The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Iodide Transport in a Continuous Line of Cultured Cells from Rat Thyroid
Abstract
The properties of TSH-dependent iodide (I-) uptake are defined for a cloned, continuously growing, functioning rat thyroid cell line (FRTL-5 cells). Since these cells grow without a lumen and are therefore restricted in their ability to iodinate thyroglobulin, the FRTL-5 cells offer the opportunity to directly study transport processes across the membrane into the cell as well as the process whereby I- moves from the cell. FRTL-5 cells concentrate I- approximately 30-fold and exhibit many of the properties of I- uptake seen in thyroid tissue slice and primary cell culture systems. In these cells, accumulation of I- is consistent with a Na+-dependent carrier model for I- uptake, and effects on the influx and efflux processes can be dissociated. Because FRTL-5 cells can be maintained in culture indefinitely and can provide large quantities of a homogeneous functional thyroid cell preparation for study, these cells offer the unique opportunity to further define the mechanism and kinetics of I- transport in a less complex system.
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Cites
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Crane, R. K. (2005) · Reviews of Physiology, Biochemistry and Pharmacology · doi:10.1007/bfb0027722 · Cited by 324
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VALENTE, W. A., VITTI, P., KOHN, L. D., BRANDI, M. L., ROTELLA, C. M., TOCCAFONDI, R., TRAMONTANO, D., ALOJ, S. M., & AMBESI-IMPIOMBATO, F. S. (1983) · Endocrinology · doi:10.1210/endo-112-1-71 · Cited by 204
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Cited by
Cloning and characterization of the thyroid iodide transporter
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The Sodium/Iodide symporter (NIS): Molecular physiology and preclinical and clinical applications
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Post-transcriptional regulation of the sodium/iodide symporter by thyrotropin
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Bianco, A. C., Anderson, G., Forrest, D., Galton, V. A., Gereben, B., Kim, B. W., Kopp, P. A., Liao, X. H., Obregon, M. J., Peeters, R. P., et al. (2014) · Thyroid · doi:10.1089/thy.2013.0109 · Cited by 205
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Metadata
- Authors
- WEISS, S. J., PHILP, N. J., & GROLLMAN, E. F.
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 1984-04
- Volume
- 114
- Issue
- 4
- Pages
- 1090-1098
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2023180335
- Cited by
- 337
- References
- 13
- FWCI
- 7.16
- Type
- journal article
- Language
- en
- Open access
- closed
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- WEISS, S. J., PHILP, N. J., & GROLLMAN, E. F. (1984). Iodide Transport in a Continuous Line of Cultured Cells from Rat Thyroid. Endocrinology. https://doi.org/10.1210/endo-114-4-1090
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
