Chemerin and its receptors in leukocyte trafficking, inflammation and metabolism
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Chemerin was isolated as the natural ligand of the G protein-coupled receptor ChemR23. Chemerin acts as a chemotactic factor for leukocyte populations expressing ChemR23, particularly immature plasmacytoid dendritic cells, but also immature myeloid DCs, macrophages and natural killer cells. Chemerin is expressed by epithelial and non-epithelial cells as an inactive precursor, present at nanomolar concentrations in plasma. Processing of the precursor C-terminus is required for generating bioactive forms of chemerin. Various proteases mediate this processing, including neutrophil serine proteases and proteases from coagulation and fibrinolytic cascades. ChemR23-expressing cells are recruited in human inflammatory diseases, such as psoriasis and lupus. In animal models, both pro-inflammatory and anti-inflammatory roles of chemerin have been reported. Recently, two other receptors for chemerin were described, GPR1 and CCRL2, but their functional relevance is largely unknown. Both chemerin and ChemR23 are also expressed by adipocytes, and the emerging role of chemerin as an adipokine regulating lipid and carbohydrate metabolism is an area of intense research.
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Chemerin and CMKLR1 recruit immune cells to injury sites and might affect the occurrence and development of inflammation.
“Chemerin and CMKLR1 (which is expressed on immature dendritic cells, myeloid dendritic cells, macrophages, and natural killer cells) were later shown to recruit immune cells to injury sites and might affect the occurrence and development of inflammation (37, 38).”
From Circulating Adipokine Levels in Nonobese Women with Polycystic Ovary Syndrome and in Nonobese Control Women: A Systematic Review and Meta-Analysis (2021) · cites this paper as [38]
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- Authors
- Bondue, B., Wittamer, V., & Parmentier, M.
- Affiliations
- Université Libre de Bruxelles (BE)
- Corresponding author
- Parmentier, Marc
- Venue
- Cytokine & Growth Factor Reviews
- Publisher
- Elsevier BV
- Published
- 2011-10
- Volume
- 22
- Issue
- 5-6
- Pages
- 331-338
- ISSN
- 1359-6101 (ISSN-L)
- OpenAlex
- W2015466197
- Cited by
- 294
- References
- 61
- Citations by year
- 2026: 14 · 2025: 9 · 2024: 24 · 2023: 19 · 2022: 27 · 2021: 23 · 2020: 23 · 2019: 25 · 2018: 26 · 2017: 21 · 2016: 24 · 2015: 7 · 2014: 20 · 2013: 23 · 2012: 9
- FWCI
- 1.53
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Cytokine & Growth Factor Reviews (publishedVersion)
- PubMed (publishedVersion)
- Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
- Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
- Keywords
- chemerin, ChemR23, GPR1, CCRL2, leukocyte migration, inflammation, chemotaxis, plasmacytoid dendritic cells, macrophages, natural killer cells, precursor processing, serine protease, psoriasis, lupus, adipokines, adipocytes, lipid metabolism, carbohydrate metabolism
- MeSH terms
- Amino Acid Sequence, Animals, Chemotaxis, Leukocyte, Inflammation, Oligopeptides, Chemokines, Receptors, Chemokine, Intercellular Signaling Peptides and Proteins
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