Phytotherapy in diabetes: Review on potential mechanistic perspectives
Open accessAbstract
Diabetes mellitus (DM) is a widely spread epidemic disease that results from the absence of insulin, decreased secretion and/or impaired function. Since DM is a multi-factorial disease, the available pharmaceuticals, despite their sensible treatment, target mostly one pathway to control hyperglycemia and encounter several side effects. Therefore, new therapeutic paradigms aim to hit several pathways using only one agent. Traditionally, antidiabetic plants and/or their active constituents may fulfill this need. More than 200 species of plants possess antidiabetic properties which were evaluated mostly by screening tests without digging far for the exact mode of action. Searching among the different literature resources and various database and in view of the above aspects, the present article provides a comprehensive review on the available antidiabetic plants that have been approved by pharmacological and clinical evaluations, and which their mechanism(s) of action is assured. These plants are categorized according to their proved mode of action and are classified into those that act by inhibiting glucose absorption from intestine, increasing insulin secretion from the pancreas, inhibiting glucose production from hepatocytes, or enhancing glucose uptake by adipose and muscle tissues. The current review also highlights those that mimic in their action the new peptide analogs, such as exenatide, liraglutide and dipeptidylpeptidase-4 inhibitors that increase glucagon-like peptide-1 serum concentration and slow down the gastric emptying.
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Extracts of various medicinal plants act at different levels by inhibiting glucose absorption from the intestine, increasing insulin secretion from the pancreas, increasing glucose uptake by adipose and muscle cells, and inhibiting glucose production from hepatocytes.
“Extracts of various medicinal plants act at different levels by inhibiting the glucose absorption from intestine, increasing the insulin secretion from pancreas, increasing the uptake of glucose by adipose and muscle cells, inhibiting the glucose production from hepatocytes [57] .”
From Alternative Medicine: New Ways to Treat Diseases and Therapies (2021) · cites this paper as [57]
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Sorted by citations
Natural Products for the Treatment of Type 2 Diabetes Mellitus
Rı́os, J. L., Francini, F., & Schinella, G. R. (2015) · Planta Medica · doi:10.1055/s-0035-1546131 · Cited by 456 · see citing works
Khan, M., Liu, H., Wang, J., & Sun, B. (2019) · Food Research International · doi:10.1016/j.foodres.2019.108933 · Cited by 227 · see citing works
Coffee consumption and disease correlations
Gökcen, B. B., & Şanlıer, N. (2017) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2017.1369391 · Cited by 188 · see citing works
“…anti-genotoxic, antiinflammatory, cytotoxic and immunomodulator agent and invasion, metastasis, angiogenesis, cell cycle progression and cell proliferation inhibitor (Chen, Teoh, Chitturi, & Farrell, 2014; El-Abhar & Schaalan, 2014; Gaascht, Dicato, & Diederich, 2015; Pan, et al., 2016).”
Jugran, A. K., Rawat, S., Devkota, H. P., BHATT, I. D., & Rawal, R. S. (2020) · Phytotherapy Research · doi:10.1002/ptr.6821 · Cited by 167 · see citing works
“…enhancing glucose uptake in peripheral organs and up-regulation of glucose transporter, activation of insulin receptors, enhancing the release of adiponectin, changes in glycogen metabolism, insulin-mimetic and insulino-tropic effects, and regulation of oxidative stress (El-Abhar & Schaalan, 2014).”
BackgroundBuchholz, T., & Melzig, M. F. (2015) · Phytotherapy Research · doi:10.1002/ptr.5525 · Cited by 131 · see citing works
A role of Ficus species in the management of diabetes mellitus: A review
Deepa, P., Sowndhararajan, K., Kim, S., & Park, S. J. (2018) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2017.12.045 · Cited by 132 · see citing works
Cordycepin from Cordyceps militaris prevents hyperglycemia in alloxan-induced diabetic mice
Ma, L., Zhang, S., & Du, M. (2015) · Nutrition Research · doi:10.1016/j.nutres.2015.04.011 · Cited by 111 · see citing works
“westernized diet is considered to be the cornerstone for the development of type II diabetes [8].”
BackgroundRamadan, B., Schaalan, M., & Tolba, A. M. (2017) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-016-1530-1 · Cited by 95
“To date, more than 800 species have been investigated and their hypoglycemic effects reported [7].”
BackgroundSelf-citationSpínola, V., & Castilho, P. (2017) · Phytochemistry · doi:10.1016/j.phytochem.2017.07.006 · Cited by 90 · see citing works
Withaferin-A attenuates multiple low doses of Streptozotocin (MLD-STZ) induced type 1 diabetes
Tekula, S., Khurana, A., Anchi, P., & Godugu, C. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.07.090 · Cited by 84 · see citing works
Gupta, P., Bala, M., Gupta, S. K., Dua, A., Dabur, R., Injeti, E. R., & Mittal, A. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.09.029 · Cited by 90 · see citing works
Inhibitory Properties of Phenolic Compounds Against Enzymes Linked with Human Diseases
Gonçalves, S., & Romano, A. (2017) · InTech eBooks · doi:10.5772/66844 · Cited by 69 · see citing works
“In the last years, several reviews have been published focusing on the antidiabetic potential of natural products including on the inhibitory properties of phenolic compounds against carbohydrates-hydrolyzing enzymes [29, 30, 37, 38].”
BackgroundYılmaz, M. İ., Romano, M., Başaralı, M. K., Elzagallaai, A. A., Karaman, M., Demir, Z., Demir, M. F., Akçay, F., Seyrek, M., Haksever, N., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-65528-6 · Cited by 69 · see citing works
Coffee and its effects on the immune system
Açıkalın, B., & Şanlıer, N. (2021) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2021.06.023 · Cited by 59 · see citing works
Algenstaedt, P., Stumpenhagen, A., & Westendorf, J. (2018) · Evidence-Based Complementary and Alternative Medicine · doi:10.1155/2018/3565427 · Cited by 49 · see citing works
“Noni was one of the most important medicinal plants for Polynesian people, who used it for multiple reasons, among which was also the treatment of diabetes [19, 20].”
BackgroundMechanism of the antidiabetic action of Nigella sativa and Thymoquinone: a review
Shaukat, A., Zaidi, A., Anwar, H., & Kizilbash, N. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1126272 · Cited by 47 · see citing works
“The possibility of using TQ to augment the new diabetic therapy based on the gut hormone incretin has gained much currency because of its few side effects compared to conventional drugs and the absence of any other herbal derivatives that demonstrably modulate incretin (GLP-1) (248, 311, 312).”
BackgroundDas, S., Dutta, M., Chaudhury, K., & De, B. (2016) · European Food Research and Technology · doi:10.1007/s00217-015-2581-0 · Cited by 41 · see citing works
“Due to unwanted side effects of oral synthetic hypoglycemic agents, attention has been directed toward nutraceuticals from plants rich in antidiabetic phytoconstituents [5].”
BackgroundIheagwam, F. N., Iheagwam, O. T., Onuoha, M. K., Ogunlana, O. O., & Chinedu, S. N. (2022) · Scientific Reports · doi:10.1038/s41598-022-15114-9 · Cited by 48 · see citing works
Singh, A., Singh, K., Kaur, K., Sharma, A., Mohana, P., Prajapati, J., Kaur, U., Goswami, D., Arora, S., Chadha, R., et al. (2023) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2023.115948 · Cited by 42 · see citing works
The role of prophetic medicine in the management of diabetes mellitus: A review of literature
Sheikh, B. Y. (2016) · Journal of Taibah University Medical Sciences · doi:10.1016/j.jtumed.2015.12.002 · Cited by 33 · see citing works
Farshid, A., & Tamaddonfard, E. (2015) · Avicenna Journal of Phytomedicine · doi:10.22038/ajp.2015.4666 · Cited by 32
Herbal Medicine as an Alternative Medicine for Treating Diabetes: The Global Burden
Watal, G., Dhar, P., Srivastava, S., & Sharma, B. (2014) · Evidence-Based Complementary and Alternative Medicine · doi:10.1155/2014/596071 · Cited by 32
Selected Phyto and Marine Bioactive Compounds: Alternatives for the Treatment of Type 2 Diabetes
Reyes, B. A. S., Dufourt, E. C., Ross, J. A., Warner, M. J., Tanquilut, N., & Leung, A. B. (2017) · Studies in natural products chemistry · doi:10.1016/b978-0-444-64068-0.00004-8 · Cited by 35 · see citing works
Ojo, O., Ajiboye, B., Ojo, A., Oyinloye, B., Imiere, O., & Adeyonu, O. (2017) · Journal of Complementary and Integrative Medicine · doi:10.1515/jcim-2016-0145 · Cited by 26
Othman, A. I., Amer, M. A., Basos, A. S., & El-Missiry, M. A. (2019) · Clinical Phytoscience · doi:10.1186/s40816-019-0140-0 · Cited by 33 · see citing works
Chatterji, S., & Fogel, D. (2018) · Integrative Medicine Research · doi:10.1016/j.imr.2018.04.002 · Cited by 26 · see citing works
Tabatabaie, P. S., & Yazdanparast, R. (2017) · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · doi:10.1016/j.biopha.2017.06.082 · Cited by 25
Abdallah, I. Z. A., Salem, I. S., & El-Salam, N. A. S. A. (2017) · The Egyptian Journal of Hospital Medicine · doi:10.12816/0037829 · Cited by 23 · see citing works
El-Askary, H., Salem, H., & Motaal, A. A. A. (2022) · Molecules · doi:10.3390/molecules27030857 · Cited by 23 · see citing works
“Various plant products exert their antidiabetic effects through inhibiting the activity of several enzymes critical for diabetes management, including α-glucosidase, α-amylase, dipeptidyl peptidase IV (DPP IV) and aldose reductase [11,12].”
BackgroundMela, D. J., Cao, X.-Z., Dobriyal, R., Fowler, M. I., Li, L., Joshi, M. K., MULDER, T. P. J., Murray, P., Peters, H. P. F., Vermeer, M. A., et al. (2020) · Nutrition & Metabolism · doi:10.1186/s12986-020-00471-x · Cited by 23 · see citing works
Jiménez-García, S. N., Vazquez-Cruz, M. A., Rámirez-Gómez, X. S., Beltrán-Campos, V., Contreras-Medina, L. M., García-Trejo, J. F., & Feregrino-Pérez, A. A. (2020) · Molecules · doi:10.3390/molecules25071601 · Cited by 23
ANTIDIABETIC EFFECT OF THYMUS SATUREIOIDES AQUEOUS EXTRACT IN STREPTOZOTOCIN-INDUCED DIABETIC RATS
Kabbaoui, M. E., Chda, A., Mejrhit, N., Farah, A., Aarab, L., Bencheikh, R., & Tazi, A. (2016) · International Journal of Pharmacy and Pharmaceutical Sciences · doi:10.22159/ijpps.2016v8i9.12647 · Cited by 24 · see citing works
Chowdhury, S. S., Poddar, S. K., Zaheen, S., Noor, F. A., Ahmed, N., Haque, S., Sukul, A., Sunjida, S. B., Mazumder, M. M. U., & Akbar, N. (2017) · doi:10.1016/j.apjtb.2016.09.009 · Cited by 21
“There have also been many reported bioactivities like antioxidant, immunomodulatory, antiinflammatory, anti-allergic, antiviral, antibacterial, antifungal and monoamine oxidase inhibitory activities of this plant [4].”
BackgroundDiabetes Mellitus: The Pathophysiology as a Canvas for Management Elucidation and Strategies
Iheagwam, F., & Iheagwam, O. T. (2025) · Medicine in Novel Technology and Devices · doi:10.1016/j.medntd.2025.100351 · Cited by 20 · see citing works
El-Sayed, M.-I. K., Al-Massarani, S., El-Gamal, A., El-Shaibany, A., & Al-Mahbashi, H. (2020) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-020-03087-z · Cited by 20
“Many plant species worldwide are antidiabetic due to their hypolipidemic, antioxidant, and anti-inflammatory activities [1, 15].”
BackgroundJibril, M. M., Hamid, A. A., Ghazali, H. M., Dek, M. S. P., Ramli, N. S., Jaafar, A. H., Jeeven, K., & Mohammed, A. S. (2019) · Universiti Putra Malaysia Institutional Repository (Universiti Putra Malaysia) · doi:10.12691/jfnr-7-1-10 · Cited by 21 · see citing works
“These findings are similar to the extraction yields in the work of other researchers [33,35,36].”
ResultDermatological and musculoskeletal assessment of diabetic foot: A narrative review.
Shirazi, A. A., Nasiri, M., & Yazdanpanah, L. (2016) · Diabetes & metabolic syndrome · doi:10.1016/j.dsx.2016.03.004 · Cited by 20
Investigation of medicinal plants from Madagascar against DPP-IV linked to type 2 diabetes
Beidokhti, M., Lobbens, E., Rasoavaivo, P., Staerk, D., & Jäger, A. (2018) · South African Journal of Botany · doi:10.1016/j.sajb.2018.01.018 · Cited by 18 · see citing works
Osigwe, C., Akah, P., Nworu, C., Okoye, T., & Tchimene, M. (2015) · Pharmacology & Pharmacy · doi:10.4236/pp.2015.611054 · Cited by 18 · see citing works
“Phytotherapy have demonstrated at least in animal models to prevent and/or halt the disease at different points of its natural history [64] [65].”
BackgroundInfluentialMicroencapsulated Bilberry and Chokeberry Leaf Extracts with Potential Health Benefits
Nedeljković, S. K., Radan, M., Nikolić, N. Ć., Mutavski, Z., Krgović, N., Markovic, S. B., Stević, T. R., Živković, J., & Šavikin, K. (2023) · Plants · doi:10.3390/plants12233979 · Cited by 16 · see citing works
Amin, E., Abdelbakky, M., Darwish, M., Mohammed, H., Chigurupati, S., Qureshi, K. A., & Hassan, M. H. A. (2022) · Molecules · doi:10.3390/molecules27030973 · Cited by 17
“It has been stated that maintaining a healthy blood glucose level is an important strategy for the treatment of T2DM [11,12].”
BackgroundInfluentialChandana, N. G. A. S. S., & Morlock, G. (2021) · Talanta: The International Journal of Pure and Applied Analytical Chemistry · doi:10.1016/j.talanta.2020.121701 · Cited by 16
Jyothi, D., Koland, M., Priya, S., & James, J. (2017) · doi:10.5530/jyp.2017.9.70 · Cited by 16
Algae as a Source of Bioactive Compounds to Prevent the Development of Type 2 Diabetes Mellitus
Popović‐Djordjević, J. B., Stanković, J. S. K., Mihailović, V. B., Pereira, A. G., Garcia‐Oliveira, P., Prieto, M. A., & Simal‐Gándara, J. (2021) · Current Medicinal Chemistry · doi:10.2174/0929867328666210325100654 · Cited by 24 · see citing works
β-cell replenishment: Possible curative approaches for diabetes mellitus
RATHWA, N. N., Patel, R., Palit, S. P., PARMAR, N. R., Rana, S., Ansari, M. I., Ramachandran, A. V., & Begum, R. (2020) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2020.08.006 · Cited by 14 · see citing works
Bastos, R. G., Salles, B. C. C., Bini, I., Castaldini, L., Silva, L., Vilela, A., Micheloni, A., da Silva, G. M., da Silva, P. D., Maure, A., et al. (2019) · South African Journal of Botany · doi:10.1016/j.sajb.2019.03.006 · Cited by 15 · see citing works
Insulinotropic Effect of Herbal Drugs for Management of Diabetes Mellitus: A Congregational Approach
Islam, M. (2016) · Biosensors Journal · doi:10.4172/2090-4967.1000142 · Cited by 14 · see citing works
“More than 200 species (1200) of medicinal plants have been claimed to have antidiabetic properties [3].”
BackgroundEffect and Mechanism of Herbal Ingredients in Improving Diabetes Mellitus Complications
Ebrahimi, E., Shirali, S., & Afrisham, R. (2016) · Jundishapur Journal of Natural Pharmaceutical Products · doi:10.5812/jjnpp.31657 · Cited by 14 · see citing works
Abid, A., Wafa, Z., Belguidoum, M., Touahria, T., Mekhadmi, N., Dekmouche, M., Bechki, L., Bireche, K., Boussebaa, W., & al-Farga, A. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.118252 · Cited by 13
Inflammatory stress induces lipid accumulation in multi-organs of db/db mice.
Ma, K., Zhang, Y., Liu, J., Wu, Y., Hu, Z.-P., Liu, L., & Liu, B.-C. (2015) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmv079 · Cited by 13 · see citing works
“Diabetes mellitus (DM) and its associated complications represent a public health problem that has reached epidemic proportions due to the rapidly increasing rates of DM throughout the world [1].”
BackgroundHidayat, M., Soeng, S., Prahastuti, S., Erawijantari, P., & Widowati, W. (2015) · doi:10.9734/jsrr/2015/16273 · Cited by 13
“G6PD can accelerate adipogenesis through generating ligand peroxisome proliferatoractivated receptor γ (PPARγ) which is transcription factor in adipogenesis [22,30,31].”
BackgroundGhanbari, M., Shokrzadeh, M., Habibi, E., & Sadeghimahalli, F. (2022) · Journal of pharmacopuncture · doi:10.3831/kpi.2022.25.2.130 · Cited by 15 · see citing works
“A few traditional plants used to treat diabetes mellitus have been scientifically and medically assessed [1].”
BackgroundAlabdan, M. A. (2015) · doi:10.12691/bb-3-2-1 · Cited by 12
“Many plant extracts and their purified compounds have been reported to control blood glucose and reverse physiological abnormalities [9].”
BackgroundKhator, R., & Monga, V. (2024) · Future Medicinal Chemistry · doi:10.4155/fmc-2023-0285 · Cited by 14 · see citing works
Kausar, M. A., Anwar, S., Eltayb, W. A., Kuddus, M., Khatoon, F., El‐Arabey, A. A., Khalifa, A. M., Rizvi, M. R., Najm, M. Z., Thakur, L., et al. (2022) · Molecules · doi:10.3390/molecules27154980 · Cited by 15 · see citing works
“) have shown therapeutic value in the case of diabetes [27,28].”
BackgroundJibril, M. M., Hamid, A. A., Abas, F., Jeeven, K., Mohammed, A. S., Jaafar, A. H., Dek, M. S. P., & Ramli, N. S. (2022) · Journal of Food Biochemistry · doi:10.1111/jfbc.14058 · Cited by 11 · see citing works
Antidiabetic bioactive compounds from plants
Missoun, F. (2018) · Medical Technologies Journal · doi:10.26415/2572-004x-vol2iss2p199-214 · Cited by 9 · see citing works
Bansode, T., Salalkar, B., Dighe, D. D., Nirmal, S., & Dighe, S. (2017) · Ayu · doi:10.4103/ayu.ayu_18_17 · Cited by 11 · see citing works
“Phytotherapy that is, treatment with the bioactive phytoconstituents obtained from medicinal plants is the potential mechanistic perspective in the management of diabetes.[11] Although lot of antidiabetic agents are available to treat the disease, the total recovery, which avoids adverse effects, late‐stage diabetic c…”
BackgroundNajafian, M., Najafian, B., & Najafian, Z. (2016) · Zahedan Journal of Research in Medical Sciences · doi:10.17795/zjrms-4963 · Cited by 11 · see citing works
“As mentioned before, new diabetic therapies seek ways to affect multiple targets at the same time with consideration of fewer side effects [27-30].”
BackgroundElrherabi, A., Bouhrim, M., Abdnim, R., Berraaouan, A., Ziyyat, A., Mekhfi, H., Legssyer, A., & Bnouham, M. (2023) · Journal of Natural Remedies · doi:10.18311/jnr/2023/29451 · Cited by 10
Guzmán, T. J., & Gurrola‐Díaz, C. M. (2019) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2019.1627458 · Cited by 13 · see citing works
“This rises cytosolic [Ca2þ], triggering the fusion of insulin vesicles with the plasmatic membrane and a subsequent content release (Rorsman et al. 2000, Straub and Sharp 2002, Wang and Thurmond 2009, Ferrannini and Mari 2014).”
BackgroundAbbas, A., Muhammad, I., AbdulRahman, M. B., Bilbis, L. S., Saidu, Y., & Onu, A. (2018) · Nigerian Journal of Basic and Applied Sciences · doi:10.4314/njbas.v25i2.11 · Cited by 10
Mela, D., Cao, X.-Z., Govindaiah, S., Hiemstra, H., Kalathil, R., Lin, L., Manoj, J., Mi, T., & Verhoeven, C. (2022) · British Journal of Nutrition · doi:10.1017/s0007114522000824 · Cited by 9
“One potential approach to reduce the PPG and PPI responses to commercial foods is the use of natural sources of inhibitors of enzymes or transporters involved in carbohydrate digestion and uptake (5) .”
Iftikhar, A. (2018) · Pakistan Veterinary Journal · doi:10.29261/pakvetj/2018.036 · Cited by 9
“Medicinal plants or combination of plants have therapeutic properties due to the presence of different complex substances known as secondary metabolites such as flavonoids, polyphenols and alkaloids (El-Abhar and Schaalan, 2014).”
Attanayake, A., Jayatilaka, K., Mudduwa, L., & Pathirana, C. (2018) · Journal of Botany · doi:10.1155/2018/4204519 · Cited by 9 · see citing works
“The results are in accordance with our previously published data on investigation of detailed antidiabetic mechanisms of the selected extracts in streptozotocin induced diabetic rats [13, 15, 16, 34, 35].”
Alternative Medicine: New Ways to Treat Diseases and Therapies
RAO, M. T., YAMINI, M., PHANINDRA, C., & RAO, Y. S. (2021) · Indian Journal of Pharmaceutical Sciences · doi:10.36468/pharmaceutical-sciences.744 · Cited by 8 · see citing works
Loizzo, M., Bonesi, M., Nabavi, S., Sobarzo-Sánchez, E., Rastrelli, L., & Tundis, R. (2017) · doi:10.1002/9783527805921.ch6 · Cited by 8
Afshari, A., Salimi, F., Nowrouzi, A., Khalili, M. B., Bakhtiyari, S., Hassanzadeh, G., Shabani, M., Ahadi, A., & Farhadiannezhad, M. (2021) · Clinical Phytoscience · doi:10.1186/s40816-021-00324-x · Cited by 4 · see citing works
Ohikhena, F. U., Wintola, O., & Afolayan, A. (2018) · doi:10.1080/10496475.2017.1423437 · Cited by 7
“Antidiabetic mechanisms of action act by lowering the blood glucose levels by inhibiting glucose digestion and/or absorption in/from the small intestine, increment of the secretion of insulin from the pancreas β-cells, elevation of the insulin activities in the peripheral tissues, inhibition of gluconeogenesis by redu…”
BackgroundHoogenraad, A.-R., Geldof, M., Hiemstra, H., de Jong, A., Duchateau, G. S. M. J. E., & Mela, D. J. (2025) · Journal of Nutrition · doi:10.1016/j.tjnut.2025.05.037 · Cited by 7 · see citing works
Gobinath, R., Parasuraman, S., Sreeramanan, S., & SUMITHA (2020) · International Journal of Research in Pharmaceutical Sciences · doi:10.26452/ijrps.v11ispl4.4460 · Cited by 6
“This encourages the inding for effective and safer anti-diabetic compounds obtained from medicinal plants (El-Abhar and Schaalan, 2014).”
BackgroundRole of Plant Secondary Metabolites as Antidiabetic Agents
Sonkamble, V., Wagh, N. S., & Pai, S. (2019) · Natural Bio-active Compounds · doi:10.1007/978-981-13-7154-7_18 · Cited by 6
Cheun-Arom, T., Kitisripanya, T., Nuntawong, P., Sritularak, B., & Chuanasa, T. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e34502 · Cited by 5 · see citing works
Mela, D. J., Boers, H. M., Kadam, T., Hiemstra, H., Kalathil, R., & ten Hoorn, J. W. M. S. (2023) · British Journal Of Nutrition · doi:10.1017/s0007114523001319 · Cited by 6 · see citing works
“One potential approach to reduce the PPG and PPI responses to commercial foods is the use of plant extracts that may slow the rate of carbohydrate digestion and glucose uptake (6) .”
BackgroundRomano, M., Garcia-Bournissen, F., Piskin, D., Rodoplu, U., Piskin, L., Elzagallaai, A. A., Tunçer, T., Sezer, S., UCUNCUOGLU, D., Honca, T., et al. (2022) · Life · doi:10.3390/life12060896 · Cited by 5 · see citing works
“Since inflammation, oxidative stress, and endothelial dysfunction jointly contribute to morbidity and mortality in this patient group, our approach is to modulate these pathways by using a combination of health supplements with anti-atherosclerotic properties (containing Morinda citrifolia) [19,20], anti-inflammatory…”
BackgroundMollania, F., & Sahabi, H. (2021) · Nanotechnology for Environmental Engineering · doi:10.1007/s41204-021-00177-2 · Cited by 5
Najafian, M., Amini, S., Dehestani, B., Parivar, K., & Ebrahim‐Habibi, A. (2014) · Pharmacological Reports · doi:10.1016/j.pharep.2014.10.013 · Cited by 5 · see citing works
Phytoparmaceuticals and Its Applications in Therapy
Hernández-Ceruelos, A., Juárez, S. M., & Vázquez-Alvarado, P. (2016) · Advances in medical technologies and clinical practice book series · doi:10.4018/978-1-5225-0754-3.ch007 · Cited by 2 · see citing works
Aazza, S., El-Guendouz, S., & Miguel, M. D. G. (2024) · Letters in Applied NanoBioScience · doi:10.33263/lianbs131.017 · Cited by 4
“…a significant in vivo hypoglycaemic effect by reducing the plasma glucose level by 0.64% in patients with type II non-controlled diabetes mellitus [80], maybe due to the presence of flavonoids and, particularly, phenylethanoid glycosides such as verbascoside derivatives, known as antidiabetic…”
InfluentialAli, R. F. M. (2023) · Cogent Food & Agriculture · doi:10.1080/23311932.2023.2291226 · Cited by 4
“…anti-inflammatory, cytotoxic, and immunomodulator substance as well as a tumor metastatic disease, vascular development, cell cycle progression, and proliferation of cells inhibitor (Chen et al., 2014; El-Abhar & Schaalan, 2014; Gaascht et al., 2015; Gokcen & Sanlier, 2017; Pan et al., 2016).”
BackgroundJosephat, I. O., Ogochukwu, N. U., Chukwuemeka, C., Sabinus, I. O., & Benjamin, C. (2019) · Scientific Research and Essays · doi:10.5897/sre2019.6620 · Cited by 4
“A new approach Ogbonna et al. 75 to the treatment of diabetes is to target several pathways using one agent or preparation (El-Abhar and Schaalan, 2014).”
MethodEl-komy, M. M., Serag, M., & Emsalam, A. A. (2017) · doi:10.12816/0041521 · Cited by 4
Akakpo, B., Akpovi, C., Aïkpé, J. F. A., Kinsou, L. D. C., Gbénou, J., & Dansou, P. (2017) · doi:10.22192/ijcrcps.2017.04.04.004 · Cited by 4
Preliminary Study of Hypoglycemic Effect of Locust Bean ( Parkia biglobosa) on Wistar Albino Rat
Sule, O., Godwin, J., & Abdu, A. (2015) · doi:10.9734/jsrr/2015/8044 · Cited by 4
“However it is possible that it decreases blood glucose concentration by mechanisms similar to those reported by earlier studies: including [22,23,24], cited by El-Abhar and Schaalan [25] for the medicinal plants of Campomanesin xanthocarpa (Berg) leaf, Annona seuamosa (Annonaceae), and Trigonella”
ResultLima, K., Malmir, M., Sabiha, S., Pinto, R. M. A., da Silva, I. M., Figueira, M. E., Rocha, J. P., Duarte, M. P., & Silva, O. M. D. (2025) · Pharmaceuticals · doi:10.3390/ph18060913 · Cited by 3 · see citing works
“…antihyperglycemic actions of medicinal plants are associated with their ability to modulate glucose metabolism through different pathways, such as restoring β -cell integrity, enhancing insulin-releasing activity, and increasing cellular glucose uptake, which can improve insulin resistance [19–21].”
Coffee: Constituents and Health Benefits
Shah, S., & Kumar, A. (2020) · Biotechnology Journal International · doi:10.9734/bji/2020/v24i530115 · Cited by 5 · see citing works
“modulator agent; and also acts as inhibitor for invasion, angiogenesis, metastasis, cell cycle progression and cell proliferation [11-14].”
BackgroundDoes Lycium europaeum leaf have antihyperglycemic, antihyperlipidemic and antioxidant effects
Tej, R., Hamdi, A., Beji, R. S., Wannes, W. A., Rebey, I. B., Oueslati, S., Ksouri, R., Tounsi, M. S., Lachaâl, M., & Karray‐Bouraoui, N. (2019) · Brazilian Journal of Pharmaceutical Sciences · doi:10.1590/s2175-97902019000118064 · Cited by 5 · see citing works
Hussain, M., Hossain, M. S., Sen, N., Rahman, M. A., & Halim, M. A. (2017) · doi:10.15562/phytomedicine.2017.35 · Cited by 3
“8 Discovery Phytomedicine 2017; 4 (1): 8-12.”
InfluentialAlkandahri, M. Y., Sadino, A., Usman, W. F., Feriadi, E., Oktoba, Z., Ulandari, A. S., Yulyana, A., Fathurrohmah, A., Khairunnisa, S., Nisa, I. S. A., et al. (2026) · Journal of Applied Pharmaceutical Sciences · doi:10.7324/japs.2025.264681 · Cited by 2
“Furthermore, more than 800 species of medicinal plants were reported to have antihyperglycemic effects [26].”
Gliptin induced acute pancreatitis: a literature review.
Pragadeesh, G. J., Sali, S. A. A., Kumar, S. R., Babu, D., & Dheepthi, D. (2025) · Acta gastro-enterologica Belgica · doi:10.51821/88.1.13722 · Cited by 2
Cakmak, U., Tuncay, F. O., & Kolcuoğlu, Y. (2024) · Food Research International · doi:10.1016/j.foodres.2024.115535 · Cited by 2
Chen, W.-T., Zhong, Y.-G., Shu, J., Yu, H.-J., Chen, Z., Ren, X., Hui, Z.-Y., & Li, Z. (2021) · Proteins: Structure, Function, and Bioinformatics · doi:10.1002/prot.26163 · Cited by 2
Afshari, A., Salimi, F., Babaie, M., Bakhtiyari, S., Hassanzadeh, G., Shabani, M., & Nowrouzi, A. (2020) · doi:10.21203/rs.3.rs-29655/v1 · Cited by 1 · see citing works
“Medicinal plants with sugar lowering properties are presumed to exert their antidiabetic activity via a variety of mechanisms, such as inhibition of intestinal glucose absorption, suppression of hepatic glucose production, induction of pancreatic insulin secretion, promotion of peripheral tissue (adipose and muscle) g…”
BackgroundDewi, S. N., Handayani, S. I., Stephanie, M., Nurbaya, S., & Prasasty, V. D. (2020) · OnLine Journal of Biological Sciences · doi:10.3844/ojbsci.2020.50.56 · Cited by 1 · see citing works
Tsykalo, T., & Trzhetsynskyi, S. (2020) · Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti · doi:10.36290/csf.2020.021 · Cited by 2
Youssef, E. A. (2016) · Journal of Bioscience and Applied Research/Journal of Bioscience and Applied Research · doi:10.21608/jbaar.2015.106489 · Cited by 3 · see citing works
Bendaoud, W., Farihi, A., Loukili, E., Elrherabi, A., Khibech, O., Laaraj, S., Shahat, A., Herqash, R. N., Eto, B., Chigr, F., et al. (2026) · Scientific Reports · doi:10.1038/s41598-026-47853-4 · Cited by 1
“…elements (Cu ++, Mg ++, Ca ++ ) for β-cell function 52,53 , acting on liver enzymes by stimulating glycogenesis and/or inhibiting glycogenolysis 54 , modifying gene expression and hormone activity involved in digestion 55 , inhibiting renal glucose reabsorption, inhibiting enzymes such as…”
Evaluation of Potential Toxicity Associated with Antidiabetic Herbs in Saudi Arabia
Domnic, I., Mohanabhaskaran, P., Zaheer, I., Meerasa, S., & Prabhakar, R. (2024) · Pharmacognosy Journal · doi:10.5530/pj.2024.16.90 · Cited by 1
“6,10 In developing countries, herbal medicines are often used to treat diabetes, especially when the cost of conventional medicines is quite high.”
BackgroundWang, J.-H., Hwang, S.-J., Choi, Y.-J., Woo, T.-W., & Son, C.-G. (2024) · The FASEB Journal · doi:10.1096/fj.202400552r · Cited by 1 · see citing works
“32 Also, through production of microbial enzymes in the fermentation process, such as glucosidase and esterase, Lactobacillus spp. can facilitate the release of the phenolic and flavonoid compounds from their conjugated forms in herbs, making them more accessible and enhancing their bioactivity.”
BackgroundIheagwam, F., Avwaghwaruvwe, O. E., Jack, L., Odedeyi, D. A., & Chinedu, S. (2024) · Letters in Applied NanoBioScience · doi:10.33263/lianbs131.046 · Cited by 1
“Diverse polyphenolic compounds present in medicinal and food plants can interact with proteins and suppress carbohydrate‐hydrolyzing enzymes to elicit their anti-diabetic effects [32].”
- Authors
- El-Abhar, H. S., & Schaalan, M. F.
- Affiliations
- Cairo University (EG)
- Venue
- World Journal of Diabetes
- Publisher
- Baishideng Publishing Group Inc.
- Published
- 2014
- Volume
- 5
- Issue
- 2
- Pages
- 176
- ISSN
- 1948-9358 (ISSN-L)
- PMC
- PMC3990312
- OpenAlex
- W2115594023
- Cited by
- 145
- References
- 244
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 12 · 2023: 9 · 2022: 11 · 2021: 17 · 2020: 19 · 2019: 12 · 2018: 12 · 2017: 14 · 2016: 14 · 2015: 10 · 2014: 3
- FWCI
- 2.18
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- World Journal of Diabetes (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Keywords
- herbal medicine, diabetes mellitus, antidiabetic plants, plant extracts, mechanism of action, glucose absorption inhibition, insulin secretion, hepatic glucose production, glucose uptake, exenatide, liraglutide, glucagon-like peptide-1, gastric emptying, hyperglycemia
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