The DOI matches its Crossref record; 165 of the 166 references it cites were found in a registry or an index, and 1 are not checked yet.
The Diverse Metabolic Roles of Peripheral Serotonin
Open accessAbstract
Serotonin (5-hydroxytryptamine or 5-HT) is a multifunctional bioamine with important signaling roles in a range of physiological pathways. Almost all of the 5-HT in our bodies is synthesized in specialized enteroendocrine cells within the gastrointestinal (GI) mucosa called enterochromaffin (EC) cells. These cells provide all of our circulating 5-HT. We have long appreciated the important contributions of 5-HT within the gut, including its role in modulating GI motility. However, evidence of the physiological and clinical significance of gut-derived 5-HT outside of the gut has recently emerged, implicating 5-HT in regulation of glucose homeostasis, lipid metabolism, bone density, and diseases associated with metabolic syndrome, such as obesity and type 2 diabetes. Although a new picture has developed in the last decade regarding the various metabolic roles of peripheral serotonin, so too has our understanding of the physiology of EC cells. Given that they are scattered throughout the lining of the GI tract within the epithelial cell layer, these cells are typically difficult to study. Advances in isolation procedures now allow the study of pure EC-cell cultures and single cells, enabling studies of EC-cell physiology to occur. EC cells are sensory cells that are capable of integrating cues from ingested nutrients, the enteric nervous system, and the gut microbiome. Thus, levels of peripheral 5-HT can be modulated by a multitude of factors, resulting in both local and systemic effects for the regulation of a raft of physiological pathways related to metabolism and obesity.
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“Furthermore, gut-derived 5-HT can also modulate glucose and energy homeostasis (68-70), and is augmented in patients with type 2 diabetes (71) and the obese (9).”
From Gut mechanisms linking intestinal sweet sensing to glycemic control (2018) · cites this paper as [69]
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1 retracted
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The Influence of the Gut Microbiome on Host Metabolism Through the Regulation of Gut Hormone Release
Martin, A. M., Sun, E. W. L., Rogers, G. B., & Keating, D. J. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00428 · Cited by 402
Self-citationThe ever-changing roles of serotonin
Jones, L. A., Sun, E. W. L., Martin, A. M., & Keating, D. J. (2020) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2020.105776 · Cited by 265
Self-citationThe Mechanism of Secretion and Metabolism of Gut-Derived 5-Hydroxytryptamine
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Metadata
- Authors
- Martin, A. M., Young, R. L., Leong, L., Rogers, G. B., Spencer, N. J., Jessup, C. F., & Keating, D. J.
- Affiliations
- Flinders University (AU)
- South Australian Health and Medical Research Institute (AU)
- ORCID
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2017-03-01
- Volume
- 158
- Issue
- 5
- Pages
- 1049-1063
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2611159081
- Cited by
- 261
- References
- 166
- Citations by year
- 2026: 29 · 2025: 18 · 2024: 41 · 2023: 19 · 2022: 38 · 2021: 43 · 2020: 26 · 2019: 26 · 2018: 17 · 2017: 3
- FWCI
- 2.38
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Flinders University
- University of South Australia
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- peripheral serotonin, enterochromaffin cells, enteroendocrine cells, gut-brain axis, glucose homeostasis, lipid metabolism, bone mineral density, metabolic syndrome, obesity, type 2 diabetes, gut microbiota, enteric nervous system, gastrointestinal motility
- MeSH terms
- Animals, Energy Metabolism, Gastrointestinal Motility, Humans, Serotonin, Signal Transduction, Enteric Nervous System, Enteroendocrine Cells, Gastrointestinal Tract
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