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Cited by 148Renin-Angiotensin System StudiesStress Responses and CortisolNeuropeptides and Animal Physiology

The DOI matches its Crossref record; 49 of the 50 references it cites were found in a registry or an index.

Peripheral Administration of an Angiotensin II AT1 Receptor Antagonist Decreases the Hypothalamic-Pituitary-Adrenal Response to Isolation Stress

Armando, Ines, Carranza, Andrea, Nishimura, Yasuaki, Hoe, Kwang-Lae, Barontini, Marta, Terrón, José A., Falcón-Neri, Alicia, Ito, Takeshi, Juorio, Augusto V., Saavedra, Juan M.·2001·Endocrinology
DOI 10.1210/endo.142.9.8366
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Abstract

Angiotensin II, which stimulates AT(1) receptors, is a brain and peripheral stress hormone. We pretreated rats with the AT(1) receptor antagonist candesartan for 13 d via sc-implanted osmotic minipumps, followed by 24-h isolation in individual metabolic cages. We measured angiotensin II receptor-type binding and mRNAs and tyrosine hydroxylase mRNA by quantitative autoradiography and in situ hybridization, catecholamines by HPLC, and hormones by RIA. Isolation increased AT(1) receptor binding in hypothalamic paraventricular nucleus as well as anterior pituitary ACTH, and decreased posterior pituitary AVP. Isolation stress also increased AT(1) receptor binding and AT(1B) mRNA in zona glomerulosa and AT(2) binding in adrenal medulla, adrenal catecholamines, tyrosine hydroxylase mRNA, aldosterone, and corticosterone. Candesartan blocked AT(1) binding in paraventricular nucleus and adrenal gland; prevented the isolation-induced alterations in pituitary ACTH and AVP and in adrenal corticosterone, aldosterone, and catecholamines; abolished the increase in AT(2) binding in adrenal medulla; and substantially decreased urinary AVP, corticosterone, aldosterone, and catecholamines during isolation. Peripheral pretreatment with an AT(1) receptor antagonist blocks brain and peripheral AT(1) receptors and inhibits the hypothalamic-pituitary-adrenal response to stress, suggesting a physiological role for peripheral and brain AT(1) receptors during stress and a possible beneficial effect of AT(1) antagonism in stress-related disorders.

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Crossref · 10.1210/endo.142.9.8366

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Metadata

Authors
Armando, I., Carranza, A., Nishimura, Y., Hoe, K.-L., Barontini, M., Terrón, J. A., Falcón-Neri, A., Ito, T., Juorio, A. V., & Saavedra, J. M.
Affiliations
  • Centro de Investigaciones Endocrinologicas, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Buenos Aires (I.A., A.C., M.B.), Buenos Aires 1013, Argentina
  • Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
  • National Institutes of Health (US)
  • Section on Pharmacology, National Institute of Mental Health, National Institutes of Health (I.A., Y.N., K.-L.H., J.A.T., A.F.-N., T.I., A.V.J., J.M.S.), Bethesda, Maryland 20814
ORCID
Venue
Endocrinology
Publisher
The Endocrine Society
Published
2001-09-01
Volume
142
Issue
9
Pages
3880-3889
ISSN
  • 0013-7227 (ISSN-L)
  • 1945-7170
DOI
10.1210/endo.142.9.8366
OpenAlex
W1985671788
Cited by
148
References
50
Citations by year
2026: 3 · 2024: 1 · 2023: 2 · 2022: 6 · 2021: 9 · 2020: 3 · 2019: 4 · 2018: 7 · 2017: 7 · 2016: 5 · 2015: 8 · 2014: 3 · 2013: 6 · 2012: 7
FWCI
5.12
Type
journal article
Language
en
Open access
closed
Locations
  • Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords
angiotensin II, AT1 receptor antagonists, candesartan, isolation stress, hypothalamic-pituitary-adrenal axis, paraventricular nucleus, ACTH, vasopressin, aldosterone, corticosterone, adrenal catecholamines, angiotensin II type 2 receptor, zona glomerulosa, stress response
MeSH terms
Adrenal Cortex Hormones, Adrenal Glands, Animals, Benzimidazoles, Biphenyl Compounds, Brain, Catecholamines, Hormones, Hypothalamo-Hypophyseal System, Infusion Pumps, Injections, Subcutaneous, Male, Pituitary Hormones, Pituitary-Adrenal System, Receptors, Angiotensin, RNA, Messenger, Social Isolation, Stress, Psychological, Tetrazoles, Tyrosine 3-Monooxygenase, Rats, Wistar, Receptor, Angiotensin, Type 2, Receptor, Angiotensin, Type 1, Rats, Angiotensin Receptor Antagonists

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