Oxytocin unlike vasopressin is a stress hormone in the rat.
Abstract
The functions of oxytocin in the female are thought to be confined to the processes of milk ejection and parturition. In this study the role of oxytocin in the body's response to stressful stimuli has been examined. Physical immobilization of rats and forced swimming caused large increases in the secretion of the hormone, whereas vasopressin levels remained unchanged. These findings classify oxytocin, in contrast to vasopressin, as a so-called 'stress hormone' and suggest its importance in processes other than those related to reproduction.
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The study cannot completely rule out interactions between differential endogenous OXT levels in EXP 1 and EXP 2 and treatment.
“we cannot completely rule out interactions between differential endogenous OXT levels in EXP 1 and EXP 2 and treatment.”
From Oxytocin Enhancement of Emotional Empathy: Generalization Across Cultures and Effects on Amygdala Activity (2018) · cites this paper as Lang et al., 1983
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“Studies in rats have indicated that OT secretion is s t imulated by emotional , and some types of physical, stress (Lang et al., 1983; Gibbs, 1984), whereas it is thought that AVP secretion responds only to physical stress (Hussain et al.”
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“Factors that could affect endogenous OT include stress (Lang et al., 1983; Englemann et al., 1999), maternal/offspring interaction (Francis et al., 2002), and treatment with drugs such as Pitocin, a synthetic OT, used for labor induction/enhancement (Malek et al., 1996) or Atosiban, an OTA, used to…”
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Nomura, M., Saito, J., Ueta, Y., Muglia, L. J., Pfaff, D. W., & Ogawa, S. (2003) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2003.01095.x · Cited by 69 · see citing works
Chronic variable stress alters hypothalamic–pituitary–adrenal axis function in the female mouse
Borrow, A. P., Heck, A. L., Miller, A. M., Sheng, J. A., Stover, S. A., Daniels, R. M., Bales, N. J., Fleury, T. K., & Handa, R. J. (2019) · Physiology & Behavior · doi:10.1016/j.physbeh.2019.112613 · Cited by 68 · see citing works
“Although restraint stress has been shown to induce activation of PVN OT neurons [58], OT mRNA [44] and OT secretion [59] in male rats, we also observed no effect of restraint stress on OT mRNA in control animals in our studies.”
ResultSex differences in hormonal responses to social conflict in the monogamous California mouse
Trainor, B. C., Takahashi, E. Y., Silva, A. L., Crean, K. K., & Hostetler, C. M. (2010) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.04.008 · Cited by 66 · see citing works
“Oxytocin is released peripherally under a number of stressful contexts including forced swim (Wotjak et al. 1998) and restraint (Lang et al. 1983).”
BackgroundThe cardiovascular effects of oxytocin in conscious male rats
Petty, M. A., Lang, R. E., Unger, T., & Ganten, D. (1985) · European Journal of Pharmacology · doi:10.1016/0014-2999(85)90497-2 · Cited by 65 · see citing works
Self-citationSerotonergic involvement in stress-induced vasopressin and oxytocin secretion
Jorgensen, H., Knigge, U., Kjær, A., & Warberg, J. (2002) · European Journal of Endocrinology · doi:10.1530/eje.0.1470815 · Cited by 66 · see citing works
“Cold-swim stress stimulated OT but not AVP secretion, which is in agreement with previous observations ( 6 , 59).”
ResultRelease of vasopressin within the brain contributes to neuroendocrine and behavioral regulation
Landgraf, R., Wotjak, C. T., Neumann, I. D., & Engelmann, M. (1999) · Progress in brain research · doi:10.1016/s0079-6123(08)61571-x · Cited by 66 · see citing works
Prepartal chronic stress increases anxiety and decreases aggression in lactating female mice.
Maestripieri, D., Badiani, A., & Puglisi‐Allegra, S. (1991) · Behavioral Neuroscience · doi:10.1037/0735-7044.105.5.663 · Cited by 65 · see citing works
Imaki, T., Katsumata, H., Miyata, M., Naruse, M., Imaki, J., & Minami, S. (2001) · Neuroendocrinology · doi:10.1159/000054646 · Cited by 64 · see citing works
“Thus, vasopressin gene expression in parvocellular as well as magnocellular neurons is increased in response to stress. Our observation that stress induced the expression of c- fos mRNA in a subset of the vasopressin neurons of the PVN further supports the role of vasopressin in the stress response. Stress-induced exp…”
BackgroundOxytocin-induced inhibition of feeding and drinking: No sexual dimorphism in rats
Benelli, A., Bertolini, A., & Arletti, R. (1991) · Neuropeptides · doi:10.1016/0143-4179(91)90040-p · Cited by 61 · see citing works
Shan, J., & Krukoff, T. L. (2001) · The Journal of Comparative Neurology · doi:10.1002/cne.1090 · Cited by 62 · see citing works
“Our data also suggest that ADM may affect oxytocin production in, or release from, magnocellular neurons, as oxytocin is released into the plasma in response to psychological stressors (Lang et al., 1983; Jezova et al., 1995; Hashiguchi et al., 1997; Nishioka et al., 1998).”
MethodMiyata, S., Itoh, T., Lin, S., Ishiyama, M., Nakashima, T., & Kiyohara, T. (1995) · Brain Research Bulletin · doi:10.1016/0361-9230(95)00017-8 · Cited by 62 · see citing works
Link, H., Dayanithi, G., Föhr, K. J., & Gratzl, M. (1992) · Endocrinology · doi:10.1210/endo.130.4.1312449 · Cited by 61 · see citing works
Wotjak, C. T., Ludwig, M., Ebner, K., Russell, J. A., Singewald, N., Landgraf, R., & Engelmann, M. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02101.x · Cited by 61 · see citing works
“Indeed, a variety of stressors stimulate the release of OXT, but not AVP, from magnocellular neurons into the blood circulation (Lang et al., 1983; Kasting, 1988; Wotjak et al., 1998a).”
Background
- Authors
- Lang, R. E., Heil, J. W. E., Ganten, D., Hermann, K., Unger, T., & Rascher, W.
- Affiliations
- Heidelberg University (DE)
- Venue
- Neuroendocrinology
- Publisher
- S. Karger AG
- Published
- 2008-03-27
- Volume
- 37
- Issue
- 4
- Pages
- 314-316
- ISSN
- 0028-3835 (ISSN-L)
- 1423-0194
- OpenAlex
- W2072568231
- Cited by
- 304
- References
- 0
- Citations by year
- 2025: 3 · 2023: 3 · 2022: 4 · 2021: 5 · 2020: 4 · 2019: 7 · 2018: 10 · 2017: 6 · 2016: 8 · 2015: 5 · 2014: 4 · 2013: 6 · 2012: 4
- FWCI
- 8.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- oxytocin, vasopressin, stress hormones, stress response, restraint stress, forced swim test, hormone secretion
- MeSH terms
- Animals, Cold Temperature, Physical Exertion, Female, Immobilization, Male, Oxytocin, Rats, Inbred Strains, Stress, Physiological, Vasopressins, Rats
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