The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
Minireview: Inflammation and Obesity Pathogenesis: The Hypothalamus Heats Up
Open accessAbstract
Obesity induced by high-fat (HF) feeding is associated with low-grade inflammation in peripheral tissues that predisposes to insulin resistance. Recent evidence suggests the occurrence of a similar process in the hypothalamus, which favors weight gain through impairment of leptin and insulin signaling. In addition to its implications for obesity pathogenesis, this hypothesis suggests that centrally targeted antiinflammatory therapies may prove effective in prevention and treatment of this disorder. This article highlights molecular and cellular mechanisms by which hypothalamic inflammation predisposes to diet-induced obesity.
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“Neuroinflammation in the hypothalamus has been extensively implicated in the pathogenesis of various metabolic disorders, including obesity, insulin resistance, and type 2 diabetes [1, 2].”
From The Resistin/TLR4/miR-155-5p axis: a novel signaling pathway in the onset of hypothalamic neuroinflammation (2025) · cites this paper as [1]
In the citing paper
“Recent evidence suggests that consumption of a HFD also induces inflammation in the hypothalamus, an effect that itself could favor weight gain by impairing the neuronal response to input from leptin and insulin (184).”
From Leptin and the Central Nervous System Control of Glucose Metabolism (2011) · cites this paper as [184]
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Citations
Cites
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041
Inflammation and metabolic disorders
Hotamisligil, G. S. (2006) · Nature · doi:10.1038/nature05485 · Cited by 9,199
Prevalence and Trends in Obesity Among US Adults, 1999-2008
Flegal, K. M. (2010) · JAMA · doi:10.1001/jama.2009.2014 · Cited by 7,580
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Metabolic Endotoxemia Initiates Obesity and Insulin Resistance
Cani, P. D., Amar, J., Iglesias, M. A., Poggi, M., Knauf, C., Bastelica, D., Neyrinck, A. M., Fava, F., Tuohy, K. M., Chabo, C., et al. (2007) · Diabetes · doi:10.2337/db06-1491 · Cited by 6,638
Central nervous system control of food intake
Schwartz, M. W., Woods, S. C., Porte, D., Seeley, R. J., & Baskin, D. G. (2000) · Nature · doi:10.1038/35007534 · Cited by 6,451
Self-citationInflammation and insulin resistance
Shoelson, S. E. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29069 · Cited by 4,769
Effects of Bariatric Surgery on Mortality in Swedish Obese Subjects
Sjöström, L., Narbro, K., Sjöström, C. D., Karason, K., Larsson, B., Wedel, H., Lystig, T., Sullivan, M., Bouchard, C., Carlsson, B., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa066254 · Cited by 4,668
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Long-term mortality after gastric bypass surgery
Adams, T. D., Gress, R. E., Smith, S. C., Halverson, R. C., Simper, S. C., Rosamond, W. D., LaMonte, M. J., Stroup, A. M., & Hunt, S. C. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa066603 · Cited by 2,572
Cited by
Sorted by citations
Inflammatory links between obesity and metabolic disease
Lumeng, C. N., & Saltiel, A. R. (2011) · Journal of Clinical Investigation · doi:10.1172/jci57132 · Cited by 2,319
Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future
Kahn, S. E., Cooper, M. E., & Del Prato, S. (2014) · The Lancet · doi:10.1016/s0140-6736(13)62154-6 · Cited by 1,743
Obesity is associated with hypothalamic injury in rodents and humans.
Thaler, J. P., Yi, C.-X., Schur, E. A., Guyenet, S. J., Hwang, B. H., Dietrich, M. O., Zhao, X., Sarruf, D. A., Izgur, V., Maravilla, K. R., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59660 · Cited by 1,857
Self-citationImmune system to brain signaling: Neuropsychopharmacological implications
Capuron, L., & Miller, A. H. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.01.014 · Cited by 1,195
Obesity and neuroinflammation: A pathway to cognitive impairment
Miller, A. A., & Spencer, S. J. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.04.001 · Cited by 834
Metadata
- Authors
- Thaler, J. P., & Schwartz, M. W.
- Affiliations
- University of Washington (US)
- Corresponding author
- Schwartz, Michael W.
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2010-07-23
- Volume
- 151
- Issue
- 9
- Pages
- 4109-4115
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- PMC
- PMC2940486
- OpenAlex
- W1998525855
- Cited by
- 313
- References
- 58
- Citations by year
- 2026: 7 · 2025: 15 · 2024: 11 · 2023: 10 · 2022: 14 · 2021: 19 · 2020: 21 · 2019: 21 · 2018: 16 · 2017: 12 · 2016: 27 · 2015: 24 · 2014: 34 · 2013: 34 · 2012: 31
- FWCI
- 2.96
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Endocrinology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Diabetes Association (DK052989)
- University of Washington (DK007247)
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-083042, DK068384, DK052989, R01DK052989, DK-007247, P01DK068384, R01DK090320, R01DK083042, T32DK007247)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- hypothalamic inflammation, diet-induced obesity, high-fat feeding, insulin resistance, leptin signaling, insulin signaling, obesity pathogenesis, anti-inflammatory therapy, low-grade inflammation
- MeSH terms
- Animals, Humans, Hypothalamus, Inflammation, Insulin Resistance, Models, Biological, Obesity, Weight Gain, Glucose Intolerance, Leptin
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