Developmental Programming: Impact of Gestational Steroid and Metabolic Milieus on Mediators of Insulin Sensitivity in Prenatal Testosterone–Treated Female Sheep

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

Bligh, E. G., & Dyer, W. J. (1959) · Canadian Journal of Biochemistry and Physiology · doi:10.1139/o59-099 · Cited by 54,751 · see citing works

A power primer.

Cohen, J. (1992) · Psychological Bulletin · doi:10.1037//0033-2909.112.1.155 · Cited by 8,771 · see citing works

Inflammation and insulin resistance

Shoelson, S. E. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29069 · Cited by 4,769 · see citing works

Insulin Resistance: A Multifaceted Syndrome Responsible for NIDDM, Obesity, Hypertension, Dyslipidemia, and Atherosclerotic Cardiovascular Disease

DeFronzo, R. A., & Ferrannini, E. (1991) · Diabetes Care · doi:10.2337/diacare.14.3.173 · Cited by 4,555 · see citing works

Effect size, confidence interval and statistical significance: a practical guide for biologists

Nakagawa, S., & Cuthill, I. C. (2007) · Biological Reviews · doi:10.1111/j.1469-185x.2007.00027.x · Cited by 3,835 · see citing works

Global Burden of Cardiovascular Diseases

Yusuf, S., Reddy, S., Ôunpuu, S., & Anand, S. S. (2001) · Circulation · doi:10.1161/hc4601.099487 · Cited by 2,979 · see citing works

Adiponectin and Adiponectin Receptors

Kadowaki, T., & Yamauchi, T. (2005) · Endocrine Reviews · doi:10.1210/er.2005-0005 · Cited by 2,634 · see citing works

AdipoQ Is a Novel Adipose-specific Gene Dysregulated in Obesity

Hu, E., Liang, P., & Spiegelman, B. M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.18.10697 · Cited by 2,239 · see citing works

Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes

Esser, N., Legrand-Poels, S., Piette, J., Scheen, A. J., & Paquot, N. (2014) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2014.04.006 · Cited by 1,981 · see citing works

Insulin Resistance and the Polycystic Ovary Syndrome Revisited: An Update on Mechanisms and Implications

Diamanti-Kandarakis, E., & Dunaif, A. (2012) · Endocrine Reviews · doi:10.1210/er.2011-1034 · Cited by 1,947 · see citing works

Are oxidative stress-activated signaling pathways mediators of insulin resistance and β-cell dysfunction?

Evans, J. L., Goldfine, I. D., Maddux, B. A., & Grodsky, G. M. (2003) · Diabetes · doi:10.2337/diabetes.52.1.1 · Cited by 1,482 · see citing works

Oxidative stress, insulin signaling, and diabetes

Rains, J., & Jain, S. K. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.12.006 · Cited by 1,445 · see citing works

Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity

Pajvani, U. B., Hawkins, M., Combs, T. P., Rajala, M. W., Doebber, T., Berger, J. P., Wagner, J. A., Wu, M., Knopps, A., Xiang, A. H., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311113200 · Cited by 1,163 · see citing works

Oxidative stress and metabolic disorders: Pathogenesis and therapeutic strategies

Rani, V., Deep, G., Singh, R. K., Palle, K., & Yadav, U. C. S. (2016) · Life Sciences · doi:10.1016/j.lfs.2016.02.002 · Cited by 1,151 · see citing works

Ectopic Fat in Insulin Resistance, Dyslipidemia, and Cardiometabolic Disease

Shulman, G. I. (2014) · New England Journal of Medicine · doi:10.1056/nejmra1011035 · Cited by 1,126 · see citing works

Imaging of neutral lipids by oil red O for analyzing the metabolic status in health and disease

Mehlem, A., Hagberg, C. E., Muhl, L., Eriksson, U., & Falkevall, A. (2013) · Nature Protocols · doi:10.1038/nprot.2013.055 · Cited by 897 · see citing works

AMPK, insulin resistance, and the metabolic syndrome

Ruderman, N. B., Carling, D., Prentki, M., & Cacicedo, J. M. (2013) · Journal of Clinical Investigation · doi:10.1172/jci67227 · Cited by 872 · see citing works

Cellular and molecular players in adipose tissue inflammation in the development of obesity-induced insulin resistance

Lee, B.-C., & Lee, J. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.05.017 · Cited by 697 · see citing works

The Effects of Rosiglitazone on Insulin Sensitivity, Lipolysis, and Hepatic and Skeletal Muscle Triglyceride Content in Patients With Type 2 Diabetes

Mayerson, A. B., Hundal, R. S., Dufour, S., Lebon, V., Befroy, D., Cline, G. W., Enocksson, S., Inzucchi, S. E., Shulman, G. I., & Petersen, K. F. (2002) · Diabetes · doi:10.2337/diabetes.51.3.797 · Cited by 647 · see citing works

Association of increased intramyocellular lipid content with insulin resistance in lean nondiabetic offspring of type 2 diabetic subjects.

Jacob, S., Machann, J., Rett, K., Brechtel, K., Volk, A., Renn, W., Maerker, E., Matthaei, S., Schick, F., Claussen, C. D., et al. (1999) · Diabetes · doi:10.2337/diabetes.48.5.1113 · Cited by 643 · see citing works

The Molecular Basis for Oxidative Stress-Induced Insulin Resistance

Evans, J. L., Maddux, B. A., & Goldfine, I. D. (2005) · Antioxidants & Redox Signaling · doi:10.1089/ars.2005.7.1040 · Cited by 587 · see citing works

Inflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer’s Disease

Verdile, G., Keane, K. N., Cruzat, V. F., Medic, S., Sabale, M., Rowles, J., Wijesekara, N., Martins, R. N., Fraser, P. E., & Newsholme, P. (2015) · Mediators of Inflammation · doi:10.1155/2015/105828 · Cited by 501 · see citing works

Adiponectin signaling and function in insulin target tissues

Ruan, H., & Dong, L. Q. (2016) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjw014 · Cited by 395 · see citing works

Role of estrogens in adipocyte development and function

Cooke, P. S., & Naaz, A. (2004) · Experimental Biology and Medicine · doi:10.1177/153537020422901107 · Cited by 370 · see citing works

Structural and biochemical characteristics of various white adipose tissue depots

Wrońska, A., & Kmieć, Z. (2012) · Acta Physiologica · doi:10.1111/j.1748-1716.2012.02409.x · Cited by 370 · see citing works

Genetic and non-genetic vulnerability factors in schizophrenia: the basis of the “Two hit hypothesis.”

Bayer, T. A., Falkai, P., & Maier, W. (1999) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(99)00039-4 · Cited by 346 · see citing works

Physiological and pathophysiological roles of adiponectin and adiponectin receptors in the integrated regulation of metabolic and cardiovascular diseases

Yamauchi, T., & Kadowaki, T. (2008) · International Journal of Obesity · doi:10.1038/ijo.2008.233 · Cited by 339 · see citing works

Manual of histological techniques

(1985) · Food and Chemical Toxicology · doi:10.1016/0278-6915(85)90125-5 · Cited by 331 · see citing works

Oxidative stress and diabetes: What can we learn about insulin resistance from antioxidant mutant mouse models?

Styskal, J., Remmen, H. V., Richardson, A. G., & Salmon, A. B. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.10.441 · Cited by 286 · see citing works

Estrogen Promotes Early Osteoblast Differentiation and Inhibits Adipocyte Differentiation in Mouse Bone Marrow Stromal Cell Lines that Express Estrogen Receptor (ER) α or β

Okazaki, R., Inoue, D., Shibata, M., Saika, M., Kido, S., Ooka, H., Tomiyama, H., Sakamoto, Y., & Matsumoto, T. (2002) · Endocrinology · doi:10.1210/endo.143.6.8854 · Cited by 271 · see citing works

The Developmental Origins, Mechanisms, and Implications of Metabolic Syndrome1–3

Bruce, K. D., & Hanson, M. A. (2010) · Journal of Nutrition · doi:10.3945/jn.109.111179 · Cited by 266 · see citing works

Polycystic Ovary Syndrome with Hyperandrogenism Is Characterized by an Increased Risk of Hepatic Steatosis Compared to Nonhyperandrogenic PCOS Phenotypes and Healthy Controls, Independent of Obesity and Insulin Resistance

Jones, H., Sprung, V. S., Pugh, C. J. A., Daousi, C., Irwin, A., Aziz, N., Adams, V. L., Thomas, E. L., Bell, J. D., Kemp, G. J., et al. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-1382 · Cited by 256 · see citing works

Fetal Programming: Prenatal Testosterone Excess Leads to Fetal Growth Retardation and Postnatal Catch-Up Growth in Sheep

Manikkam, M., Crespi, E. J., Doop, D. D., Herkimer, C., Lee, J. S., Yu, S., Brown, M. B., Foster, D. L., & Padmanabhan, V. (2003) · Endocrinology · doi:10.1210/en.2003-0478 · Cited by 254 · see citing works

Heterogeneity of white adipose tissue: molecular basis and clinical implications

Kwok, K. H. M., Lam, K. S. L., & Xu, A. (2016) · Experimental & Molecular Medicine · doi:10.1038/emm.2016.5 · Cited by 250 · see citing works

Pathogenesis of nonalcoholic steatohepatitis

Liu, W., Baker, R. D., Bhatia, T., Zhu, L., & Baker, S. S. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2161-x · Cited by 225 · see citing works

Sheep models of polycystic ovary syndrome phenotype

Padmanabhan, V., & Veiga‐Lopez, A. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2012.10.005 · Cited by 222 · see citing works

Neuroendocrine androgen action is a key extraovarian mediator in the development of polycystic ovary syndrome

Caldwell, A. S. L., Edwards, M. C., Desai, R., Jimenez, M., Gilchrist, R. B., Handelsman, D. J., & Walters, K. A. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1616467114 · Cited by 222 · see citing works

Lipotoxic diseases of nonadipose tissues in obesity

Rh, U., & Orci, L. (2000) · International Journal of Obesity · doi:10.1038/sj.ijo.0801498 · Cited by 204 · see citing works

Insulin resistance in polycystic ovary syndrome: progress and paradoxes.

Venkatesan, A. M., Dunaif, A., & Corbould, A. (2001) · Recent Progress in Hormone Research · doi:10.1210/rp.56.1.295 · Cited by 175 · see citing works

Perinatal nicotine exposure induces asthma in second generation offspring

Rehan, V. K., Liu, J., Naeem, E., Tian, J., Sakurai, R., Kwong, K., Akbari, O., & Torday, J. S. (2012) · BMC Medicine · doi:10.1186/1741-7015-10-129 · Cited by 175 · see citing works

Differential Gene Expression Profile in Omental Adipose Tissue in Women with Polycystic Ovary Syndrome

Cortón, M., Botella-Carretero, J. I., Benguría, A., Villuendas, G., Zaballos, Á., Millán, J. L. S., Escobar-Morreale, H. F., & Peral, B. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1665 · Cited by 174 · see citing works

Comparison of Circulating Adiponectin and Proinflammatory Markers Regarding Their Association With Metabolic Syndrome in Japanese Men

Matsushita, K., Yatsuya, H., Tamakoshi, K., Wada, K., Otsuka, R., Takefuji, S., Sugiura, K., Kondo, T., Murohara, T., & Toyoshima, H. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000208363.85388.8f · Cited by 169 · see citing works

The Effect of a Pure Antiandrogen Receptor Blocker, Flutamide, on the Lipid Profile in the Polycystic Ovary Syndrome

Diamanti‐Kandarakis, E., Mitrakou, A., Raptis, S. A., Tolis, G., & Dulęba, A. J. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.8.5041 · Cited by 162 · see citing works

Transient prenatal androgen exposure produces metabolic syndrome in adult female rats

Demissie, M., Lazić, M., Foecking, E. M., Aird, F., Dunaif, A. E., & Levine, J. E. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90208.2008 · Cited by 143 · see citing works

Increased androgen bioavailability is associated with non-alcoholic fatty liver disease in women with polycystic ovary syndrome

Vassilatou, E., Lafoyianni, S., Vryonidou, A., Ioannidis, D., Kosma, L. K., Katsoulis, K., Papavassiliou, E. D., & Tzavara, I. (2009) · Human Reproduction · doi:10.1093/humrep/dep380 · Cited by 142 · see citing works

Dyslipidemia and Oxidative Stress in PCOS

Μacut, D., Bjekić-Macut, J., & Savic-Radojevic, A. R. (2012) · Frontiers of hormone research · doi:10.1159/000341683 · Cited by 139 · see citing works

Developmental Programming: Impact of Prenatal Testosterone Excess and Postnatal Weight Gain on Insulin Sensitivity Index and Transfer of Traits to Offspring of Overweight Females

Padmanabhan, V., Veiga‐Lopez, A., Abbott, D. H., Recabarren, S. E., & Herkimer, C. (2009) · Endocrinology · doi:10.1210/en.2009-1015 · Cited by 136 · see citing works

Developmental programming: prenatal androgen excess disrupts ovarian steroid receptor balance

Ortega, H. H., Salvetti, N. R., & Padmanabhan, V. (2009) · Reproduction · doi:10.1530/rep-08-0491 · Cited by 133 · see citing works

Animal models of the polycystic ovary syndrome phenotype

Padmanabhan, V., & Veiga‐Lopez, A. (2013) · Steroids · doi:10.1016/j.steroids.2013.05.004 · Cited by 131 · see citing works

Intrinsic Depot-Specific Differences in the Secretome of Adipose Tissue, Preadipocytes, and Adipose Tissue–Derived Microvascular Endothelial Cells

HOCKING, S. L., Wu, L. E., Guilhaus, M., Chisholm, D. J., & James, D. E. (2010) · Diabetes · doi:10.2337/db10-0483 · Cited by 126 · see citing works

Metabolic profiling of fatty liver in young and middle‐aged adults: Cross‐sectional and prospective analyses of the Young Finns Study

Kaikkonen, J., Würtz, P., Suomela, E., Lehtovirta, M., Kangas, A. J., Jula, A., Mikkilä, V., Viikari, J. S. A., Juonala, M., Rönnemaa, T., et al. (2016) · Hepatology · doi:10.1002/hep.28899 · Cited by 123 · see citing works

IMPORTANCE OF VARIATIONS IN BEHAVIOURAL AND FEEDBACK ACTIONS OF OESTRADIOL TO THE CONTROL OF SEASONAL BREEDING IN THE EWE

Goodman, R. L., Legan, S. J., Ryan, K. D., Foster, D. L., & Karsch, F. J. (1981) · Journal of Endocrinology · doi:10.1677/joe.0.0890229 · Cited by 120 · see citing works

Developmental Programming: Impact of Excess Prenatal Testosterone on Intrauterine Fetal Endocrine Milieu and Growth in Sheep1

Veiga‐Lopez, A., Steckler, T. L., Abbott, D. H., Welch, K. B., MohanKumar, P. S., Phillips, D. J., Refsal, K. R., & Padmanabhan, V. (2010) · Biology of Reproduction · doi:10.1095/biolreprod.110.086686 · Cited by 118 · see citing works

Role of adiponectin system in insulin resistance

Caselli, C. (2014) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2014.09.003 · Cited by 110 · see citing works

Adiponectin action in skeletal muscle

Liu, Y., & Sweeney, G. (2013) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2013.08.003 · Cited by 107 · see citing works

Endocrine disruptors: New players in the pathophysiology of type 2 diabetes?

Chevalier, N., & Fénichel, P. (2014) · Diabetes & Metabolism · doi:10.1016/j.diabet.2014.09.005 · Cited by 106 · see citing works

Inflammation in subcutaneous adipose tissue: relationship to adipose cell size

McLaughlin, T., Deng, A., Yee, G., Lamendola, C., Reaven, G., Tsao, P. S., Cushman, S. W., & Sherman, A. (2010) · Diabetologia · doi:10.1007/s00125-009-1496-3 · Cited by 105 · see citing works

Tissue-Specific Effects of Rosiglitazone and Exercise in the Treatment of Lipid-Induced Insulin Resistance

Lessard, S. J., Rivas, D. A., Chen, Z.-P., Bonen, A., Febbraio, M. A., Reeder, D. W., Kemp, B. E., Yaspelkis, B. B., & Hawley, J. A. (2007) · Diabetes · doi:10.2337/db06-1065 · Cited by 103 · see citing works

Association of abdominal obesity, insulin resistance, and oxidative stress in adipose tissue in women with polycystic ovary syndrome

Chen, L., Xu, W., & Zhang, D. (2014) · Fertility and Sterility · doi:10.1016/j.fertnstert.2014.06.027 · Cited by 89 · see citing works

Effect of maternal PCOS and PCOS-like phenotype on the offspring's health

Puttabyatappa, M., Cardoso, R. C., & Padmanabhan, V. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.11.030 · Cited by 86 · see citing works

The In Utero Programming Effect of Increased Maternal Androgens and a Direct Fetal Intervention on Liver and Metabolic Function in Adult Sheep

Hogg, K., Wood, C., McNeilly, A. S., & Duncan, W. C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024877 · Cited by 84 · see citing works

High-Molecular-Weight Adiponectin Is Selectively Reduced in Women with Polycystic Ovary Syndrome Independent of Body Mass Index and Severity of Insulin Resistance

O’Connor, A. S., Phelan, N., Tun, T. K., Boran, G. P., Gibney, J., & Roche, H. M. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-1557 · Cited by 83 · see citing works

Fetal Programming of Adrenal Androgen Excess: Lessons from a Nonhuman Primate Model of Polycystic Ovary Syndrome

Abbott, D. H., Zhou, R., Bird, I. M., Dumesic, D. A., & Conley, A. J. (2008) · KARGER eBooks · doi:10.1159/000134831 · Cited by 81 · see citing works

Quantification of diverse subcellular immunohistochemical markers with clinicobiological relevancies: validation of a new computer‐assisted image analysis procedure

Lejeune, M., Jaén, J., Pons, L. E., López, C., Salvadó-Usach, T., Bosch, R., García, M., Escrivá, P., Baucells, J., Cugat, X., et al. (2008) · Journal of Anatomy · doi:10.1111/j.1469-7580.2008.00910.x · Cited by 76 · see citing works

Insulin Resistance, Hyperinsulinemia, Dyslipidemia, Hypertension, and Accelerated Atherosclerosis

Sowers, J. R. (1992) · The Journal of Clinical Pharmacology · doi:10.1177/009127009203200607 · Cited by 71 · see citing works

Developmental reprogramming of reproductive and metabolic dysfunction in sheep: native steroids vs. environmental steroid receptor modulators

Padmanabhan, V., Sarma, H. N., Savabieasfahani, M., Steckler, T. L., & Veiga‐Lopez, A. (2010) · International Journal of Andrology · doi:10.1111/j.1365-2605.2009.01024.x · Cited by 69 · see citing works

Developmental Programming: Excess Weight Gain Amplifies the Effects of Prenatal Testosterone Excess On Reproductive Cyclicity—Implication for Polycystic Ovary Syndrome

Steckler, T. L., Herkimer, C., Dumesic, D. A., & Padmanabhan, V. (2008) · Endocrinology · doi:10.1210/en.2008-1256 · Cited by 67 · see citing works

Developmental Programming: Impact of Gestational Steroid and Metabolic Milieus on Adiposity and Insulin Sensitivity in Prenatal Testosterone-Treated Female Sheep

Cardoso, R. C., Veiga‐Lopez, A., Moeller, J., Beckett, E. M., Pease, A. P., Keller, E., Madrigal, V., Chazenbalk, G. D., Dumesic, D. A., & Padmanabhan, V. (2015) · Endocrinology · doi:10.1210/en.2015-1565 · Cited by 67 · see citing works

Developmental Programming: Impact of Prenatal Testosterone Excess on Insulin Sensitivity, Adiposity, and Free Fatty Acid Profile in Postpubertal Female Sheep

Veiga‐Lopez, A., Moeller, J., Patel, D., Ye, W., Pease, A. P., Kinns, J., & Padmanabhan, V. (2013) · Endocrinology · doi:10.1210/en.2012-2145 · Cited by 64 · see citing works

Development, validation, and pilot application of a semiquantitative Western blot analysis and an ELISA for bovine adiponectin

Mielenz, M., Mielenz, B., SINGH, S. P., Kopp, C., Heinz, J. F. L., Häussler, S., & Sauerwein, H. (2012) · Domestic Animal Endocrinology · doi:10.1016/j.domaniend.2012.10.004 · Cited by 64 · see citing works

Steroidogenic versus Metabolic Programming of Reproductive Neuroendocrine, Ovarian and Metabolic Dysfunctions

Cardoso, R. C., Puttabyatappa, M., & Padmanabhan, V. (2015) · Neuroendocrinology · doi:10.1159/000381830 · Cited by 62 · see citing works

Developmental Programming: Prenatal and Postnatal Androgen Antagonist and Insulin Sensitizer Interventions Prevent Advancement of Puberty and Improve LH Surge Dynamics in Prenatal Testosterone-Treated Sheep

Padmanabhan, V., Veiga‐Lopez, A., Herkimer, C., Salloum, B. A., Moeller, J., Beckett, E. M., & Sreedharan, R. (2015) · Endocrinology · doi:10.1210/en.2015-1235 · Cited by 54 · see citing works

Developmental Programming: Differential Effects of Prenatal Testosterone Excess on Insulin Target Tissues

Nada, S. E., Thompson, R. C., & Padmanabhan, V. (2010) · Endocrinology · doi:10.1210/en.2010-0666 · Cited by 54 · see citing works

Quantitative Analysis of Amino Acid Oxidation Markers by Tandem Mass Spectrometry

Vivekanandan‐Giri, A., Byun, J., & Pennathur, S. (2011) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/b978-0-12-385928-0.00005-5 · Cited by 52 · see citing works

Developmental Programming: Exposure to Testosterone Excess Disrupts Steroidal and Metabolic Environment in Pregnant Sheep

Salloum, B. A., Veiga‐Lopez, A., Abbott, D. H., Burant, C., & Padmanabhan, V. (2015) · Endocrinology · doi:10.1210/en.2014-2006 · Cited by 51 · see citing works

Sexual Differentiation of the External Genitalia and the Timing of Puberty in the Presence of an Antiandrogen in Sheep

Jackson, L. M., Timmer, K. M., & Foster, D. L. (2008) · Endocrinology · doi:10.1210/en.2007-1382 · Cited by 45 · see citing works

Developmental Programming: Prenatal Testosterone Excess and Insulin Signaling Disruptions in Female Sheep1

Lu, C., Cardoso, R. C., Puttabyatappa, M., & Padmanabhan, V. (2016) · Biology of Reproduction · doi:10.1095/biolreprod.115.136283 · Cited by 40 · see citing works

Developmental Programming: Prenatal and Postnatal Contribution of Androgens and Insulin in the Reprogramming of Estradiol Positive Feedback Disruptions in Prenatal Testosterone-Treated Sheep

Salloum, B. A., Herkimer, C., Lee, J. S., Veiga‐Lopez, A., & Padmanabhan, V. (2012) · Endocrinology · doi:10.1210/en.2011-2074 · Cited by 32 · see citing works

Let's shift lipid burden—From large to small adipocytes

Müller, G. A. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.01.035 · Cited by 31 · see citing works

Developmental Programming: Insulin Sensitizer Treatment Improves Reproductive Function in Prenatal Testosterone-Treated Female Sheep

Veiga‐Lopez, A., Lee, J. S., & Padmanabhan, V. (2010) · Endocrinology · doi:10.1210/en.2010-0124 · Cited by 30 · see citing works

Adiponectin Signaling and Metabolic Syndrome

Fu, Y. (2014) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-800101-1.00009-0 · Cited by 29 · see citing works

Differential adipogenic and inflammatory properties of small adipocytes in Zucker Obese and Lean rats

Liu, A., Sönmez, A., Yee, G., Bazuine, M., Arroyo, M., Sherman, A., McLaughlin, T., Reaven, G. M., Cushman, S. W., & Tsao, P. S. (2010) · Diabetes and Vascular Disease Research · doi:10.1177/1479164110386126 · Cited by 25 · see citing works

Blood triacylglycerols: a lipidomic window on diet and disease

Sanders, F., McNally, B. D., & Griffin, J. L. (2016) · Biochemical Society Transactions · doi:10.1042/bst20150235 · Cited by 22 · see citing works

[Evaluation of a new association between insulin-sensitizers and α-lipoic acid in obese women affected by PCOS].

Cappelli, V., Sabatino, A. D., Musacchio, M. C., & Leo, V. D. (2013) · PubMed · Cited by 16 · see citing works

Animal Models to Understand the Etiology and Pathophysiology of Polycystic Ovary Syndrome

Stener‐Victorin, E., Padmanabhan, V., Walters, K. A., Campbell, R. E., Benrick, A., Giacobini, P., Dumesic, D. A., & Abbott, D. H. (2020) · Endocrine Reviews · doi:10.1210/endrev/bnaa010 · Cited by 378 · see citing works

Biomechanics and mechanical signaling in the ovary: a systematic review

Shah, J. S., Sabouni, R., Vaught, K. C. C., Owen, C. M., Albertini, D. F., & Segars, J. H. (2018) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-018-1180-y · Cited by 153 · see citing works

Molecular Mechanisms of Insulin Resistance in Polycystic Ovary Syndrome: Unraveling the Conundrum in Skeletal Muscle?

Stepto, N. K., Moreno‐Asso, A., McIlvenna, L. C., Walters, K. A., & Rodgers, R. J. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2019-00167 · Cited by 78 · see citing works

Androgen Action in Adipose Tissue and the Brain are Key Mediators in the Development of PCOS Traits in a Mouse Model

Cox, M. J., Edwards, M. C., Paris, V. R., Aflatounian, A., Ledger, W. J., Gilchrist, R. B., Padmanabhan, V., Handelsman, D. J., & Walters, K. A. (2020) · Endocrinology · doi:10.1210/endocr/bqaa061 · Cited by 59 · see citing works

Developmental programming of offspring adipose tissue biology and obesity risk

Rodgers, A., & Sferruzzi-Perri, A. N. (2021) · International Journal of Obesity · doi:10.1038/s41366-021-00790-w · Cited by 57 · see citing works

Developmental programming: Prenatal bisphenol A treatment disrupts mediators of placental function in sheep

Song, W., Puttabyatappa, M., Zeng, L., Vázquez, D. M., Pennathur, S., & Padmanabhan, V. (2019) · Chemosphere · doi:10.1016/j.chemosphere.2019.125301 · Cited by 47 · see citing works

DNA methylation in promoter regions of genes involved in the reproductive and metabolic function of children born to women with PCOS

Echiburú, B., Milagro, F. I., Crisosto, N., Pérez‐Bravo, F., Flores, C., Arpón, A., Salas‐Pérez, F., Recabarren, S. E., Sir‐Petermann, T., & Maliqueo, M. A. (2020) · Epigenetics · doi:10.1080/15592294.2020.1754674 · Cited by 43 · see citing works

Ovarian and extra-ovarian mediators in the development of polycystic ovary syndrome

Puttabyatappa, M., & Padmanabhan, V. (2018) · Journal of Molecular Endocrinology · doi:10.1530/jme-18-0079 · Cited by 43 · see citing works

Developmental Programming: Contribution of Epigenetic Enzymes to Antral Follicular Defects in the Sheep Model of PCOS

Guo, X., Puttabyatappa, M., Thompson, R. C., & Padmanabhan, V. (2019) · Endocrinology · doi:10.1210/en.2019-00389 · Cited by 38 · see citing works

Developmental Programming of PCOS Traits: Insights from the Sheep

Cardoso, R. C., & Padmanabhan, V. (2019) · Medical Sciences · doi:10.3390/medsci7070079 · Cited by 35 · see citing works

Developmental Programming: Impact of Prenatal Testosterone Excess on Steroidal Machinery and Cell Differentiation Markers in Visceral Adipocytes of Female Sheep

Puttabyatappa, M., Lu, C., Martin, J. D., Chazenbalk, G., Dumesic, D., & Padmanabhan, V. (2018) · Reproductive Sciences · doi:10.1177/1933719117746767 · Cited by 32 · see citing works

Prenatal Steroids and Metabolic Dysfunction: Lessons from Sheep

Cardoso, R. C., & Padmanabhan, V. (2018) · Annual Review of Animal Biosciences · doi:10.1146/annurev-animal-020518-115154 · Cited by 34 · see citing works

Sodium acetate and androgen receptor blockade improve gestational androgen excess-induced deteriorated glucose homeostasis and antioxidant defenses in rats: roles of adenosine deaminase and xanthine oxidase activities

Usman, T. O., Areola, E. D., Badmus, O. O., Kim, I., & Olatunji, L. A. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.08.018 · Cited by 32 · see citing works

Developmental programming: Changes in mediators of insulin sensitivity in prenatal bisphenol A-treated female sheep

Puttabyatappa, M., Martin, J. D., Andriessen, V. C., Stevenson, M. J., Zeng, L., Pennathur, S., & Padmanabhan, V. (2019) · Reproductive Toxicology · doi:10.1016/j.reprotox.2019.03.002 · Cited by 31 · see citing works

Developmental Programming: Prenatal Testosterone Induced Changes in Epigenetic Modulators and Gene Expression in Metabolic Tissues of Female Sheep

Guo, X., Puttabyatappa, M., Domino, S., & Padmanabhan, V. (2020) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2020.110913 · Cited by 17 · see citing works

Developmental programming of insulin resistance: are androgens the culprits?

Puttabyatappa, M., Sargis, R. M., & Padmanabhan, V. (2020) · Journal of Endocrinology · doi:10.1530/joe-20-0044 · Cited by 22 · see citing works

Prenatal Testosterone Programming of Insulin Resistance in the Female Sheep

Puttabyatappa, M., & Padmanabhan, V. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-70178-3_25 · Cited by 21 · see citing works

Developmental Programming: Prenatal Testosterone Excess on Liver and Muscle Coding and Noncoding RNA in Female Sheep

Saadat, N., Puttabyatappa, M., Elangovan, V. R., Dou, J., Ciarelli, J. N., Thompson, R. C., Bakulski, K. M., & Padmanabhan, V. (2021) · Endocrinology · doi:10.1210/endocr/bqab225 · Cited by 12 · see citing works

Developmental programming: adverse sexually dimorphic transcriptional programming of gestational testosterone excess in cardiac left ventricle of fetal sheep

Elangovan, V. R., Saadat, N., Ghnenis, A. B., Padmanabhan, V., & Vyas, A. K. (2023) · Scientific Reports · doi:10.1038/s41598-023-29212-9 · Cited by 12 · see citing works

Developmental programming: Adipose depot-specific transcriptional regulation by prenatal testosterone excess in a sheep model of PCOS

Dou, J., Puttabyatappa, M., Padmanabhan, V., & Bakulski, K. M. (2020) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2020.111137 · Cited by 13 · see citing works

Developmental programming: Adipose depot-specific changes and thermogenic adipocyte distribution in the female sheep

Puttabyatappa, M., Ciarelli, J. N., Chatoff, A. G., Singer, K., & Padmanabhan, V. (2019) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2019.110691 · Cited by 10 · see citing works

Developmental programming: Transcriptional regulation of visceral and subcutaneous adipose by prenatal bisphenol-A in female sheep

Dou, J., Puttabyatappa, M., Padmanabhan, V., & Bakulski, K. M. (2020) · Chemosphere · doi:10.1016/j.chemosphere.2020.127000 · Cited by 10 · see citing works

Unpacking PCOS Inflammation: From Misconceptions to Immune Networks

Robles, G. D., Wiggins, K. D., Mundo, Z. D. D., Ujagar, N. S., Nguyen, C. M., Seldin, M. M., Pacheco-Sanchez, G., & Nicholas, D. (2025) · Endocrinology · doi:10.1210/endocr/bqaf166 · Cited by 9 · see citing works

Developmental programming: Prenatal testosterone excess disrupts pancreatic islet developmental trajectory in female sheep

Jackson, I. J., Puttabyatappa, M., Anderson, M. J., Muralidharan, M., Veiga‐Lopez, A., Gregg, B. E., Limesand, S. W., & Padmanabhan, V. (2020) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2020.110950 · Cited by 9 · see citing works

Developmental Programming: Impact of Prenatal Exposure to Bisphenol A on Senescence and Circadian Mediators in the Liver of Sheep

Motta, G., Thangaraj, S. V., & Padmanabhan, V. (2023) · Toxics · doi:10.3390/toxics12010015 · Cited by 8 · see citing works

Role of Hormones During Gestation and Early Development: Pathways Involved in Developmental Programming

Abruzzese, G. A., Arboccó, F. C. V., Ferrer, M. J., Silva, A. F., & Motta, A. B. (2023) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-32554-0_2 · Cited by 8 · see citing works

Developmental programming: Testosterone excess masculinizes female pancreatic transcriptome and function in sheep

Halloran, K. M., Saadat, N., Pallas, B. D., Vyas, A. K., Sargis, R. M., & Padmanabhan, V. (2024) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2024.112234 · Cited by 8 · see citing works

The Influences of Perinatal Androgenic Exposure on Cardiovascular and Metabolic Disease of Offspring of PCOS

Guo, F., Mao, S. H., Long, Y., Zhou, B., Gao, L., & Huang, H. (2023) · Reproductive Sciences · doi:10.1007/s43032-023-01286-w · Cited by 7 · see citing works

Gestational testosterone excess early to mid-pregnancy disrupts maternal lipid homeostasis and activates biosynthesis of phosphoinositides and phosphatidylethanolamines in sheep

Saadat, N., Pallas, B. D., Ciarelli, J. N., Vyas, A. K., & Padmanabhan, V. (2024) · Scientific Reports · doi:10.1038/s41598-024-56886-6 · Cited by 7 · see citing works

Androgen actions in metabolic tissues in polycystic ovary syndrome

MacRae, C. L., & Campbell, R. E. (2026) · Endocrinology · doi:10.1210/endocr/bqag001 · Cited by 5 · see citing works

Acetate causes renoprotection like androgen and mineralocorticoid receptors blockade in testosterone-exposed pregnant rats

Usman, T. O., Adeyanju, O. A., Areola, E. D., Badmus, O. O., Oyeyipo, I. P., Olaniyi, K. S., Oyabambi, A. O., & Olatunji, L. A. (2021) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-020-04031-y · Cited by 5 · see citing works

Developmental programming: Adipose depot-specific regulation of non-coding RNAs and their relation to coding RNA expression in prenatal testosterone and prenatal bisphenol-A -treated female sheep

Dou, J., Thangaraj, S. V., Puttabyatappa, M., Elangovan, V. R., Bakulski, K. M., & Padmanabhan, V. (2023) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2023.111868 · Cited by 5 · see citing works

Sex-Specific Perturbation of Systemic Lipidomic Profile in Newborn Lambs Impacted by Prenatal Testosterone Excess

Saadat, N., Ciarelli, J. N., Pallas, B. D., Padmanabhan, V., & Vyas, A. K. (2023) · Endocrinology · doi:10.1210/endocr/bqad187 · Cited by 5 · see citing works

Developmental programming: An exploratory analysis of pancreatic islet compromise in female sheep resulting from gestational BPA exposure

Ciarelli, J. N., Thangaraj, S. V., Sun, H., Domke, S., Alkhatib, B., Vyas, A. K., Gregg, B. E., Sargis, R. M., & Padmanabhan, V. (2024) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2024.112202 · Cited by 4 · see citing works

Intrauterine androgen exposure impairs gonadal adipose tissue functions of adult female rats

Ferrer, M. J., Abruzzese, G. A., Heber, M. F., Ferreira, S. R., Arboccó, F. C. V., & Motta, A. B. (2022) · Theriogenology · doi:10.1016/j.theriogenology.2022.12.035 · Cited by 4 · see citing works

Developmental programming: Metabolic tissue-specific changes in endoplasmic reticulum stress, mitochondrial oxidative and telomere length status induced by prenatal testosterone excess in the female sheep

Puttabyatappa, M., Ciarelli, J. N., Chatoff, A. G., & Padmanabhan, V. (2021) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2021.111207 · Cited by 4 · see citing works

Developmental programming: Differing impact of prenatal testosterone and prenatal bisphenol-A -treatment on hepatic methylome in female sheep

Dou, J., Thangaraj, S. V., Zhou, Y., Padmanabhan, V., & Bakulski, K. M. (2025) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2025.112655 · Cited by 3 · see citing works

POLYCYSTIC OVARY SYNDROME: ORIGINS AND IMPLICATIONS: Gestational anti-Müllerian hormone and testosterone excess combined with maternal adiposity program for polycystic ovary syndrome

Abbott, D. H., Levine, J. E., Dumesic, P. A., Padmanabhan, V., & Dumesic, D. A. (2025) · Reproduction · doi:10.1530/rep-25-0120 · Cited by 3 · see citing works

Developmental programming: gestational exposure to excess testosterone disrupts maternal steroid homeostasis and perturbs the steroid-lipid relationship in sheep

Saadat, N., Saeed, R., Pallas, B. D., Vyas, A. K., Auchus, R. J., & Padmanabhan, V. (2025) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2025.112706 · Cited by 1 · see citing works

Oxidative stress and biochemical markers in prenatally androgenized sheep after neonatal treatment with GnRH agonist

da Nóbrega, J. E., dos Santos, J. T., Mujica, L. K. S., Bochi, G. V., Moresco, R. N., Rissi, V. B., Glanzner, W. G., Langer, F. W., Antoniazzi, A. Q., Gonçalves, P. B. D., et al. (2019) · Journal of Inflammation Research · doi:10.2147/jir.s190260 · Cited by 1 · see citing works

Androgen excess uncouples circulating and hepatic lipid homeostasis in females on a high-calorie diet

Joseph, S., Ubba, V., Kalim, R., Gunaydin, S., Dass, M., Waheed, D., Hilovsky, D. L., Hartsell, J., Shpargel, J., Liu, X., et al. (2026) · Journal of Lipid Research · doi:10.1016/j.jlr.2026.101031

Preventive effects of estrogen and progesterone against adiposity are promoted by testosterone in ovariectomized female rats

Takahashi, A., Arata, M., Noguchi, H., Purevdorj, T., Tamura, K., Takeda, A., Sugimoto, T., Shinohara, A., Aoki, H., Kinouchi, R., et al. (2026) · Steroids · doi:10.1016/j.steroids.2026.109809

Developmental Programming: Impact of Gestational Steroid and Metabolic Milieus on Adiposity and Insulin Sensitivity in Prenatal Testosterone-Treated Female Sheep

Cardoso, R. C., Veiga‐Lopez, A., Moeller, J., Beckett, E. M., Pease, A. P., Keller, E., Madrigal, V., Chazenbalk, G. D., Dumesic, D. A., & Padmanabhan, V. (2015) · Endocrinology · doi:10.1210/en.2015-1565 · Cited by 67 · see citing works

Developmental Programming: Prenatal Testosterone Excess and Insulin Signaling Disruptions in Female Sheep1

Lu, C., Cardoso, R. C., Puttabyatappa, M., & Padmanabhan, V. (2016) · Biology of Reproduction · doi:10.1095/biolreprod.115.136283 · Cited by 40 · see citing works

Developmental Programming: Impact of Prenatal Testosterone Excess on Insulin Sensitivity, Adiposity, and Free Fatty Acid Profile in Postpubertal Female Sheep

Veiga‐Lopez, A., Moeller, J., Patel, D., Ye, W., Pease, A. P., Kinns, J., & Padmanabhan, V. (2013) · Endocrinology · doi:10.1210/en.2012-2145 · Cited by 64 · see citing works

MON-LB039 Developmental Programming: Prenatal Testosterone Excess Induces Endoplasmic Reticulum (ER) Stress in the Metabolic Tissues of the Female Sheep

Puttabyatappa, M., & Padmanabhan, V. (2019) · Journal of the Endocrine Society · doi:10.1210/js.2019-mon-lb039

Developmental Programming: Increased Pituitary Sensitivity of Prenatal Testosterone-Treated Sheep to GnRH Is a Function of Their Hyperinsulinemic Status.

Moeller, J., Veiga‐Lopez, A., & Padmanabhan, V. (2012) · Biology of Reproduction · doi:10.1093/biolreprod/87.s1.154