The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Identification, Expression, and Physiological Functions of Siberian Hamster Gonadotropin-Inhibitory Hormone
Open accessAbstract
Gonadotropin-inhibitory hormone (GnIH) is a hypothalamic neuropeptide that inhibits gonadotropin secretion in birds and mammals. To further understand its physiological roles in mammalian reproduction, we identified its precursor cDNA and endogenous mature peptides in the Siberian hamster brain. The Siberian hamster GnIH precursor cDNA encoded two RFamide-related peptide (RFRP) sequences. SPAPANKVPHSAANLPLRF-NH(2) (Siberian hamster RFRP-1) and TLSRVPSLPQRF-NH(2) (Siberian hamster RFRP-3) were confirmed as mature endogenous peptides by mass spectrometry from brain samples purified by immunoaffinity chromatography. GnIH mRNA expression was higher in long days (LD) compared with short days (SD). GnIH mRNA was also highly expressed in SD plus pinealectomized animals, whereas expression was suppressed by melatonin, a nocturnal pineal hormone, administration. GnIH-immunoreactive (-ir) neurons were localized to the dorsomedial region of the hypothalamus, and GnIH-ir fibers projected to hypothalamic and limbic structures. The density of GnIH-ir perikarya and fibers were higher in LD and SD plus pinealectomized hamsters than in LD plus melatonin or SD animals. The percentage of GnRH neurons receiving close appositions from GnIH-ir fiber terminals was also higher in LD than SD, and GnIH receptor was expressed in GnRH-ir neurons. Finally, central administration of hamster RFRP-1 or RFRP-3 inhibited LH release 5 and 30 min after administration in LD. In sharp contrast, both peptides stimulated LH release 30 min after administration in SD. These results suggest that GnIH peptides fine tune LH levels via its receptor expressed in GnRH-ir neurons in an opposing fashion across the seasons in Siberian hamsters.
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Cites
Structure of the porcine LH- and FSH-releasing hormone. I. The proposed amino acid sequence
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Mammalian reproductive biology
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Structure of the porcine LH- and FSH-releasing hormone. I. The proposed amino acid sequence
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A Novel Avian Hypothalamic Peptide Inhibiting Gonadotropin Release
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Self-citationNew neuropeptides containing carboxy-terminal RFamide and their receptor in mammals
Hinuma, S., Shintani, Y., Fukusumi, S., Iijima, N., Matsumoto, Y., Hosoya, M., Fujii, R., Watanabe, T., Kikuchi, K., Terao, Y., et al. (2000) · Nature Cell Biology · doi:10.1038/35036326 · Cited by 565
Identification and characterization of a gonadotropin-inhibitory system in the brains of mammals
Kriegsfeld, L. J., Mei, D. F., Bentley, G. E., Ubuka, T., Mason, A. O., Inoue, K., Ukena, K., Tsutsui, K., & Silver, R. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0511003103 · Cited by 552
Self-citationPrimary Structure of the Ovine Hypothalamic Luteinizing Hormone-Releasing Factor (LRF)
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Cited by
Knockdown of hypothalamic RFRP3 prevents chronic stress-induced infertility and embryo resorption
Geraghty, A. C., Muroy, S. E., Zhao, S., Bentley, G. E., Kriegsfeld, L. J., & Kaufer, D. (2015) · eLife · doi:10.7554/elife.04316 · Cited by 87
Self-citationYeo, S.-H., & Colledge, W. H. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00188 · Cited by 76
Ullah, R., Shen, Y., Zhou, Y.-D., Huang, K., Fu, J.-F., Wahab, F., & Shahab, M. (2016) · Neuropeptides · doi:10.1016/j.npep.2016.05.004 · Cited by 30
A "Timed" Kiss Is Essential for Reproduction: Lessons from Mammalian Studies
Putteeraj, M., Soga, T., Ubuka, T., & Parhar, I. S. (2016) · Frontiers in Endocrinology · doi:10.3389/fendo.2016.00121 · Cited by 28
Self-citationRegulation and Function of RFRP-3 (GnIH) Neurons during Postnatal Development
Poling, M. C., & Kauffman, A. S. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00150 · Cited by 27
Metadata
- Authors
- Ubuka, T., Inoue, K., Fukuda, Y., Mizuno, T., Ukena, K., Kriegsfeld, L. J., & Tsutsui, K.
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2012-01-01
- Volume
- 153
- Issue
- 1
- Pages
- 373-385
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2009424714
- Cited by
- 279
- References
- 51
- FWCI
- 24.73
- Type
- journal article
- Language
- en
- Open access
- green
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- Ubuka, T., Inoue, K., Fukuda, Y., Mizuno, T., Ukena, K., Kriegsfeld, L. J., & Tsutsui, K. (2012). Identification, Expression, and Physiological Functions of Siberian Hamster Gonadotropin-Inhibitory Hormone. Endocrinology. https://doi.org/10.1210/en.2011-1110
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