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Conversion of Androstenedione to Estrone by Neural Tissues from Fetal and Neonatal Rats12
Abstract
Incubation of hypothalamic and limbic system homogenates from 21-day rat fetuses and 1, 5, 10-day-old or adult rats with Ε4- androstene-3-17-dione 7-3H resulted in the formation of 3H-estrone by all tissues with the exception of the limbic system from the female fetuses. In each paired experiment the activity in male tissues exceeded that of the females. In general, the activities of perinatal tissues either equaled or exceeded those of comparable adult tissues. These results support the hypothesis that neuroendocrine effects of androgens on fetal, neonatal, prepubertal and adult rats could be mediated by estrogen metabolites. (Endocrinology94: 117, 197.4)
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Cited by
The Formation of Estrogens by Central Neuroendocrine Tissues
NAFTOLIN, F., RYAN, K. J., DAVIES, I. J., REDDY, V. V., FLORES, F., PETRO, Z., KUHN, M., WHITE, R. J., TAKAOKA, Y., & WOLIN, L. (1975) · Proceedings of the 1974 Laurentian Hormone Conference · doi:10.1016/b978-0-12-571131-9.50012-8 · Cited by 793
Self-citationA review of brain aromatase cytochrome P450
LEPHART, E. (1996) · Brain Research Reviews · doi:10.1016/0165-0173(96)00002-1 · Cited by 505
Imperato-McGinley, J., Peterson, R. E., Gautier, T., & Sturla, E. (1979) · New England Journal of Medicine · doi:10.1056/nejm197905313002201 · Cited by 445
Roles of steroid hormones and their receptors in structural organization in the nervous system
Kawata, M. (1995) · Neuroscience Research · doi:10.1016/0168-0102(96)81278-8 · Cited by 332
ROSELLI, C. E. (1991) · Endocrinology · doi:10.1210/endo-128-3-1310 · Cited by 139
Metadata
- Authors
- REDDY, V. V. R., NAFTOLIN, F., & RYAN, K. J.
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 1974-01
- Volume
- 94
- Issue
- 1
- Pages
- 117-121
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2027260586
- Cited by
- 225
- References
- 0
- FWCI
- 9.89
- Type
- journal article
- Language
- en
- Open access
- closed
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- REDDY, V. V. R., NAFTOLIN, F., & RYAN, K. J. (1974). Conversion of Androstenedione to Estrone by Neural Tissues from Fetal and Neonatal Rats12. Endocrinology. https://doi.org/10.1210/endo-94-1-117
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