The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Increased Hypothalamic Content of Preproneuropeptide Y Messenger Ribonucleic Acid in Genetically Obese Zucker Rats and Its Regulation by Food Deprivation*
Abstract
Neuropeptide Y (NPY) is a potent orexigenic agent capable of producing hyperphagia and obesity. NPY-containing neurons project from the hypothalmic arcuate nucleus to the paraventricular nucleus, an area known to be sensitive to the orexigenic effects of NPY. In this study we investigated the possibility that preproNPY messenger RNA (mRNA) content may be altered in obese Zucker rats compared to that of their lean littermates. Total RNA was isolated from hypothalamic dissections from male and female, obese and lean Zucker rats. RNA was also isolated from dissections of: olfactory bulb, entorhinal cortex, hippocampus, and striatum of female obese and lean rats. PreproNPY mRNA content was determined by solution hybridization-RNase protection analysis. The results revealed a 2- to 3-fold increase in preproNPY mRNA levels in the hypothalamus of obese animals compared to lean. The increase was observed in both sexes and was specific to the hypothalamus. In situ hybridization localized this increase to the arcuate nucleus. An additional RNase protection study was pursued to investigate the effects of 72 h food deprivation on hypothalamic preproNPY mRNA levels in lean and obese animals. Lean animals displayed an approximate 2-fold increase in preproNPY mRNA content, whereas obese animals showed no significant increase after food deprivation. These data are consistent with the hypothesis that NPY projections within the hypothalamus are involved in regulating feeding behavior and weight gain, and that disturbed regulation of hypothalamic NPY expression may play a role in the etiology of obesity in the genetically obese Zucker rat.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Glenn Stanley, B., Kyrkouli, S. E., Lampert, S., & Leibowitz, S. F. (1986) · Peptides · doi:10.1016/0196-9781(86)90149-x · Cited by 849
Insulin and insulin-like growth factors in the CNS
Baskin, D. G., Wilcox, B. J., Figlewicz, D. P., & Dorsa, D. M. (1988) · Trends in Neurosciences · doi:10.1016/0166-2236(88)90155-5 · Cited by 330
Intraventricular insulin reduces food intake and body weight of lean but not obese zucker rats
Ikeda, H., West, D. B., Pustek, J. J., Figlewicz, D. P., Greenwood, M. R. C., Porte, D., & Woods, S. C. (1986) · Appetite · doi:10.1016/s0195-6663(86)80006-x · Cited by 230
Cited by
Targeted disruption of the melanocortin-4 receptor results in obesity in mice
Huszar, D., Lynch, C. A., Fairchild-Huntress, V., Dunmore, J. H., Fang, Q., Berkemeier, L. R., Gu, W., Kesterson, R. A., Boston, B. A., Cone, R. D., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)81865-6 · Cited by 3,030
A Neural Circuit Mechanism Integrating Motivational State with Memory Expression in Drosophila
Krashes, M. J., DasGupta, S., Vreede, A., White, B., Armstrong, J. D., & Waddell, S. (2009) · Cell · doi:10.1016/j.cell.2009.08.035 · Cited by 598
Layered reward signalling through octopamine and dopamine in Drosophila
Burke, C. J., Huetteroth, W., Owald, D., Perisse, E., Krashes, M. J., Das, G., Gohl, D., Silies, M., Certel, S., & Waddell, S. (2012) · Nature · doi:10.1038/nature11614 · Cited by 614
Hormonal regulation of food intake
Stanley, S., Wynne, K., McGowan, B., & Bloom, S. (2005) · Physiological Reviews · doi:10.1152/physrev.00015.2004 · Cited by 372
Takahashi, K. A., & Cone, R. D. (2005) · Endocrinology · doi:10.1210/en.2004-1397 · Cited by 308
Meeran, K., O’Shea, D., Edwards, C. M. B., Turton, M. D., Heath, M. M., Gunn, I., Abusnana, S., Rossi, M., Small, C. J., Goldstone, A. P., et al. (1999) · Endocrinology · doi:10.1210/endo.140.1.6421 · Cited by 303
Schwartz, M. W., Marks, J. L., Sipolst, A. J., Basking, D. G., Woods, S. C., Kahn, S. E., & Porte, D. (1991) · Endocrinology · doi:10.1210/endo-128-5-2645 · Cited by 245
Légrádi, G., Emerson, C. H., Ahima, R. S., Flier, J. S., & Lechan, R. M. (1997) · Endocrinology · doi:10.1210/en.138.6.2569 · Cited by 505
Legradi, G., Emerson, C. H., Ahima, R. S., Rand, W. M., Flier, J. S., & Lechan, R. M. (1998) · Neuroendocrinology · doi:10.1159/000054354 · Cited by 131
Tritos, N. A., Elmquist, J. K., W. Mastaitis, J., Flier, J. S., & Maratos-Flier, E. (1998) · Endocrinology · doi:10.1210/endo.139.11.6308 · Cited by 82
Expression Levels of Genes Likely Involved in Glucose-sensing in the Obese Zucker Rat Brain
Bogacka, I., Roane, D. S., Xi, X., Zhou, J., Li, B., Ryan, D. H., & Martin, R. J. (2004) · Nutritional Neuroscience · doi:10.1080/10284150410001710401 · Cited by 22
Metadata
- Authors
- SANACORA, G., KERSHAW, M., FINKELSTEIN, J. A., & WHITE, J. D.
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 1990-08
- Volume
- 127
- Issue
- 2
- Pages
- 730-737
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2042604118
- Cited by
- 310
- References
- 3
- FWCI
- 11.99
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
