The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Influence of Corticotropin-Releasing Factor on Reproductive Functions in the Rat*
Abstract
The acute administration of 0.015-1.5 nmol ovine corticotropin-releasing factor (CRF) into the lateral ventricle of gonadectomized (or gonadectomized/adrenalectomized) female rats caused a rapid and prolonged dose-related inhibition of LH (but not FSH) secretion. By contrast, the acute peripheral injection of up to 15 nmol CRF was without effect in the same animal preparations. In cycling intact female rats, injection of 1.5 nmol CRF into the brain or of 75 nmol CRF sc inhibited ovulation and blocked the proestrous LH surge in about 50% of the animals. Lower doses of peripherally administered CRF were ineffective. Finally, CRF injected daily sc (15 nmol/day) to female rats during the first 12 days after mating caused a 40% disruption of pregnancy. These results indicate that CRF will lower plasma LH levels and can exert this effect in the absence of circulating steroids of either adrenal or gonadal origin. CRF inhibition of LH secretion, which we have previously reported to be absent in vitro, was unaltered by the opiate receptor antagonist naltrexone or by the ganglionic blocker chlorisondamine. Furthermore, blockade of CRF-induced beta-endorphin or ACTH release into the general circulation by dexamethasone did not interfere with the inhibitory effect of CRF on LH secretion. Such observations suggest that CRF exerts deleterious actions on reproductive functions through brain sites of action which, at least under the experimental mental design used, do not appear to directly…
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In the citing paper
“Additionally, CRH injected daily to female rats during the first 12 days after mating caused a 40% disruption of pregnancy [35].”
From Stress and the HPA Axis: Balancing Homeostasis and Fertility. (2017) · cites this paper as [35]
In the citing paper
“In a study consisting of acute administration of ovine CRH into the lateral ventricle of gonadectomized, adrenalectomized female rats, a rapid and prolonged dose-related inhibition of LH (but not FSH) secretion was exhibited [35].”
From Stress and the HPA Axis: Balancing Homeostasis and Fertility. (2017) · cites this paper as [35]
In the citing paper
“Animal studies have linked increased corticotropin releasing factor (CRF) to decreased LH [12,13] and FSH [12] secretion and hypercortisolemia.”
From Suppression of the Hypothalamic-Pituitary-Ovarian Axis in Normal Women by Glucocorticoids1 (1993) · cites this paper as [13]
In the citing paper
“Direct implantation of CRF into the brain of rodents was observed to inhibit LH secretion [13], and peripheral infusion of CRF decreased LH and FSH secretion in the monkey [12].”
From Suppression of the Hypothalamic-Pituitary-Ovarian Axis in Normal Women by Glucocorticoids1 (1993) · cites this paper as [13]
Citations
Cites
Vale, W., Spiess, J., RIVIER, C. L., & Rivier, J. (1982) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-198205000-00013 · Cited by 3,904
Self-citationEndogenous opioid peptides: multiple agonists and receptors
Lord, J. A. H., Waterfield, A. A., Hughes, J., & Kosterlitz, H. W. (1977) · Nature · doi:10.1038/267495a0 · Cited by 2,485
Corticotropin-Releasing Factor: Actions on the Sympathetic Nervous System and Metabolism*
Brown, M. R., Fisher, L. A., Spiess, J., RIVIER, C. L., Rivier, J., & Vale, W. (1982) · Endocrinology · doi:10.1210/endo-111-3-928 · Cited by 651
Self-citationBruni, J. F., Vugt, D. V., Marshall, S., & Meites, J. (1977) · Life Sciences · doi:10.1016/0024-3205(77)90528-8 · Cited by 578
RIVIER, C. L., Brownstein, M. J., Spiess, J., Rivier, J., & Vale, W. (1982) · Endocrinology · doi:10.1210/endo-110-1-272 · Cited by 555
Self-citationRegional dissociation of beta-endorphin and enkephalin contents in rat brain and pituitary.
Rossier, J., Vargo, T. M., Minick, S., LING, N. C., Bloom, F. E., & Guillemin, R. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.11.5162 · Cited by 452
BAMBINO, T. H., & HSUEH, A. J. W. (1981) · Endocrinology · doi:10.1210/endo-108-6-2142 · Cited by 360
Cicero, T., Schainker, B., & Meyer, E. (1979) · Endocrinology · doi:10.1210/endo-104-5-1286 · Cited by 328
Krulich, L., Hefco, E., Illner, P., & Read, C. B. (2008) · Neuroendocrinology · doi:10.1159/000122576 · Cited by 262
THE ROLE OF ENDOCRINES IN THE SELF-REGULATION OF MAMMALIAN POPULATIONS.
Jj, C., Lloyd, J. A., & DAVIS, D. E. (1965) · PubMed · Cited by 260
Cited by
Sorted by citations
Sapolsky, R. M., Romero, L. M., & Munck, A. U. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.1.0389 · Cited by 7,541
Dunn, A. J., & Berridge, C. W. (1990) · Brain Research Reviews · doi:10.1016/0165-0173(90)90012-d · Cited by 1,352
Gold, P. W., & Chrousos, G. P. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001032 · Cited by 1,274
Pickup, J. C., Mattock, M. B., Chusney, G. D., & Burt, D. J. (1997) · Diabetologia · doi:10.1007/s001250050822 · Cited by 1,246
Clinical and Biochemical Manifestations of Depression
Gold, P. W., Goodwin, F. K., & Chrousos, G. P. (1988) · New England Journal of Medicine · doi:10.1056/nejm198808183190706 · Cited by 1,057
Metadata
- Authors
- RIVIER, C., & VALE, W.
- Affiliations
- Salk Institute for Biological Studies (US)
- ORCID
- VALE, WYLIE
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 1984-03
- Volume
- 114
- Issue
- 3
- Pages
- 914-921
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2030989982
- Cited by
- 356
- References
- 56
- Citations by year
- 2024: 3 · 2022: 2 · 2021: 6 · 2020: 4 · 2019: 2 · 2018: 5 · 2017: 3 · 2016: 6 · 2015: 2 · 2014: 5 · 2013: 3 · 2012: 6
- FWCI
- 13.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- corticotropin-releasing factor, luteinizing hormone secretion, LH inhibition, ovulation, luteinizing hormone surge, hypothalamic-pituitary-gonadal axis, gonadectomy, adrenalectomy, beta-endorphin, ACTH, naltrexone, chlorisondamine, dexamethasone, female reproduction
- MeSH terms
- Adrenalectomy, Animals, beta-Endorphin, Castration, Corticotropin-Releasing Hormone, Dexamethasone, Endorphins, Female, Luteinizing Hormone, Pregnancy, Pregnancy, Animal, Rats, Inbred Strains, Reproduction, Rats
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