Cited by 85Nuclear Receptors and SignalingAdrenal Hormones and DisordersEstrogen and related hormone effects

Nuclear Receptors Nor1 and NGFI-B/Nur77 Play Similar, Albeit Distinct, Roles in the Hypothalamo-Pituitary-Adrenal Axis1

Fernandez, Pablo M., Brunel, Franck, Jimenez, María Arroyo, Saez, José M., Cereghini, Silvia, Zakin, Mario M.·2000·Endocrinology

Abstract

Studies in Nur77-deficient mice have shown that the basal regulation of hypothalamic and pituitary functions as well as the adrenocortical steroidogenesis in these animals is normal. This indicates that Nur77-related orphan receptors may substitute Nur77 functions in the hypothalamo-pituitary-adrenal axis by a compensatory mechanism. Nor1 is the most recently cloned member of the NGFI-B/Nur77 subfamily, and its properties are still largely unknown. We demonstrate here that Nor1 is expressed in the pituitary gland and adrenal cortex, and that ACTH and angiotensin II (AngII) treatment of adrenal fasciculata cells induces Nor1 expression. Time-course analysis with both hormones on steroidogenic capacity and the specific gene expression in adrenal cells strongly suggest that Nor1 is an intermediate in the long-term consequences of ACTH or AngII treatment. The Nor1 and NGFI-B/Nur77 amino acid sequence homology and the analysis of the trans-activation properties of Nor1 show that the overall structural and functional organization of the two proteins is similar. As observed with NGFI-B/Nur77, Nor1 activates the expression of genes encoding steroidogenic enzymes as P450c21, through its interaction with NGFI-B response element promoter sequences. In contrast, binding experiments of Nor1 with the palindromic NurRE sequence suggest that Nor1 is not an efficient substitute for the NGFI-B/Nur77 activation of the POMC gene expression in pituitary glands. All these results indicate that Nor1 and NGFI-B/Nur77 may play similar albeit distinct roles in the hypothalamo-pituitary-adrenal axis. Further experiments also show that the mechanisms responsible for the transcriptional regulation of Nor1 in adrenal cells appear to depend on the protein kinase A and protein kinase C cascades.

Integrity signals

Registry

Crossref · 10.1210/endo.141.7.7562

Cites

38 of 38 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Additional relevant transcription factors include nerve growth factor induced-B and Nur-related factor 1, which may overlap in their functions.

    “Additional relevant transcription factors include nerve growth factor induced-B (NGFI-B, Nur77, NR4A1)(169,184), and Nur-related factor 1 (NURR1) (NR4A2); they may overlap in their functions (185).”

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Fernandez, P. M., Brunel, F., Jimenez, M. A., Saez, J. M., Cereghini, S., & Zakin, M. M.
Affiliations
  • Institut Pasteur (FR)
  • Inserm (FR)
  • Hôpital Necker-Enfants Malades (FR)
Corresponding author
Zakin, Mario M.
Venue
Endocrinology
Published
2000-07
Volume
141
Issue
7
Pages
2392-2400
ISSN
  • 0013-7227 (ISSN-L)
  • 1945-7170
OpenAlex
W2069436500
Cited by
85
References
38
Citations by year
2026: 1 · 2025: 2 · 2024: 3 · 2023: 1 · 2022: 1 · 2021: 4 · 2020: 5 · 2019: 2 · 2018: 1 · 2016: 2 · 2015: 1 · 2014: 5 · 2013: 4 · 2012: 2
FWCI
2.21
Type
journal article
Language
en
Open access
closed
Locations
  • Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Keywords
NOR-1, nuclear receptors, hypothalamic-pituitary-adrenal axis, ACTH, angiotensin II, adrenal fasciculata cells, steroidogenesis, P450c21, proopiomelanocortin, transcriptional activation, protein kinase A, protein kinase C
MeSH terms
Adrenal Cortex, Adrenal Glands, Adrenocorticotropic Hormone, Angiotensin II, Animals, Cell Nucleus, Cytochrome P-450 Enzyme System, DNA-Binding Proteins, Hypothalamo-Hypophyseal System, Nerve Tissue Proteins, Nuclear Proteins, Pituitary Gland, Pituitary-Adrenal System, Pro-Opiomelanocortin, Promoter Regions, Genetic, Receptors, Steroid, Receptors, Thyroid Hormone, RNA, Messenger, Steroid 21-Hydroxylase, Transcription Factors, Second Messenger Systems, Transcriptional Activation, Gene Expression, Genes, Reporter, Receptors, Cytoplasmic and Nuclear, COS Cells, Nuclear Receptor Subfamily 4, Group A, Member 1

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review