005) · Clinical Diabetes · doi:10.2337/diaclin.23.4.171 · Cited by 147

Proinflammatory NFkB signalling promotes mitochondrial dysfunction in skeletal muscle in response to cellular fuel overloading

Nisr, R. B., Shah, D. S., Ganley, I. G., & Hundal, H. S. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03148-8 · Cited by 142

A Lipidomics Analysis of the Relationship Between Dietary Fatty Acid Composition and Insulin Sensitivity in Young Adults

Kien, C. L., Bunn, J. Y., Poynter, M. E., Stevens, R., Bain, J. R., IIkayeva, O., Fukagawa, N. K., Champagne, C. M., Crain, K. I., Koves, T. R., et al. (2012) · Diabetes · doi:10.2337/db12-0363 · Cited by 138

Lysophosphatidylcholine as an effector of fatty acid-induced insulin resistance

Han, M. S., Lim, Y.-M., Quan, W., Kim, J. R., Chung, K. W., Kang, M., Kim, S., Park, S. Y., Han, J., Park, S., et al. (2011) · Journal of Lipid Research · doi:10.1194/jlr.m014787 · Cited by 136

Tissue resident macrophages: Key players in the pathogenesis of type 2 diabetes and its complications

Meshkani, R., & Vakili, S. (2016) · Clinica Chimica Acta · doi:10.1016/j.cca.2016.08.015 · Cited by 136

Protectin DX alleviates insulin resistance by activating a myokine-liver glucoregulatory axis

White, P. J., St‐Pierre, P., Charbonneau, A., Mitchell, P. L., St-Amand, E., Marcotte, B., & Marette, A. (2014) · Nature Medicine · doi:10.1038/nm.3549 · Cited by 136

Dietary intakes of fat and antioxidant vitamins are predictors of subclinical inflammation in overweight Swiss children

Herter‐Aeberli, I., Molinari, L., Spinas, G. A., Lehmann, R., l’Allemand, D., & Zimmermann, M. B. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.4.748 · Cited by 129

Plasma phospholipid very-long-chain saturated fatty acids and incident diabetes in older adults: the Cardiovascular Health Study

Lemaitre, R. N., Fretts, A. M., Sitlani, C. M., Biggs, M. L., Mukamal, K., King, I. B., Song, X., Djoussé, L., Siscovick, D. S., McKnight, B., et al. (2015) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.101857 · Cited by 117

Saturated fatty acid palmitate-induced insulin resistance is accompanied with myotube loss and the impaired expression of health benefit myokine genes in C2C12 myotubes

Yang, M. J., Wei, D., Mo, C., Zhang, J., Wang, X., Han, X., Wang, Z., & Xiao, H. (2013) · Lipids in Health and Disease · doi:10.1186/1476-511x-12-104 · Cited by 122

Pro-Inflammatory Mediation of Myoblast Proliferation

Otis, J. S., Niccoli, S., Hawdon, N., Sarvas, J. L., Frye, M. A., Chicco, A. J., & Lees, S. J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0092363 · Cited by 120

Tribbles 3 mediates endoplasmic reticulum stress-induced insulin resistance in skeletal muscle

Koh, H.-J., Toyoda, T., Didesch, M. M., Lee, M.-Y., Sleeman, M. W., Kulkarni, R., Musi, N., Hirshman, M. F., & Goodyear, L. J. (2013) · Nature Communications · doi:10.1038/ncomms2851 · Cited by 114

Muscle insulin resistance: assault by lipids, cytokines and local macrophages

Kewalramani, G., Bilan, P. J., & Klip, A. (2010) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32833aabd9 · Cited by 105

Physical inactivity, insulin resistance, and the oxidative-inflammatory loop

Gratas-Delamarche, A., Derbré, F., Vincent, S., & Cillard, J. (2014) · Free Radical Research · doi:10.3109/10715762.2013.847528 · Cited by 99

Multiple Toll-like receptor ligands induce an IL-6 transcriptional response in skeletal myocytes

Frost, R. A., Nystrom, G. J., & Lang, C. H. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00490.2005 · Cited by 96

Fatty acid-induced NF-κB activation and insulin resistance in skeletal muscle are chain length dependent

Hommelberg, P. P. H., Plat, J., LANGEN, R. C. J., Schols, A. M. W. J., & Mensink, R. P. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00436.2007 · Cited by 100

Activation of Peroxisome Proliferator-Activated Receptor-δ by GW501516 Prevents Fatty Acid-Induced Nuclear Factor-κB Activation and Insulin Resistance in Skeletal Muscle Cells

Coll, T., Álvarez-Guardia, D., Barroso, E., Gómez-Foix, A. M., Palomer, X., Laguna, J. C., & Vázquez-Carrera, M. (2010) · Endocrinology · doi:10.1210/en.2009-1211 · Cited by 90

Increased ceramide content and NFκB signaling may contribute to the attenuation of anabolic signaling after resistance exercise in aged males

Rivas, D. A., Morris, E. P., Haran, P. H., Pasha, E. P., Morais, M. D. S., Dolnikowski, G. G., Phillips, E. M., & Fielding, R. A. (2012) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00412.2012 · Cited by 95

Palmitate-induced Down-regulation of Sortilin and Impaired GLUT4 Trafficking in C2C12 Myotubes

Tsuchiya, Y., Hatakeyama, H., Emoto, N., Wagatsuma, F., Matsushita, S., & Kanzaki, M. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.128520 · Cited by 91

Toll-like receptor 2 deficiency improves insulin sensitivity and hepatic insulin signalling in the mouse

Kuo, L.-H., Tsai, P.-J., Jiang, M.-Z., CHUANG, Y.-M., Yu, L., Lai, K.-T. A., & Tsai, Y.-S. (2010) · Diabetologia · doi:10.1007/s00125-010-1931-5 · Cited by 93

Direct and macrophage-mediated actions of fatty acids causing insulin resistance in muscle cells

Bilan, P. J., Samokhvalov, V., Koshkina, A., Schertzer, J. D., Samaan, M. C., & Klip, A. (2009) · Archives of Physiology and Biochemistry · doi:10.1080/13813450903079314 · Cited by 88

Resveratrol Ameliorates Palmitate-Induced Inflammation in Skeletal Muscle Cells by Attenuating Oxidative Stress and JNK/NF-κB Pathway in a SIRT1-Independent Mechanism

Sadeghi, A., Ebrahimi, S. S. S., Golestani, A., & Meshkani, R. (2017) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25868 · Cited by 88

DHA at nutritional doses restores insulin sensitivity in skeletal muscle by preventing lipotoxicity and inflammation

Capel, F., Acquaviva, C., Pitois, E., Laillet, B., Rigaudière, J.-P., Jouve, C., Pouyet, C., Gladine, C., Comte, B., Vianey Saban, C., et al. (2015) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2015.04.003 · Cited by 86

Time‐dependent effects of fatty acids on skeletal muscle metabolism

Hirabara, S. M., Silveira, L. R., Abdulkader, F., Carvalho, C. R. D. O., Procópio, J., & Curi, R. (2006) · Journal of Cellular Physiology · doi:10.1002/jcp.20811 · Cited by 80

Counter-modulation of fatty acid-induced pro-inflammatory nuclear factor κB signalling in rat skeletal muscle cells by AMP-activated protein kinase

Green, C. J., Macrae, K., Fogarty, S., Hardie, D. G., Sakamoto, K., & Hundal, H. S. (2011) · Biochemical Journal · doi:10.1042/bj20101517 · Cited by 78

Activation of Peroxisome Proliferator–Activated Receptor-β/-δ (PPAR-β/-δ) Ameliorates Insulin Signaling and Reduces SOCS3 Levels by Inhibiting STAT3 in Interleukin-6–Stimulated Adipocytes

Serrano, L., Rodríguez‐Calvo, R., Kochairi, I. E., Palomer, X., Michalik, L., Wahli, W., & Vázquez‐Carrera, M. (2011) · Diabetes · doi:10.2337/db10-0704 · Cited by 80

Dietary interventions for metabolic syndrome: Role of modifying dietary fats

Kien, C. L. (2009) · Current Diabetes Reports · doi:10.1007/s11892-009-0009-6 · Cited by 71

Dietary determinants of subclinical inflammation, dyslipidemia and components of the metabolic syndrome in overweight children: a review

Zimmermann, M. B., & Herter‐Aeberli, I. (2008) · International Journal of Obesity · doi:10.1038/ijo.2008.202 · Cited by 67

Inhibition of Insulin Receptor Gene Expression and Insulin Signaling by Fatty Acid: Interplay of PKC Isoforms Therein

Dey, D., Mukherjee, M., Basu, D., Datta, M., Roy, S. S., Bandyopadhyay, A., & Bhattacharya, S. (2005) · Cellular Physiology and Biochemistry · doi:10.1159/000089847 · Cited by 63

UAS domain of Ubxd8 and FAF1 polymerizes upon interaction with long-chain unsaturated fatty acids

Kim, H., Zhang, H., Meng, D., Russell, G., Lee, J. N., & Ye, J. (2013) · Journal of Lipid Research · doi:10.1194/jlr.m037218 · Cited by 60

Fatty acid binding protein 4 (FABP4) as a potential biomarker reflecting myocardial lipid storage in type 2 diabetes

Rodríguez‐Calvo, R., Girona, J., Rodríguez, M. M., Samino, S., Barroso, E., de Gonzalo‐Calvo, D., Guaita‐Esteruelas, S., Heras, M., van der Meer, R. W., Lamb, H. J., et al. (2019) · Metabolism · doi:10.1016/j.metabol.2019.04.007 · Cited by 63

Lipid induced overexpression of NF-κB in skeletal muscle cells is linked to insulin resistance

Barma, P., Bhattacharya, S., Bhattacharya, A., Kundu, R., Dasgupta, S., Biswas, A., Bhattacharya, S., Roy, S. S., & Bhattacharya, S. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2008.11.014 · Cited by 59

Insulin-stimulated glucose uptake and pathways regulating energy metabolism in skeletal muscle cells: The effects of subcutaneous and visceral fat, and long-chain saturated, n-3 and n-6 polyunsaturated fatty acids

Lam, Y. Y., Hatzinikolas, G., Weir, J. M., Janovská, A., McAinch, A. J., Game, P. A., Meikle, P. J., & Wittert, G. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2011.04.011 · Cited by 60

Different impacts of saturated and unsaturated free fatty acids on COX-2 expression in C2C12myotubes

Kadotani, A., Tsuchiya, Y., Hatakeyama, H., Katagiri, H., & Kanzaki, M. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00293.2009 · Cited by 62

Soy phosphatidylcholine inhibited TLR4-mediated MCP-1 expression in vascular cells

Ishikado, A., Nishio, Y., Yamane, K., Mukose, A., Morino, K., Murakami, Y., Sekine, O., Makino, T., Maegawa, H., & Kashiwagi, A. (2009) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2009.01.010 · Cited by 57

Palmitate-Activated Macrophages Confer Insulin Resistance to Muscle Cells by a Mechanism Involving Protein Kinase C θ and ε

Kewalramani, G., Fink, L. N., Asadi, F., & Klip, A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026947 · Cited by 57

Phenylmethimazole blocks palmitate-mediated induction of inflammatory cytokine pathways in 3T3L1 adipocytes and RAW 264.7 macrophages

McCall, K. D., Holliday, D. K., Dickerson, E., Wallace, B., Schwartz, A. L., Schwartz, C., Lewis, C. J., Kohn, L. D., & Schwartz, F. (2010) · Journal of Endocrinology · doi:10.1677/joe-09-0370 · Cited by 59

Cyclooxygenase 2 Inhibition Exacerbates Palmitate-Induced Inflammation and Insulin Resistance in Skeletal Muscle Cells

Coll, T., Palomer, X., Blanco‐Vaca, F., Escolá‐Gil, J. C., Sánchez, R. M., Laguna, J. C., & Vázquez‐Carrera, M. (2009) · Endocrinology · doi:10.1210/en.2009-0874 · Cited by 56

Palmitate Contributes to Insulin Resistance through Downregulation of the Src-Mediated Phosphorylation of Akt in C2C12 Myotubes

Feng, X., Tian-Zhan, W. A. N. G., Leng, J., Chen, Y., Ji-Bo, L. I. U., Liu, Y., & Wang, W. (2012) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.120107 · Cited by 56

Muscle cells challenged with saturated fatty acids mount an autonomous inflammatory response that activates macrophages

Pillon, N. J., Arane, K., Bilan, P. J., Chiu, T. T., & Klip, A. (2012) · Cell Communication and Signaling · doi:10.1186/1478-811x-10-30 · Cited by 53

Sphingosine Kinase 1 Is Regulated by Peroxisome Proliferator-activated Receptor α in Response to Free Fatty Acids and Is Essential for Skeletal Muscle Interleukin-6 Production and Signaling in Diet-induced Obesity

Ross, J. S., Hu, W. M., Rosen, B. P., Snider, A. J., Obeid, L. M., & Cowart, L. A. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.477786 · Cited by 58

Dietary fat modification in patients with chronic kidney disease: n-3 fatty acids and beyond

Huang, X., Lindholm, B., Stenvinkel, P., & Carrero, J. J. (2013) · Journal of Nephrology · doi:10.5301/jn.5000284 · Cited by 53

Protein tyrosine phosphatase 1B inhibition ameliorates palmitate-induced mitochondrial dysfunction and apoptosis in skeletal muscle cells

Taheripak, G., Bakhtiyari, S., Rajabibazl, M., Pasalar, P., & Meshkani, R. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.09.019 · Cited by 48

Mitofusin 2 deficiency leads to oxidative stress that contributes to insulin resistance in rat skeletal muscle cells

Nie, Q., Wang, C., Song, G., Ma, H., Kong, D., Zhang, X., Gan, K., & Tang, Y. (2014) · Molecular Biology Reports · doi:10.1007/s11033-014-3584-9 · Cited by 47

Overactivation of NF-κB impairs insulin sensitivity and mediates palmitate-induced insulin resistance in C2C12 skeletal muscle cells

Zhang, J., Wu, W., Li, D., Guo, Y., & Ding, H. (2009) · Endocrine · doi:10.1007/s12020-009-9283-y · Cited by 48

Leptin, skeletal muscle lipids, and lipid-induced insulin resistance

Dubé, J. J., Bhatt, B. A., Dedousis, N., Bonen, A., & O'Doherty, R. M. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00133.2007 · Cited by 47

Sunflower Oil Supplementation Has Proinflammatory Effects and Does Not Reverse Insulin Resistance in Obesity Induced by High-Fat Diet in C57BL/6 Mice

Masi, L. N., Martins, A. R., Neto, J. C. R., do Amaral, C. L., Crisma, A. R., Vinolo, M. A. R., Júnior, E. A. D. L., Hirabara, S. M., & Curi, R. (2012) · BioMed Research International · doi:10.1155/2012/945131 · Cited by 47

Effects of palmitate and astaxanthin on cell viability and proinflammatory characteristics of mesenchymal stem cells

Yaghooti, H., Mohammadtaghvaei, N., & Mahboobnia, K. (2019) · International Immunopharmacology · doi:10.1016/j.intimp.2018.12.063 · Cited by 48

Palmitate-induced PTP1B expression is mediated by ceramide-JNK and nuclear factor κB (NF-κB) activation

Mohammadtaghvaei, N., Taheripak, G., Taghikhani, M., & Meshkani, R. (2012) · Cellular Signalling · doi:10.1016/j.cellsig.2012.04.019 · Cited by 42

EPA inhibits the inhibitor of κBα (IκBα)/NF-κB/muscle RING finger 1 pathway in C2C12 myotubes in a PPARγ-dependent manner

Huang, F., Wei, H., Luo, H., Jiang, S., & Peng, J. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114510003703 · Cited by 40

Palmitate and inflammatory state additively induce the expression of PTP1B in muscle cells

Parvaneh, L., Meshkani, R., Bakhtiyari, S., Mohammadtaghvaei, N., Gorgani‐Firuzjaee, S., Taheripak, G., Golestani, A., Foruzandeh, M., Larijani, B. A., & Taghikhani, M. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.04.118 · Cited by 39

Palmitate-induced ER stress and inhibition of protein synthesis in cultured myotubes does not require Toll-like receptor 4

Perry, B. D., Rahnert, J. A., Xie, Y., Zheng, B., Woodworth‐Hobbs, M. E., & Price, S. R. (2018) · PLoS ONE · doi:10.1371/journal.pone.0191313 · Cited by 42

DHA Inhibits Protein Degradation More Efficiently than EPA by Regulating the PPARγ/NFκB Pathway in C2C12 Myotubes

Wang, Y., Lin, Q.-W., Zheng, P.-P., Zhang, J.-S., & Huang, F.-R. (2013) · BioMed Research International · doi:10.1155/2013/318981 · Cited by 38

Oleate dose-dependently regulates palmitate metabolism and insulin signaling in C2C12 myotubes

Capel, F., Cheraïti, N., Acquaviva, C., Hénique, C., Bertrand‐Michel, J., Vianey‐Saban, C., Prip‐Buus, C., & Morio, B. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2016.10.002 · Cited by 37

Erythrocyte saturated fatty acids and systemic inflammation in adults

Mu, L., Mukamal, K. J., & Naqvi, A. Z. (2014) · Nutrition · doi:10.1016/j.nut.2014.04.020 · Cited by 35

Oleic and linoleic fatty acids downregulate Slc2a4/GLUT4 expression via NFKB and SREBP1 in skeletal muscle cells

Poletto, A. C., Furuya, D. T., David-Silva, A., Silva, P. E., Santos, C. L., Corrêa‐Giannella, M. L., Passarelli, M., & Machado, U. F. (2014) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2014.12.001 · Cited by 36

cis-9,trans-11-Conjugated Linoleic Acid Activates AMP-Activated Protein Kinase in Attenuation of Insulin Resistance in C2C12 Myotubes

Qin, H., Liu, Y., Lu, N., Li, Y., & Sun, C. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf900534w · Cited by 35

3T3-L1 Preadipocytes Exhibit Heightened Monocyte-Chemoattractant Protein-1 Response to Acute Fatty Acid Exposure

Dordevic, A. L., Konstantopoulos, N., & Cameron‐Smith, D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0099382 · Cited by 32

Temporal Differences in the Ability of Ethanol to Modulate Endotoxin‐Induced Increases in Inflammatory Cytokines in Muscle Under In Vivo Conditions

Frost, R. A., Nystrom, G. J., Burrows, P. V., & Lang, C. H. (2005) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000171935.06914.5d · Cited by 30

Tumour necrosis factor alpha, interleukin 1 beta and interferon gamma have detrimental effects on equine tenocytes that cannot be rescued by IL-1RA or mesenchymal stromal cell–derived factors

Smith, E. J., Beaumont, R. E., McClellan, A., Sze, C., Lago, E. P., Hazelgrove, L., Dudhia, J., Smith, R. K. W., & Guest, D. J. (2022) · Cell and Tissue Research · doi:10.1007/s00441-022-03726-6 · Cited by 30

Long-chain polyunsaturated fatty acids amend palmitate-induced inflammation and insulin resistance in mouse C2C12 myotubes

Chen, S., Chen, P., Wu, Y., Chen, C., Chen, H., Lii, C., Sun, H., & Liu, K. (2015) · Food & Function · doi:10.1039/c5fo00704f · Cited by 26

Ras Inhibition Induces Insulin Sensitivity and Glucose Uptake

Mor, A., Aizman, E., George, J., & Kloog, Y. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021712 · Cited by 27

Insulin resistance due to lipid-induced signaling defects could be prevented by mahanine

Biswas, A., Bhattacharya, S., Dasgupta, S., Kundu, R., Roy, S. S., Pal, B. C., & Bhattacharya, S. (2009) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-009-0257-4 · Cited by 25

The Effects of Palmitic Acid on Nitric Oxide Production by Rat Skeletal Muscle: Mechanism via Superoxide and iNOS Activation

Lambertucci, R. H., Leandro, C. G., Vinolo, M. A. R., Nachbar, R. T., Silveira, L. R., Hirabara, S. M., Curi, R., & Pithon‐Curi, T. C. (2012) · Cellular Physiology and Biochemistry · doi:10.1159/000343307 · Cited by 25

Lipid accumulation facilitates mitotic slippage-induced adaptation to anti-mitotic drug treatment

Wong, A. X. F., Chen, S., Yang, L. K., Kanagasundaram, Y., & Crasta, K. (2018) · Cell Death Discovery · doi:10.1038/s41420-018-0127-5 · Cited by 23

β-Arrestins: multifunctional signaling adaptors in type 2 diabetes

Feng, X., Wang, W., Liu, J., & Liu, Y. (2010) · Molecular Biology Reports · doi:10.1007/s11033-010-0389-3 · Cited by 23

Trans‐10, cis‐12 conjugated linoleic acid inhibits skeletal muscle differentiation and GLUT4 expression independently from NF‐κB activation

Hommelberg, P. P. H., Plat, J., Remels, A. H. V., van Essen, A. L. M., KELDERS, M. C. J. M., Mensink, R. P., Schols, A. M. W. J., & LANGEN, R. C. J. (2010) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201000103 · Cited by 23

Effects of polymorphisms in nucleotide-binding oligomerization domains 1 and 2 on biomarkers of the metabolic syndrome and type II diabetes

Cuda, C., Badawi, A. F., Karmali, M. A., & El‐Sohemy, A. (2012) · Genes & Nutrition · doi:10.1007/s12263-012-0287-5 · Cited by 24

Local activation of the IκK-NF-κB pathway in muscle does not cause insulin resistance

Polkinghorne, E., Lau, Q., Cooney, G. J., Kraegen, E. W., & Cleasby, M. E. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00537.2007 · Cited by 21

The effect of omega-3 polyunsaturated fatty acids on the inflammatory response of the amnion

Frew, L., Sugiarto, N., Rajagopal, S. P., He, J., Leask, R., Norman, J. E., Riley, S. C., & Stock, S. J. (2013) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2013.07.001 · Cited by 20

Effect of Short-Chain Fatty Acids on Inflammatory and Metabolic Function in an Obese Skeletal Muscle Cell Culture Model

Van, K., Burns, J. L., & Monk, J. M. (2024) · Nutrients · doi:10.3390/nu16040500 · Cited by 19

Cardiomyocyte lipotoxicity is mediated by Il-6 and causes down-regulation of PPARs

Haffar, T., Bérubé‐Simard, F., & Bousette, N. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.02.062 · Cited by 20

18-Carbon polyunsaturated fatty acids ameliorate palmitate-induced inflammation and insulin resistance in mouse C2C12 myotubes

Chen, P., Wang, J. C. K., Lin, Y., Li, C., Tsai, C.-W., Liu, T.-C., Chen, H., Huang, C., Lii, C., & Liu, K. (2015) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2014.12.007 · Cited by 19

Hybrid training of voluntary and electrical muscle contractions decreased fasting blood glucose and serum interleukin-6 levels in elderly people: a pilot study

Kawaguchi, T., Shiba, N. N., Takano, Y., Maeda, T., & Sata, M. (2011) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h10-108 · Cited by 20

Stachydrine alleviates lipid-induced skeletal muscle insulin resistance via AMPK/HO-1-mediated suppression of inflammation and endoplasmic reticulum stress

Jung, T. W., Kim, H., Park, S. Y., Cho, W., Oh, H., Lee, H. J., El‐Aty, A. M. A., Hacımüftüoğlu, A., & Jeong, J. H. (2022) · Journal of Endocrinological Investigation · doi:10.1007/s40618-022-01866-8 · Cited by 18

Palmitate Potentiates Lipopolysaccharide-Induced IL-6 Production via Coordinated Acetylation of H3K9/H3K18, p300, and RNA Polymerase II

Kochumon, S., JACOB, T. K., Koshy, M., Al‐Rashed, F., Sindhu, S. T. A. K., Al‐Ozairi, E., Al‐Mulla, F., Rosen, E. D., & Ahmad, R. (2022) · The Journal of Immunology · doi:10.4049/jimmunol.2100928 · Cited by 19

Acute Changes in Non-esterified Fatty Acids in Patients with Type 2 Diabetes Receiving Bariatric Surgery

Nemati, R., Lu, J., Tura, A., Smith, G., & Murphy, R. (2016) · Obesity Surgery · doi:10.1007/s11695-016-2323-9 · Cited by 17

Contraction-induced signaling: evidence of convergent cascades in the regulation of muscle fatty acid metabolism

Turcotte, L. P., & Abbott, M. J. (2012) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y2012-124 · Cited by 15

De novo lipid synthesis in cardiovascular tissue and disease

Khan, T. J., Semenkovich, C. F., & Zayed, M. A. (2024) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2024.119066 · Cited by 12

Adipokines promote lipotoxicity in human skeletal muscle cells

Taube, A., Lambernd, S., van Echten‐Deckert, G., Eckardt, K., & Eckel, J. (2012) · Archives of Physiology and Biochemistry · doi:10.3109/13813455.2012.688751 · Cited by 14

Trans Fatty Acid‐Induced NF‐κB Activation Does Not Induce Insulin Resistance in Cultured Murine Skeletal Muscle Cells

Hommelberg, P. P. H., LANGEN, R. C. J., Schols, A. M. W. J., van Essen, A. L. M., Snepvangers, F. J. M., Mensink, R. P., & Plat, J. (2010) · Lipids · doi:10.1007/s11745-010-3388-1 · Cited by 11

Saturated Fatty Acid-Induced Endoplasmic Reticulum Stress and Insulin Resistance Are Prevented by Imoxin in C2C12 Myotubes

Eo, H., & Valentine, R. J. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.842819 · Cited by 10

The beneficial impact of curcumin on cardiac lipotoxicity

Abolfazli, S., Butler, A. E., Kesharwani, P., & Sahebkar, A. (2024) · Journal of Pharmacy and Pharmacology · doi:10.1093/jpp/rgae102 · Cited by 10

Extracellular ATP Increases Glucose Metabolism in Skeletal Muscle Cells in a P2 Receptor Dependent Manner but Does Not Contribute to Palmitate-Induced Insulin Resistance

Cruz, A. M., & Beall, C. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.567378 · Cited by 8

Effects of Aronia melanocarpa juice on plasma and liver phospholipid fatty acid composition in Wistar rats

Zec, M. M., Debeljak-Martačić, J., Ranković, S., Pokimica, B., Tomić, M., Ignjatović, Đ., Glibetić, M., & Popović, T. B. (2017) · Acta veterinaria · doi:10.1515/acve-2017-0010 · Cited by 8

El ácido palmítico estimula la producción de interleucina 6 en células musculares esqueléticas por activación de la proteincinasa C y el factor nuclear κB

Jové, M., Planavila, A., & Vázquez‐Carrera, M. (2005) · Clínica e Investigación en Arteriosclerosis · doi:10.1016/s0214-9168(05)73353-2 · Cited by 1

Palmitate induces tumor necrosis factor-α expression in C2C12 skeletal muscle cells by a mechanism involving protein kinase C and nuclear factor-κB activation

Jové, M., Planavila, A., Sánchez, R. M., Merlos, M., Laguna, J. C., & Vázquez-Carrera, M. (2006) · Endocrinology · doi:10.1210/en.2005-0440 · Cited by 172

Palmitate, but Not Unsaturated Fatty Acids, Induces the Expression of Interleukin-6 in Human Myotubes through Proteasome-dependent Activation of Nuclear Factor-κB

Weigert, C., Brodbeck, K., Staiger, H., Kausch, C., Machicao, F., Häring, H. U., & Schleicher, E. D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312692200 · Cited by 269

Lipid induced overexpression of NF-κB in skeletal muscle cells is linked to insulin resistance

Barma, P., Bhattacharya, S., Bhattacharya, A., Kundu, R., Dasgupta, S., Biswas, A., Bhattacharya, S., Roy, S. S., & Bhattacharya, S. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2008.11.014 · Cited by 59

Agonist-induced activation releases peroxisome proliferator-activated receptor β/δ from its inhibition by palmitate-induced nuclear factor-κB in skeletal muscle cells

Jové, M., Laguna, J. C., & Vázquez‐Carrera, M. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2005.02.002 · Cited by 24