The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Regional Concentrations of Insulin in the Rat Brain*
Abstract
Recent evidence that insulin receptors are concentrated in the hypothalamus and olfactory bulb suggests that insulin may have an important regulatory function in these regions. This hypothesis would be supported by finding that insulin itself is concentrated in the hypothalamus and olfactory bulb. Therefore, we extracted the hypothalamus and olfactory bulb, as well as the amygdala, hippocampus, cerebral cortex, hindbrain, midbrain, and whole brains, of fasted male Wistar rats and measured immunoreactive insulin (IRI). Recovery of insulin added to extraction volumes of 500-1000 microliters was 90-100%, whereas recovery of insulin from tissue extracts was 63%. Mean IRI concentrations were relatively uniform throughout the brain (0.19 ng/g wet wt; uncorrected for recovery) and were significantly lower than plasma levels (1.03 ng/ml). Nevertheless, IRI concentrations were significantly higher in hypothalamus (0.39 +/- 0.02 ng/g; P less than 0.01) and olfactory bulb (0.37 +/- 0.02 ng/g; P less than 0.05) compared to those in other brain regions sampled.
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Citations
Cites
Evidence against extrapancreatic insulin synthesis.
Eng, J., & Yalow, R. S. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.7.4576 · Cited by 66
Cited by
The source of cerebral insulin
Banks, W. A. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.02.040 · Cited by 489
Insulin signaling in the central nervous system: Learning to survive
van der Heide, L. P., Ramakers, G. M. J., & Smidt, M. P. (2006) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2006.06.003 · Cited by 444
The Catabolic Action of Insulin in the Brain Is Mediated by Melanocortins
Benoit, S. C., Air, E. L., Coolen, L. M., Strauss, R., Jackman, A., Clegg, D. J., Seeley, R. J., & Woods, S. C. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-20-09048.2002 · Cited by 417
Insulin and insulin-like growth factors in the CNS
Baskin, D. G., Wilcox, B. J., Figlewicz, D. P., & Dorsa, D. M. (1988) · Trends in Neurosciences · doi:10.1016/0166-2236(88)90155-5 · Cited by 330
Self-citationBosco, D., Fava, A., Plastino, M., Montalcini, T., & Pujia, A. (2011) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2011.01318.x · Cited by 283
Metadata
- Authors
- BASKIN, D. G., PORTE, D., GUEST, K., & DORSA, D. M.
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 1983-03
- Volume
- 112
- Issue
- 3
- Pages
- 898-903
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2092376456
- Cited by
- 212
- References
- 1
- FWCI
- 6.88
- Type
- journal article
- Language
- en
- Open access
- closed
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- BASKIN, D. G., PORTE, D., GUEST, K., & DORSA, D. M. (1983). Regional Concentrations of Insulin in the Rat Brain*. Endocrinology. https://doi.org/10.1210/endo-112-3-898
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
