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Cited by 48Hypothalamic control of reproductive hormonesNeuropeptides and Animal PhysiologyNeuroendocrine regulation and behavior

The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.

Ultrashort Feedback Control of Luteinizing Hormone-Releasing Hormone Secretion in Vitro*

ZANISI, MARIAROSA, MESSI, ELIO, MOTTA, MARCELLA, MARTINI, LUCIANO·1987·Endocrinology
DOI 10.1210/endo-121-6-2199
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Abstract

The present experiments were performed to clarify whether LHRH might inhibit its own secretion via an ultrashort feedback mechanism acting directly on the hypothalamus. Using an in vitro system, mediobasal hypothalami (MBHs) of adult male rats were perifused in either the presence or absence of a LHRH agonistic analog [D-Ser(TBU)6,Des-Gly10] LHRH ethylamide shown not to cross-react in the LHRH RIA. In the first series of experiments, six MBHs per chamber were initially perifused with control medium and submitted to two K+ stimulations (110 mM) for 5 min every 30 min; the control medium was then replaced by medium containing the LHRH analog (5 microM), and three additional K+ pulses were applied. In the second series of experiments, a single MBH per chamber was exposed for the duration of the experiments to either control medium or medium containing the LHRH analog (5 microM). In both cases, pulses of K+ were applied to the tissue. The amounts of endogenous LHRH released both under basal conditions and after K+ stimulation were measured in the effluent (1 ml every 5 min) with a specific RIA. The results show that the LHRH analog inhibits basal secretion of endogenous LHRH from the MBH, and diminishes or abolishes the response to K+ stimulations. The specificity of the inhibitory effect exerted by the LHRH analog on LHRH secretion was shown by the inability of TRH to mimic the effect of the LHRH analog. The data are consistent with the hypothesis that LHRH, acting at a hypothal…

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Crossref · 10.1210/endo-121-6-2199

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38 of 38 references verified0 citation errors · 0 not checkable

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  • Unlike previous models, the production of CRH up-regulates its own production in accordance with experimental evidence.

    “Unlike the previous considered models, the production of CRH up-regulates its own production in accordance with experimental evidence reported in the literature [33, 35, 53].”

    From Patient specific modeling of the HPA axis related to clinical diagnosis of depression (2017) · cites this paper as [53]

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Metadata

Authors
ZANISI, M., MESSI, E., MOTTA, M., & MARTINI, L.
Affiliations
University of Milan (IT)
ORCID
MESSI, ELIO
Venue
Endocrinology
Publisher
The Endocrine Society
Published
1987-12
Volume
121
Issue
6
Pages
2199-2204
ISSN
  • 0013-7227 (ISSN-L)
  • 1945-7170
DOI
10.1210/endo-121-6-2199
OpenAlex
W2025887039
Cited by
48
References
38
Citations by year
2016: 2 · 2014: 2
FWCI
1.31
Type
journal article
Language
en
Open access
closed
Locations
  • Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Keywords
gonadotropin-releasing hormone, potassium stimulation, mediobasal hypothalamus, thyrotropin-releasing hormone
MeSH terms
Animals, Circadian Rhythm, Feedback, Hypothalamus, Gonadotropin-Releasing Hormone, Male, Potassium, Rats, Inbred Strains, Rats, In Vitro Techniques

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