The DOI matches its Crossref record.
Histopathology Associated with Elevated Levels of Growth Hormone and Insulin-Like Growth Factor I in Transgenic Mice*
Abstract
Serum levels of GH and insulin-like growth factor I (IGF-I) were genetically increased to investigate the physiological activities of these proteins. Lines of mice expressing chimeric genes composed of bovine GH, human GRF, or human IGF-I coding sequences fused to the mouse metallothionein I promoter were examined for consequences of chronic exposure to high levels of these peptides. Animals with elevated serum levels of GH (either bovine GH or mouse GH) have selective splanchnomegaly coupled with glomerular sclerosis and hepatocellularmegaly. Serum levels of insulin and cholesterol are increased. In contrast (with the exception of selective enlargement of organs), the chronic expression of IGF-I results in a different pattern of abnormalities. These findings suggest that the pathogenesis of GH-related disorders is not mediated solely by IGF-I.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Fero, M. L., Rivkin, M., Tasch, M., Porter, P., Carow, C. E., Firpo, E., Polyak, K., Tsai, L.-H., Broudy, V., Perlmutter, R. M., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81239-8 · Cited by 1,457
The GH/IGF-1 axis in ageing and longevity
Junnila, R. K., List, E. O., Berryman, D. E., Murrey, J. W., & Kopchick, J. J. (2013) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.67 · Cited by 574
Genetic Engineering of Livestock
Pursel, V. G., Pinkert, C. A., Miller, K. F., Bolt, D. J., Campbell, R. G., Palmiter, R. D., Brinster, R. L., & Hammer, R. E. (1989) · Science · doi:10.1126/science.2499927 · Cited by 437
Self-citationFranklin, D. S., Godfrey, V. L., Lee, H., Kovalev, G. I., Schoonhoven, R., Chen-Kiang, S., Su, L., & Xiong, Y. (1998) · Genes & Development · doi:10.1101/gad.12.18.2899 · Cited by 412
Life Extension in the Dwarf Mouse
Bartke, A., & Brown-Borg, H. (2004) · Current Topics in Developmental Biology · doi:10.1016/s0070-2153(04)63006-7 · Cited by 356
Metadata
- Authors
- QUAIFE, C. J., MATHEWS, L. S., PINKERT, C. A., HAMMER, R. E., BRINSTER, R. L., & PALMITER, R. D.
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 1989-01
- Volume
- 124
- Issue
- 1
- Pages
- 40-48
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W1986826730
- Cited by
- 232
- References
- 0
- FWCI
- 11.74
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Histopathology Associated with Elevated Levels of Growth Hormone and Insulin-Like Growth Factor I in Transgenic Mice*. https://app.cochat.ai/papers/10.1210/endo-124-1-40
- The paper
- QUAIFE, C. J., MATHEWS, L. S., PINKERT, C. A., HAMMER, R. E., BRINSTER, R. L., & PALMITER, R. D. (1989). Histopathology Associated with Elevated Levels of Growth Hormone and Insulin-Like Growth Factor I in Transgenic Mice*. Endocrinology. https://doi.org/10.1210/endo-124-1-40
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
