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Tissue Distribution of Insulin-Like Growth Factor I and II Messenger Ribonucleic Acid in the Adult Rat*
Abstract
The insulin-like growth factors (IGFs) have both metabolic and growth-promoting activities in many cell and tissue types. Although the IGFs are present in serum, they are also thought to have important autocrine and paracrine functions. Using complementary DNA (cDNA) probes for rat IGF-I and mouse IGF-II, we have investigated the tissue distribution of messenger RNAs (mRNAs) for these growth factors in adult rats. IGF-I cDNA hybridized with three groups of transcripts, 7.0, 1.8 and 0.7-1.1 kilobases, which were detectable in all tissues examined, with liver demonstrating the highest level of expression. IGF-II cDNA also hybridized to a number of mRNAs, the most abundant of which was 4.0 kilobases. Of the tissues examined, IGF-II expression was highest in the brain, barely detectable in the liver, and undetectable under the conditions used, in lung, ovary, testes, and mammary gland. These studies support the notion of paracrine or autocrine function for IGF-I and demonstrate tissue-specific IGF-II expression in the adult rat.
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Cited by
Role of insulin-like growth factors in embryonic and postnatal growth
Baker, J., Liu, J.-P., Robertson, E. J., & Efstratiadis, A. (1993) · Cell · doi:10.1016/s0092-8674(05)80085-6 · Cited by 2,463
The ovarian insulin and insulin-like growth factor system with an emphasis on domestic animals
Spicer, L. J., & Echternkamp, S. E. (1995) · Domestic Animal Endocrinology · doi:10.1016/0739-7240(95)00021-6 · Cited by 448
Insulin and insulin-like growth factors in the CNS
Baskin, D. G., Wilcox, B. J., Figlewicz, D. P., & Dorsa, D. M. (1988) · Trends in Neurosciences · doi:10.1016/0166-2236(88)90155-5 · Cited by 330
Zannini, M., Avantaggiato, V., Biffali, E., Arnone, M. I., Sato, K., Pischetola, M., Taylor, B. A., Phillips, S. J., Simeone, A., & Di Lauro, R. (1997) · The EMBO Journal · doi:10.1093/emboj/16.11.3185 · Cited by 259
Sonntag, W. E., Lynch, C. D., Cefalu, W. T., Ingram, R. L., Bennett, S. A., Thornton, P. L., & Khan, A. S. (1999) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/54.12.b521 · Cited by 229
Metadata
- Authors
- MURPHY, L. J., BELL, G. I., & FRIESEN, H. G.
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 1987-04
- Volume
- 120
- Issue
- 4
- Pages
- 1279-1282
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W1983807922
- Cited by
- 416
- References
- 0
- FWCI
- 32.00
- Type
- journal article
- Language
- en
- Open access
- closed
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- MURPHY, L. J., BELL, G. I., & FRIESEN, H. G. (1987). Tissue Distribution of Insulin-Like Growth Factor I and II Messenger Ribonucleic Acid in the Adult Rat*. Endocrinology. https://doi.org/10.1210/endo-120-4-1279
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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