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Displacement of Estradiol from Estrogen Receptors by Simple Alkyl Phenols*
Abstract
Simple alkyl phenols have been tested for their ability to prevent the binding of [3H]estradiol and to displace the prebound hormone from estrogen receptors of uterine cytosols. Tetrahydronaphthol, an analog of the A and B rings of estradiol, is highly effective in preventing the forward bindng of estradiol. p-sec-Amyl phenol (pSAP) with a flexible alkyl chain corresponding to the B ring of estradiol is highly effective at 0 C in displacing estradiol which had been prebound by the receptor. Both compounds were more effective at 0 C than at 23 C. The data are discussed in terms of sequential conformational changes which might be required for the binding and release of the natural hormones and their possible relevance to receptor action.
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Cited by
Interaction of Estrogenic Chemicals and Phytoestrogens with Estrogen Receptor β
Kuiper, G. G. J. M., Lemmen, J. G., Carlsson, B., Corton, J. C., Safe, S. H., van der Saag, P. T., van der Burg, B., & Gustafsson, J.-Å. (1998) · Endocrinology · doi:10.1210/endo.139.10.6216 · Cited by 4,203
p-Nonyl-phenol: an estrogenic xenobiotic released from "modified" polystyrene.
Soto, A. M., Justicia, H., Wray, J. W., & Sonnenschein, C. (1991) · Environmental Health Perspectives · doi:10.1289/ehp.9192167 · Cited by 1,082
Environmental Signaling: What Embryos and Evolution Teach Us About Endocrine Disrupting Chemicals
McLachlan, J. A. (2001) · Endocrine Reviews · doi:10.1210/edrv.22.3.0432 · Cited by 608
Occurrence of Surface Active Agents in the Environment
Olkowska, E., Ruman, M., & Polkowska, Ż. (2014) · Journal of Analytical Methods in Chemistry · doi:10.1155/2014/769708 · Cited by 142
Metadata
- Authors
- MUELLER, G. C., & KIM, U.-H.
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 1978-05
- Volume
- 102
- Issue
- 5
- Pages
- 1429-1435
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2125590866
- Cited by
- 170
- References
- 0
- FWCI
- 0.86
- Type
- journal article
- Language
- en
- Open access
- closed
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- MUELLER, G. C., & KIM, U.-H. (1978). Displacement of Estradiol from Estrogen Receptors by Simple Alkyl Phenols*. Endocrinology. https://doi.org/10.1210/endo-102-5-1429
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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