Matrix extracellular phosphoglycoprotein (MEPE) is a new bone renal hormone and vascularization modulator
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Increased matrix extracellular phosphoglycoprotein (MEPE) expression occurs in several phosphate and bone-mineral metabolic disorders. To resolve whether MEPE plays a role, we created a murine model overexpressing MEPE protein (MEPE tgn) in bone. MEPE tgn mice displayed a growth and mineralization defect with altered bone-renal vascularization that persisted to adulthood. The growth mineralization defect was due to a decrease in bone remodeling, and MEPE tgn mice were resistant to diet-induced renal calcification. MEPE protein-derived urinary ASARM peptides and reduced urinary Ca X PO4 product mediated the suppressed renal calcification. Osteoblastic cells displayed reduced activity but normal differentiation. Osteoclastic precursors were unable to differentiate in the presence of osteoblasts. In the kidney, NPT2a up-regulation induced an increase in phosphate renal reabsorption, leading to hyperphosphatemia. We conclude MEPE and MEPE-phosphate-regulating gene with homologies to endopeptidases on the X chromosome (MEPE-PHEX) interactions are components to an age-diet-dependent pathway that regulates bone turnover and mineralization and suppresses renal calcification. This novel pathway also modulates bone-renal vascularization and bone turnover.
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A study demonstrated that transgenic mice overexpressing MEPE exhibited reduced renal calcification despite hyperphosphatemia.
“A study demonstrated that transgenic mice overexpressing MEPE exhibited reduced renal calcification despite hyperphosphatemia 46 .”
From Sex-specific gene expression signatures of calcific aortic valve stenosis in a large collection of human tissues (2026) · cites this paper as [46]
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Endocrine regulation of energy metabolism by the skeleton
Lee, N. K., Sowa, H., Hinoi, E., Ferron, M., Ahn, J. D., Confavreux, C., Dacquin, R., Mee, P. J., McKee, M. D., Jung, D. Y., et al. (2007) · Cell · doi:10.1016/j.cell.2007.05.047 · Cited by 2,554 · see citing works
Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia
Shimada, T., Mizutani, S., Muto, T., Yoneya, T., Hino, R., Takeda, S., Takeuchi, Y., Fujita, T., Fukumoto, S., & Yamashita, T. (2001) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.101545198 · Cited by 1,391 · see citing works
Larsson, T. E., Marsell, R., Schipani, E., Ohlsson, C., Ljunggren, Ö., Tenenhouse, H. S., Jüppner, H., & Jonsson, K. B. (2004) · Endocrinology · doi:10.1210/en.2003-1768 · Cited by 497 · see citing works
MEPE, a New Gene Expressed in Bone Marrow and Tumors Causing Osteomalacia
Rowe, P. S., de Zoysa, P. A., Dong, R., Wang, H. R., White, K. E., Econs, M. J., & Oudet, C. L. (2000) · Genomics · doi:10.1006/geno.2000.6235 · Cited by 360 · see citing works
Self-citationAldosterone impairs vascular reactivity by decreasing glucose-6-phosphate dehydrogenase activity
Leopold, J. A., Dam, A., Maron, B. A., Scribner, A. W., Liao, R., Handy, D. E., Stanton, R. C., Pitt, B., & Loscalzo, J. (2007) · Nature Medicine · doi:10.1038/nm1545 · Cited by 346 · see citing works
Effects of Aldosterone on the Vasculature
Schiffrin, E. L. (2006) · Hypertension · doi:10.1161/01.hyp.0000201443.63240.a7 · Cited by 299 · see citing works
Dacquin, R., Starbuck, M. W., Schinke, T., & Karsenty, G. (2002) · Developmental Dynamics · doi:10.1002/dvdy.10100 · Cited by 295 · see citing works
Gowen, L. C., Petersen, D. N., Mansolf, A. L., Qi, H., Stock, J. L., Tkalcevic, G. T., Simmons, H. A., Crawford, D. T., Chidsey-Frink, K. L., Ke, H. Z., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m203250200 · Cited by 295 · see citing works
Angiotensin II accelerates osteoporosis by activating osteoclasts
Shimizu, H., Nakagami, H., Osako, M. K., Hanayama, R., Kunugiza, Y., Kizawa, T., Tomita, T., Yoshikawa, H., Ogihara, T., & Morishita, R. (2008) · The FASEB Journal · doi:10.1096/fj.07-098954 · Cited by 294 · see citing works
MEPE has the properties of an osteoblastic phosphatonin and minhibin
Rowe, P. S., Kumagai, Y., Gutierrez, G., Garrett, I. R., Blacher, R. W., Rosen, D., Cundy, J., Navvab, S., Chen, D., Drezner, M. K., et al. (2003) · Bone · doi:10.1016/j.bone.2003.10.005 · Cited by 268 · see citing works
Self-citationQin, C., D’Souza, R. N., & Feng, J. Q. (2007) · Journal of Dental Research · doi:10.1177/154405910708601202 · Cited by 240 · see citing works
Octreotide Therapy for Tumor-Induced Osteomalacia
Seufert, J., Ebert, K., Müller, J. G., Eulert, J., Hendrich, C., Werner, E., Schütze, N., Schulz, G. V., Kenn, W., Richtmann, H., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa010839 · Cited by 233 · see citing works
Addison, W. N., Nakano, Y., Loisel, T., Crine, P., & McKee, M. D. (2008) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.080601 · Cited by 214 · see citing works
Tumors Associated With Oncogenic Osteomalacia Express Genes Important in Bone and Mineral Metabolism
de Beur, S. M. J., Finnegan, R. B., Vassiliadis, J., Cook, B. P., Barberio, D. M., Estes, S. D., Manavalan, P., Petroziello, J. M., Madden, S. L., Cho, J. Y., et al. (2002) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2002.17.6.1102 · Cited by 211 · see citing works
Yuan, B., Takaiwa, M., Clemens, T. L., Feng, J. Q., Kumar, R., Rowe, P. S., Xie, Y., & Drezner, M. K. (2008) · Journal of Clinical Investigation · doi:10.1172/jci32702 · Cited by 178 · see citing works
Self-citationExpression of SIBLINGs and Their Partner MMPs in Salivary Glands
Ogbureke, K. U. E., & Fisher, L. W. (2004) · Journal of Dental Research · doi:10.1177/154405910408300902 · Cited by 174 · see citing works
Activation of Renin-Angiotensin System Induces Osteoporosis Independently of Hypertension
Asaba, Y., Ito, M., Fumoto, T., Watanabe, K., Fukuhara, R., Takeshita, S., Nimura, Y., Ishida, J., Fukamizu, A., & Ikeda, K. (2008) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.081006 · Cited by 173 · see citing works
Martin, A., David, V., Laurence, J. S., Schwarz, P. M., Lafer, E. M., Hedge, A.-M., & Rowe, P. S. N. (2008) · Endocrinology · doi:10.1210/en.2007-1205 · Cited by 173 · see citing works
Self-citationZhao, M., Harris, S. E., Horn, D., Geng, Z., Nishimura, R., Mundy, G. R., & Chen, D. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200109012 · Cited by 171 · see citing works
T he W rickkened P athways of FGF23, MEPE and PHEX
Rowe, P. S. (2004) · Critical Reviews in Oral Biology & Medicine · doi:10.1177/154411130401500503 · Cited by 154 · see citing works
Self-citationArgiro, L., Desbarats, M., Glorieux, F. H., & Ecarot, B. (2001) · Genomics · doi:10.1006/geno.2001.6553 · Cited by 150 · see citing works
Rowe, P. S. N., Garrett, I. R., Schwarz, P. M., Carnes, D. L., Lafer, E. M., Mundy, G. R., & Gutierrez, G. E. (2005) · Bone · doi:10.1016/j.bone.2004.09.015 · Cited by 149 · see citing works
Self-citationRenal expression of SIBLING proteins and their partner matrix metalloproteinases (MMPs)
Ogbureke, K. U. E., & Fisher, L. W. (2005) · Kidney International · doi:10.1111/j.1523-1755.2005.00389.x · Cited by 148 · see citing works
Takayama, S., Ishii, S., Ikeda, T., Masamura, S., Doi, M., & Kitajima, M. (2005) · PubMed · Cited by 134 · see citing works
Matrix extracellular phosphoglycoprotein (MEPE) is highly expressed in osteocytes in human bone
Yamada, T., Matsukawa, N., Matsumoto, M., Morimoto, S., Ogihara, T., Ochi, T., Yoshikawa, H., Nampei, A., Hashimoto, J., Hayashida, K., et al. (2004) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-003-0468-9 · Cited by 116 · see citing works
Bresler, D., Bruder, J., Mohnike, K. L., Fraser, W. D., & Rowe, P. S. (2004) · Journal of Endocrinology · doi:10.1677/joe.1.05989 · Cited by 114 · see citing works
Self-citationRenal Calcification in Mice Homozygous for the Disrupted Type IIa Na/Pi Cotransporter Gene Npt2
Chau, H., El-Maadawy, S., McKee, M. D., & Tenenhouse, H. S. (2003) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2003.18.4.644 · Cited by 107 · see citing works
Strom, T. M., & Jüppner, H. (2008) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0b013e3282fd6e5b · Cited by 106 · see citing works
Campos, M., COUTURE, C., Hirata, I. Y., Juliano, M. A., Loisel, T. P., Crine, P., Juliano, L., Boileau, G., & Carmona, A. K. (2003) · Biochemical Journal · doi:10.1042/bj20030287 · Cited by 98 · see citing works
Liu, S., Rowe, P. S., Vierthaler, L., Zhou, J., & Quarles, L. D. (2007) · Journal of Endocrinology · doi:10.1677/joe.1.07059 · Cited by 92 · see citing works
Self-citationAldosterone Enhances Ischemia-Induced Neovascularization Through Angiotensin II–Dependent Pathway
Michel, F. S., Ambroisine, M.-L., Duriez, M., Delcayre, C., Levy, B. I., & Silvestre, J. (2004) · Circulation · doi:10.1161/01.cir.0000127112.36796.9b · Cited by 85 · see citing works
Barou, O., VALENTIN, D., Vico, L., TIRODE, C., Barbier, A., Alexandre, C., & Lafage‐Proust, M. (2002) · Investigative Radiology · doi:10.1097/00004424-200201000-00008 · Cited by 85 · see citing works
David, V., Lafage‐Proust, M., Laroche, N., Alexandre, C., Ruegsegger, P., & Vico, L. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00293.2004 · Cited by 77 · see citing works
Self-citationHarris, S. E., Gluhak‐Heinrich, J., Harris, M. A., Yang, W., Bonewald, L. F., Riha, D., Rowe, P. S., Robling, A. G., Turner, C. H., Feng, J. Q., et al. (2007) · PubMed · Cited by 74 · see citing works
Self-citationRecent advances in the renal–skeletal–gut axis that controls phosphate homeostasis
Kiela, P. R., & Ghishan, F. K. (2008) · Laboratory Investigation · doi:10.1038/labinvest.2008.114 · Cited by 68 · see citing works
Matrix Extracellular Phosphoglycoprotein Inhibits Phosphate Transport
Marks, J., Churchill, L. J., Debnam, E. S., & Unwin, R. J. (2008) · Journal of the American Society of Nephrology · doi:10.1681/asn.2008030315 · Cited by 66 · see citing works
Jain, A., Fedarko, N. S., Collins, M. T., Gelman, R. S., Ankrom, M. A., Tayback, M., & Fisher, L. W. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-032031 · Cited by 65 · see citing works
Preconditioning of the distal tubular epithelium of the human kidney precedes nephrocalcinosis
Verhulst, A., Asselman, M., Naeyer, S. D., Vervaet, B. A., Mengel, M., Gwinner, W., D’Haese, P. C., Verkoelen, C. F., & Broe, M. E. D. (2005) · Kidney International · doi:10.1111/j.1523-1755.2005.00584.x · Cited by 59 · see citing works
Rowe, P. S., Matsumoto, N., Jo, O. D., Shih, R. N. J., Oconnor, J., Roudier, M. P., Bain, S., Liu, S., Harrison, J. S., & Yanagawa, N. (2006) · Bone · doi:10.1016/j.bone.2006.04.012 · Cited by 58 · see citing works
Self-citationDobbie, H., Unwin, R. J., Faria, N., & Shirley, D. G. (2007) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfm535 · Cited by 58 · see citing works
Hayashibara, T., Hiraga, T., Sugita, A., Wang, L., Hata, K., Ooshima, T., & Yoneda, T. (2007) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.070709 · Cited by 50 · see citing works
Solari, F., Flamant, F., Cherel, Y., Wyers, M., & Jurdic, P. (1996) · Journal of Cell Science · doi:10.1242/jcs.109.6.1203 · Cited by 33 · see citing works
Habra, M. A., Jiménez, C., Huang, S.-C. E., Cote, G. J., Murphy, W. A., Gagel, R. F., & Hoff, A. O. (2008) · Endocrine Practice · doi:10.4158/ep.14.9.1108 · Cited by 25 · see citing works
Clarke, B. L. (2009) · Yearbook of Endocrinology · doi:10.1016/s0084-3741(09)79295-9 · Cited by 23 · see citing works
Increased cathepsin D release byHypmouse osteoblast cells
Matsumoto, N., Jo, O. D., Shih, R. N. J., Brochmann, E. J., Murray, S. S., Hong, V. A. D. C., Yanagawa, J., & Yanagawa, N. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00562.2004 · Cited by 17 · see citing works
Dubois, S. G., Ruchon, A. F., Delalandre, A., Boileau, G., & Lajeunesse, D. (2002) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00135.2002 · Cited by 15 · see citing works
Woznowski, M., Quack, I., Stegbauer, J., Rump, L. C., Schieren, G., & Buchner, N. (2008) · Clinical Nephrology · doi:10.5414/cnp70431 · Cited by 13 · see citing works
Hoffman, W. H., Jain, A., Chen, H., & Fedarko, N. S. (2008) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.32395 · Cited by 11 · see citing works
Martin, A., David, V., Vico, L., & Thomas, T. (2008) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.080708 · Cited by 11 · see citing works
Self-citationAltered cathepsin D metabolism in PHEX antisense human osteoblast cells
Matsumoto, N., Jo, O. D., Shih, R. N. J., & Yanagawa, N. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.04.116 · Cited by 7 · see citing works
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Dallas, S. L., Prideaux, M., & Bonewald, L. F. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1026 · Cited by 1,042 · see citing works
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David, V., Martin, A., Isakova, T., Spaulding, C., Qi, L., Ramirez, V., Zumbrennen‐Bullough, K. B., Sun, C. C., Lin, H. Y.-F., Babitt, J. L., et al. (2015) · Kidney International · doi:10.1038/ki.2015.290 · Cited by 495 · see citing works
Self-citationMartin, A., Liu, S., David, V., Li, H., Karydis, A., Feng, J. Q., & Quarles, L. D. (2011) · The FASEB Journal · doi:10.1096/fj.10-177816 · Cited by 254 · see citing works
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Staines, K. A., MacRae, V. E., & Farquharson, C. (2012) · Journal of Endocrinology · doi:10.1530/joe-12-0143 · Cited by 234 · see citing works
Dai, B., David, V., Martin, A., Huang, J., Li, H., Jiao, Y., Gu, W., & Quarles, L. D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044161 · Cited by 195 · see citing works
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Rowe, P. S. N. (2012) · Critical Reviews™ in Eukaryotic Gene Expression · doi:10.1615/critreveukargeneexpr.v22.i1.50 · Cited by 173 · see citing works
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Kulkarni, R. N., Bakker, A. D., Everts, V. E., & Klein‐Nulend, J. (2010) · Calcified Tissue International · doi:10.1007/s00223-010-9407-7 · Cited by 103 · see citing works
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Yuan, Q., Jiang, Y., Zhao, X., Sato, T., Densmore, M., Schüler, C., Erben, R. G., McKee, M. D., & Lanske, B. (2013) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2079 · Cited by 102 · see citing works
Bouleftour, W., Juignet, L., Bouet, G., Granito, R. N., Vanden‐Bossche, A., Laroche, N., Aubin, J. E., Lafage‐Proust, M., Vico, L., & Malaval, L. (2016) · Matrix Biology · doi:10.1016/j.matbio.2015.12.011 · Cited by 99 · see citing works
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BONUCCI, E. (2011) · Frontiers in bioscience · doi:10.2741/3918 · Cited by 89 · see citing works
Roche, B., David, V., Vanden‐Bossche, A., Peyrin, F., Malaval, L., Vico, L., & Lafage‐Proust, M. (2011) · Bone · doi:10.1016/j.bone.2011.09.051 · Cited by 83 · see citing works
Self-citationSah, N., Kuehu, D. L., Khadka, V. S., Deng, Y., Peplowska, K., Jha, R., & Mishra, B. (2018) · Scientific Reports · doi:10.1038/s41598-018-35203-y · Cited by 80 · see citing works
McKee, M. D., Hoac, B., Addison, W. N., Barros, N. M. T., Millán, J. L., & Chaussain, C. (2013) · Periodontology 2000 · doi:10.1111/prd.12029 · Cited by 73 · see citing works
Salmon, B. J. R., Bardet, C., Khaddam, M., Jiar, N., Coyac, B. R., Baroukh, B., Letourneur, F., Lesieur, J., Decup, F., Denmat, D. L., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056749 · Cited by 69 · see citing works
Self-citationYang, W., Guo, D., Harris, M. A., Cui, Y., Gluhak‐Heinrich, J., Wu, J., Chen, X., Skinner, C., Nyman, J. S., Edwards, J., et al. (2013) · Journal of Cell Science · doi:10.1242/jcs.118596 · Cited by 68 · see citing works
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Imanishi, Y., Hashimoto, J., Ando, W., Kobayashi, K., Ueda, T., Nagata, Y., Miyauchi, A., Koyano, H. M., Kaji, H., Saito, T., et al. (2011) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-011-0290-8 · Cited by 34 · see citing works
Branković, M., Akkerhuis, K. M., Mouthaan, H., Constantinescu, A. A., Çalişkan, K., van Ramshorst, J., Germans, T., Umans, V. A. W. M., & Kardys, I. (2018) · International Journal of Cardiology · doi:10.1016/j.ijcard.2018.08.001 · Cited by 32 · see citing works
Surakka, I. L., Fritsche, L. G., Zhou, W., Backman, J., Kosmicki, J. A., Lu, H., Brumpton, B. M., Nielsen, J. B., Gabrielsen, M. E., Skogholt, A. H., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17315-0 · Cited by 32 · see citing works
Bouleftour, W., Juignet, L., Verdière, L., Machuca‐Gayet, I., Thomas, M., Laroche, N., Vanden‐Bossche, A., Farlay, D., Thomas, C., Gineyts, É., et al. (2018) · Bone · doi:10.1016/j.bone.2018.12.001 · Cited by 30 · see citing works
In vivo impact of Dlx3 conditional inactivation in neural crest‐derived craniofacial bones
Duverger, O., Isaac, J., Zah, A., Hwang, J., Berdal, A., Lian, J. B., & Morasso, M. I. (2012) · Journal of Cellular Physiology · doi:10.1002/jcp.24175 · Cited by 28 · see citing works
A unified model for bone–renal mineral and energy metabolism
Rowe, P. S. (2015) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2015.03.006 · Cited by 27 · see citing works
Self-citationShirley, D. G., Faria, N., Unwin, R. J., & Dobbie, H. (2010) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfq263 · Cited by 27 · see citing works
Schrauwen, I., Valgaeren, H., Tomás‐Roca, L., Sommen, M., Altunoğlu, U., Wesdorp, M., Beyens, M., Fransén, E., Nasır, A., Vandeweyer, G., et al. (2018) · Genetics in Medicine · doi:10.1038/s41436-018-0300-5 · Cited by 23 · see citing works
Acharya, B., Chun, S., Kim, S., Moon, C., Shin, H., & Park, E. K. (2012) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.32648 · Cited by 22 · see citing works
Ramchandani, D., & Weber, G. F. (2015) · Bone · doi:10.1016/j.bone.2015.05.047 · Cited by 21 · see citing works
Kang, H., C, S. A. A., Barnes, A. M., Martin, A., David, V., Crawford, S. E., & Marini, J. C. (2020) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.4540 · Cited by 21 · see citing works
Self-citationMEPE Localization in the Craniofacial Complex and Function in Tooth Dentin Formation
Gullard, A., Gluhak-Heinrich, J., Papagerakis, S., Sohn, P., Unterbrink, A., Chen, S., & MacDougall, M. (2016) · Journal of Histochemistry & Cytochemistry · doi:10.1369/0022155416635569 · Cited by 20 · see citing works
Reijnders, C. M. A., van Essen, H. W., van Rens, B. T. T. M., van Beek, H., Ylstra, B., Blankenstein, M. A., Lips, P. T. A. M., & Bravenboer, N. (2013) · PLoS ONE · doi:10.1371/journal.pone.0079672 · Cited by 20 · see citing works
PHEX Mimetic (SPR4-Peptide) Corrects and Improves HYP and Wild Type Mice Energy-Metabolism
Zelenchuk, L. V., Hedge, A.-M., & Rowe, P. S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097326 · Cited by 19 · see citing works
Self-citationFujikawa, K., Yokohama‐Tamaki, T., Morita, T., Baba, O., Qin, C., & Shibata, S. (2015) · European Journal of Histochemistry · doi:10.4081/ejh.2015.2553 · Cited by 19 · see citing works
Clinical Disorders of Phosphate Homeostasis
Hansen, K. E., & Drezner, M. K. (2011) · Elsevier eBooks · doi:10.1016/b978-0-12-381978-9.10063-0 · Cited by 17 · see citing works
Calcium-dependent activation of PHEX, MEPE and DMP1 in osteocytes
Donmez, B., Karagur, E., Donmez, A., Choi, J., & Akkus, O. (2022) · Molecular Medicine Reports · doi:10.3892/mmr.2022.12876 · Cited by 14 · see citing works
Kidney stone formation in a novel murine model of polycystic kidney disease
Riddle, H. A., Zhang, S., Qian, F., Williams, J. C., Stubbs, J. R., Rowe, P. S., & Parnell, S. C. (2022) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00165.2021 · Cited by 15 · see citing works
Self-citationDo ASARM peptides play a role in nephrogenic systemic fibrosis?
Rowe, P. S., Zelenchuk, L. V., Laurence, J. S., Lee, P., Brooks, W. M., & McCarthy, E. T. (2015) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00201.2015 · Cited by 15 · see citing works
Self-citationTwo Novel FAM20C Variants in a Family with Raine Syndrome
Hernández‐Zavala, A., Cortés-Camacho, F., Lara, I. P., Godínez-Aguilar, R., Espinosa-García, A. M., Duran, J. P., Villanueva-Ocampo, P., Ugarte-Briones, C., Serrano-Bello, C. A., Sánchez-Santiago, P. J., et al. (2020) · Genes · doi:10.3390/genes11020222 · Cited by 15 · see citing works
Feng, L., Cain, J. D., Tombran‐Tink, J., & Niyibizi, C. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.07.034 · Cited by 14 · see citing works
Ramon, I., Kleynen, P., Valsamis, J., Body, J., & Karmali, R. (2011) · Calcified Tissue International · doi:10.1007/s00223-011-9527-8 · Cited by 14 · see citing works
SPR4-peptide alters bone metabolism of normal and HYP mice
Zelenchuk, L. V., Hedge, A.-M., & Rowe, P. S. (2014) · Bone · doi:10.1016/j.bone.2014.11.011 · Cited by 14 · see citing works
Self-citationRemodeling process in bone of aged rats in response to resistance training
de Farias, G. C., Neto, I. V. D. S., Guzzoni, V., Pisani, G. F. D., Royer, C., de Lima, C. L., Neves, F. D. A. R., Bogni, F. H., Nonaka, K. O., Durigan, J. L. Q., et al. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118008 · Cited by 14 · see citing works
Muhammad, A. I., Dalia, A. M., Loh, T. C., Akit, H., & Samsudin, A. A. (2021) · BMC Veterinary Research · doi:10.1186/s12917-021-02964-0 · Cited by 13 · see citing works
Akyer, Ş. P., Karagür, E. R., Tunç-Ata, M., Kılıç-Toprak, E., Çört, A., & Dönmez, B. Ö. (2023) · Current Issues in Molecular Biology · doi:10.3390/cimb45110550 · Cited by 12 · see citing works
Öztürk, Ş., Cüneyit, İ., Altıntaş, F., Karagür, E. R., Donmez, A. C., Ocak, M., Ünal, M., Sarıkanat, M., & Dönmez, B. Ö. (2023) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-023-01416-z · Cited by 12 · see citing works
ASARM mineralization hypothesis: A bridge too far?
David, V., & Quarles, L. D. (2010) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.69 · Cited by 9 · see citing works
Self-citationThe Intricacies of Renal Phosphate Reabsorption—An Overview
Walker, V. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25094684 · Cited by 8 · see citing works
Wang, N., Niger, C., Li, N., Richards, G. O., & Skerry, T. M. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.581002 · Cited by 10 · see citing works
The Bioactive Acidic Serine- and Aspartate-Rich Motif Peptide
Minamizaki, T., & Yoshiko, Y. (2015) · Current Protein and Peptide Science · doi:10.2174/1389203716666150206122839 · Cited by 9 · see citing works
Moriyama, K., Hanai, A., Mekada, K., Yoshiki, A., Ogiwara, K., Kimura, A. P., & Takahashi, T. (2011) · Journal of Biomedical Science · doi:10.1186/1423-0127-18-60 · Cited by 9 · see citing works
Isolation of Primary Avian Osteocytes
Semeins, C. M., Bakker, A. D., & Klein‐Nulend, J. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-415-5_4 · Cited by 9 · see citing works
Li, F., Cain, J. D., Tombran‐Tink, J., & Niyibizi, C. (2019) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-018-0982-4 · Cited by 9 · see citing works
Shavadia, J., Granger, C. B., Alemayehu, W. G., Westerhout, C. M., Povsic, T. J., Brener, S. J., van Diepen, S., deFilippi, C. R., & Armstrong, P. W. (2019) · American Heart Journal · doi:10.1016/j.ahj.2019.09.015 · Cited by 9 · see citing works
Active sites of human MEPE-ASARM regulating bone matrix mineralization
Minamizaki, T., Sakurai, K., Hayashi, I., Toshishige, M., Yoshioka, H., Kozai, K., & Yoshiko, Y. (2020) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2020.110931 · Cited by 8 · see citing works
PHEXL222P Mutation Increases Phex Expression in a New ENU Mouse Model for XLH Disease
Hakam, C. E., Parenté, A., Baraige, F., Magnol, L., Forestier, L., Meo, F. D., & Blanquet, V. (2022) · Genes · doi:10.3390/genes13081356 · Cited by 8 · see citing works
Eller, O. C., Stair, R. N., Neal, C. A., Rowe, P. S., Nelson‐Brantley, J., Young, E. E., & Baumbauer, K. M. (2022) · Neurobiology of Pain · doi:10.1016/j.ynpai.2022.100097 · Cited by 8 · see citing works
Self-citationCorrection of Vascular Calcification and Hyperphosphatemia in CKD Rats Treated with ASARM Peptide
Rowe, P. S., McCarthy, E. M., Yu, A. S. L., & Stubbs, J. R. (2022) · Kidney360 · doi:10.34067/kid.0002782022 · Cited by 7 · see citing works
Self-citationRadiation activated CHK1/MEPE pathway may contribute to microgravity-induced bone density loss
Zhang, X., Wang, P., & Wang, Y. (2015) · Life Sciences in Space Research · doi:10.1016/j.lssr.2015.08.004 · Cited by 6 · see citing works
Ozsen, A., Furman, A., Güran, T., Bereket, A., & Turan, S. (2019) · Hormone Research in Paediatrics · doi:10.1159/000506477 · Cited by 6 · see citing works
Li, T., Cao, S., Liao, X., Shao, Y., Zhang, L., Lü, L., Liu, Z., & Luo, X. (2022) · Frontiers in Veterinary Science · doi:10.3389/fvets.2022.855405 · Cited by 5 · see citing works
Bouleftour, W., Granito, R. N., Vanden‐Bossche, A., Sabido, O., Roche, B., Thomas, M., Linossier, M., Aubin, J. E., Lafage‐Proust, M., Vico, L., et al. (2016) · Journal of Cellular Physiology · doi:10.1002/jcp.25630 · Cited by 5 · see citing works
Jin, J., & Zandieh‐Doulabi, B. (2024) · Current Issues in Molecular Biology · doi:10.3390/cimb46110738 · Cited by 4 · see citing works
Szumera‐Ciećkiewicz, A., Ptaszyński, K., Pawełas, A., & Rutkowski, P. L. (2009) · PubMed · Cited by 4 · see citing works
FAM20C: A key protein kinase in multiple diseases
Zhang, R., Ren, Y., Ju, Y., Zhang, Y., Zhang, Y., & Wang, Y. (2023) · Genes & Diseases · doi:10.1016/j.gendis.2023.101179 · Cited by 3 · see citing works
The Role of Non-collagenous Proteins and Other Matrix Molecules in Vertebrate Mineralization
Shapiro, I. M., & Landis, W. J. (2023) · Springer eBooks · doi:10.1007/978-3-031-34304-9_8 · Cited by 3 · see citing works
3D genomic alterations during development of skeletal muscle in chicken
Xu, Z., Wang, T., Zhu, W., Yang, M., Leng, D., Li, Z., Zhang, J., Liu, P., Wu, Z., He, M., et al. (2024) · Journal of Integrative Agriculture · doi:10.1016/j.jia.2024.03.052 · Cited by 3 · see citing works
Heritable Renal Phosphate Wasting Disorders
Drezner, M. K., & Whyte, M. P. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804182-6.00040-x · Cited by 3 · see citing works
Levasseur, R. (2019) · EMC - Aparato Locomotor · doi:10.1016/s1286-935x(19)42130-8 · Cited by 2 · see citing works
Levasseur, R. (2019) · EMC - Podología · doi:10.1016/s1762-827x(19)42712-0 · Cited by 1 · see citing works
Mariano, A., d’Abusco, A. S., & Ammendola, S. (2026) · Nutrients · doi:10.3390/nu18061003 · Cited by 1 · see citing works
Heritable Renal Phosphate Wasting Disorders
Drezner, M. K. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-387829-8.00032-9 · Cited by 1 · see citing works
Ohlsson, M. A., Molvin, J., Isholth, H. H., Nezami, Z., Laučytė-Cibulskienė, A., Christensson, A. G., Jujić, A., & Magnusson, M. (2025) · Cardiorenal Medicine · doi:10.1159/000546236 · Cited by 1 · see citing works
A Synopsis of Phosphate Disorders in the Nursing Home
Xing, X. S., Yamaguchi, D. T., & Weintraub, N. T. (2010) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2009.10.007 · Cited by 1 · see citing works
Nguyen, H. N., & Kampa, N. (2013) · The Thai Journal of Veterinary Medicine · doi:10.56808/2985-1130.2488 · Cited by 1 · see citing works
Houessou, U., Zamani, P., Manikpurage, H. D., Li, Z., Gaudreault, N., Dahmene, M., Dagenais, F., Couture, C., Clavel, M.-A., Pibarot, P., et al. (2026) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2026.120791 · Cited by 1 · see citing works
Raine Syndrome and FAM20C Variants in a Mexican Family
Palacios‐Reyes, C., Espinosa-García, A. M., Lara, I. P., Godínez-Aguilar, R., Duran, J. P., Alonso-Themann, P. G., Hernández‐Zavala, A., Cortés-Camacho, F., Villanueva-Ocampo, P., Ugarte-Briones, C., et al. (2020) · Vide Leaf, Hyderabad eBooks · doi:10.37247/pag.1.2020.9
Muhammad, A. I., Dalia, A. M., Loh, T. C., Akit, H., & Samsudin, A. A. (2020) · Research Square · doi:10.21203/rs.3.rs-127962/v1
Eller, O. C., Stair, R. N., Neal, C. A., Rowe, P. S., Nelson‐Brantley, J., Young, E. E., & Baumbauer, K. M. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.06.15.448577
Self-citation
- Authors
- David, V., Martin, A., Hedge, A.-M., & Rowe, P. S. N.
- Affiliations
- University of Kansas Medical Center (US)
- Corresponding author
- Rowe, Peter S. N.
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2009-09-01
- Volume
- 150
- Issue
- 9
- Pages
- 4012-4023
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- PMC
- PMC2819738
- OpenAlex
- W2000443667
- Cited by
- 106
- References
- 50
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 3 · 2023: 4 · 2022: 7 · 2021: 3 · 2020: 9 · 2019: 5 · 2018: 6 · 2017: 2 · 2016: 5 · 2015: 10 · 2014: 3 · 2013: 15 · 2012: 9
- FWCI
- 6.68
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Endocrinology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ar051598-09)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01-AR051598)
- Topics
- Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Alkaline Phosphatase Research Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Keywords
- MEPE, bone mineralization, bone remodeling, renal calcification, phosphate metabolism, hyperphosphatemia, Npt2a, osteogenic differentiation, osteoclastogenesis, bone turnover
- MeSH terms
- Aging, Aldosterone, Animals, Animal Nutritional Physiological Phenomena, Bone and Bones, Bone Development, Calcitriol, Glycoproteins, Hypocalcemia, Kidney, Mice, Inbred C57BL, Mice, Transgenic, Neovascularization, Pathologic, Parathyroid Hormone, Phosphoproteins, Extracellular Matrix Proteins, Vascular Endothelial Growth Factor A, Mice, PHEX Phosphate Regulating Neutral Endopeptidase, Osteopontin, Hyperphosphatemia
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