Cited by 313Adipokines, Inflammation, and Metabolic DiseasesRegulation of Appetite and ObesityNeuroinflammation and Neurodegeneration Mechanisms

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Minireview: Inflammation and Obesity Pathogenesis: The Hypothalamus Heats Up

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Thaler, Joshua P., Schwartz, Michael W.·2010·Endocrinology

DOI 10.1210/en.2010-0336PMC PMC2940486

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Abstract

Obesity induced by high-fat (HF) feeding is associated with low-grade inflammation in peripheral tissues that predisposes to insulin resistance. Recent evidence suggests the occurrence of a similar process in the hypothalamus, which favors weight gain through impairment of leptin and insulin signaling. In addition to its implications for obesity pathogenesis, this hypothesis suggests that centrally targeted antiinflammatory therapies may prove effective in prevention and treatment of this disorder. This article highlights molecular and cellular mechanisms by which hypothalamic inflammation predisposes to diet-induced obesity.

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Authors: Thaler, J. P., & Schwartz, M. W.
Affiliations: University of Washington (US)
Corresponding author: Schwartz, Michael W.
ORCID: Thaler, Joshua P.
Schwartz, Michael W.
Venue: Endocrinology
Publisher: The Endocrine Society
Published: 2010-07-23
Volume: 151
Issue: 9
Pages: 4109-4115
ISSN: 0013-7227 (ISSN-L)
1945-7170
DOI: 10.1210/en.2010-0336
PMC: PMC2940486
OpenAlex: W1998525855
Cited by: 313
References: 58
Citations by year: 2026: 7 · 2025: 15 · 2024: 11 · 2023: 10 · 2022: 14 · 2021: 19 · 2020: 21 · 2019: 21 · 2018: 16 · 2017: 12 · 2016: 27 · 2015: 24 · 2014: 34 · 2013: 34 · 2012: 31
FWCI: 2.96
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Endocrinology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: American Diabetes Association (DK052989)
University of Washington (DK007247)
National Institutes of Health
National Institute of Diabetes and Digestive and Kidney Diseases (DK-083042, DK068384, DK052989, R01DK052989, DK-007247, P01DK068384, R01DK090320, R01DK083042, T32DK007247)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: hypothalamic inflammation, diet-induced obesity, high-fat feeding, insulin resistance, leptin signaling, insulin signaling, obesity pathogenesis, anti-inflammatory therapy, low-grade inflammation
MeSH terms: Animals, Humans, Hypothalamus, Inflammation, Insulin Resistance, Models, Biological, Obesity, Weight Gain, Glucose Intolerance, Leptin

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