Peripheral Administration of an Angiotensin II AT1 Receptor Antagonist Decreases the Hypothalamic-Pituitary-Adrenal Response to Isolation Stress

Angiotensin II receptors and angiotensin II receptor antagonists.

Timmermans, P. B. M. W. M., Wong, P. C., Chiu, A. T., Herblin, W. F., Benfield, P. A., Carini, D. J., Lee, R. J., Wexler, R. R., Saye, J. A., & Smith, R. D. (1993) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)00446-6 · Cited by 1,854

Isolation of a cDNA encoding the vascular type-1 angiotensin II receptor

Murphy, T. J., Alexander, R. W., Griendling, K. K., Runge, M. S., & Bernstein, K. E. (1991) · Nature · doi:10.1038/351233a0 · Cited by 1,250

Expression cloning of type 2 angiotensin II receptor reveals a unique class of seven-transmembrane receptors.

Mukoyama, M., Nakajima, M., Horiuchi, M., Sasamura, H., Pratt, R. E., & Dzau, V. J. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)74498-6 · Cited by 768

Vasopressinergic control of pituitary adrenocorticotropin secretion comes of age

Antoni, F. A. (1993) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1993.1004 · Cited by 636

Complete coding sequence of rat tyrosine hydroxylase mRNA.

Grima, B., Lamouroux, A., Blanot, F., Biguet, N. F., & Mallet, J. J. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.2.617 · Cited by 534

Brain and Pituitary Angiotensin

Saavedra, J. M. (1992) · Endocrine Reviews · doi:10.1210/edrv-13-2-329 · Cited by 460

Characterization and development of angiotensin II receptor subtypes (AT1 and AT2) in rat brain

Tsutsumi, K., & Saavedra, J. M. (1991) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1991.261.1.r209 · Cited by 336

Angiotensin II type-1 receptor subtype cDNAs: Differential tissue expression and hormonal regulation

Kakar, S. S., Sellers, J. C., Devor, D. C., Musgrove, L. C., & Neill, J. D. (1992) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(05)80302-x · Cited by 326

Functional studies of nonpeptide angiotensin II receptor subtype-specific ligands: DuP 753 (AII-1) and PD123177 (AII-2).

Wong, P. C., Hart, S. D., Zaspel, A. M., Chiu, A. T., Ardecky, R., Smith, R. D., & Timmermans, P. B. M. W. M. (1990) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)23123-8 · Cited by 295

Angiotensin II in central nervous system physiology

Phillips, M. I., & Sumners, C. (1998) · Regulatory Peptides · doi:10.1016/s0167-0115(98)00122-0 · Cited by 245

Investigations in foot shock stress of variable intensity in mice: Adaptation and role of angiotensin II

Bali, A., & Jaggi, A. S. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.04.037 · Cited by 10

Is there an association between anxiety symptoms and valsartan treatment?

Shad, M. U. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.10.004 · Cited by 10

Chapter 4.1 Peptide receptor ligands to treat anxiety disorders

Steckler, T. (2008) · Handbook of behavioral neuroscience · doi:10.1016/s1569-7339(07)00010-0 · Cited by 10

Role of angiotensin II and corticotropin-releasing hormone in hemodynamic responses to cocaine and stress

Knuepfer, M. M., Rowe, K. D., Schwartz, J. A., & Lomax, L. L. (2005) · Regulatory Peptides · doi:10.1016/j.regpep.2004.12.010 · Cited by 9

Angiotensin II type 1 receptors may not influence response of spinal autonomic neurons to axonal damage

Tang, H., Pavel, J., Saavedra, J. M., & Brimijoin, S. (2008) · Neurological Research · doi:10.1179/174313208x298020 · Cited by 9

Decreased Hypothalamic and Adrenal Angiotensin II Receptor Expression and Adrenomedullary Catecholamines in Transgenic Mice with Impaired Glucocorticoid Receptor Function

Jain, P., Armando, I., Juorio, A. V., Barden, N., Benický, J., & Saavedra, J. M. (2004) · Neuroendocrinology · doi:10.1159/000082358 · Cited by 9

The effect of telmisartan, an angiotensin receptor blocker, on alcohol consumption and alcohol-induced dopamine release in the nucleus accumbens

Tezcan, K., Yananlı, H. R., Demirkapu, M. J., Gören, M. Z., Sakallı, H. E., Colombo, G., & Aker, R. G. (2021) · Alcohol · doi:10.1016/j.alcohol.2021.08.004 · Cited by 8

Influence of up-regulated renin—angiotensin system on the exploration, anxiety-related behavior and object recognition

Kršková, L., Vrabcová, M., Talarovičová, A., & Zeman, M. (2009) · Acta Biologica Hungarica · doi:10.1556/abiol.60.2009.4.4 · Cited by 8

BEHAVIOURAL CHANGES INDUCED BY ANGIOTENSIN‐CONVERTING ENZYME INHIBITION DURING PREGNANCY AND LACTATION IN ADULT OFFSPRING RATS

Mecawi, A. S., Araujo, I., Fonseca, F. C. V. L., Almeida‐Pereira, G., Côrtes, W. D. S., Rocha, F., & Reis, L. C. (2009) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2008.05108.x · Cited by 8

The AT-1 Angiotensin Receptor is Involved in the Autonomic and Neuroendocrine Responses to Acute Restraint Stress in Male Rats

Brasil, T. F. S., Belém-Filho, I. J. A., Fortaleza, E. A. T., Antunes‐Rodrigues, J., & Corrêa, F. M. D. A. (2021) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-021-01090-7 · Cited by 7

Angiotensin II AT 1 receptors mediate neuronal sensitization and sustained blood pressure response induced by a single injection of amphetamine

Marchese, N. A., Paz, M. C., Caeiro, X. E., Dadam, F., Baiardi, G., Pérez, M. F., & Bregonzio, C. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.11.006 · Cited by 7

Adaptive remodeling of the stimulus-secretion coupling: Lessons from the ‘stressed’ adrenal medulla

Guérineau, N. C. (2023) · Vitamins and hormones · doi:10.1016/bs.vh.2023.05.004 · Cited by 5

Differential role of angiotensin neuropeptides in repeated exposure of immobilization stress of varying duration in mice

Bali, A., & Jaggi, A. S. (2015) · Life Sciences · doi:10.1016/j.lfs.2015.09.005 · Cited by 6

The brain renin–angiotensin system: a target for novel antidepressants and anxiolytics

Gard, P. R. (2005) · Drug Development Research · doi:10.1002/ddr.20028 · Cited by 6

Effect of AT1 Angiotensin II Receptor Antagonists on the Sympathetic Response to a Cold Pressor Test in Healthy Volunteers

Israel, A. L., Zavala, L. E., Cierco, M., Gutiérrez, A., & Garrido, M. D. R. (2007) · American Journal of Therapeutics · doi:10.1097/01.mjt.0000245235.88942.20 · Cited by 6

Is RAS the Link Between COVID-19 and Increased Stress in Head and Neck Cancer Patients?

Iftikhar, A., Islam, M. R., Shepherd, S. D., Jones, S., & Ellis, I. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.714999 · Cited by 5

Angiotensin II AT1 Receptor Antagonism Downregulates Stress‐Related Gene Expression in Brain Microvessels from Spontaneously Hypertensive and Normotensive Rats

Zhou, J., JEZOVA, M., ELKAHLOUN, A. G., & Saavedra, J. M. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1296.059 · Cited by 5

Effect of eprosartan on the sympathetic response to cold pressor test in healthy volunteers

Israel, A. L., Zavala, L. E., Cierco, M., Gutierrez, A., & Garrido, M. D. R. (2006) · Autonomic Neuroscience · doi:10.1016/j.autneu.2006.02.020 · Cited by 5

Effects of Losartan on Catecholamine Release in the Isolated Rat Adrenal Gland

Noh, H.-J., Kang, Y., & Lim, D. (2009) · Korean Journal of Physiology and Pharmacology · doi:10.4196/kjpp.2009.13.4.327 · Cited by 4

Effects of angiotensin (5-8) microinfusions into the ventrolateral periaqueductal gray on defensive behaviors in rats

Genaro, K., Juliano, M. A., Prado, W. A., Brandão, M. L., & Martins, A. R. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.09.023 · Cited by 4

Influence of Fimasartan (a Novel AT1Receptor Blocker) on Catecholamine Release in the Adrenal Medulla of Spontaneously Hypertensive Rats

Lim, H.-J., Lee, S.-K., & Lim, D. (2013) · Korean Journal of Physiology and Pharmacology · doi:10.4196/kjpp.2013.17.1.99 · Cited by 4

The influence of chromosome 4 on high ethanol consumption and blood pressure

Anjos, P. A. R., Marchette, R. C. N., Kremer, R., Granzotto, N., Alves, T. M., Fadanni, G. P., Mazur, F. G., Anton, E. L., da Silva‐Santos, J. E., Linder, A. E., et al. (2022) · Alcohol · doi:10.1016/j.alcohol.2022.04.004 · Cited by 4

A Bitter Experience That Enlightens the Future: COVID-19 Neurological Affection and Perspectives on the Orexigenic System

Abdelmissih, S. (2022) · Cureus · doi:10.7759/cureus.30788 · Cited by 4

[Angiotensin II AT1 receptor antagonists as antiinflammatory and gastric protection drugs].

Laudanno, O. M. O., & Cesolari, J. A. M. (2006) · PubMed · Cited by 3

Combinational Approaches Targeting Various Aspects Involved in Intestinal Barrier Dysfunction-Induced Anxiety

Kale, P. P., & Pallar, A. (2022) · Current Drug Targets · doi:10.2174/1389450123666220428093419 · Cited by 4

Post-traumatic stress disorder and cardiometabolic dysfunction: Molecular mechanisms and therapeutic targets

Song, J. (2026) · iScience · doi:10.1016/j.isci.2026.115447 · Cited by 3

Inhibitory Effects of Olmesartan on Catecholamine Secretion from the Perfused Rat Adrenal Medulla

Lim, H.-J., Kim, S.-Y., & Lim, D. (2010) · Korean Journal of Physiology and Pharmacology · doi:10.4196/kjpp.2010.14.4.241 · Cited by 2

Interaction between Nuclear Receptor and Alpha‐Adrenergic Agonist Subtypes in Metabolism and Systemic Hemodynamics of Spontaneously Hypertensive Rats

Afzal, S., Sattar, M. Z. A., Albokhadaim, I. F., Attiq, A., Kandeel, M. K., Manap, A. S. A., & Alhojaily, S. (2024) · PPAR Research · doi:10.1155/2024/5868010 · Cited by 1

The effect of acute angiotensin receptor blockade on subjective and biological markers of stress response

Shkreli, L., Morse, L., Scaife, J. C., Browning, M. D., Murphy, S. E., Kirschbaum, C., & Reinecke, A. (2026) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2026.107944 · Cited by 1

Stress-Induced Atherosclerosis: Clinical Evidence and Possible Underlying Mechanism

Chung, I. M. (2005) · Korean Circulation Journal · doi:10.4070/kcj.2005.35.2.101 · Cited by 1

The role and mechanisms of angiotensin II in regulating the natriuretic peptide gene expression in response to cardiac overload

Suo, M. (2002) · Cited by 1

Brain Poster Session: Neuroprotection

(2009) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2009.156 · Cited by 1

Déjà vu: angiotensin and stress

Antoni, F. A., & Kenyon, C. J. (2003) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(03)00109-7 · Cited by 1

Stress and Sympathoadrenomedullary Mechanisms

Nostramo, R., & Sabban, E. L. (2015) · doi:10.1002/9781118921692.ch5 · Cited by 1

Renin-angiotensin System: A New Promising Therapeutic and Mechanisms for Depression and AnxietyPreprint

Gong, S., & Deng, F. (2022) · doi:10.22541/au.166376718.84383561/v1 · Cited by 1

La angiotensina II y la respuesta neurohumoral frente al estrés

Israel, A. L., Sosa-Canache, B., & Medina, I. (2005) · Archivos Venezolanos de Farmacología y Terapéutica

Involvement of the Renin Angiotensin System in the Regulation of the Hypothalamic Pituitary Adrenal Axis

Aguilera, G. (2004) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-18497-0_6

Preclinical evidence for the efficacy of angiotensin receptor antagonism in a rodent model of vulnerability to comorbid depression and cardiovascular disease

Stedenfeld, K. A. (2011) · D-Scholarship@Pitt (University of Pittsburgh)

AngiotensinType1AReceptorsinC1NeuronsoftheRostral VentrolateralMedullaModulatethePressorResponseto AversiveStress

Bassi, J. K. (2012)

Role of the Neuropeptide Angiotensin II in Stress and Related Disorders

Bregonzio, C., Marinzalda, M. D. L. Á., & Baiardi, G. (2015) · Springer eBooks · doi:10.1007/978-3-319-17103-6_8

and onset of obesity

Roberge, C., Carpentier, A. C., Langlois, M., Baillargeon, J., Ardilouze, J., & Gallo‐Payet, N. (2007)

Papel de la NAD(P)H Oxidasa y el Anión Superóxido en la respuesta cardiovascular al estrés Role of NAD(P)H Oxidase and Superoxide in the cardiovascular response to stress

Medina, I., & Israel, E. (2009)

Chronic Swim Stress Attenuates Endocrine Response and Improves Cardiac Function in Mice Lacking the Angiotensin II Type 1a Receptor

Almahroug, N. K. (2013) · OhioLink ETD Center (Ohio Library and Information Network)

Histamine and the Kidney: In Vivo Animal Models

Pini, A., Veglia, E., & Rosa, A. C. (2017) · Methods in pharmacology and toxicology · doi:10.1007/978-1-4939-6843-5_11

Envolvimento da neurotransmissão angiotensinérgica do córtex pré-límbico na modulação de respostas autonômicas, hormonal e status oxidativo evocados pelo estresse de restrição em ratos

da Silva, T. F. B. (2017) · doi:10.11606/d.17.2017.tde-05012017-113115

[Heart involvement in patients with multiple myeloma based on echocardiographic data].

Бессмелъцев, С. С., & Abdulkadyrov, K. M. (1991) · PubMed

USO DE ANTI-HIPERTENSIVOS NA MODULAÇÃO DA ANSIEDADE EM MODELOS ANIMAIS

ALVES, L. B. D. S. (2021) · doi:10.17771/pucrio.acad.53170

The role of renin-angiotensin system modulation in the pathophysiology of neuropsychiatric disorders

Sharma, A., Goel, T., Mannan, A., Subramaniyan, V., & Singh, T. G. (2026) · Hormones and Behavior · doi:10.1016/j.yhbeh.2026.106003

0013-7227/01/$03.00/0 Endocrinology 142(9):3880–3889 Printed in U.S.A. Copyright © 2001 by The Endocrine Society Peripheral Administration of an Angiotensin II AT 1 Receptor Antagonist Decreases the Hypothalamic- Pituitary-Adrenal Response to Isolation St

Armando, I., Carranza, A., Nishimura, Y., Hoe, K.-L., Barontini, M., Terrón, J. A., Falcón‐Neri, A., Ito, T., Juorio, A. V., Juan, et al. (2013)

Candesartan decreases the sympatho-adrenal and hormonal response to isolation stress

Armando, I., Carranza, A., Nishimura, Y., Barontini, M., Ito, T., & Saavedra, J. M. (2001) · Journal of the Renin-Angiotensin-Aldosterone System · doi:10.1177/14703203010020012301 · Cited by 4

Angiotensin II AT1 receptor blockade prevents the hypothalamic corticotropin-releasing factor response to isolation stress

Armando, I., Volpi, S., Aguilera, G., & Saavedra, J. M. (2007) · Brain Research · doi:10.1016/j.brainres.2007.01.037 · Cited by 86

A Centrally Acting, Anxiolytic Angiotensin II AT1 Receptor Antagonist Prevents the Isolation Stress-Induced Decrease in Cortical CRF1 Receptor and Benzodiazepine Binding

Saavedra, J. M., Armando, I., Bregonzio, C., Juorio, A. V., Macova, M., Pavel, J., & Sánchez-Lemus, E. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300921 · Cited by 109

Anti-stress and anti-anxiety effects of centrally acting angiotensin II AT1 receptor antagonists

Saavedra, J. M., Ando, H., Armando, I., Baiardi, G., Bregonzio, C., Juorio, A. V., & Macova, M. (2005) · Regulatory Peptides · doi:10.1016/j.regpep.2004.12.015 · Cited by 119