Cited by 334Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismPeroxisome Proliferator-Activated Receptors

The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.

Macrophage-Secreted Factors Impair Human Adipogenesis: Involvement of Proinflammatory State in Preadipocytes

Lacasa, Danièle, Taleb, Soraya, Keophiphath, Mayoura, Miranville, Alexandra, Clement, Karine·2007·Endocrinology

DOI 10.1210/en.2006-0687

Open this paper in CoChat — free account

Abstract

Obesity is considered a chronic low-grade inflammatory state. The white adipose tissue produces a variety of inflammation-related proteins whose expression is increased in obese subjects. The nonadipose cell fraction, which includes infiltrated macrophages, is a determinant source of inflammation-related molecules within the adipose tissue. Our working hypothesis is that macrophage infiltration affects fat expansion through a paracrine action on adipocyte differentiation. Human primary preadipocytes were then differentiated in the presence of conditioned media obtained from macrophages differentiated from blood monocytes. Preadipocytes treated by macrophage-conditioned medium displayed marked reduction of adipogenesis as assessed by decreased cellular lipid accumulation and reduced gene expression of adipogenic and lipogenic markers. In addition to this effect, the activation of macrophages by lipopolysaccharides stimulated nuclear factor κB signaling, increased gene expression and release of proinflammatory cytokines and chemokines, and induced preadipocyte proliferation. This phenomenon was associated with increased cyclin D1 gene expression and maintenance of the fibronectin-rich matrix. Anti-TNFα neutralizing antibody inhibits the inflammatory state of preadipocytes positioning TNFα as an important mediator of inflammation in preadipocytes. Strikingly, conditioned media produced by macrophages isolated from human adipose tissue exerted comparable effects with activated macrophages, i.e. decreased adipogenesis and increased inflammatory state in the preadipocytes. These data show that macrophage-secreted factors inhibit the formation of mature adipocytes, suggesting possible role in limiting adipose tissue expansion in humans.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1210/en.2006-0687

Cites

42 of 42 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

1 retracted

Cytokines suppress adipogenesis and PPAR-γ function through the TAK1/TAB1/NIK cascade
Suzawa, M., Takada, I., Yanagisawa, J., Ohtake, F., Ogawa, S., Yamauchi, T., Kadowaki, T., Takeuchi, Y., Shibuyà, H., Gotoh, Y., et al. (2003) · Nature Cell Biology · doi:10.1038/ncb942 · Cited by 292
Retracted
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760
Alternative activation of macrophages
Gordon, S. (2003) · Nature Reviews Immunology · doi:10.1038/nri978 · Cited by 6,189
Understanding Adipocyte Differentiation
Gregoire, F. M., Smas, C. M., & Sul, H. S. (1998) · Physiological Reviews · doi:10.1152/physrev.1998.78.3.783 · Cited by 2,406
Adipokines: inflammation and the pleiotropic role of white adipose tissue
Trayhurn, P., & Wood, I. S. (2004) · British Journal of Nutrition · doi:10.1079/bjn20041213 · Cited by 2,210
PPARγ Is Required for the Differentiation of Adipose Tissue In Vivo and In Vitro
Rosen, E. D., Sarraf, P., Troy, A. E., Bradwin, G., Moore, K. J., Milstone, D. S., Spiegelman, B. M., & Mortensen, R. M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80211-7 · Cited by 2,081
Comparison of the Release of Adipokines by Adipose Tissue, Adipose Tissue Matrix, and Adipocytes from Visceral and Subcutaneous Abdominal Adipose Tissues of Obese Humans
Fain, J. N., Madan, A. K., Hiler, M. L., Cheema, P. S., & Bahouth, S. W. (2004) · Endocrinology · doi:10.1210/en.2003-1336 · Cited by 1,619
C/EBPα induces adipogenesis through PPARγ: a unified pathwayPreprint
Rosen, E. D., Hsu, C.-H., Wang, X., Sakai, S., Freeman, M. W., Gonzalez, F. J., & Spiegelman, B. M. (2002) · Genes & Development · doi:10.1101/gad.948702 · Cited by 1,497
CCR2 modulates inflammatory and metabolic effects of high-fat feeding
Weisberg, S. P., Hunter, D., Huber, R., Lemieux, J., Slaymaker, S., Vaddi, K., Charo, I., Leibel, R. L., & Jr., A. W. F. (2006) · Journal of Clinical Investigation · doi:10.1172/jci24335 · Cited by 1,497

Flagged first, then by citations

Show all 42 references

Sorted by citations

Items 201–300 of 334

Growth hormone (GH) differentially regulates NF-kB activity in preadipocytes and macrophages: implications for GH’s role in adipose tissue homeostasis in obesity
Kumar, P. A., Chitra, P. S., Lü, C., Sobhanaditya, J., & Menon, R. K. (2014) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-014-0321-8 · Cited by 15
The activation state of macrophages alters their ability to suppress preadipocyte apoptosis
Molgat, A. S. D., Gagnon, A., Foster, C. E., & Sorisky, A. (2012) · Journal of Endocrinology · doi:10.1530/joe-12-0114 · Cited by 15
PCR array and protein array studies demonstrate that IL-1β(interleukin-1β) stimulates the expression and secretion of multiple cytokines and chemokines in human adipocytes
Alomar, S. Y., Zaibi, M. S., Kępczyńska, M. A., Gentili, A., ALKHURIJI, A. F., Mansour, L. A., Dar, J. A., & Trayhurn, P. (2015) · Archives of Physiology and Biochemistry · doi:10.3109/13813455.2015.1087034 · Cited by 15
Tackling the effects of extracellular vesicles in fibrosis
Martín-Taboada, M., Corrales, P., Medina‐Gómez, G., & Vila‐Bedmar, R. (2022) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2022.151221 · Cited by 14
Inflammation Precedes Fat Deposition in an Experimental Model of Lymphedema
Cuadrado, G. D. A., Andrade, M., Ariga, S. K. K., de Lima, T. M., & de Souza, H. P. (2020) · Lymphatic Research and Biology · doi:10.1089/lrb.2020.0061 · Cited by 13
Effects of macrophage regulation on fat grafting survival: Improvement, mechanisms, and potential application—A review
Chen, Q., Liu, S., Cao, L., Yu, M., & Wang, H. (2021) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.14295 · Cited by 15
Cellular and Molecular Basis of Functional Differences among Fat Depots
Thomou, T., Tchkonia, T., & Kirkland, J. L. (2010) · Wiley eBooks · doi:10.1002/9783527629527.ch2 · Cited by 16
Dynamic Roles and Expanding Diversity of Adipose Tissue Macrophages in Obesity
Soedono, S., Julietta, V., Nawaz, H., & Cho, K. W. (2024) · Journal of Obesity & Metabolic Syndrome · doi:10.7570/jomes24030 · Cited by 16
Histology of Adipose Tissue
Tordjman, J. (2012) · Springer eBooks · doi:10.1007/978-2-8178-0343-2_6 · Cited by 15
Alterations to adipose tissue morphology during inflammatory arthritis is indicative of vasculopathology in DBA/1 mice
Sime, K., Choy, E., & Williams, A. S. (2017) · Adipocyte · doi:10.1080/21623945.2017.1295174 · Cited by 13
Brucella abortus Infection Modulates 3T3-L1 Adipocyte Inflammatory Response and Inhibits Adipogenesis
Viglietti, A. I. P., Giambartolomei, G. H., Quarleri, J. F., & Delpino, M. V. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.585923 · Cited by 13
Differentiation of human adipose stromal cells in vitro into insulin-sensitive adipocytes
Huttala, O., Mysore, R., Sarkanen, J., Heinonen, T., Olkkonen, V. M., & Ylikomi, T. J. (2016) · Cell and Tissue Research · doi:10.1007/s00441-016-2409-7 · Cited by 12
Lipoteichoic acid induces surfactant protein-A biosynthesis in human alveolar type II epithelial cells through activating the MEK1/2-ERK1/2-NF-κB pathway
Liu, F.-L., Chuang, C.-Y., Tai, Y., Tang, H.-L., Chen, T., Chen, T.-L., & Chen, R. (2012) · Respiratory Research · doi:10.1186/1465-9921-13-88 · Cited by 12
Effect of High Glucose Concentration on Human Preadipocytes and Their Response to Macrophage-Conditioned Medium
Peshdary, V., Gagnon, A., & Sorisky, A. (2016) · Canadian Journal of Diabetes · doi:10.1016/j.jcjd.2016.02.012 · Cited by 12
La fibrose du tissu adipeux
Marcelin, G., & Clément, K. (2018) · médecine/sciences · doi:10.1051/medsci/20183405015 · Cited by 14
Enhancement of adipogenesis induction by conditioned media obtained from cancer cells
Hirano, T., Morii, H., Nakazawa, K., Murakami, D., Yamashita, A., Asahi, J., Orimo, H., Tamae, K., & TOKURA, Y. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.04.005 · Cited by 12
Advanced oxidation protein products inhibit differentiation and activate inflammation in 3T3‐L1 preadipocytes
Zhou, Q. G., Peng, X., Hu, L. L., Xie, D., Zhou, M., & Hou, F. F. (2010) · Journal of Cellular Physiology · doi:10.1002/jcp.22189 · Cited by 11
Analysis of the Cellular Infiltration of Benzyl-Esterified Hyaluronan Sponges Implanted in Rats
Rhodes, N. P., Bartolo, C. D., & Hunt, J. A. (2007) · Biomacromolecules · doi:10.1021/bm070368p · Cited by 11
Circulating sex steroids coregulate adipose tissue immune cell populations in healthy men
Rubinow, K. B., Chao, J. H., Hagman, D. K., Kratz, M., Yserloo, B. V., Gaikwad, N. W., Amory, J. K., & Page, S. T. (2017) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00075.2017 · Cited by 11
Serum MMP‐3 and its association with central arterial stiffness among young adults is moderated by smoking and BMI
Iannarelli, N. J., MacNeil, A. J., Dempster, K. S., Wade, T. J., & O’Leary, D. D. (2021) · Physiological Reports · doi:10.14814/phy2.14920 · Cited by 9
Obesity activates immunomodulating properties of mesenchymal stem cells in adipose tissue with differences between localizations
Lefevre, C., Chartoire, D., Ferraz, J. C., Verdier, T., Pinteur, C., Chanon, S., Pesenti, S., Vieille‐Marchiset, A., Genestier, L., Vidal, H., et al. (2021) · The FASEB Journal · doi:10.1096/fj.202002046rr · Cited by 12
Human Monocytes Accelerate Proliferation and Blunt Differentiation of Preadipocytes in Association With Suppression of C/Ebpα mRNA
Couturier, J. P., Patel, S. G., Iyer, D., Balasubramanyam, A., & Lewis, D. E. (2011) · Obesity · doi:10.1038/oby.2011.275 · Cited by 12
Human Milk Drives the Intimate Interplay Between Gut Immunity and Adipose Tissue for Healthy Growth
van den Elsen, L. W. J., & Verhasselt, V. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.645415 · Cited by 9
In vivo imaging of obesity-induced inflammation in adipose tissue
Fushiki, H., Hayakawa, Y., Gomori, A., Seo, T., Tewari, S., Ozaki, S., & Yoshimoto, R. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.11.119 · Cited by 9
Neuroendocrine Inflammatory Responses in Overweight/Obese Infants
Camargos, A. C. R., Mendonça, V. A., de Andrade, C. A., Oliveira, K. S. C., Tossige-Gomes, R., Rocha‐Vieira, E., Neves, C. D. C., Vieira, É. L. M., Leite, H. R., Oliveira, M. X., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0167593 · Cited by 9
Navigating the Adipocyte Precursor Niche: Cell-Cell Interactions, Regulatory Mechanisms and Implications for Adipose Tissue Homeostasis
Kesharwani, D., & Brown, A. C. (2024) · Journal of Cellular Signaling · doi:10.33696/signaling.5.114 · Cited by 9
Chemically induced hypoxia promotes differential outcomes over preadipocyte– or adipocyte–macrophage communication
Avila-George, K., Ramos-Olivares, K., Vasquez-Munoz, K., Villanueva-Morales, V., Reyes‐Farias, M., Quintero, P., Garcı́a, L., & García‐Díaz, D. F. (2017) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2017.1285318 · Cited by 8
The anti‐adipogenic effect of peripheral blood mononuclear cells is absent with PCSK 9 loss‐of‐function variants
Gagnon, A., Ooi, T. C., Cousins, M., Favreau, C., Henry, K., Landry, A., & Sorisky, A. (2016) · Obesity · doi:10.1002/oby.21656 · Cited by 9
Activated macrophages as key mediators of capsule formation on adipose constructs in tissue engineering chamber models
Zhan, W., & Lu, F. (2017) · Cell Biology International · doi:10.1002/cbin.10731 · Cited by 8
Development of in vitro three-dimensional drug screening system for obesity-related metabolic syndrome
Choi, K. J., Lee, J. H., Park, S. B., Na, Y.-J., Jung, W. H., Lee, H., & Kim, K. Y. (2022) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2022.02.002 · Cited by 9
Imatinib induces body mass changes in women with chronic myeloid leukemia
Breccia, M., Salaroli, A., Serrao, A., Zacheo, I., & Alimena, G. (2013) · Annals of Hematology · doi:10.1007/s00277-013-1752-y · Cited by 8
linc-ADAIN, a human adipose lincRNA, regulates adipogenesis by modulating KLF5 and IL-8 mRNA stability
O’Reilly, M. E., Ho, S., Coronel, J., Zhu, L., Liu, W., Xue, C., Kim, E., Cynn, E., Matias, C. V., Soni, R. K., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114240 · Cited by 7
6.22 Adipose Tissue Engineering
Gomillion, C. T., & Burg, K. J. L. (2017) · Elsevier eBooks · doi:10.1016/b978-0-08-100691-7.00032-x · Cited by 9
Screening for anti-adipogenic, pro-lipolytic and thermogenic plant extracts by models associating intestinal epithelial cells with human adipose cells
Guillemet, D., Belles, C., Gomes, A., Azalbert, V., André, M., Faresse, N., Burcelin, R., Lagarde, J., Lacasa, D., & Kéophiphath, M. (2022) · European Journal of Nutrition · doi:10.1007/s00394-021-02794-8 · Cited by 7
Self-citation
Adipocyte Precursors: Developmental Origins, Self-Renewal, and Plasticity
Dani, C., & Billon, N. (2011) · Springer eBooks · doi:10.1007/978-1-4614-0965-6_1 · Cited by 7
Bone marrow-derived mesenchymal stem cells ameliorate nephrosis through repair of impaired podocytes
Chen, Y., Chen, J., Wan, J., Gao, N., Cui, J., You, D., & Zou, Z. (2017) · Clinical and investigative medicine · doi:10.25011/cim.v40i1.28050 · Cited by 6
Subcutaneous Adipocyte Adenosine Triphosphate Levels in HIV Infected Patients
Gojanovich, G. S., Shikuma, C. M., Milne, C. I. P., Libutti, D. E., Chow, D. C., & Gerschenson, M. (2019) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2019.0121 · Cited by 6
Inflammation et immunité : implications dans l’obésité et le diabète de type 2
Khan, N. A. (2006) · Oléagineux Corps gras Lipides · doi:10.1051/ocl.2006.0047 · Cited by 8
Inflammation du tissu adipeux au cours de l’obésité
Poitou, C., Dalmas, É., & Clément, K. (2013) · Springer eBooks · doi:10.1007/978-2-8178-0332-6_20 · Cited by 6
Lifestyle Intervention and Fatty Liver Disease: the Importance of Both Disrupting Inflammation and Reducing Visceral Fat
Malavazos, A. E., Gobbo, G. F. D., Zelaschi, R., & Cereda, E. (2009) · Hepatology · doi:10.1002/hep.23409 · Cited by 6
Harnessing Regenerative Science in Aesthetic Surgery: The Biologically Driven Future
Olivas, C. G., Shauly, O., Hutchison, D. M., & Gould, D. J. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14176205 · Cited by 9
Adipose Tissue Engineering
Gomillion, C. T., & Burg, K. J. L. (2011) · Elsevier eBooks · doi:10.1016/b978-0-08-055294-1.00189-6 · Cited by 6
Adipose Stem Cells and Adipogenesis
White, U. A., & Tchoukalova, Y. D. (2014) · Humana Press eBooks · doi:10.1007/978-1-62703-770-9_2 · Cited by 5
Is Adipose Tissue the Fountain of Youth? The Impact of Adipose Stem Cell Aging on Metabolic Homeostasis, Longevity, and Cell-Based Therapies
Gijsen, H. S. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-55035-6_16 · Cited by 6
Cecal Ligation and Puncture-Induced Sepsis Promotes Brown Adipose Tissue Inflammation Without Any Impact on Expression of Thermogenic-Related Genes
Moreno‐Navarrete, J. M., Comas, F., de Jager, V. D., Fernández‐Real, J. M., & Bouma, H. R. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.692618 · Cited by 5
Functional diversity of human adipose tissue revealed by spatial mapping
Schéele, C., & Wolfrum, C. (2021) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00582-2 · Cited by 6
Macrophages and Inflammation
Dalmas, É., Tordjman, J., Guerre-Millo, M., & Clément, K. (2011) · Springer eBooks · doi:10.1007/978-1-4614-0965-6_6 · Cited by 5
Macrophages and Inflammation
Dalmas, É., Tordjman, J., Guerre-Millo, M., & Clément, K. (2017) · Springer eBooks · doi:10.1007/978-3-319-52031-5_7 · Cited by 5
The Sick Adipocyte Theory: The Forces of Clustering at Glance
Bermúdez, V., Rojas, J., Aguirre, M., Cano, C., Arráiz, N., Silva, C., Lima, M. A. M., Cano, R., Fonseca, E., & Velasco, M. (2011) · InTech eBooks · doi:10.5772/20963 · Cited by 4
Obésité et troubles respiratoires nocturnes chez l’enfant
Dubern, B. (2011) · Archives de Pédiatrie · doi:10.1016/j.arcped.2011.07.003 · Cited by 4
Short-chain fatty acids increase expression and secretion of stromal cell-derived factor-1 in mouse and human pre-adipocytes
Vangaveti, V., Rush, C. M., Thomas, L., Rasalam, R. R., Malabu, U. H., McCoombe, S. G., & Kennedy, R. L. (2014) · HORMONES · doi:10.14310/horm.2002.1519 · Cited by 4
Anthropometric measures of obesity-their association with type 2 diabetes and hypertension across ethnic groups
Nyamdorj, R. (2010) · Työväentutkimus Vuosikirja · Cited by 4
The positive correlation between the triglyceride glucose-body mass index and the presence and severity of early-onset coronary artery disease
Liu, R., Li, J., Sun, Z., Zhou, T., Zhao, C., Tian, Q., Guo, J.-J., & Xuan, C. (2025) · Annals of Medicine · doi:10.1080/07853890.2025.2564277 · Cited by 3
Implications of2H-labeling of DNA protocol to measure in vivo cell turnover in adipose tissue
White, U. A., & Tchoukalova, Y. D. (2012) · Adipocyte · doi:10.4161/adip.20817 · Cited by 3
Adipokines: linking obesity and cardiovascular disease
Bell-Anderson, K. S. (2007) · Expert Review of Endocrinology & Metabolism · doi:10.1586/17446651.3.1.61 · Cited by 3
Phosphatidylserine, another player in macrophage recruitment in white adipose tissue?
Renes, J. (2010) · Adipobiology · doi:10.14748/adipo.v2.257 · Cited by 3
Histologie du tissu adipeux blanc normal et pathologique
Tordjman, J. (2013) · Obésité · doi:10.1007/s11690-013-0404-7 · Cited by 5
CARACTERÍSTICAS INFLAMATORIAS DE LA OBESIDAD
Marcela Reyes, J. (2010) · Revista chilena de nutrición · doi:10.4067/s0717-75182010000400011 · Cited by 3
Optimal time for the addition of non-corticosteroid immunosuppressants in myasthenia gravis: a single-center retrospective study in China
Ma, J., Chen, D., Yi, F., Song, J., Luo, S., Zhong, H., Xi, J., Wu, Z., Li, Z., & Zhao, C. (2024) · Frontiers in Neurology · doi:10.3389/fneur.2024.1474508 · Cited by 2
Postnatal Immune Dysfunction and Its Impact on Growth Parameters
DeWitt, J. C., & Dietert, R. R. (2011) · Springer eBooks · doi:10.1007/978-1-4419-1795-9_43 · Cited by 2
Remodeling Phenotype of Macrophages in steroid-induced osteonecrosis: switching from M1 to M2 polarization
(2015) · Macrophage · doi:10.14800/macrophage.1007 · Cited by 2
Características biológicas del tejido adiposo: el adipocito como célula endocrina
Marcela, R. J. (2012) · Revista Médica Clínica Las Condes · doi:10.1016/s0716-8640(12)70290-0 · Cited by 2
L’obésité, une maladie en soi
Basdevant, A., & Ciangura, C. (2010) · Bulletin de l Académie Nationale de Médecine · doi:10.1016/s0001-4079(19)32345-3 · Cited by 8
L’adipogenèse des tissus adipeux blancs : influence du microenvironnement
Boulet, N., Estève, D., Bouloumié, A., & Galitzky, J. (2013) · Obésité · doi:10.1007/s11690-013-0412-7 · Cited by 2
Tejido Adiposo ¿amigo o enemigo?
López, V. (2021) · Ediciones de la Universidad de Castilla-La Mancha eBooks · doi:10.18239/atenea_2021.23.03 · Cited by 1
Adipose Tissue Inflammation in Obesity
Poitou, C., Dalmas, É., & Clément, K. (2012) · Springer eBooks · doi:10.1007/978-2-8178-0343-2_20 · Cited by 2
α-Naphthoflavone modulates inflammatory response in adipocytes-macrophages interaction through NFκB signaling.
Sun, Y., Xie, M., Huang, T., Zhang, X., Lei, S.-C., Shi, Q., Wang, S., Fan, C., & Zhang, J. (2014) · Europe PMC (PubMed Central) · Cited by 1
Cellular Remodeling during the Growth of the Adipose Tissue
Sengenès, C., Bourlier, V., Galitzky, J., Zakaroff‐Girard, A., Lafontan, M., & Bouloumié, A. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-374995-6.10017-9 · Cited by 1
Histology of normal and pathological white adipose tissue
Tordjman, J. (2013) · Obésité · Cited by 1
Inflammatory Cross-Talk Between Short Sleep Duration and Obesity in Development of Insulin Resistance: Narrative Review
Gangwar, A. K., Rawat, A., Tiwari, S., Kumar, S., & Upadhyay, P. K. (2020) · Sleep and Vigilance · doi:10.1007/s41782-020-00115-3 · Cited by 1
Pathological Alteration of Human Adipose Tissue in Obesity
Clément, K. (2010) · Research and perspectives in endocrine interactions · doi:10.1007/978-3-642-13517-0_1 · Cited by 1
Le tissu adipeux : un acteur majeur du syndrome inflammatoire de l’obésité ?
Poitou, C., & Clément, K. (2007) · Cahiers de Nutrition et de Diététique · doi:10.1016/s0007-9960(07)88707-4 · Cited by 1
Alimentación y cerebro
Castillo Sarmiento, C. A., & Rodríguez-Martín, B. (2021) · Ediciones de la Universidad de Castilla-La Mancha eBooks · doi:10.18239/atenea_2021.23.00 · Cited by 2
Adipokines, Inflammation, and Obesity
Clément, K. (2010) · Wiley eBooks · doi:10.1002/9783527629527.ch14 · Cited by 1
Development of obesity-induced inflammation and insulin resistance: The role of adipose tissue, fatty acids, and toll-like receptors
Davis, J. E. (2008) · Iowa State University Digital Repository (Iowa State University) · doi:10.31274/etd-180810-1101 · Cited by 1
Nouveaux regards sur les déterminants de l’obésité
Basdevant, A., & Ciangura, C. (2009) · Bulletin de l Académie Nationale de Médecine · doi:10.1016/s0001-4079(19)32465-3 · Cited by 1
The Expression of Inflammatory Genes in 3T3-L1 Adipocytes Exhibits a Memory to Stimulation by Macrophage SecretionsPreprint
Hancock, D., Meng, L., Holliday, M., Yuwono, N. L., Zhang, N., & Denyer, G. S. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/336610 · Cited by 1
TGF-β and Metabolic Homeostasis
Bennett, G., & Rane, S. G. (2013) · Springer eBooks · doi:10.1007/978-4-431-54409-8_18
Quelle implication pour la cathepsine S dans l’obésité ?
Naour, N., Taleb, S., Guerre-Millo, M., & Clément, K. (2007) · Obésité · doi:10.1007/s11690-007-0071-7
Self-citation
Oxidised fatty acid derivatives and their putative receptors in atherosclerosis and diabetes
Vangaveti, V. (2011) · ResearchOnline - JCU (James Cook University) · doi:10.25903/ymvt-ma64
Possíveis impactos da cirurgia bariátrica sobre a saúde periodontal de indivíduos obesos. Determinação do perfil microbiológico e imunológico.
Nishiyama, S. A. B. (2013) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.42.2013.tde-26062014-141424 · Cited by 23
Progresión del Síndrome Metabólico desde el feto a la adolescencia. Cuando la inflamación toca la puerta
Aguirre, M., Rojas, J., & Souki, A. J. (2011)
THE ROLE OF RENIN IN THE ADIPOSE TISSUE RENIN-ANGIOTENSIN SYSTEM
Fowler, J. D. (2009) · University of Minnesota Digital Conservancy (University of Minnesota)
Histologie et histopathologie du tissu adipeux dans l’obésité
Tordjman, J. (2013) · Springer eBooks · doi:10.1007/978-2-8178-0332-6_6 · Cited by 1
Understanding adipokine secretion and adipocyte-macrophage cellular interactions, in search for the molecular basis of insulin sensitivity and resistance
Xie, L. (2008) · K-State Research Exchange (Kansas State University)
Que devient le tissu adipeux dans l’obésité ?
Clément, K., & Guerre-Millo, M. (2011) · Cahiers de Nutrition et de Diététique · doi:10.1016/j.cnd.2011.06.003
Efeitos da atorvastatina sobre a inflamação e resistência à insulina em camundongos obesos.
Furuya, D. T. (2008) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.42.2008.tde-16032009-125905
The role of the farnesoid X receptor in metabolic control
Stroeve, J. H. M. (2011) · University of Groningen research database (University of Groningen / Centre for Information Technology)
Pentoxifylline in the management of metabolic syndrome and chronic hepatitis C
Metwally, A. H. (2014) · Medical Hypotheses · doi:10.1016/j.mehy.2014.10.020
A Role for PFKFB3/IPFK2 in Overnutrition-Associated Adipose Tissue and Intestine Inflammatory Responses and Insulin Resistance
Guo, X. (2013) · OakTrust (Texas A&M University Libraries)
Understanding The Regulation Of Adipogenesis And Adipocyte Metabolism In Obesity
Zhao, M. (2015) · University of Minnesota Digital Conservancy (University of Minnesota)
Effects of Chronic Insulin and High Glucose on Insulin-Stimulated Responses in Human Preadipocytes
Bilali, J. E. (2016) · uO Research (University of Ottawa) · doi:10.20381/ruor-5962
Changes in Cardiotrophin-1 and Fibroblast Growth Factor-21 with Weight Loss
Bowers, R. L. (2009)
Osteopontin action on adipose tissue macrophages and adipocytes
Gollinger, K. (2008) · University of Vienna · doi:10.25365/thesis.1671
THE ROLE OF DIETARY FAT AND CARBOHYDRATES IN DEVELOPMENT OF ADIPOSE TISSUE INFLAMMATION
Ngo, H. T. (2009) · NORA - Norwegian Open Research Archives
Expression and Function Analysis of Cholinergic Components nAChRα7 in Preadipocytes
Wu, J., Yang, Y., & Xia, Z. (2008) · Zhongguo shengwu huaxue yu fenzi shengwu xuebao
Effects of nutrients and exercise on skeletal muscle and adipose tissue
Rokling-Andersen, M. H. (2009) · NORA - Norwegian Open Research Archives
Effects of Macrophage-conditioned Medium on Preadipocyte Cyclin-dependent Kinase Regulation During Adipogenesis
Ide, J. C. (2011) · Library and Archives Canada (Government of Canada) · doi:10.20381/ruor-4408
Effect of Glucose on Human Adipogenesis and its Regulation by Macrophages
Peshdary, V. (2016) · uO Research (University of Ottawa) · doi:10.20381/ruor-838
Leading Opinion Inflammatory signals in the development of tissue-engineered soft tissue $
Rhodes, N. P. (2007)

Authors: Lacasa, D., Taleb, S., Keophiphath, M., Miranville, A., & Clement, K.
Affiliations: Inserm (FR)
Goethe University Frankfurt (DE)
ORCID: Taleb, Soraya
Venue: Endocrinology
Publisher: The Endocrine Society
Published: 2007-02-01
Volume: 148
Issue: 2
Pages: 868-877
ISSN: 0013-7227 (ISSN-L)
1945-7170
DOI: 10.1210/en.2006-0687
OpenAlex: W2121845219
Cited by: 334
References: 42
Citations by year: 2026: 4 · 2025: 3 · 2024: 12 · 2023: 10 · 2022: 12 · 2021: 19 · 2020: 14 · 2019: 10 · 2018: 15 · 2017: 18 · 2016: 19 · 2015: 12 · 2014: 19 · 2013: 22 · 2012: 16
FWCI: 17.32
Type: journal article
Language: en
Open access: closed
Locations: Endocrinology (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Funders: Institut National de la Santé et de la Recherche Médicale
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Keywords: adipogenesis, preadipocytes, obesity, low-grade inflammation, macrophage infiltration, paracrine signaling, TNF-α, NF-κB signaling, lipopolysaccharide, inflammatory cytokines, chemokines, cyclin D1, adipose tissue expansion
MeSH terms: Adipose Tissue, Cell Differentiation, Cells, Cultured, Culture Media, Female, Humans, Inflammation, Lipopolysaccharides, Macrophages, Stem Cells, Signal Transduction, Biomarkers, Gene Expression, Cytokines, NF-kappa B, Adipocytes, Inflammation Mediators, Chemokines, Cyclin D1, Cell Proliferation, Adipogenesis, Lipid Metabolism

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Macrophage-Secreted Factors Impair Human Adipogenesis: Involvement of Proinflammatory State in Preadipocytes

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks