The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Macrophage-Secreted Factors Impair Human Adipogenesis: Involvement of Proinflammatory State in Preadipocytes
Abstract
Obesity is considered a chronic low-grade inflammatory state. The white adipose tissue produces a variety of inflammation-related proteins whose expression is increased in obese subjects. The nonadipose cell fraction, which includes infiltrated macrophages, is a determinant source of inflammation-related molecules within the adipose tissue. Our working hypothesis is that macrophage infiltration affects fat expansion through a paracrine action on adipocyte differentiation. Human primary preadipocytes were then differentiated in the presence of conditioned media obtained from macrophages differentiated from blood monocytes. Preadipocytes treated by macrophage-conditioned medium displayed marked reduction of adipogenesis as assessed by decreased cellular lipid accumulation and reduced gene expression of adipogenic and lipogenic markers. In addition to this effect, the activation of macrophages by lipopolysaccharides stimulated nuclear factor κB signaling, increased gene expression and release of proinflammatory cytokines and chemokines, and induced preadipocyte proliferation. This phenomenon was associated with increased cyclin D1 gene expression and maintenance of the fibronectin-rich matrix. Anti-TNFα neutralizing antibody inhibits the inflammatory state of preadipocytes positioning TNFα as an important mediator of inflammation in preadipocytes. Strikingly, conditioned media produced by macrophages isolated from human adipose tissue exerted comparable effects with activated macrophages, i.e. decreased adipogenesis and increased inflammatory state in the preadipocytes. These data show that macrophage-secreted factors inhibit the formation of mature adipocytes, suggesting possible role in limiting adipose tissue expansion in humans.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Nevertheless, two longitudinal studies in athletes show that regular training induces a reduction in CRP concentration (211,212) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [212]
In the citing paper
“Recent data provided by our team showed that human pre-adipocytes in contact with activated macrophage media display a fibroblastic-like appearance, significantly proliferate and acquire pro-inflammatory properties [42].”
From Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity (2008) · cites this paper as [42]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
Cytokines suppress adipogenesis and PPAR-γ function through the TAK1/TAB1/NIK cascade
Suzawa, M., Takada, I., Yanagisawa, J., Ohtake, F., Ogawa, S., Yamauchi, T., Kadowaki, T., Takeuchi, Y., Shibuyà, H., Gotoh, Y., et al. (2003) · Nature Cell Biology · doi:10.1038/ncb942 · Cited by 292
RetractedObesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760
Alternative activation of macrophages
Gordon, S. (2003) · Nature Reviews Immunology · doi:10.1038/nri978 · Cited by 6,189
Understanding Adipocyte Differentiation
Gregoire, F. M., Smas, C. M., & Sul, H. S. (1998) · Physiological Reviews · doi:10.1152/physrev.1998.78.3.783 · Cited by 2,406
Adipokines: inflammation and the pleiotropic role of white adipose tissue
Trayhurn, P., & Wood, I. S. (2004) · British Journal of Nutrition · doi:10.1079/bjn20041213 · Cited by 2,210
PPARγ Is Required for the Differentiation of Adipose Tissue In Vivo and In Vitro
Rosen, E. D., Sarraf, P., Troy, A. E., Bradwin, G., Moore, K. J., Milstone, D. S., Spiegelman, B. M., & Mortensen, R. M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80211-7 · Cited by 2,081
Fain, J. N., Madan, A. K., Hiler, M. L., Cheema, P. S., & Bahouth, S. W. (2004) · Endocrinology · doi:10.1210/en.2003-1336 · Cited by 1,619
C/EBPα induces adipogenesis through PPARγ: a unified pathwayPreprint
Rosen, E. D., Hsu, C.-H., Wang, X., Sakai, S., Freeman, M. W., Gonzalez, F. J., & Spiegelman, B. M. (2002) · Genes & Development · doi:10.1101/gad.948702 · Cited by 1,497
CCR2 modulates inflammatory and metabolic effects of high-fat feeding
Weisberg, S. P., Hunter, D., Huber, R., Lemieux, J., Slaymaker, S., Vaddi, K., Charo, I., Leibel, R. L., & Jr., A. W. F. (2006) · Journal of Clinical Investigation · doi:10.1172/jci24335 · Cited by 1,497
Cited by
Sorted by citations
Fat tissue, aging, and cellular senescence
Tchkonia, T., Morbeck, D. E., Von Zglinicki, T., Van Deursen, J., Lustgarten, J., Scrable, H., Khosla, S., Jensen, M. D., & Kirkland, J. L. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00608.x · Cited by 1,094
Dietary factors and low-grade inflammation in relation to overweight and obesity
Calder, P. C., Ahluwalia, N., Brouns, F., Buetler, T., Clement, K., Cunningham, K., Esposito, K., Jönsson, L. S., Kolb, H., Lansink, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114511005460 · Cited by 1,098
Adipocyte Death, Adipose Tissue Remodeling, and Obesity Complications
Strissel, K. J., Stancheva, Z., Miyoshi, H., Perfield, J. W., DeFuria, J., Jick, Z., Greenberg, A. S., & Obin, M. S. (2007) · Diabetes · doi:10.2337/db07-0767 · Cited by 1,007
Hypoxia and Adipose Tissue Function and Dysfunction in Obesity
Trayhurn, P. (2013) · Physiological Reviews · doi:10.1152/physrev.00017.2012 · Cited by 932
Mechanisms and Metabolic Implications of Regional Differences among Fat Depots
Tchkonia, T., Thomou, T., Zhu, Y. Z., Karagiannides, I., Pothoulakis, C., Jensen, M. D., & Kirkland, J. L. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.03.008 · Cited by 768
Divoux, A., Tordjman, J., Lacasa, D., Veyrie, N., Hugol, D., Aissat, A., Basdevant, A., Guerre-Millo, M., Poitou, C., Zucker, J., et al. (2010) · Diabetes · doi:10.2337/db10-0585 · Cited by 654
Self-citationThe role of adipose tissue dysfunction in the pathogenesis of obesity-related insulin resistance
Goossens, G. H. (2008) · Physiology & Behavior · doi:10.1016/j.physbeh.2007.10.010 · Cited by 591
Henegar, C., Tordjman, J., Achard, V., Lacasa, D., Cremer, I., Guerre-Millo, M., Poitou, C., Basdevant, A., Stich, V., Viguerie, N., et al. (2008) · Genome Biology · doi:10.1186/gb-2008-9-1-r14 · Cited by 471
Self-citationSpencer, M., Yao-Borengasser, A., Unal, R., Rasouli, N., Gurley, C. M., Zhu, B., Peterson, C. A., & Kern, P. A. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00329.2010 · Cited by 439
Gustafson, B., Hammarstedt, A., Andersson, C. X., & Smith, U. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.147835 · Cited by 447
Adipose tissue plasticity: how fat depots respond differently to pathophysiological cues
Pellegrinelli, V., Carobbio, S., & Vidal-Puig, A. (2016) · Diabetologia · doi:10.1007/s00125-016-3933-4 · Cited by 432
Adipose tissue macrophages: going off track during obesity
Boutens, L., & Stienstra, R. (2016) · Diabetologia · doi:10.1007/s00125-016-3904-9 · Cited by 454
Molecular Mechanisms and Therapeutic Targets in Steatosis and Steatohepatitis
Anderson, N., & Borlak, J. T. (2008) · Pharmacological Reviews · doi:10.1124/pr.108.00001 · Cited by 395
Aron‐Wisnewsky, J., Tordjman, J., Poitou, C., Darakhshan, F., Hugol, D., Basdevant, A., Aissat, A., Guerre-Millo, M., & Clément, K. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0925 · Cited by 379
Remodeling Phenotype of Human Subcutaneous Adipose Tissue Macrophages
Bourlier, V., Zakaroff‐Girard, A., Miranville, A., Barros, S. D., Maumus, M., Sengenès, C., Galitzky, J., Lafontan, M., Karpe, F., Frayn, K. N., et al. (2008) · Circulation · doi:10.1161/circulationaha.107.724096 · Cited by 390
Self-citationAdipose tissue fibrosis, hypertrophy, and hyperplasia: Correlations with diabetes in human obesity
Muir, L. A., Neeley, C. K., Meyer, K. A., Baker, N. A., Brosius, A. M., Washabaugh, A. R., Varban, O. A., Finks, J. F., Zamarron, B. F., Flesher, C. G., et al. (2016) · Obesity · doi:10.1002/oby.21377 · Cited by 367
Vitamin D signalling in adipose tissue
Ding, C., Gao, D., Wilding, J. P. H., Trayhurn, P., & Chen, B. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114512003285 · Cited by 321
Zeyda, M., & Stulnig, T. M. (2007) · Immunology Letters · doi:10.1016/j.imlet.2007.07.003 · Cited by 316
Adipocyte-derived exosomal miRNAs: a novel mechanism for obesity-related disease
Ferrante, S. C., Nadler, E. P., Pillai, D. K., Hubal, M. J., Wang, Z., Wang, J. M., Gordish‐Dressman, H., Koeck, E. S., Sevilla, S., Wiles, A. A., et al. (2014) · Pediatric Research · doi:10.1038/pr.2014.202 · Cited by 317
Pietiläinen, K. H., Naukkarinen, J., Rissanen, A., Saharinen, J., Ellonen, P., Keränen, H., Suomalainen, A., Götz, A., Suortti, T., Yki‐Järvinen, H., et al. (2008) · PLoS Medicine · doi:10.1371/journal.pmed.0050051 · Cited by 303
Activins and Inhibins: Roles in Development, Physiology, and Disease
Namwanje, M., & Brown, C. W. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a021881 · Cited by 294
Cellular hypoxia and adipose tissue dysfunction in obesity
Wood, I. S., de Heredia, F. P., Wang, B., & Trayhurn, P. (2009) · Proceedings of The Nutrition Society · doi:10.1017/s0029665109990206 · Cited by 302
Macrophage-Secreted Factors Promote a Profibrotic Phenotype in Human Preadipocytes
Kéophiphath, M., Achard, V., Hénégar, C., Rouault, C., Clément, K., & Lacasa, D. (2008) · Molecular Endocrinology · doi:10.1210/me.2008-0183 · Cited by 295
Self-citationInflammation, obesity and comorbidities: the role of diet
Bulló, M., Casas‐Agustench, P., Amigó‐Correig, P., Bartrina, J. A., & Salas‐Salvadó, J. (2007) · Public Health Nutrition · doi:10.1017/s1368980007000663 · Cited by 237
CCL5 Promotes Macrophage Recruitment and Survival in Human Adipose Tissue
Kéophiphath, M., Rouault, C., Divoux, A., Clément, K., & Lacasa, D. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.197442 · Cited by 244
Self-citationYvan‐Charvet, L., & Quignard‐Boulangé, A. (2010) · Kidney International · doi:10.1038/ki.2010.391 · Cited by 221
Gao, D., Madi, M., Ding, C., Fok, M., Steele, T., Ford, C. T., Hunter, L., & Chen, B. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00430.2013 · Cited by 216
Chiowchanwisawakit, P., Lambert, R. G. W., Conner-Spady, B. L., & Maksymowych, W. P. (2011) · Arthritis & Rheumatism · doi:10.1002/art.30393 · Cited by 199
Adipose Tissue Function and Expandability as Determinants of Lipotoxicity and the Metabolic Syndrome
Carobbio, S., Pellegrinelli, V., & Vidal‐Puig, A. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-48382-5_7 · Cited by 198
Adipose Tissue Immune Response: Novel Triggers and Consequences for Chronic Inflammatory Conditions
Ghigliotti, G., Barisione, C., Garibaldi, S., Fabbi, P., Brunelli, C., Spallarossa, P., Altieri, P., Rosa, G., Spinella, G., Palombo, D., et al. (2014) · Inflammation · doi:10.1007/s10753-014-9914-1 · Cited by 205
Activin A Plays a Critical Role in Proliferation and Differentiation of Human Adipose Progenitors
Zaragosi, L.-E., Wdziekonski, B., Villageois, P., Keophiphath, M., Maumus, M., Tchkonia, T., Bourlier, V., Mohsen-Kanson, T., Ladoux, A., Elabd, C., et al. (2010) · Diabetes · doi:10.2337/db10-0013 · Cited by 184
Self-citationPotential Contribution of Adipose Tissue to Elevated Serum Cystatin C in Human Obesity
Naour, N., Fellahi, S., Renucci, J., Poitou, C., Rouault, C., Basdevant, A., Dutour, A., Alessi, M., Bastard, J., Clément, K., et al. (2009) · Obesity · doi:10.1038/oby.2009.96 · Cited by 171
Adipose tissues and thyroid hormones
Obregon, M.-J. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00479 · Cited by 167
Vila, I. K., Badin, P.-M., Marques, M.-A., Monbrun, L., Lefort, C., Mir, L., Louche, K., Bourlier, V., Roussel, B., Gui, P., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.03.062 · Cited by 165
Louwen, F., Ritter, A., Kreis, N., & Yuan, J. (2018) · Obesity Reviews · doi:10.1111/obr.12679 · Cited by 163
Caër, C., Rouault, C., Roy, T. L., Poitou, C., Aron‐Wisnewsky, J., Torcivia, A., Bichet, J.-C., Clément, K., Guerre-Millo, M., & André, S. (2017) · Scientific Reports · doi:10.1038/s41598-017-02660-w · Cited by 165
Adipose tissue macrophages as potential targets for obesity and metabolic diseases
Li, X., Ren, Y., Chang, K.-W., Wu, W., Griffiths, H. R., Lu, S., & Gao, D. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1153915 · Cited by 181
Gao, D., Trayhurn, P., & Bing, C. (2012) · International Journal of Obesity · doi:10.1038/ijo.2012.53 · Cited by 149
Wang, B., Wood, I. S., & Trayhurn, P. (2008) · Journal of Endocrinology · doi:10.1677/joe-08-0156 · Cited by 153
Adipose Tissue Fibrosis: Mechanisms, Models, and Importance
DeBari, M. K., & Abbott, R. D. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176030 · Cited by 153
Thyroid Hormone and Adipocyte Differentiation
Obregón, M.-J. (2008) · Thyroid · doi:10.1089/thy.2007.0254 · Cited by 145
Is interleukin-1β a culprit in macrophage-adipocyte crosstalk in obesity?
Bing, C. (2015) · Adipocyte · doi:10.4161/21623945.2014.979661 · Cited by 127
Role of macrophage tissue infiltration in obesity and insulin resistance
Bourlier, V., & Bouloumié, A. (2009) · Diabetes & Metabolism · doi:10.1016/j.diabet.2009.05.001 · Cited by 141
Rouault, C., Pellegrinelli, V., Schilch, R., Cotillard, A., Poitou, C., Tordjman, J., Sell, H., Clément, K., & Lacasa, D. (2013) · Endocrinology · doi:10.1210/en.2012-1415 · Cited by 119
Self-citationDatta, R., Podolsky, M. J., & Atabai, K. (2018) · JCI Insight · doi:10.1172/jci.insight.122289 · Cited by 131
Badimón, L., & Cubedo, J. (2017) · Cardiovascular Research · doi:10.1093/cvr/cvx096 · Cited by 123
Karaman, S., Hollmén, M., Robciuc, M. R., Alitalo, A. K., Nurmi, H. J., Morf, B., Buschle, D., Alkan, H. F., Ochsenbein, A. M., Alitalo, K. K., et al. (2014) · Molecular Metabolism · doi:10.1016/j.molmet.2014.11.006 · Cited by 113
Immune cells in adipose tissue: Key players in metabolic disorders
Lolmède, K., Duffaut, C., Zakaroff‐Girard, A., & Bouloumié, A. (2011) · Diabetes & Metabolism · doi:10.1016/j.diabet.2011.03.002 · Cited by 122
O’Hara, A., Lim, F.-L., Mazzatti, D. J., & Trayhurn, P. (2009) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-009-0693-8 · Cited by 108
Naour, N., Rouault, C., Fellahi, S., Lavoie, M.-È., Poitou, C., Kéophiphath, M., Eberlé, D., Shoelson, S. E., Rizkalla, S. W., Bastard, J., et al. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-1894 · Cited by 102
Moratal, C., Raffort, J., Arrighi, N., Rekima, S., Schaub, S., Dechesne, C. A., Chinetti, G., & Dani, C. (2018) · Scientific Reports · doi:10.1038/s41598-018-35429-w · Cited by 101
Dutour, A., Achard, V., Sell, H., Naour, N., Collart, F., Gaborit, B., Silaghi, C. A., Eckel, J., Alessi, M., Hénégar, C., et al. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-1222 · Cited by 101
Dietert, R. R., DeWitt, J. C., Germolec, D. R., & Zelikoff, J. T. (2010) · Environmental Health Perspectives · doi:10.1289/ehp.1001971 · Cited by 97
Rouault, C., Marcelin, G., Adriouch, S., Rose, C., Genser, L., Ambrosini, M., Bichet, J.-C., Zhang, Y., Marquet, F., Aron-Wisnewsky, J., et al. (2021) · Diabetologia · doi:10.1007/s00125-020-05307-0 · Cited by 95
Chazenbalk, G. D., Bertolotto, C., Heneidi, S. G., Jumabay, M., Trivax, B., Aronowitz, J. A., Yoshimura, K., Simmons, C. F., Dumesic, D. A., & Azziz, R. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017834 · Cited by 97
Inhibition of Adipocyte Differentiation by Nur77, Nurr1, and Nor1
Chao, L. C., Bensinger, S. J., Villanueva, C. J., Wroblewski, K., & Tontonoz, P. (2008) · Molecular Endocrinology · doi:10.1210/me.2008-0161 · Cited by 93
Bourlier, V., Sengenès, C., Zakaroff‐Girard, A., Decaunes, P., Wdziekonski, B., Galitzky, J., Villageois, P., Estève, D., Chiotasso, P., Dani, C., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031274 · Cited by 100
Age and Sex: Impact on adipose tissue metabolism and inflammation
Varghese, M., Song, J., & Singer, K. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111563 · Cited by 100
Adipose Tissue Macrophage Polarization in Healthy and Unhealthy Obesity
Ruggiero, A. D., Key, C.-C. C., & Kavanagh, K. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.625331 · Cited by 93
The Positive Effects of Yerba Maté (Ilex paraguariensis) in Obesity
Gambero, A., & Ribeiro, M. L. (2015) · Nutrients · doi:10.3390/nu7020730 · Cited by 98
Inflamed macrophage microvesicles induce insulin resistance in human adipocytes
Zhang, Y., Shi, L., Mei, H., Zhang, J., Zhu, Y., Han, X., & Zhu, D. (2015) · Nutrition & Metabolism · doi:10.1186/s12986-015-0016-3 · Cited by 87
Silva, K. R., Liechocki, S., Carneiro, J. R. I., Cláudio-da-Silva, C. S., Maya‐Monteiro, C. M., Borojević, R., & Baptista, L. S. (2015) · Stem Cell Research & Therapy · doi:10.1186/s13287-015-0029-x · Cited by 95
Larter, C. Z., Yeh, M. M., Rooyen, D. M. V., Teoh, N., Brooling, J. T., Hou, J. Y., Williams, J., Clyne, M., Nolan, C. J., & Farrell, G. C. (2009) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2009.05996.x · Cited by 87
Zeyda, M., Gollinger, K., Todoric, J., Kiefer, F. W., Keck, M. K., Aszmann, O. C., Prager, G., Zlabinger, G. J., Petzelbauer, P., & Stulnig, T. M. (2011) · Endocrinology · doi:10.1210/en.2010-1328 · Cited by 90
Growth hormone and adipose tissue: Beyond the adipocyte
Berryman, D. E., List, E. O., Sackmann‐Sala, L., Lubbers, E. R., Munn, R. D., & Kopchick, J. J. (2011) · Growth Hormone & IGF Research · doi:10.1016/j.ghir.2011.03.002 · Cited by 88
Transfused Macrophages Ameliorate Pancreatic and Renal Injury in Murine Diabetes Mellitus
Zheng, D., Wang, Y., Cao, Q., Lee, V. W., Zheng, G., Sun, Y., Tan, T. K., Wang, Y., Alexander, S. I., & Harris, D. C. H. (2011) · Nephron Experimental Nephrology · doi:10.1159/000321034 · Cited by 82
Needle and surgical biopsy techniques differentially affect adipose tissue gene expression profiles
Mutch, D. M., Tordjman, J., Pelloux, V., Hanczar, B., Hénégar, C., Poitou, C., Veyrie, N., Zucker, J., & Clément, K. (2008) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26802 · Cited by 81
1,2-Vinyldithiin from garlic inhibits differentiation and inflammation of human preadipocytes
Keophiphath, M., Priem, F., Jacquemond-Collet, I., Clément, K., & Lacasa, D. (2009) · The Journal of Nutrition · doi:10.3945/jn.109.105452 · Cited by 77
Self-citationInteractive Changes between Macrophages and Adipocytes
Xie, L., Ortega, M. T., Mora, S., & Chapes, S. K. (2010) · Clinical and Vaccine Immunology · doi:10.1128/cvi.00494-09 · Cited by 78
Kuwabara, W. M. T., Panveloski-Costa, A. C., Yokota, C. N. F., Pereira, J. N. B., Filho, J. M., Torres, R. P., Hirabara, S. M., Curi, R., & Alba‐Loureiro, T. C. (2017) · PLoS ONE · doi:10.1371/journal.pone.0189622 · Cited by 76
Single‐nucleotide Polymorphism of CD36 Locus and Obesity in European Adolescents
Bokor, S., Legry, V., Meirhaeghe, A., Ruiz, J. R., Mauro, B., Widhalm, K., Μanios, Y., Amouyel, P., Moreno, L. A., Molnár, D., et al. (2009) · Obesity · doi:10.1038/oby.2009.412 · Cited by 80
Sorisky, A., Molgat, A. S. D., & Gagnon, A. (2013) · Advances in Nutrition · doi:10.3945/an.112.003020 · Cited by 75
Macrophages Play a Key Role in Angiogenesis and Adipogenesis in a Mouse Tissue Engineering Model
Debels, H., Galea, L. A., Han, X., Palmer, J. A., van Rooijen, N., Morrison, W. A., & Abberton, K. M. (2013) · Tissue Engineering Part A · doi:10.1089/ten.tea.2013.0071 · Cited by 72
Role of TLR4 in the induction of inflammatory changes in adipocytes and macrophages
McKernan, K. E., Varghese, M., Patel, R. R., & Singer, K. (2020) · Adipocyte · doi:10.1080/21623945.2020.1760674 · Cited by 70
Study of the proinflammatory role of human differentiated omental adipocytes
Bassols, J., Ortega, F. J., Moreno‐Navarrete, J. M., Peral, B., Ricart, W., & Fernández‐Real, J. M. (2009) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22208 · Cited by 70
Pellegrinelli, V., Rouault, C., Veyrie, N., Clément, K., & Lacasa, D. (2013) · Diabetes · doi:10.2337/db13-0537 · Cited by 70
Self-citationAdipose tissue inflammation and liver pathology in human obesity
Tordjman, J., Guerre-Millo, M., & Clément, K. (2008) · Diabetes & Metabolism · doi:10.1016/s1262-3636(08)74601-9 · Cited by 71
Lü, C., Pasupulati, A. K., Fan, Y., Sperling, M. A., & Menon, R. K. (2010) · Endocrinology · doi:10.1210/en.2009-1194 · Cited by 67
Role of Serum Amyloid A in Adipocyte-Macrophage Cross Talk and Adipocyte Cholesterol Efflux
Poitou, C., Divoux, A., Faty, A., Tordjman, J., Hugol, D., Aissat, A., Kéophiphath, M., Hénégar, C., Commans, S., & Clément, K. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-2040 · Cited by 66
Zymosan-induced inflammation stimulates neo-adipogenesis
Thomas, G. P. L., Hemmrich, K., Abberton, K. M., McCombe, D., Penington, A., Thompson, E. W., & Morrison, W. A. (2007) · International Journal of Obesity · doi:10.1038/sj.ijo.0803702 · Cited by 65
Preadipocyte Factor-1 Is Associated with Metabolic Profile in Severe Obesity
O’Connell, J., Lynch, L., Hogan, A. E., Cawood, T., & O'Shea, D. B. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-2026 · Cited by 61
Oxidative stress, body fat composition, and endocrine status in pre- and postmenopausal women
Pansini, F. S., Cervellati, C., Guariento, A., Stacchini, M. A., Castaldini, M. C., Bernardi, A., Pascale, G., Bonaccorsi, G., Patella, A., Bagni, B., et al. (2008) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e318068b285 · Cited by 61
Estrogens and Body Weight Regulation in Men
Rubinow, K. B. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-70178-3_14 · Cited by 62
Adipose Tissue Deficiency and Chronic Inflammation in Diabetic Goto-Kakizaki Rats
Bai, X., Sukumaran, S., Nie, J., Jusko, W. J., DuBois, D. C., & Almon, R. R. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017386 · Cited by 59
New aspects of adipogenesis: Radicals and oxidative stress
Gummersbach, C., Hemmrich, K., Kröncke, K., Suschek, C. V., Fehsel, K., & Pallua, N. (2009) · Differentiation · doi:10.1016/j.diff.2008.09.009 · Cited by 59
Angiotensin receptor blockers in the treatment of NASH/NAFLD: Could they be a first-class option?
Georgescu, E. F. (2008) · Advances in Therapy · doi:10.1007/s12325-008-0110-2 · Cited by 59
Hemmrich, K., Thomas, G. P. L., Abberton, K. M., Thompson, E. W., Rophael, J. A., Penington, A., & Morrison, W. A. (2007) · Obesity · doi:10.1038/oby.2007.352 · Cited by 62
Pellegrinelli, V., Rodríguez‐Cuenca, S., Rouault, C., Figueroa‐Juárez, E., Schilbert, H. M., Virtue, S., Moreno‐Navarrete, J. M., Bidault, G., Vazquez-Borrego, M. C., Dias, A. R., et al. (2022) · Nature Metabolism · doi:10.1038/s42255-022-00561-5 · Cited by 58
Lilja, H. E., Morrison, W. A., Han, X., Palmer, J. A., Taylor, C. J., Tee, R., Möller, A., Thompson, E. W., & Abberton, K. M. (2012) · Stem Cells and Development · doi:10.1089/scd.2012.0451 · Cited by 57
Küpeli̇, E., Ulubay, G., Ulaşlı, S. S., Sahin, T., Ozen, Z. E., & Gürsoy, A. (2010) · Endocrine · doi:10.1007/s12020-010-9351-3 · Cited by 56
Kim, T. H., Yu, S. H., Choi, S. H., Yoon, J. W., Kang, S. M., Chun, E. J., Choi, S. I., Shin, H., Lee, H. K., Park, K. S., et al. (2010) · Obesity · doi:10.1038/oby.2010.246 · Cited by 57
Jang, J. E., Ko, M. S., Yun, J.-Y., Kim, M., Kim, J. H., Park, H. S., Kim, A.-R., Kim, H.-J., Kim, B. J., Ahn, Y. E., et al. (2016) · Diabetes · doi:10.2337/db15-1624 · Cited by 59
Macrophage-secreted factors inhibit ZAG expression and secretion by human adipocytes
Gao, D., Trayhurn, P., & Bing, C. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.05.020 · Cited by 56
Macrophage JAK2 deficiency protects against high-fat diet-induced inflammation
Desai, H. R., Sivasubramaniyam, T., Revelo, X. S., Schroer, S. A., Luk, C. T., Rikkala, P. R., Metherel, A. H., Dodington, D. W., Park, Y. J., Kim, M. J., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-07923-0 · Cited by 56
“Spexin improves adipose tissue inflammation and macrophage recruitment in obese mice”
Gambaro, S. E., Zubiría, M. G., Giordano, A. P., Portales, A. E., Alzamendi, A., Rumbo, M., & Giovambattista, A. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2020.158700 · Cited by 58
Scheidl, T. B., Brightwell, A. L., Easson, S., & Thompson, J. A. (2023) · BMC Medicine · doi:10.1186/s12916-023-02730-z · Cited by 61
Adipose-derived stromal/stem cells from different adipose depots in obesity development
Silva, K. R., & Baptista, L. S. (2019) · World Journal of Stem Cells · doi:10.4252/wjsc.v11.i3.147 · Cited by 62
Activins in adipogenesis and obesity
Dani, C. (2012) · International Journal of Obesity · doi:10.1038/ijo.2012.28 · Cited by 64
Gao, D., & Chen, B. Y. (2011) · Journal of Cellular Physiology · doi:10.1002/jcp.22630 · Cited by 53
Adipose tissue macrophages impair preadipocyte differentiation in humans
Liu, L. F., Craig, C. M., Tolentino, L. L., Choi, O., Morton, J. M., Rivas, H., Cushman, S. W., Engleman, E. G., & McLaughlin, T. (2017) · PLoS ONE · doi:10.1371/journal.pone.0170728 · Cited by 52
Metadata
- Authors
- Lacasa, D., Taleb, S., Keophiphath, M., Miranville, A., & Clement, K.
- Affiliations
- Inserm (FR)
- Goethe University Frankfurt (DE)
- ORCID
- Taleb, Soraya
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2007-02-01
- Volume
- 148
- Issue
- 2
- Pages
- 868-877
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2121845219
- Cited by
- 334
- References
- 42
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 12 · 2023: 10 · 2022: 12 · 2021: 19 · 2020: 14 · 2019: 10 · 2018: 15 · 2017: 18 · 2016: 19 · 2015: 12 · 2014: 19 · 2013: 22 · 2012: 16
- FWCI
- 17.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- Institut National de la Santé et de la Recherche Médicale
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Keywords
- adipogenesis, preadipocytes, obesity, low-grade inflammation, macrophage infiltration, paracrine signaling, TNF-α, NF-κB signaling, lipopolysaccharide, inflammatory cytokines, chemokines, cyclin D1, adipose tissue expansion
- MeSH terms
- Adipose Tissue, Cell Differentiation, Cells, Cultured, Culture Media, Female, Humans, Inflammation, Lipopolysaccharides, Macrophages, Stem Cells, Signal Transduction, Biomarkers, Gene Expression, Cytokines, NF-kappa B, Adipocytes, Inflammation Mediators, Chemokines, Cyclin D1, Cell Proliferation, Adipogenesis, Lipid Metabolism
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
