Cited by 106Parathyroid Disorders and TreatmentsAlkaline Phosphatase Research StudiesBone Metabolism and Diseases

Matrix extracellular phosphoglycoprotein (MEPE) is a new bone renal hormone and vascularization modulator

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David, Valentin, Martin, Aline, Hedge, Anne-Marie, Rowe, Peter S. N.·2009·Endocrinology

Abstract

Increased matrix extracellular phosphoglycoprotein (MEPE) expression occurs in several phosphate and bone-mineral metabolic disorders. To resolve whether MEPE plays a role, we created a murine model overexpressing MEPE protein (MEPE tgn) in bone. MEPE tgn mice displayed a growth and mineralization defect with altered bone-renal vascularization that persisted to adulthood. The growth mineralization defect was due to a decrease in bone remodeling, and MEPE tgn mice were resistant to diet-induced renal calcification. MEPE protein-derived urinary ASARM peptides and reduced urinary Ca X PO4 product mediated the suppressed renal calcification. Osteoblastic cells displayed reduced activity but normal differentiation. Osteoclastic precursors were unable to differentiate in the presence of osteoblasts. In the kidney, NPT2a up-regulation induced an increase in phosphate renal reabsorption, leading to hyperphosphatemia. We conclude MEPE and MEPE-phosphate-regulating gene with homologies to endopeptidases on the X chromosome (MEPE-PHEX) interactions are components to an age-diet-dependent pathway that regulates bone turnover and mineralization and suppresses renal calcification. This novel pathway also modulates bone-renal vascularization and bone turnover.

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Crossref · 10.1210/en.2009-0216

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Authors
David, V., Martin, A., Hedge, A.-M., & Rowe, P. S. N.
Affiliations
University of Kansas Medical Center (US)
Corresponding author
Rowe, Peter S. N.
Venue
Endocrinology
Published
2009-09-01
Volume
150
Issue
9
Pages
4012-4023
ISSN
  • 0013-7227 (ISSN-L)
  • 1945-7170
OpenAlex
W2000443667
Cited by
106
References
50
Citations by year
2026: 4 · 2025: 1 · 2024: 3 · 2023: 4 · 2022: 7 · 2021: 3 · 2020: 9 · 2019: 5 · 2018: 6 · 2017: 2 · 2016: 5 · 2015: 10 · 2014: 3 · 2013: 15 · 2012: 9
FWCI
6.68
Type
journal article
Language
en
Open access
Locations
  • Endocrinology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01ar051598-09)
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01-AR051598)
Topics
  • Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Alkaline Phosphatase Research Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Keywords
MEPE, bone mineralization, bone remodeling, renal calcification, phosphate metabolism, hyperphosphatemia, Npt2a, osteogenic differentiation, osteoclastogenesis, bone turnover
MeSH terms
Aging, Aldosterone, Animals, Animal Nutritional Physiological Phenomena, Bone and Bones, Bone Development, Calcitriol, Glycoproteins, Hypocalcemia, Kidney, Mice, Inbred C57BL, Mice, Transgenic, Neovascularization, Pathologic, Parathyroid Hormone, Phosphoproteins, Extracellular Matrix Proteins, Vascular Endothelial Growth Factor A, Mice, PHEX Phosphate Regulating Neutral Endopeptidase, Osteopontin, Hyperphosphatemia

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