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Cited by 158Hypothalamic control of reproductive hormonesGrowth Hormone and Insulin-like Growth FactorsHormonal and reproductive studies

Linear growth as a function of age at onset of puberty and sex steroid dosage: therapeutic implications

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BOURGUIGNON, JEAN-PIERRE·1988·Endocrine Reviews
DOI 10.1210/edrv-9-4-467
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Abstract

PUBERTY plays a dual role in growth: height velocity is markedly accelerated while the rate of skeletal maturation is also increased with resultant fusion of epiphyseal cartilages. Thus, puberty can be considered as a growth-promoting event as well as the final height-limiting process. This concept is illustrated by early exposure to sex steroids such as occurs in central precocious puberty or congenital adrenal hyperplasia. These conditions accelerate growth but result in short adult height (1–6). The basic question addressed in this paper is how hormonal changes at puberty and the age of their occurrence influence growth rate and adult height. This query has practical implications including timing and dosage of sex steroid replacement therapy in hypogonadal patients and the use of GnRH agonist therapy in patients with precocious puberty or short stature. These issues may have profound social import since numerous (mostly uncharted) psychological aspects of adolescence may be related to stature and the timing of sexual development.

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Research works printed but not linked: 6

  1. Styne DM, Richards GE, Bell JJ, Conte FA, Morishima A, Kaplan SL, Grumbach MM 1975 Growth patterns in congenital adrenal hyperplasia. Correlation of glucocorticoid therapy with stature. In: Lee PA, Plotnick LP, Kowarski AA, Migeon CJ (eds) Congenital Adrenal Hyperplasia. University Park Press, Baltimore, MD, p 247
  2. Blizzard RM, Thompson RG, Baghdassarian A, Kowarski A, Migeon CJ, Rodriguez A 1974 The interrelationship of steroids, growth hormone and other hormones on pubertal growth. In: Grumbach MM, Grave GD, Mayer FE (eds) The control of the Onset of Puberty. John Wiley & Sons, New York, p 342
  3. Kulin HE, Coen P, Santen RJ, Ballantine T, Zaino R, Boal D, Inkster S, Brodie A, Gynecomastia in the Peutz-Jeghers syndrome is caused by testicular tumor aromatase production. Pediatr Res, in press (abstract)
  4. Ranke MB, Butenandt O 1988 Idiopathic growth hormone deficiency: final height to treatment with growth hormone and effects of puberty and sex steroids. In: Frisch H, Laron Z (eds) Induction of Puberty in Hypopituitarism. Serono symposia review 16, Aris-Serono Symposia, Rome, p 85
  5. Van De Koppel J, Hewlett B 1985 Growth of Aka pygmies and Bagandus of the central African Republic. In: Cavalli-Sforza LL (ed) African Pygmies. Academic Press, New York, p 95
  6. Boepple PA, Mansfield MJ, Crawford JD, Crigler JF, Link K, Blizzard RM, Crowley WF, The effects of gonadal sex steroids and their reversible suppression on statural growth and skeletal maturation in girls with central precocious puberty. In: Grave GD, Cassorla F (eds) Disorders of Human Growth: Advances in Research and Treatment. Charles C Thomas, Springfield, IL, in press

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Authors
BOURGUIGNON, J.-P.
Affiliations
University of Liège (BE)
Corresponding author
BOURGUIGNON, JEAN-PIERRE
Venue
Endocrine Reviews
Publisher
The Endocrine Society
Published
1988-11
Volume
9
Issue
4
Pages
467-488
ISSN
  • 0163-769X (ISSN-L)
  • 1945-7189
DOI
10.1210/edrv-9-4-467
OpenAlex
W1969903517
Cited by
158
References
166
Citations by year
2024: 2 · 2022: 1 · 2020: 1 · 2019: 2 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 1 · 2013: 4
FWCI
8.53
Type
journal article
Language
en
Open access
Licence
other-oa
Locations
  • Endocrine Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • Open Repository and Bibliography (University of Liège) (submittedVersion, other-oa)
Funders
  • Université Catholique de Louvain
  • Pennsylvania State University
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Keywords
puberty, puberty onset, linear growth, adult height, central precocious puberty, congenital adrenal hyperplasia, hypogonadism, GnRH agonist therapy, short stature, skeletal maturation, height velocity
MeSH terms
Adolescent, Aging, Androgens, Body Height, Child, Estrogens, Female, Growth Disorders, Humans, Male, Puberty

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