The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Sexual Dimorphism in the Posterior Pituitary Response to Stress in the Rat*
Abstract
The posterior pituitary response to immobilization was studied in male and female rats. Plasma levels of arginine vasopressin (AVP) and oxytocin (OT) were measured both in control rats and in rats immobilized in an acrylic restrainer for 1 min. In male rats immobilization did not result in any change in AVP (control: 1.3 +/- 0.2 pmol/liter, mean +/- SEM; immobilized: 2.3 +/- 0.6 pmol/liter), although there was a small but significant increase in OT (control; 4.1 +/- 0.5 pmol/liter; immobilized: 10.2 +/- 2.2 pmol/liter; P less than 0.005). In female rats a marked rise was observed in AVP (control: 1.4 +/- 0.3 pmol/liter; immobilized: 5.5 +/- 1.3 pmol/liter; P less than 0.005), and the rise in OT was considerably greater (P less than 0.01) than that found in males (control: 4.7 +/- 0.8 pmol/liter; immobilized: 26.0 +/- 5.6 pmol/liter; P less than 0.001). Further groups of male and female rats were gonadectomized 2 weeks before immobilization. Basal levels of AVP and OT were unchanged. Orchidectomized males had an increased OT response to immobilization compared with sham-operated males (P less than 0.05) whereas the AVP response was not significantly changed. Ovariectomy did not significantly affect either the AVP or OT responses. Although the neural pathways responsible for the neurohypophyseal response to immobilization are not known, this data demonstrate that the response is dependent on the sex of the rat.
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“female rats have a much stronger release of AVP following stress”
From Hypothalamic–pituitary–adrenal and hypothalamic–pituitary–gonadal axes: sex differences in regulation of stress responsivity (2017) · cites this paper as Williams, Carter, & Lightman, 1985
Citations
Cites
Oxytocin unlike vasopressin is a stress hormone in the rat.
Lang, R. E., Heil, J. W. E., Ganten, D., Hermann, K., Unger, T., & Rascher, W. (2008) · Neuroendocrinology · doi:10.1159/000123566 · Cited by 304
Effects of Sex Steroid Hormones on Arginine Vasopressin in Intact and Castrated Male and Female Rats
Skowsky, R., Swan, L., & Smith, P. B. W. (1979) · Endocrinology · doi:10.1210/endo-104-1-105 · Cited by 160
A new extraction of arginine vasopressin from blood: The use of octadecasilyl-silica
Larochelle, F. T., North, W. G., & Stern, P. (1980) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00580849 · Cited by 145
Husain, M., Manger, W. M., ROCK, T. W., Weiss, R., & FRANTZ, A. G. (1979) · Endocrinology · doi:10.1210/endo-104-3-641 · Cited by 121
A New Sensitive Radioimmunoassay for Plasma Arginine Vasopressin
Rooke, P., & Baylis, P. H. (1982) · Journal of Immunoassay · doi:10.1080/15321818208056990 · Cited by 112
Increase in oxytocin secretion at ejaculation in male
OGAWA, S., KUDO, S., KITSUNAI, Y., & FUKUCHI, S. (1980) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1980.tb01027.x · Cited by 86
Robinson, I. C. A. F. (1980) · Journal of Immunoassay · doi:10.1080/01971528008058475 · Cited by 82
Salacinski, P., Hope, J., McLean, C., Clement-Jones, V., Sykes, J. E., Price, J., & Pj, L. (1979) · PubMed · Cited by 36
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The oxytocin receptor: from intracellular signaling to behavior
Jurek, B., & Neumann, I. D. (2018) · Physiological Reviews · doi:10.1152/physrev.00031.2017 · Cited by 999
Oyola, M. G., & Handa, R. J. (2017) · Stress · doi:10.1080/10253890.2017.1369523 · Cited by 710
A review on sex differences in processing emotional signals
Kret, M. E., & De Gelder, B. (2012) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2011.12.022 · Cited by 584
Oxytocin in general anxiety and social fear: a translational approach
Neumann, I. D., & Slattery, D. A. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.06.004 · Cited by 468
McCormick, C. M., & Zovkic, I. B. (2006) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2006.07.012 · Cited by 397
Metadata
- Authors
- WILLIAMS, T. D. M., CARTER, D. A., & LIGHTMAN, S. L.
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 1985-02
- Volume
- 116
- Issue
- 2
- Pages
- 738-740
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2037355675
- Cited by
- 128
- References
- 8
- Citations by year
- 2022: 2 · 2021: 6 · 2019: 1 · 2018: 3 · 2017: 3 · 2016: 1 · 2015: 1 · 2012: 2
- FWCI
- 24.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- sexual dimorphism, neurohypophysis, restraint stress, vasopressin, oxytocin, gonadectomy, orchiectomy, ovariectomy, stress hormones, rats
- MeSH terms
- Animals, Arginine Vasopressin, Castration, Female, Male, Oxytocin, Pituitary Gland, Posterior, Rats, Inbred Strains, Sex Characteristics, Stress, Physiological, Rats
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