Expression and activity of 3β-hydroxysteroid dehydrogenase/Δ5-Δ4 isomerase in the rat Purkinje neuron during neonatal life
Abstract
Recently, we demonstrated that cytochrome P450 side-chain cleavage enzyme (P450scc) occurs in the rat cerebellar Purkinje cell after differentiation and remains during neonatal development and into adulthood. 3Beta-hydroxysteroid dehydrogenase/delta5-delta4-isomerase (3betaHSD) is also an essential enzyme for progesterone biosynthesis not only in peripheral steroidogenic glands but also in the nervous system. In the present study, therefore, the expression of 3betaHSD in the rat cerebellum was investigated during neonatal development and in the adult. RT-PCR analysis showed that the expression of 3betaHSD messenger RNA (mRNA) in the cerebellum was higher at 7-14 days of age than at other times. Biochemical studies together with HPLC analysis revealed that cerebellar slices at 10 days of age converted pregnenolone to progesterone, suggesting enzymatic activity of 3betaHSD. This conversion was significantly reduced by trilostane, a specific inhibitor of 3betaHSD. A specific RIA indicated that progesterone concentrations in the cerebellum were higher at 3 and 10 days of age than at 60 days of age. The progesterone level in the cerebellum was significantly higher than that in plasma at 10 days of age. In contrast, the concentrations in both cerebellum and plasma at 3 and 60 days of age were similar. In the present study, the site of 3betaHSD mRNA expression in the cerebellum was further examined in neonatal and adult rats using in situ hybridization. The cerebellar expression of 3betaHSD mRNA was obscure at 3 days of age, whereas intense expression occurred in Purkinje cells and external granule cells throughout the cerebellum at 10 days of age. 3BetaHSD mRNA was also expressed in Purkinje cells and granule cells at 60 days of age, but a restricted expression was observed along the cerebellar meninges. These results suggest that the steroidogenic enzyme 3betaHSD as well as P450scc are expressed at least in the cerebellar Purkinje cell. The expression of 3betaHSD, however, may increase for a limited period around 10 days of age, unlike P450scc.
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Cites
Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction
Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1006/abio.1987.9999 · Cited by 65,240 · see citing works
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
Chomczyński, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1016/0003-2697(87)90021-2 · Cited by 47,092 · see citing works
Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor
Majewska, M. D., Harrison, N. L., Schwartz, R. D., Barker, J. L., & Paul, S. M. (1986) · Science · doi:10.1126/science.2422758 · Cited by 2,225 · see citing works
Molecular biology of steroid hormone synthesis
MILLER, W. L. (1988) · Endocrine Reviews · doi:10.1210/edrv-9-3-295 · Cited by 1,397 · see citing works
Paul, S. M., & Purdy, R. H. (1992) · The FASEB Journal · doi:10.1096/fasebj.6.6.1347506 · Cited by 1,328 · see citing works
Majewska, M. D. (1992) · Progress in Neurobiology · doi:10.1016/0301-0082(92)90025-a · Cited by 1,087 · see citing works
The nucleotide sequence of the rat cytoplasmic β–actin gene
Nudel, U., Zakut, R., Shani, M., Neuman, S., Levy, Z., & Yaffe, D. (1983) · Nucleic Acids Research · doi:10.1093/nar/11.6.1759 · Cited by 1,025 · see citing works
Altman, J. (1972) · Journal of Comparative Neurology · doi:10.1002/cne.901450402 · Cited by 996 · see citing works
Altman, J. (1972) · The Journal of Comparative Neurology · doi:10.1002/cne.901450305 · Cited by 912 · see citing works
Characterization and measurement of dehydroepiandrosterone sulfate in rat brain
Corpéchot, C., Robel, P., Axelson, M., Sjövall, J., & Baulieu, E. E. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.8.4704 · Cited by 656 · see citing works
(1997) · PubMed · Cited by 643 · see citing works
Neurosteroids act on recombinant human GABAA receptors
Puia, G., Santi, M., Vicini, S., Pritchett, D. B., Purdy, R. H., Paul, S. M., Seeburg, P. H., & Costa, E. (1990) · Neuron · doi:10.1016/0896-6273(90)90202-q · Cited by 519 · see citing works
Progesterone synthesis and myelin formation by Schwann cells
Koenig, H. L., Schumacher, M., Ferzaz, B., Thi, A. N. D., Ressouches, A., Guennoun, R., Jung-Testas, I., Robel, P., Akwa, Y., & Baulieu, E.-E. (1995) · Science · doi:10.1126/science.7770777 · Cited by 480 · see citing works
Neurosteroid biosynthesis: genes for adrenal steroidogenic enzymes are expressed in the brain
Mellon, S. H., & Deschepper, C. F. (1993) · Brain Research · doi:10.1016/0006-8993(93)91332-m · Cited by 398 · see citing works
Pregnenolone and its sulfate ester in the rat brain
Corpéchot, C., Synguelakis, M., Talha, S., Axelson, M., Sjövall, J., Vihko, R., Baulieu, E.-E., & Robel, P. (1983) · Brain Research · doi:10.1016/0006-8993(83)90797-7 · Cited by 385 · see citing works
Neurosteroids: Biosynthesis of Pregnenolone and Progesterone in Primary Cultures of Rat Glial Cells*
Jung‐Testas, I., Hu, Z. Y., BAULIEUf, E. E., & ROBEL, A. P. (1989) · Endocrinology · doi:10.1210/endo-125-4-2083 · Cited by 366 · see citing works
Neurosteroids: Cytochrome P-450 scc in Rat Brain
Goascogne, C. L., Röbel, P., Gouézou, M., Sananès, N., Baulieu, É.-É., & Waterman, M. R. (1987) · Science · doi:10.1126/science.3306919 · Cited by 363 · see citing works
Corpechot, C., Young, J., Calvel, M., Wehrey, C., Veltz, J.-N., Touyer, G., Mouren, M.-C., Prasad, V. V., Banner, C., & Sjövall, J. (1993) · Endocrinology · doi:10.1210/endo.133.3.8365352 · Cited by 353 · see citing works
Morrow, A. L., Pace, J. R., Purdy, R. H., & Paul, S. M. (1990) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09958-4 · Cited by 333 · see citing works
Uzunov, D. P., Cooper, T. B., Costa, E., & Guidotti, A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.22.12599 · Cited by 330 · see citing works
Patchev, V. K., Shoaib, M., Holsboer, F., & Almeida, O. F. X. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90330-1 · Cited by 306 · see citing works
Progesterone receptor-mediated effects of neuroactive steroids
Rupprecht, R., Reul, J. M. H. M., Trapp, T., van Steensel, B., Wetzel, C. H., Damm, K., Zieglgänsberger, W., & Holsboer, F. (1993) · Neuron · doi:10.1016/0896-6273(93)90156-l · Cited by 300 · see citing works
Neurosteroids: oligodendrocyte mitochondria convert cholesterol to pregnenolone.
Hu, Z. Y., Bourreau, E., Jung‐Testas, I., Röbel, P., & Baulieu, E. E. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.23.8215 · Cited by 293 · see citing works
Progesterone modulates a neuronal nicotinic acetylcholine receptor.
Valera, S., Ballivet, M., & Bertrand, D. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.20.9949 · Cited by 277 · see citing works
Perspectives in avian endocrinology
Harvey, S. C., & Etches, R. J. (1997) · Medical Entomology and Zoology · Cited by 251 · see citing works
Papadopoulos, V., Guarneri, P., Kreuger, K. E., Guidotti, A., & Costa, E. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.11.5113 · Cited by 224 · see citing works
Guennoun, R., Fiddes, R. J., Gouézou, M., Lombès, M., & Baulieu, E.-E. (1995) · Molecular Brain Research · doi:10.1016/0169-328x(95)00016-l · Cited by 208 · see citing works
Radioimmunoassay method for six steroids in human plasma
Brenner, P. F., Guerrero, R., Čekan, Z., & Diczfalusy, E. R. (1973) · Steroids · doi:10.1016/0039-128x(73)90053-6 · Cited by 186 · see citing works
Sex steroids and 5-en-3β-hydroxysteroids in specific regions of the human brain and cranial nerves
Lanthier, A., & Patwardhan, V. V. (1986) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(86)90259-1 · Cited by 182 · see citing works
Zhao, H., Labrie, C., Simard, J., de Launoit, Y., Trudel, C., Martel, C., Rhéaume, É., Dupont, É., Luu-The, V., & Pelletier, G. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)52475-3 · Cited by 176 · see citing works
Neuro-steroids: 3β-hydroxy-Δ5-derivatives in rat and monkey brain.
Robel, P., Bourreau, E., Corpéchot, C., Dang, D. C., Halberg, F., Clarke, C., Haug, M., Schlegel, M. L., Synguelakis, M., Vourch, C., et al. (1987) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(87)90133-6 · Cited by 175 · see citing works
Effects of subunit types of the cloned GABAA receptor on the response to a neurosteroid
Shingai, R., Sutherland, M. L., & Barnard, E. A. (1991) · European Journal of Pharmacology Molecular Pharmacology · doi:10.1016/0922-4106(91)90149-c · Cited by 173 · see citing works
Cheney, D. L., Uzunov, D. P., Costa, E., & Guidotti, A. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-06-04641.1995 · Cited by 167 · see citing works
Ukena, K., Usui, M., Kohchi, C., & Tsutsui, K. (1998) · Endocrinology · doi:10.1210/endo.139.1.5672 · Cited by 166 · see citing works
Self-citationAkwa, Y., Sananès, N., Gouézou, M., Röbel, P., Baulieu, E. E., & Goascogne, C. L. (1993) · The Journal of Cell Biology · doi:10.1083/jcb.121.1.135 · Cited by 164 · see citing works
Compagnone, N. A., Bulfone, A., Rubenstein, J. L., & Mellon, S. H. (1995) · Endocrinology · doi:10.1210/endo.136.6.7750493 · Cited by 156 · see citing works
Avian neurosteroids. I. Pregnenolone biosynthesis in the quail brain
Tsutsui, K., & Yamazaki, T. (1995) · Brain Research · doi:10.1016/0006-8993(95)00116-8 · Cited by 152 · see citing works
Self-citationSteroids and their conjugates in the mammalian brain.
Mathur, C., Prasad, V. V., Raju, V. S., Welch, M., & Lieberman, S. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.1.85 · Cited by 143 · see citing works
Lacroix, C., Fiet, J., Benais, J.-P., GUEUX, B., Boneté, R., Villette, J., Gourmel, B., & DREUX, C. (1987) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(87)91025-9 · Cited by 133 · see citing works
Mensah‐Nyagan, A. G., Feuilloley, M. G. J., Dupont, É., Do‐Régo, J., Leboulenger, F., Pelletier, G., & Vaudry, H. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-12-07306.1994 · Cited by 132 · see citing works
Sanne, J., & Krueger, K. E. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.65020528.x · Cited by 132 · see citing works
Pregnenolone, dehydroepiandrosterone, and their sulfate and fatty acid esters in the rat brain
Jo, D.-H., Abdallah, M. A., Young, J., Baulieu, É.-É., & Röbel, P. (1989) · Steroids · doi:10.1016/0039-128x(89)90003-2 · Cited by 120 · see citing works
Vanson, A., Arnold, A. P., & Schlinger, B. A. (1996) · General and Comparative Endocrinology · doi:10.1006/gcen.1996.0077 · Cited by 119 · see citing works
Biosynthesis and assay of neurosteroids in rats and mice: Functional correlates
Röbel, P., Young, J., Corpechot, C., Mayo, W., Perché, F., Haug, M., Simon, H., & Baulieu, E. E. (1995) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(95)00074-a · Cited by 108 · see citing works
Avian neurosteroids. II. Localization of a cytochrome P450scc-like substance in the quail brain
Usui, M., Yamazaki, T., Kominami, S. A. J., & Tsutsui, K. (1995) · Brain Research · doi:10.1016/0006-8993(95)00117-9 · Cited by 107 · see citing works
Self-citationBrinton, R. D. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-05-02763.1994 · Cited by 106 · see citing works
Kōji, T., & Brenner, R. (1993) · Endocrinology · doi:10.1210/endo.132.1.8419136 · Cited by 99 · see citing works
A steroid recognition site is functionally coupled to an expressed GABAA-benzodiazepine receptor
Lan, N. C., Chen, J.-S., Belelli, D., Pritchett, D. B., Seeburg, P. H., & Gee, K. W. (1990) · European Journal of Pharmacology Molecular Pharmacology · doi:10.1016/0922-4106(90)90201-8 · Cited by 90 · see citing works
Progesterone as a neurosteroid: Actions within the nervous system
Baulieu, E. E., Schumacher, M., Koenig, H. L., Jung‐Testas, I., & Akwa, Y. (1996) · Cellular and Molecular Neurobiology · doi:10.1007/bf02088173 · Cited by 88 · see citing works
Neuro-steroids: 3β-hydroxy-Δ5-derivatives in the rodent brain
Röbel, P., & Baulieu, E. E. (1985) · Neurochemistry International · doi:10.1016/0197-0186(85)90143-3 · Cited by 88 · see citing works
Simard, J., Couët, J., Durocher, F., Labrie, Y., Sánchez, R., Breton, N., Turgeon, C., & Labrie, F. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)36567-6 · Cited by 87 · see citing works
The 3β-hydroxysteroid dehydrogenase gene family of enzymes
Mason, J. I. (1993) · Trends in Endocrinology and Metabolism · doi:10.1016/1043-2760(93)90117-w · Cited by 85 · see citing works
Pregnenolone metabolism in rodent embryonic neurons and astrocytes
Kabbadj, K., El‐Etr, M., Baulieu, É.-É., & Röbel, P. (1993) · Glia · doi:10.1002/glia.440070206 · Cited by 85 · see citing works
Zhao, H., Rhgaurae, E., Trudel, C., Couët, J., Labrie, F., & Simard, J. (1990) · Endocrinology · doi:10.1210/endo-127-6-3237 · Cited by 82 · see citing works
In vitro conversion of pregnenolone to progesterone by discrete brain areas of the male rat
Weidenfeld, J., Siegel, R. A., & Chowers, I. (1980) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(80)90171-5 · Cited by 68 · see citing works
Localization of 3β-Hydroxysteroid Dehydrogenase in Rat Brain as Studied by in Situ Hybridization
Dupont, E., Simard, J., Luu-The, V., Labrie, F., & Pelletier, G. (1994) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.1994.1014 · Cited by 63 · see citing works
Koji, T., & Nakane, P. K. (1996) · Journal of Electron Microscopy · doi:10.1093/oxfordjournals.jmicro.a023420 · Cited by 62 · see citing works
Iwahashi, K., Ozaki Hiroki, S., Tsubaki, M., Ohnishi, J.-I., Takeuchi, Y., & Ichikawa, Y. (1990) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(90)90114-c · Cited by 45 · see citing works
Neuro-Steroids: 3β-Hydroxy-Δ5-Derivatives in the Rat Brain
Röbel, P., Corpechot, C., Clarke, C. L., Groyer, A., Synguélakis, M., Vourc’h, C., & Baulieu, E. E. (1986) · Springer eBooks · doi:10.1007/978-1-4684-5131-3_31 · Cited by 33 · see citing works
Tsutsui, K. (1991) · Endocrinology · doi:10.1210/endo-128-1-477 · Cited by 29 · see citing works
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The Molecular Biology, Biochemistry, and Physiology of Human Steroidogenesis and Its Disorders
Miller, W. L., & Auchus, R. J. (2011) · Endocrine Reviews · doi:10.1210/er.2010-0013 · Cited by 2,458 · see citing works
Multiple Actions of Steroid Hormones—A Focus on Rapid, Nongenomic Effects
Falkenstein, E., Tillmann, H.-C., Christ, M., Feuring, M., & Wehling, M. (2000) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01468-6 · Cited by 986 · see citing works
Neurosteroids: biosynthesis and function of these novel neuromodulators
Compagnone, N. A., & Mellon, S. H. (2000) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1999.0188 · Cited by 820 · see citing works
do Rego, J. L., Seong, J. Y., Burel, D., Leprince, J., Luu-The, V., Tsutsui, K., Tonon, M., Pelletier, G., & Vaudry, H. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.05.006 · Cited by 356 · see citing works
Self-citationSchumacher, M., Mattern, C., Ghoumari, A. M., Oudinet, J., Lière, P., Labombarda, F., Sitruk-Ware, R. L., Nicola, A. F. D., & Guennoun, R. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.09.004 · Cited by 353 · see citing works
Melatonin induces the expression of gonadotropin-inhibitory hormone in the avian brain
Ubuka, T., Bentley, G. E., Ukena, K., Wingfield, J. C., & Tsutsui, K. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403840102 · Cited by 325 · see citing works
Self-citationGhoumari, A. M., Ibanez, C., El‐Etr, M., Leclerc, P., Eychenne, B., O’Malley, B. W., Baulieu, E. E., & Schumacher, M. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01881.x · Cited by 291 · see citing works
Nakagawa, A., 佐竹, 英., Nakabayashi, H., Nishizawa, M., Furuya, K., Nakano, S., Kigoshi, T., Nakayama, K., & Uchida, K. (2004) · Autonomic Neuroscience · doi:10.1016/j.autneu.2003.11.001 · Cited by 290 · see citing works
Kimoto, T., Tsurugizawa, T., Ohta, Y., Makino, J., Tamura, H.-O., Hojo, Y., Takata, N., & Kawato, S. (2001) · Endocrinology · doi:10.1210/endo.142.8.8327 · Cited by 256 · see citing works
Novel brain function: biosynthesis and actions of neurosteroids in neurons
Tsutsui, K., Ukena, K., Usui, M., Sakamoto, H., & Takase, M. (2000) · Neuroscience Research · doi:10.1016/s0168-0102(99)00132-7 · Cited by 231 · see citing works
Self-citationSchumacher, M., Guennoun, R., Robert, F., Carelli, C., Gago, N., Ghoumari, A. M., Deniselle, M. C. G., González, S. L., Ibanez, C., Labombarda, F., et al. (2004) · Growth Hormone & IGF Research · doi:10.1016/j.ghir.2004.03.007 · Cited by 230 · see citing works
Guennoun, R., Labombarda, F., Deniselle, M. C. G., Lière, P., Nicola, A. F. D., & Schumacher, M. (2014) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2014.09.001 · Cited by 223 · see citing works
Osugi, T., Ukena, K., Bentley, G., O’Brien, S., Moore, I. T., Wingfield, J. C., & Tsutsui, K. (2004) · Journal of Endocrinology · doi:10.1677/joe.0.1820033 · Cited by 222 · see citing works
Self-citationProgesterone Synthesis in the Nervous System: Implications for Myelination and Myelin Repair
Schumacher, M., Hussain, R., Gago, N., Oudinet, J., Mattern, C., & Ghoumari, A. M. (2012) · Frontiers in Neuroscience · doi:10.3389/fnins.2012.00010 · Cited by 221 · see citing works
Biosynthesis of neurosteroids and regulation of their sysnthesis
Mellon, S. H., & Vaudry, H. (2001) · International review of neurobiology · doi:10.1016/s0074-7742(01)46058-2 · Cited by 211 · see citing works
Neurosteroid regulation of central nervous system development
Mellon, S. H. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.04.011 · Cited by 209 · see citing works
King, S. R., Manna, P. R., Ishii, T., Syapin, P. J., Ginsberg, S. D., Wilson, K. L., Walsh, L. P., Parker, K. L., Stocco, D. M., Smith, R. G., et al. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-24-10613.2002 · Cited by 209 · see citing works
Sakamoto, H., Ukena, K., & Tsutsui, K. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-16-06221.2001 · Cited by 193 · see citing works
Self-citationDistribution of a novel avian gonadotropin-inhibitory hormone in the quail brain
Ukena, K., Ubuka, T., & Tsutsui, K. (2003) · Cell and Tissue Research · doi:10.1007/s00441-003-0700-x · Cited by 189 · see citing works
Self-citationDendritic Growth and Spine Formation in Response to Estrogen in the Developing Purkinje Cell
Sakamoto, H., Mezaki, Y., Shikimi, H., Ukena, K., & Tsutsui, K. (2003) · Endocrinology · doi:10.1210/en.2003-0307 · Cited by 170 · see citing works
Self-citationProgesterone increases oligodendroglial cell proliferation in rat cerebellar slice cultures
Ghoumari, A. M., Baulieu, E. E., & Schumacher, M. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.05.023 · Cited by 161 · see citing works
Novel fish hypothalamic neuropeptide
Sawada, K., Ukena, K., Satake, H., Iwakoshi, E., Minakata, H., & Tsutsui, K. (2002) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2002.03351.x · Cited by 141 · see citing works
Self-citationShibuya, K., Takata, N., Hojo, Y., Furukawa, A., Yasumatsu, N., Kimoto, T., Enami, T., Suzuki, K., Tanabe, N., Ishii, H., et al. (2003) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(02)00489-0 · Cited by 140 · see citing works
Extra‐adrenal production of corticosteroids
Davies, E., & MacKenzie, S. M. (2003) · Clinical and Experimental Pharmacology and Physiology · doi:10.1046/j.1440-1681.2003.03867.x · Cited by 131 · see citing works
Sasahara, K., Shikimi, H., Haraguchi, S., Sakamoto, H., Honda, S.-I., Harada, N., & Tsutsui, K. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0710-07.2007 · Cited by 127 · see citing works
Self-citationProgesterone and the oligodendroglial lineage: Stage‐dependent biosynthesis and metabolism
Gago, N., Akwa, Y., Sananès, N., Guennoun, R., Baulieu, E. E., El‐Etr, M., & Schumacher, M. (2001) · Glia · doi:10.1002/glia.1117 · Cited by 127 · see citing works
Distribution of progesterone receptor immunoreactivity in the fetal and neonatal rat forebrain
Quadros, P. S., Pfau, J. L., & Wagner, C. K. (2007) · Journal of Comparative Neurology · doi:10.1002/cne.21427 · Cited by 112 · see citing works
Takase, M., Ukena, K., Yamazaki, T., Kominami, S. A. J., & Tsutsui, K. (1999) · Endocrinology · doi:10.1210/endo.140.4.6641 · Cited by 111 · see citing works
Self-citationIwakoshi‐Ukena, E., Ukena, K., Takuwa‐Kuroda, K., Kanda, A., Tsutsui, K., & Minakata, H. (2004) · The Journal of Comparative Neurology · doi:10.1002/cne.20260 · Cited by 110 · see citing works
Self-citationNeurosteroid biosynthesis in vertebrate brains
Tsutsui, K., Ukena, K., Takase, M., Kohchi, C., & Lea, R. W. (1999) · Comparative Biochemistry and Physiology Part C Pharmacology Toxicology and Endocrinology · doi:10.1016/s0742-8413(99)00065-1 · Cited by 108 · see citing works
Self-citationThe many faces of progesterone: A role in adult and developing male brain
Wagner, C. K. (2006) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2006.07.003 · Cited by 105 · see citing works
Progesterone Actions During Central Nervous System Development
González-Orozco, J. C., & Camacho‐Arroyo, I. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00503 · Cited by 104 · see citing works
Steroids, sex and the cerebellar cortex: implications for human disease
Dean, S. L., & McCarthy, M. M. (2008) · The Cerebellum · doi:10.1007/s12311-008-0003-6 · Cited by 99 · see citing works
Osugi, T., Ukena, K., Sower, S. A., Kawauchi, H., & Tsutsui, K. (2006) · FEBS Journal · doi:10.1111/j.1742-4658.2006.05187.x · Cited by 95 · see citing works
Self-citationSteroidogenic Enzymes in the Brain: Morphological Aspects
Pelletier, G. (2010) · Progress in brain research · doi:10.1016/s0079-6123(08)81011-4 · Cited by 94 · see citing works
Progesterone Oxidation by Cytochrome P450 2D Isoforms in the Brain
Hiroi, T., Kishimoto, W., Chow, T., Imaoka, S., Igarashi, T., & Funae, Y. (2001) · Endocrinology · doi:10.1210/endo.142.9.8363 · Cited by 94 · see citing works
Sakamoto, H., Ukena, K., & Tsutsui, K. (2001) · The Journal of Comparative Neurology · doi:10.1002/cne.1351 · Cited by 92 · see citing works
Self-citationMatsunaga, M., Ukena, K., Baulieu, É.-É., & Tsutsui, K. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407176101 · Cited by 91 · see citing works
Self-citationSakamoto, H., Ukena, K., & Tsutsui, K. (2002) · Neuroscience Letters · doi:10.1016/s0304-3940(02)00077-0 · Cited by 85 · see citing works
Self-citationSakamoto, H., Ukena, K., Takemori, H., Okamoto, M., Kawata, M., & Tsutsui, K. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.04.003 · Cited by 80 · see citing works
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Tsutsui, K. (2008) · Molecular Neurobiology · doi:10.1007/s12035-008-8024-1 · Cited by 79 · see citing works
Self-citationHaraguchi, S., Sasahara, K., Shikimi, H., Honda, S.-I., Harada, N., & Tsutsui, K. (2011) · The Cerebellum · doi:10.1007/s12311-011-0342-6 · Cited by 78 · see citing works
Self-citationHaraguchi, S., Koyama, T., Hasunuma, I., Vaudry, H., & Tsutsui, K. (2010) · Endocrinology · doi:10.1210/en.2009-1229 · Cited by 77 · see citing works
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Matsunaga, M., Ukena, K., & Tsutsui, K. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02217-x · Cited by 76 · see citing works
Self-citationLloyd‐Evans, E., & Waller‐Evans, H. (2020) · Essays in Biochemistry · doi:10.1042/ebc20200043 · Cited by 71 · see citing works
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Guerra‐Araiza, C., Reyna‐Neyra, A., Salazar, A. M., Cerbón, M. A., Morimoto, S., & Camacho‐Arroyo, I. (2001) · Brain Research Bulletin · doi:10.1016/s0361-9230(00)00410-x · Cited by 71 · see citing works
Sawada, K., Ukena, K., Kikuyama, S., & Tsutsui, K. (2002) · Journal of Endocrinology · doi:10.1677/joe.0.1740395 · Cited by 66 · see citing works
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Cascio, C., Russo, D., Drago, G., Galizzi, G., Passantino, R., Guarneri, R., & Guarneri, P. (2007) · Experimental Eye Research · doi:10.1016/j.exer.2007.02.008 · Cited by 64 · see citing works
Lea, R. W., Clark, J. A., & Tsutsui, K. (2001) · Microscopy Research and Technique · doi:10.1002/jemt.1152 · Cited by 63 · see citing works
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Self-citationInai, Y., Nagai, K., Ukena, K., Oishi, T., & Tsutsui, K. (2002) · Brain Research · doi:10.1016/s0006-8993(02)03745-9 · Cited by 60 · see citing works
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Frye, C. A. (2008) · International review of neurobiology · doi:10.1016/s0074-7742(08)00003-2 · Cited by 57 · see citing works
Ibanez, C., Guennoun, R., Liere, P., Eychenne, B., Pianos, A., El-Etr, M., Baulieu, E.-E., & Schumacher, M. (2003) · Endocrinology · doi:10.1210/en.2002-0073 · Cited by 56 · see citing works
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Self-citationDean, S. L., Wright, C. L., Hoffman, J. F., Wang, M., Alger, B. E., & McCarthy, M. M. (2012) · Endocrinology · doi:10.1210/en.2012-1350 · Cited by 51 · see citing works
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Self-citationOsugi, T., Uchida, K., Nozaki, M., & Tsutsui, K. (2011) · Endocrinology · doi:10.1210/en.2011-1375 · Cited by 49 · see citing works
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Self-citationdo Rego, J. L., Tremblay, Y., Luu‐The, V., Repetto, E., Castel, H., Vallarino, M., Bélanger, A., Pelletier, G., & Vaudry, H. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04209.x · Cited by 49 · see citing works
Tomy, S., Wu, G.-C., Huang, H., Dufour, S., & Chang, C. (2007) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2007.01572.x · Cited by 49 · see citing works
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Self-citationGiatti, S., Diviccaro, S., García‐Segura, L. M., & Melcangi, R. C. (2019) · Journal of Neuroendocrinology · doi:10.1111/jne.12736 · Cited by 43 · see citing works
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Shikimi, H., Sakamoto, H., Mezaki, Y., Ukena, K., & Tsutsui, K. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.04.023 · Cited by 43 · see citing works
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Keller, E. A., Zamparini, A. L., Borodinsky, L. N., Gravielle, M. C., & Fiszman, M. L. (2004) · Developmental Brain Research · doi:10.1016/j.devbrainres.2004.07.009 · Cited by 43 · see citing works
Bruzzone, F., do Rego, J. L., Luu-The, V., Pelletier, G., Vallarino, M., & Vaudry, H. (2009) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2009.08.001 · Cited by 43 · see citing works
Chowdhury, V. S., Ubuka, T., Osugi, T., Shimura, T., & Tsutsui, K. (2011) · Journal of Endocrinology · doi:10.1530/joe-10-0494 · Cited by 42 · see citing works
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Caldeira, J. C., Wu, Y., Mameli, M., Purdy, R. H., Li, P., Akwa, Y., Savage, D. D., Engen, J. R., & Valenzuela, C. F. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02686.x · Cited by 42 · see citing works
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Tsutsui, K., Sakamoto, H., & Ukena, K. (2003) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(03)00229-2 · Cited by 41 · see citing works
Self-citationSakurai, N., Maruo, K., Haraguchi, S., Uno, Y., Oshima, Y., Tsutsui, K., Matsuda, Y., do Rego, J. L., Pelletier, G., Vaudry, H., et al. (2008) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2008.07.002 · Cited by 41 · see citing works
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Self-citationGuerra‐Araiza, C., Amorim, M. A. R., Camacho‐Arroyo, I., & García‐Segura, L. M. (2007) · Developmental Neurobiology · doi:10.1002/dneu.20383 · Cited by 40 · see citing works
Tsutsui, K. (2006) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2006.09.015 · Cited by 38 · see citing works
Self-citationQuadros, P. S., Schlueter, L. J., & Wagner, C. K. (2008) · Developmental Neurobiology · doi:10.1002/dneu.20664 · Cited by 36 · see citing works
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Ukena, K., Shikano, K., Kondo, K., Taniuchi, S., Furumitsu, M., Ochi, Y., Sasaki, T., Okamoto, S., Bentley, G. E., Kriegsfeld, L. J., et al. (2017) · eLife · doi:10.7554/elife.28527 · Cited by 35 · see citing works
Self-citationPowrie, Y. S. L., & Smith, C. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1324-0 · Cited by 35 · see citing works
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Theis, V., & Theiß, C. (2019) · The Anatomical Record · doi:10.1002/ar.24121 · Cited by 32 · see citing works
Perez‐Pouchoulen, M., Toledo‐Cárdenas, M. R., García, L. I., Pérez-Estudillo, C. A., Coria‐Ávila, G. A., Hernández‐Aguilar, M. E., Carrillo, P., & Manzo, J. G. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.01.027 · Cited by 30 · see citing works
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Wessel, L., Balakrishnan-Renuka, A., Henkel, C., Meyer, H. E., Meller, K., Brand‐Saberi, B., & Theiß, C. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1448-4 · Cited by 29 · see citing works
The fetal brain: role of progesterone and allopregnanolone
Pluchino, N., Russo, M., & Genazzani, A. R. (2016) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2016-0020 · Cited by 28 · see citing works
Sakamoto, H., Ukena, K., Kawata, M., & Tsutsui, K. (2008) · The Cerebellum · doi:10.1007/s12311-008-0007-2 · Cited by 28 · see citing works
Self-citationLétourneau, D., Bédard, M., Cabana, J., Lefèbvre, A., Lehoux, J., & Lavigne, P. (2016) · Scientific Reports · doi:10.1038/srep28486 · Cited by 28 · see citing works
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Schumacher, M., Zhu, X., & Guennoun, R. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803592-4.00054-7 · Cited by 28 · see citing works
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Higo, S., Hojo, Y., Ishii, H., Kominami, T., Nakajima, K., Poirier, D., Kimoto, T., & Kawato, S. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.05.005 · Cited by 26 · see citing works
Strain differences of neurosteroid levels in mouse brain
Tagawa, N., Sugimoto, Y., Yamada, J., & Kobayashi, Y. (2006) · Steroids · doi:10.1016/j.steroids.2006.05.008 · Cited by 26 · see citing works
Localization of 5α-reductase in the rat main olfactory bulb
Kiyokage, E., Toida, K., Suzuki-Yamamoto, T., & Ishimura, K. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20760 · Cited by 26 · see citing works
Steroid Biosynthesis within the Frog Brain
do Rego, J. L., Seong, J. Y., Burel, D., Luu‐The, V., Larhammar, D., Tsutsui, K., Pelletier, G., Tonon, M., & Vaudry, H. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2008.03664.x · Cited by 22 · see citing works
Self-citation11beta-hydroxylase and aldosterone synthase expression in fetal rat hippocampal neurons
MacKenzie, S. M., Lai, M., CLARK, C. J., Fräser, R., Gómez-Sánchez, C. E., Seckl, J. R., Connell, J. M. C., & Davies, E. (2002) · Journal of Molecular Endocrinology · doi:10.1677/jme.0.0290319 · Cited by 21 · see citing works
Neurosteroid Biosynthesis in the Brain of Amphibians
Vaudry, H., do Rego, J. L., Burel, D., Luu-The, V., Pelletier, G., Vaudry, D., & Tsutsui, K. (2011) · Frontiers in Endocrinology · doi:10.3389/fendo.2011.00079 · Cited by 20 · see citing works
Self-citationMishra, S., & Chaube, R. (2016) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2016.04.031 · Cited by 20 · see citing works
Neuropeptidergic control of neurosteroids biosynthesis
Ubuka, T., & Tsutsui, K. (2022) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2021.100976 · Cited by 19 · see citing works
Self-citationExpression and localization of cytochrome P450 mRNA in the frog brain
Takase, M., Ukena, K., & Tsutsui, K. (2002) · Brain Research · doi:10.1016/s0006-8993(02)03054-8 · Cited by 19 · see citing works
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Isomura, T., Haraguchi, S., Miyamoto, K., Tsutsui, K., Nakamura, Y. T., & Nakamura, M. (2010) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2010.10.015 · Cited by 18 · see citing works
Self-citationKoyama, T., Haraguchi, S., Vaudry, H., & Tsutsui, K. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2008.03622.x · Cited by 18 · see citing works
Self-citationWessel, L., Olbrich, L., Brand‐Saberi, B., & Theiß, C. (2014) · Journal of Histochemistry & Cytochemistry · doi:10.1369/0022155414550691 · Cited by 17 · see citing works
- Authors
- Ukena, K., Kohchi, C., & Tsutsui, K.
- Affiliations
- Hiroshima University (JP)
- Corresponding author
- Tsutsui, Kazuyoshi
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 1999-02-01
- Volume
- 140
- Issue
- 2
- Pages
- 805-813
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2046524470
- Semantic Scholar
- 3e1088688415429d5478a3e54657be8a7c93ab31
- Cited by
- 141
- References
- 61
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 1 · 2022: 3 · 2021: 5 · 2020: 3 · 2019: 6 · 2018: 2 · 2017: 3 · 2016: 8 · 2015: 1 · 2014: 6 · 2013: 3 · 2012: 4
- FWCI
- 2.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Central Lancashire
- Japan Society for the Promotion of Science
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Steroid Chemistry and Biochemistry
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Keywords
- 3β-hydroxysteroid dehydrogenase/Δ5-Δ4 isomerase, Purkinje cells, neonatal development, progesterone biosynthesis, pregnenolone, trilostane, mRNA expression
- MeSH terms
- Aging, Animals, Animals, Newborn, Cerebellum, Male, Progesterone, Purkinje Cells, Radioimmunoassay, Rats, Inbred F344, RNA, Messenger, 17-Hydroxysteroid Dehydrogenases, In Situ Hybridization, Rats
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