The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Chemerin Exacerbates Glucose Intolerance in Mouse Models of Obesity and Diabetes
Abstract
Obesity, characterized by an excess of adipose tissue, is an established risk factor for cardiovascular disease and type 2 diabetes. Different mechanisms linking obesity with these comorbidities have been postulated but remain poorly understood. Adipose tissue secretes a number of hormone-like compounds, termed adipokines, that are important for the maintenance of normal glucose metabolism. Alterations in the secretion of adipokines with obesity are believed to contribute to the undesirable changes in glucose metabolism that ultimately result in the development of type 2 diabetes. In the present study, we have shown that serum levels of the novel adipokine chemerin are significantly elevated in mouse models of obesity/diabetes. The expression of chemerin and its receptors, chemokine-like receptor 1, chemokine (C-C motif) receptor-like 2, and G protein-coupled receptor 1 are altered in white adipose, skeletal muscle, and liver tissue of obese/diabetic mice. Administration of exogenous chemerin exacerbates glucose intolerance, lowers serum insulin levels, and decreases tissue glucose uptake in obese/diabetic but not normoglycemic mice. Collectively, these data indicate that chemerin influences glucose homeostasis and may contribute to the metabolic derangements characteristic of obesity and type 2 diabetes.
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Cites
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Cited by
Metabolic Syndrome and Insulin Resistance: Underlying Causes and Modification by Exercise Training
Roberts, C. K., Hevener, A. L., & Barnard, R. J. (2013) · Comprehensive Physiology · doi:10.1002/cphy.c110062 · Cited by 831
Chemerin: at the crossroads of inflammation and obesity
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Self-citationChemerin and its receptors in leukocyte trafficking, inflammation and metabolism
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Myokines and Adipokines: Involvement in the Crosstalk between Skeletal Muscle and Adipose Tissue
Li, F., Li, Y., Duan, Y., Hu, C.-A. A., Tang, Y., & Yin, Y. (2017) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2016.10.003 · Cited by 288
Towards an integrative approach to understanding the role of chemerin in human health and disease
Rourke, J. L., Dranse, H. J., & Sinal, C. J. (2013) · Obesity Reviews · doi:10.1111/obr.12009 · Cited by 281
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Metadata
- Authors
- Ernst, M. C., Issa, M., Goralski, K. B., & Sinal, C. J.
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2010-03-12
- Volume
- 151
- Issue
- 5
- Pages
- 1998-2007
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2070335885
- Cited by
- 259
- References
- 46
- FWCI
- 10.48
- Type
- journal article
- Language
- en
- Open access
- closed
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