The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Genetic Engineering of Livestock
Abstract
Genetic engineering of livestock is expected to have a major effect on the agricultural industry. However, accurate assessment of the consequences of transgene expression is impossible without multigenerational studies. A systematic study of the beneficial and adverse consequences of long-term elevations in the plasma levels of bovine growth hormone (bGH) was conducted on two lines of transgenic pigs. Two successive generations of pigs expressing the bGH gene showed significant improvements in both daily weight gain and feed efficiency and exhibited changes in carcass composition that included a marked reduction in subcutaneous fat. However, long-term elevation of bGH was generally detrimental to health: the pigs had a high incidence of gastric ulcers, arthritis, cardiomegaly, dermatitis, and renal disease. The ability to produce pigs exhibiting only the beneficial, growth-promoting effects of growth hormone by a transgenic approach may require better control of transgene expression, a different genetic background, or a modified husbandry regimen.
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Cites
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Palmiter, R. D., Brinster, R. L., Hammer, R. E., Trumbauer, M. E., Rosenfeld, M. G., Birnberg, N. C., & Evans, R. M. (1982) · Nature · doi:10.1038/300611a0 · Cited by 1,340
Self-citationGERM-LINE TRANSFORMATION OF MICE
Palmiter, R. D., & Brinster, R. L. (1986) · Annual Review of Genetics · doi:10.1146/annurev.ge.20.120186.002341 · Cited by 1,157
Self-citationProduction of transgenic rabbits, sheep and pigs by microinjection
Hammer, R. E., Pursel, V. G., Rexroad, C. E., Wall, R. J., Bolt, D. J., Ebert, K. M., Palmiter, R. D., & Brinster, R. L. (1985) · Nature · doi:10.1038/315680a0 · Cited by 1,076
Self-citationFactors affecting the efficiency of introducing foreign DNA into mice by microinjecting eggs.
Brinster, R. L., Chen, H. Y., Trumbauer, M. E., Yagle, M. K., & Palmiter, R. D. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.13.4438 · Cited by 1,027
Self-citationFurlanetto, R. W., Underwood, L. E., Van Wyk, J. J., & D'Ercole, A. J. (1977) · Journal of Clinical Investigation · doi:10.1172/jci108816 · Cited by 850
DAUGHADAY, W. H., MARIZ, I. K., & BLETHEN, S. L. (1980) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-51-4-781 · Cited by 738
Metallothionein-Human GH Fusion Genes Stimulate Growth of Mice
Palmiter, R. D., Norstedt, G., Gelinas, R. E., Hammer, R. E., & Brinster, R. L. (1983) · Science · doi:10.1126/science.6356363 · Cited by 676
Self-citationTranscriptional regulation of the mouse metallothionein-I gene by heavy metals.
Durnam, D. M., & Palmiter, R. D. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)69264-1 · Cited by 585
Self-citationRegulation of insulin-like growth factor I gene expression by growth hormone.
Mathews, L. S., Norstedt, G., & Palmiter, R. D. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.24.9343 · Cited by 553
Self-citation
Cited by
Fluctuating asymmetry: a biological monitor of environmental and genomic stress
Parsons, P. A. (1992) · Heredity · doi:10.1038/hdy.1992.51 · Cited by 560
Harnessing genomic information for livestock improvement
Georges, M., Charlier, C., & Hayes, B. (2019) · Nature Reviews Genetics · doi:10.1038/s41576-018-0082-2 · Cited by 384
Metadata
- Authors
- Pursel, V. G., Pinkert, C. A., Miller, K. F., Bolt, D. J., Campbell, R. G., Palmiter, R. D., Brinster, R. L., & Hammer, R. E.
- Venue
- Science
- Published
- 1989-06-16
- Volume
- 244
- Issue
- 4910
- Pages
- 1281-1288
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2077254097
- Cited by
- 437
- References
- 43
- FWCI
- 17.80
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Genetic Engineering of Livestock. https://app.cochat.ai/papers/10.1126/science.2499927
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- Pursel, V. G., Pinkert, C. A., Miller, K. F., Bolt, D. J., Campbell, R. G., Palmiter, R. D., Brinster, R. L., & Hammer, R. E. (1989). Genetic Engineering of Livestock. Science. https://doi.org/10.1126/science.2499927
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
