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Cited by 265

The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.

Osteoblast-Derived Cells Express Functional Glucose-Dependent Insulinotropic Peptide Receptors1

Bollag, R. J., Zhong, Q., Phillips, P., Min, L., Zhong, L., Cameron, R., Mulloy, A. L., Rasmussen, H., Qin, F., Ding, K. H., Isales, C. M.·2000·Endocrinology
DOI 10.1210/endo.141.3.7366
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Abstract

Glucose-dependent insulinotropic peptide (GIP) is a 42-amino acid peptide synthesized and secreted from endocrine cells in the small intestine. The role of GIP in coupling nutrient intake and insulin secretion, the incretin effect, is well known. We report that GIP receptor messenger RNA and protein are present in normal bone and osteoblast-like cell lines, and that high affinity receptors for GIP can be demonstrated by [125I]GIP binding studies. When applied to osteoblast-like cells (SaOS2), GIP stimulated increases in cellular cAMP content and intracellular calcium, with both responses being dose dependent. Moreover, administration of GIP results in elevated expression of collagen type I messenger RNA as well as an increase in alkaline phosphatase activity. Both of these effects reflect anabolic actions of presumptive osteoblasts. These results provide the first evidence that GIP receptors are present in bone and osteoblast-like cells and that GIP modulates the function of these cells.

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Metadata

Authors
Bollag, R. J., Zhong, Q., Phillips, P., Min, L., Zhong, L., Cameron, R., Mulloy, A. L., Rasmussen, H., Qin, F., Ding, K. H., & Isales, C. M.
Venue
Endocrinology
Publisher
The Endocrine Society
Published
2000-03
Volume
141
Issue
3
Pages
1228-1235
ISSN
  • 0013-7227 (ISSN-L)
  • 1945-7170
DOI
10.1210/endo.141.3.7366
OpenAlex
W2149137804
Cited by
265
References
27
FWCI
1.35
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Osteoblast-Derived Cells Express Functional Glucose-Dependent Insulinotropic Peptide Receptors1. https://app.cochat.ai/papers/10.1210/endo.141.3.7366
The paper
Bollag, R. J., Zhong, Q., Phillips, P., Min, L., Zhong, L., Cameron, R., Mulloy, A. L., Rasmussen, H., Qin, F., Ding, K. H., & Isales, C. M. (2000). Osteoblast-Derived Cells Express Functional Glucose-Dependent Insulinotropic Peptide Receptors1. Endocrinology. https://doi.org/10.1210/endo.141.3.7366

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.