Chiroinositol deficiency and insulin resistance. II. Acute effects of D-chiroinositol administration in streptozotocin-diabetic rats, normal rats given a glucose load, and spontaneously insulin-resistant rhesus monkeys.
Abstract
The acute effects of administration of D-chiroinositol (D-CI), a component of a putative mediator of insulin action, on plasma glucose were examined in low dose streptozotocin-treated rats and normal rats given a glucose load and the effects on plasma glucose and insulin were determined in five obese rhesus monkeys with varying degrees of spontaneous insulin resistance. Single dose intragastric D-CI (10 mg/kg) administered to streptozotocin-treated rats produced a 30-40% decrease in plasma glucose (P < 0.05) at 30-120 min. Single dose intragastric D-CI (2-15 mg/kg) administered to normal rats 2 h before ip glucose produced a 30-50% decrease (P < 0.05) in plasma glucose. D-CI (10 mg/kg) caused a 50% increase (P < 0.05) in glucose disappearance rates in these rats. Myoinositol (10 mg/kg) was without effect. Intravenously administered single dose D-CI (100 mg/kg) increased both the glucose and insulin disappearance rates by 129 +/- 41% (mean +/- SE; P < 0.06) and 89 +/- 39% (P = 0.01), respectively, in all monkeys between 0-30 min compared to control values. D-CI administration, therefore, lowered elevated plasma glucose in streptozotocin-treated hyperglycemic rats, normal rats given a glucose load, and spontaneously insulin-resistant monkeys with or without noninsulin-dependent diabetes mellitus. Intravenous D-CI also lowered plasma insulin in these monkeys.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Both myo- and d-chiro-inositol showed insulin mimetic effects in animal models of insulin resistance.
“Both myo- and d-chiro-inositol showed insulin mimetic effects in animal models of IR [71].”
From From Prediabetes to Type 2 Diabetes Mellitus in Women with Polycystic Ovary Syndrome: Lifestyle and Pharmacological Management (2020) · cites this paper as [71]
Cites
Greene, D. A., de Jesus, P. V., & Winegrad, A. I. (1975) · Journal of Clinical Investigation · doi:10.1172/jci108052 · Cited by 471 · see citing works
The Enzymatic Synthesis of Inositol Monophosphatide
Paulus, H., & Kennedy, E. P. (1960) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)69403-7 · Cited by 435 · see citing works
Larner, J., Galasko, G. T., Cheng, K., DePaoli-Roach, A. A., Huang, L., Daggy, P., & Kellogg, J. (1979) · Science · doi:10.1126/science.228395 · Cited by 370 · see citing works
Self-citationLow Urinarychiro-Inositol Excretion in Non-Insulin-Dependent Diabetes Mellitus
Kennington, A. S., Hill, C. R., Craig, J. W., Bogardus, C., Raz, I., Ortmeyer, H. K., HANSEN, B. C., Romero, G. G., & Larner, J. (1990) · New England Journal of Medicine · doi:10.1056/nejm199008093230603 · Cited by 218 · see citing works
Self-citationTakenawa, T., Saito, M., Nagai, Y., et al. (1977) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(77)90304-6 · Cited by 65 · see citing works
Suzuki, S., Sugawara, K., Satoh, Y., et al. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)92949-2 · Cited by 35 · see citing works
Neural influences on oscillations in basal plasma levels of insulin in monkeys
HANSEN, B. C., Pek, S., Koerker, D. J., Goodner, C. J., Wolfe, R. A., & Schielke, G. P. (1981) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1981.240.1.e5 · Cited by 33 · see citing works
Self-citationPinitol from Sugar Pine Stump Wood
Anderson, A. B. (1953) · Industrial & Engineering Chemistry · doi:10.1021/ie50519a037 · Cited by 30 · see citing works
Cubitt, A. B., & Gershengorn, M. C. (1989) · Biochemical Journal · doi:10.1042/bj2570639 · Cited by 27 · see citing works
Arendrup, K., Gregersen, G., Hawley, J. A., & Hawthorne, J. N. (1989) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1989.tb03848.x · Cited by 25 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Ovulatory and Metabolic Effects of d-<i>Chiro</i>-Inositol in the Polycystic Ovary Syndrome
Nestler, J. E., Jakubowicz, D. J., Reamer, P., Gunn, R. D., & Allan, G. (1999) · New England Journal of Medicine · doi:10.1056/nejm199904293401703 · Cited by 518 · see citing works
Effects of d-chiro-inositol in lean women with the polycystic ovary syndrome
Iuorno, M. J., Jakubowicz, D. J., Baillargeon, J.-P., Dillon, P., Gunn, R. D., Allan, G., & Nestler, J. E. (2002) · Endocrine Practice · doi:10.4158/ep.8.6.417 · Cited by 188 · see citing works
Phytotherapy in diabetes: Review on potential mechanistic perspectives
El-Abhar, H. S., & Schaalan, M. F. (2014) · World Journal of Diabetes · doi:10.4239/wjd.v5.i2.176 · Cited by 145 · see citing works
The Effectiveness of Myo-Inositol and D-Chiro Inositol Treatment in Type 2 Diabetes
Pintaudi, B., Di Vieste, G., & Bonomo, M. (2016) · International Journal of Endocrinology · doi:10.1155/2016/9132052 · Cited by 117 · see citing works
Pani, A., Gironi, I., Di Vieste, G., Mion, E., Bertuzzi, F., & Pintaudi, B. (2020) · International Journal of Endocrinology · doi:10.1155/2020/6276187 · Cited by 38 · see citing works
- Authors
- Ortmeyer, H. K., Huang, L. C., Zhang, L., Hansen, B. C., & Larner, J.
- Affiliations
- University of Maryland, Baltimore (US)
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 1993-02
- Volume
- 132
- Issue
- 2
- Pages
- 646-651
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2064620662
- Cited by
- 113
- References
- 10
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 5 · 2022: 3 · 2021: 1 · 2020: 4 · 2018: 6 · 2017: 1 · 2016: 6 · 2015: 5 · 2014: 4 · 2013: 8 · 2012: 3
- FWCI
- 4.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (8r01ag010612-06)
- National Institute on Aging (AG-10612)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Keywords
- insulin resistance, streptozotocin-induced diabetes, plasma glucose, glucose disappearance rate, insulin, myo-inositol, type 2 diabetes, rhesus monkeys, hyperglycemia, insulin action
- MeSH terms
- Animals, Blood Glucose, Diabetes Mellitus, Experimental, Glucose Tolerance Test, Inositol, Insulin, Insulin Resistance, Isomerism, Kinetics, Macaca mulatta, Male, Reference Values, Rats, Sprague-Dawley, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
