Stress-induced inhibition of reproductive functions: role of endogenous corticotropin-releasing factor
Abstract
In the adult castrated male rat, exposure to inescapable, intermittent electroshocks inhibited the pulsatile pattern of luteinizing hormone release and markedly lowered its plasma concentrations. The central administration of the corticotropin-releasing factor (CRF) antagonist alpha-helical ovine CRF residues 9 to 41 reversed the inhibitory action of stress. Neither its peripheral injection, nor the intraventricular injection of the inactive CRF analog des-Glu to Arg ovine CRF was effective. These results suggest that endogenous CRF may mediate some deleterious effects of noxious stimuli on reproduction.
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In castrated male rats, electroshock-induced stress inhibits LH release by acting through CRH release.
“In castrated male rats, electroshock-induced stress has inhibited LH release by acting through CRH release [92].”
From Fibromyalgia pathogenesis explained by a neuroendocrine multistable model (2024) · cites this paper as [92]
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- Authors
- Rivier, C., Rivier, J., & Vale, W.
- Affiliations
- Salk Institute for Biological Studies (US)
- ORCID
- Vale, Wylie
- Venue
- Science
- Published
- 1986-02-07
- Volume
- 231
- Issue
- 4738
- Pages
- 607-609
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2008742762
- Cited by
- 531
- References
- 2
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 3 · 2023: 10 · 2022: 3 · 2021: 11 · 2020: 12 · 2019: 3 · 2018: 7 · 2017: 5 · 2016: 7 · 2015: 5 · 2014: 11 · 2013: 8 · 2012: 7
- FWCI
- 29.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (2p01am026741-06)
- National Institute on Alcohol Abuse and Alcoholism (AA 03504)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD-1-3527)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- corticotropin-releasing factor, stress, reproductive function, luteinizing hormone, pulsatile LH secretion, castration, CRF antagonist, neuroendocrine regulation of reproduction, male reproduction
- MeSH terms
- Adrenocorticotropic Hormone, Animals, Corticotropin-Releasing Hormone, Electroshock, Female, Humans, Luteinizing Hormone, Male, Orchiectomy, Reproduction, Stress, Psychological, Rats
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