In Vivo and in Vitro Examination of an Autoregulatory Mechanism for Luteinizing Hormone-Releasing Hormone*

DEPAOLO, LOUIS V.; KING, RITA A.; CARRILLO, ALBERTO J.

doi:10.1210/endo-120-1-272

Cited by 115Hypothalamic control of reproductive hormonesNeuropeptides and Animal PhysiologyNeuroendocrine regulation and behavior

In Vivo and in Vitro Examination of an Autoregulatory Mechanism for Luteinizing Hormone-Releasing Hormone*

DEPAOLO, LOUIS V., KING, RITA A., CARRILLO, ALBERTO J.·1987·Endocrinology

DOI 10.1210/endo-120-1-272

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Abstract

Recent evidence has been presented that demonstrates the existence of ultrashort feedback circuits for a number of neuropeptides in the central nervous system. The present investigation was undertaken to examine the possible existence of an autoregulatory mechanism for LHRH. In the first experiment, long term ovariectomized rats bearing lateral ventricular and atrial cannulae received intracerebroventricular (icv) injections of saline or LHRH every hour from 1200-1500 h. Blood was collected at 10-min intervals from 1200-1500 h to assess the effects of icv LHRH on pulsatile LH and FSH release. After the 1500 h collection, LHRH was injected iv and blood was collected to determine the effects of icv LHRH on pituitary responsiveness to LHRH. Central injections of 0.1 pg and 1 ng LHRH, but not 10 pg LHRH, significantly suppressed mean LH levels, trough LH levels, and LH pulse frequency compared to those in saline-treated control rats. The amplitude of LH pulses was not significantly affected by any dose of LHRH. In contrast to LH, multiple icv injections of LHRH failed to alter pulsatile FSH release. Pituitary LH and FSH responses to iv LHRH injection were not suppressed by icv LHRH. In a second experiment, hourly icv injections of 1 ng LHRH into proestrous rats markedly suppressed preovulatory LH release only during the middle to latter phases of the surge. In a final study using an in vitro superfusion system, addition of a LHRH agonist to the superfusion medium at a concentrati…

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Unlike previous models, the production of CRH up-regulates its own production in accordance with experimental evidence.
“Unlike the previous considered models, the production of CRH up-regulates its own production in accordance with experimental evidence reported in the literature [33, 35, 53].”
From Patient specific modeling of the HPA axis related to clinical diagnosis of depression (2017) · cites this paper as [33]

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Authors: DEPAOLO, L. V., KING, R. A., & CARRILLO, A. J.
Affiliations: The University of Texas at San Antonio Health Science Center (US)
Venue: Endocrinology
Publisher: The Endocrine Society
Published: 1987-01
Volume: 120
Issue: 1
Pages: 272-279
ISSN: 0013-7227 (ISSN-L)
1945-7170
DOI: 10.1210/endo-120-1-272
OpenAlex: W2047779052
Cited by: 115
References: 35
Citations by year: 2023: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 6 · 2015: 2 · 2014: 5 · 2013: 1 · 2012: 1
FWCI: 7.40
Type: journal article
Language: en
Open access: closed
Locations: Endocrinology (publishedVersion)
PubMed (publishedVersion)
Funders: Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD 10202, HD-17807)
Topics: Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Keywords: gonadotropin-releasing hormone, negative feedback regulation, LH pulsatility, FSH release, luteinizing hormone surge, medial basal hypothalamus, median eminence, pituitary responsiveness, ovariectomized rats, proestrus, GnRH agonist
MeSH terms: Animals, Feedback, Female, Follicle Stimulating Hormone, Homeostasis, Hypothalamus, Injections, Intraventricular, Luteinizing Hormone, Gonadotropin-Releasing Hormone, Male, Ovariectomy, Ovulation, Pituitary Gland, Anterior, Potassium, Proestrus, Secretory Rate, Rats

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In Vivo and in Vitro Examination of an Autoregulatory Mechanism for Luteinizing Hormone-Releasing Hormone*

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