Function and mechanisms of enteroendocrine cells and gut hormones in metabolism

An obesity-associated gut microbiome with increased capacity for energy harvest

Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444 · see citing works

Human gut microbes associated with obesity

Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. (2006) · Nature · doi:10.1038/4441022a · Cited by 8,785 · see citing works

Obesity alters gut microbial ecology

Ley, R. E., Bäckhed, F., Turnbaugh, P., Lozupone, C. A., Knight, R. D., & Gordon, J. I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504978102 · Cited by 6,176 · see citing works

Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice

Ridaura, V. K., Faith, J. J., Rey, F. E., Cheng, J., Duncan, A. E., Kau, A. L., Griffin, N. W., Lombard, V., Henrissat, B., Bain, J. R., et al. (2013) · Science · doi:10.1126/science.1241214 · Cited by 3,788 · see citing works

A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans

Cummings, D. E., Purnell, J. Q., Frayo, R. S., Schmidova, K., Wisse, B. E., & Weigle, D. S. (2001) · Diabetes · doi:10.2337/diabetes.50.8.1714 · Cited by 2,940 · see citing works

Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2

Tolhurst, G., Heffron, H., Lam, Y. S., Parker, H. E., Habib, A. M., Diakogiannaki, E., Cameron, J., Grosse, J., Reimann, F., & Gribble, F. M. (2012) · Diabetes · doi:10.2337/db11-1019 · Cited by 2,404 · see citing works

Population-level analysis of gut microbiome variation

Falony, G., Joossens, M., Vieira-Silva, S., Wang, J., Darzi, Y., Faust, K., Kurilshikov, A., Bonder, M. J., Valles-Colomer, M., Vandeputte, D., et al. (2016) · Science · doi:10.1126/science.aad3503 · Cited by 2,400 · see citing works

Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus

Nauck, M. A., Heimesaat, M. M., Orskov, C., Holst, J. J., Ebert, R., & Creutzfeldt, W. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116186 · Cited by 1,651 · see citing works

A G Protein-coupled Receptor Responsive to Bile Acids

Kawamata, Y., Fujii, R., Hosoya, M., Harada, M., Yoshida, H., Miwa, M., Fukusumi, S., Habata, Y., Itoh, T., Shintani, Y., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209706200 · Cited by 1,628 · see citing works

Inhibition of Food Intake in Obese Subjects by Peptide YY _3–36

Batterham, R. L., Cohen, M. A., Ellis, S. M., Le Roux, C. W., Withers, D. J., Frost, G. S., Ghatei, M. A., & Bloom, S. R. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa030204 · Cited by 1,604 · see citing works

Reduced incretin effect in Type 2 (non-insulin dependent) diabetes

Nauck, M., Stöckmann, F., Ebert, R., & Creutzfeldt, W. (1986) · Diabetologia · doi:10.1007/bf02427280 · Cited by 1,307 · see citing works

Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol

Lim, E. L., Hollingsworth, K. G., Aribisala, B. S., Chen, M. J., Mathers, J. C., & Taylor, R. (2011) · Diabetologia · doi:10.1007/s00125-011-2204-7 · Cited by 1,164 · see citing works

Improvement of insulin sensitivity after lean donor feces in metabolic syndrome is driven by baseline intestinal microbiota composition

Kootte, R. S., Levin, E., Salojärvi, J., Smits, L. P., Hartstra, A. V., Udayappan, S. D., Hermes, G., Bouter, K. E., Koopen, A. M., Holst, J. J., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.09.008 · Cited by 1,039 · see citing works

Ghrelin

Müller, T. D., Nogueiras, R., Andermann, M. L., Andrews, Z. B., Anker, S. D., Argente, J., Batterham, R. L., Benoit, S. C., Bowers, C. Y., Broglio, F., et al. (2015) · Molecular Metabolism · doi:10.1016/j.molmet.2015.03.005 · Cited by 1,034 · see citing works

Conserved shifts in the gut microbiota due to gastric bypass reduce host weight and adiposity

Liou, A. P., Paziuk, M., Luevano, J.-M., Machineni, S., Turnbaugh, P. J., & Kaplan, L. M. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3005687 · Cited by 1,007 · see citing works

Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1.

Jang, H.-J., Kokrashvili, Z., Theodorakis, M. J., Carlson, O. D., Kim, B.-J., Zhou, J., Kim, H. H., Xu, X., Chan, S. L., Juhaszova, M., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706890104 · Cited by 995 · see citing works

Inhibition of gastric inhibitory polypeptide signaling prevents obesity

Miyawaki, K., Yamada, Y., Ban, N., Ihara, Y., Tsukiyama, K., Zhou, H., Fujimoto, S., Oku, A., Tsuda, K., Toyokuni, S., et al. (2002) · Nature Medicine · doi:10.1038/nm727 · Cited by 963 · see citing works

A gut-brain neural circuit for nutrient sensory transduction

Kaelberer, M. M., Buchanan, K. L., Klein, M. E., Barth, B. B., Montoya, M. M., Shen, X., & Bohórquez, D. V. (2018) · Science · doi:10.1126/science.aat5236 · Cited by 932 · see citing works

Enterochromaffin cells are gut chemosensors that couple to sensory neural pathways

Bellono, N. W., Bayrer, J. R., Leitch, D. B., Castro, J., Zhang, C., O’Donnell, T. A., Brierley, S. M., Ingraham, H. A., & Julius, D. (2017) · Cell · doi:10.1016/j.cell.2017.05.034 · Cited by 910 · see citing works

The short chain fatty acid propionate stimulates GLP-1 and PYY secretion via free fatty acid receptor 2 in rodents

Psichas, A., Sleeth, M. L., Murphy, K. G., Brooks, L., Bewick, G. A., Hanyaloglu, A. C., Ghatei, M. A., Bloom, S. R., & Frost, G. (2015) · International Journal of Obesity · doi:10.1038/ijo.2014.153 · Cited by 886 · see citing works

LY3298176, a novel dual GIP and GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus: From discovery to clinical proof of concept

Coskun, T., Sloop, K. W., Loghin, C., Alsina-Fernandez, J., Urva, S., Bokvist, K. B., Cui, X., Briere, D. A., Cabrera, O., Roell, W. C., et al. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.09.009 · Cited by 882 · see citing works

Efficacy and safety of LY3298176, a novel dual GIP and GLP-1 receptor agonist, in patients with type 2 diabetes: a randomised, placebo-controlled and active comparator-controlled phase 2 trial

Frias, J. P., Nauck, M. A., Van, J., Kutner, M. E., Cui, X., Benson, C., Urva, S., Gimeno, R. E., Milicevic, Z., Robins, D., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(18)32260-8 · Cited by 815 · see citing works

Efficacy and safety of semaglutide compared with liraglutide and placebo for weight loss in patients with obesity: a randomised, double-blind, placebo and active controlled, dose-ranging, phase 2 trial

O'Neil, P. M., Birkenfeld, A. L., McGowan, B., Mosenzon, O., Pedersen, S. D., Wharton, S., Carson, C. G., Jepsen, C. H., Kabisch, M., & Wilding, J. P. H. (2018) · The Lancet · doi:10.1016/s0140-6736(18)31773-2 · Cited by 814 · see citing works

A Neural Circuit for Gut-Induced Reward

Han, W., Téllez, L. A., Perkins, M. H., Pérez-Martínez, I. O., Qu, T., Ferreira, J. G. P., Ferreira, T. L., Quinn, D., Liu, Z.-W., Gao, X., et al. (2018) · Cell · doi:10.1016/j.cell.2018.08.049 · Cited by 739 · see citing works

Glucose Sensing in L Cells: A Primary Cell Study

Reimann, F., Habib, A. M., Tolhurst, G., Parker, H. E., Rogers, G. J., & Gribble, F. M. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.11.002 · Cited by 733 · see citing works

Na+-<scp>d</scp>-glucose Cotransporter SGLT1 is Pivotal for Intestinal Glucose Absorption and Glucose-Dependent Incretin Secretion

Gorboulev, V., Schürmann, A., Vallon, V., Kipp, H., Jaschke, A., Klessen, D., Friedrich, A., Scherneck, S., Rieg, T., Cunard, R., et al. (2012) · Diabetes · doi:10.2337/db11-1029 · Cited by 687 · see citing works

Enteroendocrine Cells: Chemosensors in the Intestinal Epithelium

Gribble, F. M., & Reimann, F. (2016) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021115-105439 · Cited by 683 · see citing works

Glucagon‐like peptide‐1 cells in the gastrointestinal tract and pancreas of rat, pig and man

EISSELE, R., GÖKE, R., WILLEMER, S., HARTHUS, H. ‐., VERMEER, H., ARNOLD, R., & GÖKE, B. (1992) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1992.tb01464.x · Cited by 654 · see citing works

Sensory neurons that detect stretch and nutrients in the digestive system

Williams, E. K., Chang, R. B., Strochlic, D. E., Umans, B. D., Lowell, B. B., & Liberles, S. D. (2016) · Cell · doi:10.1016/j.cell.2016.05.011 · Cited by 645 · see citing works

<i>Gpr40</i> Is Expressed in Enteroendocrine Cells and Mediates Free Fatty Acid Stimulation of Incretin Secretion

Edfalk, S., Steneberg, P., & Edlund, H. (2008) · Diabetes · doi:10.2337/db08-0307 · Cited by 587 · see citing works

GPR41/FFAR3 and GPR43/FFAR2 as Cosensors for Short-Chain Fatty Acids in Enteroendocrine Cells vs FFAR3 in Enteric Neurons and FFAR2 in Enteric Leukocytes

Nøhr, M. K., Pedersen, M. H., Gille, A., Egerod, K. L., Engelstoft, M. S., Husted, A. S., Sichlau, R. M., Grunddal, K. V., Poulsen, S. S., Han, S., et al. (2013) · Endocrinology · doi:10.1210/en.2013-1142 · Cited by 575 · see citing works

Bacterial metabolite indole modulates incretin secretion from intestinal enteroendocrine L cells

Chimerel, C., Emery, E., Summers, D. K., Keyser, U., Gribble, F. M., & Reimann, F. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.10.032 · Cited by 548 · see citing works

Glucagon-like peptide 1 in health and disease

Andersen, A., Lund, A., Knop, F. K., & Vilsbøll, T. (2018) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0016-2 · Cited by 543 · see citing works

Endocrine cells in human intestine: an immunocytochemical study

Sjölund, K., Sandén, G., Håkanson, R., & Sundler, F. (1983) · Gastroenterology · doi:10.1016/s0016-5085(83)80080-8 · Cited by 520 · see citing works

Additive insulinotropic effects of exogenous synthetic human gastric inhibitory polypeptide and glucagon-like peptide-1-(7-36) amide infused at near-physiological insulinotropic hormone and glucose concentrations

Nauck, M. A., Bartels, E., Ørskov, C., Ebert, R., & Creutzfeldt, W. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.76.4.8473405 · Cited by 505 · see citing works

SCFAs strongly stimulate PYY production in human enteroendocrine cells

Larraufie, P., Martin‐Gallausiaux, C., Lapaque, N., Dore, J. M., Gribble, F. M., Reimann, F. M., & Blottière, H. M. (2018) · Scientific Reports · doi:10.1038/s41598-017-18259-0 · Cited by 455 · see citing works

Gastric emptying and release of incretin hormones after glucose ingestion in humans.

Schirra, J., Katschinski, M., Weidmann, C., Schäfer, T., Wank, U., Arnold, R., & Göke, B. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118411 · Cited by 426 · see citing works

The impact of short-chain fatty acids on GLP-1 and PYY secretion from the isolated perfused rat colon

Christiansen, C. B., Gabe, M. B. N., Svendsen, B., Dragsted, L. O., ROSENKILDE, M. M., & Holst, J. J. (2018) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00346.2017 · Cited by 403 · see citing works

The gnotobiotic animal as a tool in the study of host microbial relationships

Gordon, H. A., & Pesti, L. (1971) · Bacteriological Reviews · doi:10.1128/br.35.4.390-429.1971 · Cited by 393 · see citing works

Overlap of Endocrine Hormone Expression in the Mouse Intestine Revealed by Transcriptional Profiling and Flow Cytometry

Habib, A. M., Richards, P., Cairns, L. S., Rogers, G. J., Bannon, C. A. M., Parker, H. E., Morley, T. C. E., Yeo, G. S. H., Reimann, F. M., & Gribble, F. M. (2012) · Endocrinology · doi:10.1210/en.2011-2170 · Cited by 382 · see citing works

Microbial Modulation of Energy Availability in the Colon Regulates Intestinal Transit

Wichmann, A., Allahyar, A., Greiner, T. U., Plovier, H., Östergren‐Lundén, G., Larsson, T. P., Drucker, D. J., Delzenne, N. M., Cani, P. D., & Bäckhed, F. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.09.012 · Cited by 380 · see citing works

Effect of Peptide YY3–36 on Food Intake in Humans

Degen, L. P., Oesch, S., Casanova, M., Graf, S., Ketterer, S., Drewe, J., & Beglinger, C. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.09.001 · Cited by 363 · see citing works

Bile Acids Trigger GLP-1 Release Predominantly by Accessing Basolaterally Located G Protein–Coupled Bile Acid Receptors

Brighton, C. A., Rievaj, J., Kuhre, R. E., Glasssmith, L. L., Schoonjans, K., Holst, J. J., Gribble, F. M., & Reimann, F. M. (2015) · Endocrinology · doi:10.1210/en.2015-1321 · Cited by 355 · see citing works

Effects of Gut Microbiota Manipulation by Antibiotics on Host Metabolism in Obese Humans: A Randomized Double-Blind Placebo-Controlled Trial

Reijnders, D., Goossens, G. H., Hermes, G. D. A., Neis, E. P. J. G., van der Beek, C. M., Most, J., Holst, J. J., Lenaerts, K., Kootte, R. S., Nieuwdorp, M., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.06.016 · Cited by 349 · see citing works

Physiology and Pharmacology of the Enteroendocrine Hormone Glucagon-Like Peptide-2

Drucker, D. J., & Yusta, B. (2013) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021113-170317 · Cited by 344 · see citing works

A Major Lineage of Enteroendocrine Cells Coexpress CCK, Secretin, GIP, GLP-1, PYY, and Neurotensin but Not Somatostatin

Egerod, K. L., Engelstoft, M. S., Grunddal, K. V., Nøhr, M. K., Secher, A., Sakata, I., Pedersen, J., Windeløv, J. A., Füchtbauer, E., Olsen, J., et al. (2012) · Endocrinology · doi:10.1210/en.2012-1595 · Cited by 328 · see citing works

Nutrient-dependent secretion of glucose-dependent insulinotropic polypeptide from primary murine K cells

Parker, H. E., Habib, A. M., Rogers, G. J., Gribble, F. M., & Reimann, F. (2009) · Diabetologia · doi:10.1007/s00125-008-1202-x · Cited by 324 · see citing works

A Taxonomic Signature of Obesity in the Microbiome? Getting to the Guts of the Matter

Finucane, M. M., Sharpton, T. J., Laurent, T. J., & Pollard, K. S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0084689 · Cited by 321 · see citing works

GLP-1 response to oral glucose is reduced in prediabetes, screen-detected type 2 diabetes, and obesity and influenced by sex: the ADDITION-PRO study

Færch, K., Torekov, S. S., Vistisen, D., Johansen, N. B., Witte, D. R., Jonsson, A., Pedersen, O., Hansen, T., Lauritzen, T., Sandbæk, A., et al. (2015) · Diabetes · doi:10.2337/db14-1751 · Cited by 321 · see citing works

Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells

Engelstoft, M. S., Park, W.-M., Sakata, I., Kristensen, L. V., Husted, A. S., Osborne-Lawrence, S. L., Piper, P. K., Walker, A. K., Pedersen, M. H., Nøhr, M. K., et al. (2013) · Molecular Metabolism · doi:10.1016/j.molmet.2013.08.006 · Cited by 318 · see citing works

Acute and long-term effects of Roux-en-Y gastric bypass on glucose metabolism in subjects with Type 2 diabetes and normal glucose tolerance

Jørgensen, N. B., Jacobsen, S. H., Dirksen, C., Bojsen-Møller, K. N., Naver, L., Hvolris, L., Clausen, T. R., Wulff, B. S., Worm, D., Lindqvist Hansen, D., et al. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00073.2012 · Cited by 313 · see citing works

Activation of proglucagon gene transcription by protein kinase-A in a novel mouse enteroendocrine cell line

Drucker, D. J., Jin, T., Asa, S. L., Young, T. A., & Brubaker, P. L. (1994) · Molecular Endocrinology · doi:10.1210/mend.8.12.7535893 · Cited by 303 · see citing works

Glucose-Sensing in Glucagon-Like Peptide-1-Secreting Cells

Reimann, F. M., & Gribble, F. M. (2002) · Diabetes · doi:10.2337/diabetes.51.9.2757 · Cited by 293 · see citing works

Vertical Sleeve Gastrectomy Is Effective in Two Genetic Mouse Models of Glucagon-Like Peptide 1 Receptor Deficiency

Wilson, H., Chambers, A. P., Ryan, K. K., Li, B., Sandoval, D. A., Stoffers, D. A., Drucker, D. J., Pérez–Tilve, D., & Seeley, R. J. (2013) · Diabetes · doi:10.2337/db12-1498 · Cited by 286 · see citing works

Enteroendocrine cells switch hormone expression along the crypt-to-villus BMP signalling gradient

Beumer, J., Artegiani, B., Post, Y., Reimann, F. M., Gribble, F. M., Nguyen, T. N., Zeng, H., van den Born, M., van Es, J. H., & Clevers, H. C. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0143-y · Cited by 280 · see citing works

Exaggerated Glucagon-Like Peptide 1 Response Is Important for Improved β-Cell Function and Glucose Tolerance After Roux-en-Y Gastric Bypass in Patients With Type 2 Diabetes

Jørgensen, N. B., Dirksen, C., Bojsen-Møller, K. N., Jacobsen, S. H., Worm, D., Hansen, D. L., Kristiansen, V. B., Naver, L., Madsbad, S., & Holst, J. J. (2013) · Diabetes · doi:10.2337/db13-0022 · Cited by 279 · see citing works

The role of nausea in food intake and body weight suppression by peripheral GLP-1 receptor agonists, exendin-4 and liraglutide

Kanoski, S. E., Rupprecht, L. E., Fortin, S. M., De Jonghe, B. C., & Hayes, M. R. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.12.022 · Cited by 273 · see citing works

Gastric emptying and glycaemia in health and diabetes mellitus

Phillips, L. K., Deane, A. M., Jones, K. L., Rayner, C. K., & Horowitz, M. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2014.202 · Cited by 273 · see citing works

Ingested medium-chain fatty acids are directly utilized for the acyl modification of ghrelin.

Nishi, Y., Hiejima, H., Hosoda, H., Kaiya, H., Mori, K., Fukue, Y., Yanase, T., Nawata, H., Kangawa, K., & Kojima, M. (2005) · Endocrinology · doi:10.1210/en.2004-0695 · Cited by 267 · see citing works

The diverse metabolic roles of peripheral serotonin

Martin, A. M., Young, R. L., Leong, L., Rogers, G. B., Spencer, N. J., Jessup, C. F., & Keating, D. J. (2017) · Endocrinology · doi:10.1210/en.2016-1839 · Cited by 261 · see citing works

Reversible changes in pancreatic islet structure and function produced by elevated blood glucose

Brereton, M. F., Iberl, M., Shimomura, K., Zhang, Q., Adriaenssens, A. E., Proks, P., Spiliotis, I. I., Dace, W., Mattis, K. K., Ramracheya, R., et al. (2014) · Nature Communications · doi:10.1038/ncomms5639 · Cited by 259 · see citing works

Enterochromaffin 5-HT cells – A major target for GLP-1 and gut microbial metabolites

Lund, M. L., Egerod, K. L., Engelstoft, M. S., Dmytriyeva, O., Theodorsson, E., Patel, B. A., & Schwartz, T. W. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.03.004 · Cited by 255 · see citing works

Fermentable carbohydrate stimulates FFAR2-dependent colonic PYY cell expansion to increase satiety

Brooks, L. J., Viardot, A., Tsakmaki, A., Stolarczyk, É., Howard, J. K., Cani, P. D., Everard, A., Sleeth, M., Psichas, A., Anastasovskaj, J., et al. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.10.011 · Cited by 250 · see citing works

The regulation of K‐ and L‐cell activity by GLUT2 and the calcium‐sensing receptor CasR in rat small intestine

Mace, O. J., Schindler, M., & Patel, S. J. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2011.223800 · Cited by 247 · see citing works

Enteroendocrine L Cells Sense LPS after Gut Barrier Injury to Enhance GLP-1 Secretion

Lebrun, L. J., Lenaerts, K., Kiers, D., Pais de Barros, J.-P., Le Guern, N., Plesnik, J., Thomas, C., Bourgeois, T., Dejong, C. H. C., Kox, M., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.10.008 · Cited by 238 · see citing works

Meal-Related Ghrelin Suppression Requires Postgastric Feedback

Williams, D. L., Cummings, D. E., Grill, H. J., & Kaplan, J. M. (2003) · Endocrinology · doi:10.1210/en.2003-0381 · Cited by 235 · see citing works

G-Protein-Coupled Receptors in Intestinal Chemosensation

Reimann, F. M., Tolhurst, G., & Gribble, F. M. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2011.12.019 · Cited by 235 · see citing works

Bile acids are important direct and indirect regulators of the secretion of appetite- and metabolism-regulating hormones from the gut and pancreas

Kuhre, R. E., Albrechtsen, N. J. W., Larsen, O., Jepsen, S. L., Balk-Møller, E., Andersen, D. B., Deacon, C. F., Schoonjans, K., Reimann, F. M., Gribble, F. M., et al. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.03.007 · Cited by 234 · see citing works

Optimized GIP analogs promote body weight lowering in mice through GIPR agonism not antagonism

Mroz, P. A., Finan, B., Gelfanov, V., Yang, B., Tschöp, M. H., DiMarchi, R. D., & Perez-Tilve, D. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2018.12.001 · Cited by 229 · see citing works

Transcriptomic profiling of pancreatic alpha, beta and delta cell populations identifies delta cells as a principal target for ghrelin in mouse islets

Adriaenssens, A. E., Svendsen, B., Lam, B. Y. H., Yeo, G. S. H., Holst, J. J., Reimann, F., & Gribble, F. M. (2016) · Diabetologia · doi:10.1007/s00125-016-4033-1 · Cited by 223 · see citing works

The Bile Acid Receptor TGR5 Activates the TRPA1 Channel to Induce Itch in Mice

Lieu, T., Jayaweera, G., Zhao, P., Poole, D. P., Jensen, D. D., Grace, M. S., McIntyre, P., Bron, R., Wilson, Y. M., Krappitz, M., et al. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.08.042 · Cited by 221 · see citing works

Predominant role of active versus facilitative glucose transport for glucagon-like peptide-1 secretion

Parker, H. E., Adriaenssens, A. E., Rogers, G. J., Richards, P., Koepsell, H., Reimann, F. M., & Gribble, F. M. (2012) · Diabetologia · doi:10.1007/s00125-012-2585-2 · Cited by 212 · see citing works

The gnotobiotic animal as a tool in the study of host microbial relationships.

Gordon, H. A., & Pesti, L. (1971) · Bacteriological Reviews · doi:10.1128/mmbr.35.4.390-429.1971 · Cited by 205 · see citing works

A neural circuit for gut-induced reward

Han, W., Tellez, L. A., Perkins, M. H., Perez, I. O., Qu, T., Ferreira, J., Ferreira, T. L., Quinn, D., Liu, Z.-W., Gao, X.-B., et al. (2018) · Cell · doi:10.1016/j.cell.2018.10.018 · Cited by 204 · see citing works

Oligopeptides stimulate glucagon-like peptide-1 secretion in mice through proton-coupled uptake and the calcium-sensing receptor

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Incretin release from gut is acutely enhanced by sugar but not by sweeteners in vivo

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