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Release of Somatomedin-Like Activity by Cultured WI-38 Human Fibroblasts*
Abstract
Confluent cultures of normal diploid WI-38 human embryonic lung fibroblasts released somatomedin (SM)-like activity into their incubation medium during culture in serum-free medium. This postculture medium (conditioned medium) stimulated cell division in these same cultured WI-38 fibroblasts and 35SO4 uptake by hypophysectomized rat cartilage in vitro. The conditioned medium also contained immunoreactive SM (IRSM) activity which yielded parallel dose-response curves to human serum in a RIA for SM. The IRSM activity measured in conditioned medium was not the artifactual result of effects of possible SM-binding proteins or proteolytic enzymes in conditioned medium. These studies suggest that cultured WI-38 fibroblasts produce and release SM-like activity which has SM-like biological activity and is immunoreactive with a basic SM purified from human plasma Cohn fraction and having similarity with SM-C and insulin-like growth factor-I. Human GH appears to stimulate production and release of IRSM activity by these cells.
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Citations
Cited by
Mechanism of the Stimulatory Effect of Growth Hormone on Longitudinal Bone Growth*
ISAKSSON, O. G. P., LINDAHL, A., NILSSON, A., & ISGAARD, J. (1987) · Endocrine Reviews · doi:10.1210/edrv-8-4-426 · Cited by 580
Binding proteins for the insulin-like growth factors: Structure, regulation and function
Baxter, R. C., & Martin, J. L. (1989) · Progress in Growth Factor Research · doi:10.1016/0955-2235(89)90041-0 · Cited by 566
Mechanisms of tissue repair: from wound healing to fibrosis
Mutsaers, S. E., Bishop, J. E., McGrouther, G., & Laurent, G. J. (1997) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(96)00115-x · Cited by 454
Mode of Action of Pituitary Growth Hormone on Target Cells
Isaksson, O. G. P., Eden, S., & Jansson, J. (1985) · Annual Review of Physiology · doi:10.1146/annurev.ph.47.030185.002411 · Cited by 447
BOURGUIGNON, J.-P. (1988) · Endocrine Reviews · doi:10.1210/edrv-9-4-467 · Cited by 158
Metadata
- Authors
- ATKISON, P. R., WEIDMAN, E. R., BHAUMICK, B., & BALA, R. M.
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 1980-06
- Volume
- 106
- Issue
- 6
- Pages
- 2006-2012
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2072159062
- Cited by
- 162
- References
- 0
- FWCI
- 8.64
- Type
- journal article
- Language
- en
- Open access
- closed
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- ATKISON, P. R., WEIDMAN, E. R., BHAUMICK, B., & BALA, R. M. (1980). Release of Somatomedin-Like Activity by Cultured WI-38 Human Fibroblasts*. Endocrinology. https://doi.org/10.1210/endo-106-6-2006
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