Cited by 148Renin-Angiotensin System StudiesStress Responses and CortisolNeuropeptides and Animal Physiology

The DOI matches its Crossref record; 49 of the 50 references it cites were found in a registry or an index.

Peripheral Administration of an Angiotensin II AT1 Receptor Antagonist Decreases the Hypothalamic-Pituitary-Adrenal Response to Isolation Stress

Armando, Ines, Carranza, Andrea, Nishimura, Yasuaki, Hoe, Kwang-Lae, Barontini, Marta, Terrón, José A., Falcón-Neri, Alicia, Ito, Takeshi, Juorio, Augusto V., Saavedra, Juan M.·2001·Endocrinology

DOI 10.1210/endo.142.9.8366

Open this paper in CoChat — free account

Abstract

Angiotensin II, which stimulates AT(1) receptors, is a brain and peripheral stress hormone. We pretreated rats with the AT(1) receptor antagonist candesartan for 13 d via sc-implanted osmotic minipumps, followed by 24-h isolation in individual metabolic cages. We measured angiotensin II receptor-type binding and mRNAs and tyrosine hydroxylase mRNA by quantitative autoradiography and in situ hybridization, catecholamines by HPLC, and hormones by RIA. Isolation increased AT(1) receptor binding in hypothalamic paraventricular nucleus as well as anterior pituitary ACTH, and decreased posterior pituitary AVP. Isolation stress also increased AT(1) receptor binding and AT(1B) mRNA in zona glomerulosa and AT(2) binding in adrenal medulla, adrenal catecholamines, tyrosine hydroxylase mRNA, aldosterone, and corticosterone. Candesartan blocked AT(1) binding in paraventricular nucleus and adrenal gland; prevented the isolation-induced alterations in pituitary ACTH and AVP and in adrenal corticosterone, aldosterone, and catecholamines; abolished the increase in AT(2) binding in adrenal medulla; and substantially decreased urinary AVP, corticosterone, aldosterone, and catecholamines during isolation. Peripheral pretreatment with an AT(1) receptor antagonist blocks brain and peripheral AT(1) receptors and inhibits the hypothalamic-pituitary-adrenal response to stress, suggesting a physiological role for peripheral and brain AT(1) receptors during stress and a possible beneficial effect of AT(1) antagonism in stress-related disorders.

Integrity signals

Registry

Crossref · 10.1210/endo.142.9.8366

Cites

49 of 49 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Angiotensin II receptors and angiotensin II receptor antagonists.
Timmermans, P. B. M. W. M., Wong, P. C., Chiu, A. T., Herblin, W. F., Benfield, P. A., Carini, D. J., Lee, R. J., Wexler, R. R., Saye, J. A., & Smith, R. D. (1993) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)00446-6 · Cited by 1,854
Isolation of a cDNA encoding the vascular type-1 angiotensin II receptor
Murphy, T. J., Alexander, R. W., Griendling, K. K., Runge, M. S., & Bernstein, K. E. (1991) · Nature · doi:10.1038/351233a0 · Cited by 1,250
Expression cloning of type 2 angiotensin II receptor reveals a unique class of seven-transmembrane receptors.
Mukoyama, M., Nakajima, M., Horiuchi, M., Sasamura, H., Pratt, R. E., & Dzau, V. J. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)74498-6 · Cited by 768
Vasopressinergic control of pituitary adrenocorticotropin secretion comes of age
Antoni, F. A. (1993) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1993.1004 · Cited by 636
Complete coding sequence of rat tyrosine hydroxylase mRNA.
Grima, B., Lamouroux, A., Blanot, F., Biguet, N. F., & Mallet, J. J. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.2.617 · Cited by 534
Brain and Pituitary Angiotensin
Saavedra, J. M. (1992) · Endocrine Reviews · doi:10.1210/edrv-13-2-329 · Cited by 460
Self-citation
Characterization and development of angiotensin II receptor subtypes (AT1 and AT2) in rat brain
Tsutsumi, K., & Saavedra, J. M. (1991) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1991.261.1.r209 · Cited by 336
Self-citation
Angiotensin II type-1 receptor subtype cDNAs: Differential tissue expression and hormonal regulation
Kakar, S. S., Sellers, J. C., Devor, D. C., Musgrove, L. C., & Neill, J. D. (1992) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(05)80302-x · Cited by 326
Functional studies of nonpeptide angiotensin II receptor subtype-specific ligands: DuP 753 (AII-1) and PD123177 (AII-2).
Wong, P. C., Hart, S. D., Zaspel, A. M., Chiu, A. T., Ardecky, R., Smith, R. D., & Timmermans, P. B. M. W. M. (1990) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)23123-8 · Cited by 295
Angiotensin II in central nervous system physiology
Phillips, M. I., & Sumners, C. (1998) · Regulatory Peptides · doi:10.1016/s0167-0115(98)00122-0 · Cited by 245

Show all 50 references

Sorted by citations

Brain Angiotensin II: New Developments, Unanswered Questions and Therapeutic Opportunities
Saavedra, J. M. (2005) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-005-4011-5 · Cited by 284
Self-citation
Neural mechanisms of social homeostasis
Matthews, G. A., & Tye, K. M. (2019) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14016 · Cited by 273
Blockade of brain angiotensin II AT1 receptors ameliorates stress, anxiety, brain inflammation and ischemia: Therapeutic implications
Saavedra, J. M., Sánchez-Lemus, E., & Benický, J. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.10.001 · Cited by 264
Self-citation
Angiotensin II AT1 receptor blockers as treatments for inflammatory brain disorders
Saavedra, J. M. (2012) · Clinical Science · doi:10.1042/cs20120078 · Cited by 221
Self-citation
Angiotensin II AT 1 Receptor Blockade Reverses Pathological Hypertrophy and Inflammation in Brain Microvessels of Spontaneously Hypertensive Rats
Ando, H., Zhou, J., Macova, M., Imboden, H., & Saavedra, J. M. (2004) · Stroke · doi:10.1161/01.str.0000129788.26346.18 · Cited by 181
Self-citation
Brain and peripheral angiotensin II play a major role in stress
Saavedra, J. M., & Benický, J. (2007) · Stress · doi:10.1080/10253890701350735 · Cited by 166
Self-citation
Immobilization and cold stress affect sympatho–adrenomedullary system and pituitary–adrenocortical axis of rats exposed to long-term isolation and crowding
DRONJAK, S., GAVRILOVI, L., FILIPOVI, D., & RADOJI, M. (2004) · Physiology & Behavior · doi:10.1016/j.physbeh.2004.01.011 · Cited by 142
Anti-inflammatory effects of angiotensin II AT1 receptor antagonism prevent stress-induced gastric injury
Bregonzio, C., Armando, I., Ando, H., JEZOVA, M., Baiardi, G., & Saavedra, J. M. (2003) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00058.2003 · Cited by 129
Self-citation
Anti-Inflammatory Effects of Angiotensin Receptor Blockers in the Brain and the Periphery
Benický, J., Sánchez-Lemus, E., Pavel, J., & Saavedra, J. M. (2009) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-009-9368-4 · Cited by 126
Self-citation
Long-term angiotensin II AT1 receptor inhibition produces adipose tissue hypotrophy accompanied by increased expression of adiponectin and PPARγ
Zórad, Š., Dou, J., Benický, J., Hutanu, D., Tybitanclová, K., Zhou, J., & Saavedra, J. M. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.08.062 · Cited by 124
Self-citation
Anti-stress and anti-anxiety effects of centrally acting angiotensin II AT1 receptor antagonists
Saavedra, J. M., Ando, H., Armando, I., Baiardi, G., Bregonzio, C., Juorio, A. V., & Macova, M. (2005) · Regulatory Peptides · doi:10.1016/j.regpep.2004.12.015 · Cited by 119
Self-citation
Angiotensin type 1 receptor inhibition enhances the extinction of fear memory
Marvar, P. J., Goodman, J., Fuchs, S., Choi, D. C., Banerjee, S., & Ressler, K. J. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.08.024 · Cited by 110
A Centrally Acting, Anxiolytic Angiotensin II AT1 Receptor Antagonist Prevents the Isolation Stress-Induced Decrease in Cortical CRF1 Receptor and Benzodiazepine Binding
Saavedra, J. M., Armando, I., Bregonzio, C., Juorio, A. V., Macova, M., Pavel, J., & Sánchez-Lemus, E. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300921 · Cited by 109
Self-citation
Central Angiotensin II Stimulation Promotes β Amyloid Production in Sprague Dawley Rats
Zhu, D., Shi, J., Zhang, Y., Wang, B., Liu, W., Chen, Z., & Tong, Q. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016037 · Cited by 112
Telmisartan ameliorates glutamate-induced neurotoxicity: Roles of AT1 receptor blockade and PPARγ activation
Wang, J., Pang, T., Hafko, R., Benický, J., Sánchez-Lemus, E., & Saavedra, J. M. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.11.022 · Cited by 109
Self-citation
Angiotensin II AT1 Receptor Blockers Ameliorate Inflammatory Stress: A Beneficial Effect for the Treatment of Brain Disorders
Saavedra, J. M. (2011) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-011-9754-6 · Cited by 91
Self-citation
Adrenocortical dysregulation as a major player in insulin resistance and onset of obesity
Roberge, C., Carpentier, A. C., Langlois, M., Baillargeon, J., Ardilouze, J., Maheux, P., & Gallo‐Payet, N. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00516.2007 · Cited by 88
Angiotensin II AT1 receptor blockade prevents the hypothalamic corticotropin-releasing factor response to isolation stress
Armando, I., Volpi, S., Aguilera, G., & Saavedra, J. M. (2007) · Brain Research · doi:10.1016/j.brainres.2007.01.037 · Cited by 86
Self-citation
Brain Angiotensin II, an Important Stress Hormone: Regulatory Sites and Therapeutic Opportunities
Saavedra, J. M., Ando, H., Armando, I., Baiardi, G., Bregonzio, C., JEZOVA, M., & Zhou, J. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1296.009 · Cited by 84
Self-citation
Angiotensin as stress mediator: Role of its receptor and interrelationships among other stress mediators and receptors
Bali, A., & Jaggi, A. S. (2013) · Pharmacological Research · doi:10.1016/j.phrs.2013.07.004 · Cited by 77
Human Extinction Learning Is Accelerated by an Angiotensin Antagonist via Ventromedial Prefrontal Cortex and Its Connections With Basolateral Amygdala
Zhou, F., Geng, Y., Xin, F., Li, J., Feng, P., Liu, C., Zhao, W., Feng, T., Guastella, A. J., Ebstein, R. P., et al. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.07.007 · Cited by 70
Angiotensin-II Is a Putative Neurotransmitter in Lactate-Induced Panic-Like Responses in Rats with Disruption of GABAergic Inhibition in the Dorsomedial Hypothalamus
Shekhar, A., Johnson, P. L., Sajdyk, T. J., Fitz, S. D., Keim, S. R., Kelley, P. E., Gehlert, D. R., & DiMicco, J. A. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2491-06.2006 · Cited by 77
Restraint Stress Modulates Brain, Pituitary and Adrenal Expression of Angiotensin II AT1A, AT1B and AT2 Receptors
Leong, D. S., Terrón, J. A., Falcón‐Neri, A., Armando, I., Ito, T., Jöhren, O., Tonelli, L. H., Hoe, K., & Saavedra, J. M. (2002) · Neuroendocrinology · doi:10.1159/000054714 · Cited by 77
Self-citation
Estrogen Reduces Aldosterone, Upregulates Adrenal Angiotensin II AT2 Receptors and Normalizes Adrenomedullary Fra-2 in Ovariectomized Rats
Macova, M., Armando, I., Zhou, J., Baiardi, G., Tyurmin, D., Larrayoz-Roldan, I. M., & Saavedra, J. M. (2008) · Neuroendocrinology · doi:10.1159/000150977 · Cited by 75
Self-citation
Peripherally Administered Angiotensin II AT1 Receptor Antagonists Are Anti‐stress Compounds in Vivo
Pavel, J., Benický, J., Murakami, Y., Sánchez-Lemus, E., & Saavedra, J. M. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1410.006 · Cited by 74
Self-citation
Chronic administration of an angiotensin II receptor antagonist resets the hypothalamic–pituitary–adrenal (HPA) axis and improves the affect of patients with diabetes mellitus type 2: Preliminary results: Research Report
Pavlatou, M. G., Mastorakos, G., Lekakis, I., Liatis, S., Vamvakou, G., Zoumakis, E., Papassotiriou, I., Rabavilas, A. D., Katsilambros, N., & Chrousos, G. P. (2008) · Stress · doi:10.1080/10253890701476621 · Cited by 66
Oral administration of an AT1 receptor antagonist prevents the central effects of angiotensin II in spontaneously hypertensive rats
Seltzer, A. M., Bregonzio, C., Armando, I., Baiardi, G., & Saavedra, J. M. (2004) · Brain Research · doi:10.1016/j.brainres.2004.06.079 · Cited by 63
Self-citation
Brain renin-angiotensin system in the pathophysiology of cardiovascular diseases
Huber, G., Schuster, F., & Raasch, W. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.06.016 · Cited by 62
Gene expression profiling following maternal deprivation: Involvement of the brain renin-angiotensin system
Liebl, C. (2009) · Frontiers in Molecular Neuroscience · doi:10.3389/neuro.02.001.2009 · Cited by 60
To live alone and to be depressed, an alarming combination for the renin–angiotensin–aldosterone-system (RAAS)
Häfner, S., Baumert, J., Emeny, R. T., Lacruz, M. E., Bidlingmaier, M., Reincke, M., Kuenzel, H., Holle, R., Rupprecht, R., & Ladwig, K. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.06.007 · Cited by 54
Angiotensin II AT 1 receptor blockade selectively enhances brain AT 2 receptor expression, and abolishes the cold-restraint stress-induced increase in tyrosine hydroxylase mRNA in the locus coeruleus of spontaneously hypertensive rats
Bregonzio, C., Seltzer, A. M., Armando, I., Pavel, J., & Saavedra, J. M. (2008) · Stress · doi:10.1080/10253890801892040 · Cited by 53
Self-citation
Angiotensin II Inhibition Reduces Stress Sensitivity of Hypothalamo-Pituitary-Adrenal Axis in Spontaneously Hypertensive Rats
Raasch, W., Wittmershaus, C., Dendorfer, A., Voges, I., Pahlke, F., Dodt, C., Dominiak, P., & Jöhren, O. (2006) · Endocrinology · doi:10.1210/en.2006-0198 · Cited by 52
Renal dopaminergic defect in C57Bl/6J mice
Escano, C. S., Armando, I., Wang, X., Asico, L. D., Pascua, A., Yang, Y., Wang, Z., Lau, Y., & José, P. A. (2009) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00147.2009 · Cited by 53
Self-citation
Anxiolytic- and antidepressant-like effects of angiotensin-(1–7) in hypertensive transgenic (mRen2)27 rats
Almeida-Santos, A. F., Kangussu, L. M., Moreira, F. A., Santos, R. A. S., de Aguiar, D. C., & Campagnole‐Santos, M. J. (2016) · Clinical Science · doi:10.1042/cs20160116 · Cited by 51
Antidepressant-like effect of losartan involves TRKB transactivation from angiotensin receptor type 2 (AGTR2) and recruitment of FYN
Diniz, C. R. A. F., Casarotto, P. C., Fred, S. M., Biojone, C., Ċastrén, E., & Joca, S. R. L. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.03.011 · Cited by 52
Angiotensin II AT1 Receptor Blockade Decreases Lipopolysaccharide-Induced Inflammation in the Rat Adrenal Gland
Sánchez-Lemus, E., Murakami, Y., Larráyoz, I. M., Moughamian, A. J., Pavel, J., Nishioku, T., & Saavedra, J. M. (2008) · Endocrinology · doi:10.1210/en.2008-0242 · Cited by 50
Self-citation
Losartan may prevent the elevation of plasma glucose, corticosterone and catecholamine levels induced by chronic stress
Üresin, Y., Erbaş, B., Özek, M., Özkök, E., & Gürol, A. O. (2004) · Journal of the Renin-Angiotensin-Aldosterone System · doi:10.3317/jraas.2004.017 · Cited by 49
Renin-Angiotensin System Hyperactivation Can Induce Inflammation and Retinal Neural Dysfunction
Kurihara, T., Ozawa, Y., Ishida, S., Okano, H., & Tsubota, K. (2012) · International Journal of Inflammation · doi:10.1155/2012/581695 · Cited by 53
Consequences of pandemic-associated social restrictions: Role of social support and the oxytocin system
Gryksa, K., & Neumann, I. D. (2021) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2021.105601 · Cited by 53
Angiotensin Type 1A Receptors in C1 Neurons of the Rostral Ventrolateral Medulla Modulate the Pressor Response to Aversive Stress
Chen, D., Jancovski, N., Bassi, J. K., Nguyen‐Huu, T., Choong, Y., Palma‐Rigo, K., Davern, P. J., Gurley, S. B., Thomas, W. G., Head, G. A., et al. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.5360-11.2012 · Cited by 47
The Effects of the Angiotensin II Receptor Antagonist Losartan on Appetitive Versus Aversive Learning: A Randomized Controlled Trial
Pulcu, E., Shkreli, L., Holst, C. G., Woud, M. L., Craske, M. G., Browning, M. D., & Reinecke, A. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.04.010 · Cited by 46
Angiotensin II: multitasking in the brain
Saavedra, J. M., Benický, J., & Zhou, J. (2006) · Journal of Hypertension · doi:10.1097/01.hjh.0000220418.09021.ee · Cited by 46
Self-citation
Angiotensin II AT1 and AT2 Receptors Contribute to Maintain Basal Adrenomedullary Norepinephrine Synthesis and Tyrosine Hydroxylase Transcription
JEZOVA, M., Armando, I., Bregonzio, C., Yu, Z., Qian, S., Ferrans, V. J., Imboden, H., & Saavedra, J. M. (2003) · Endocrinology · doi:10.1210/en.2002-0019 · Cited by 45
Self-citation
Coupling corticotropin-releasing-hormone and angiotensin converting enzyme 2 dampens stress responsiveness in male mice
Wang, L. A., de Kloet, A. D., Smeltzer, M. D., Cahill, K. M., Hiller, H., Bruce, E. B., Pioquinto, D. J., Ludin, J. A., Katovich, M. J., Raizada, M. K., et al. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.01.025 · Cited by 45
In vivo Angiotensin II AT1 receptor blockade selectively inhibits LPS-induced innate immune response and ACTH release in rat pituitary gland
Sánchez-Lemus, E., Benický, J., Pavel, J., & Saavedra, J. M. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2009.04.012 · Cited by 43
Self-citation
The role of the brain renin-angiotensin system (RAS) in mild traumatic brain injury (TBI)
Vadhan, J. D., & Speth, R. C. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107684 · Cited by 42
Brain angiotensin-(1–7)/Mas axis: A new target to reduce the cardiovascular risk to emotional stress
Fontes, M. A. P., Lima, A. M., & Santos, R. A. S. (2015) · Neuropeptides · doi:10.1016/j.npep.2015.10.003 · Cited by 41
Associations of trauma exposure and post-traumatic stress disorder with the activity of the renin–angiotensin–aldosterone-system in the general population
Terock, J., Hannemann, A., Janowitz, D., Freyberger, H. J., Felix, S. B., Dörr, M., Nauck, M. A., Völzke, H., & Grabe, H. J. (2018) · Psychological Medicine · doi:10.1017/s0033291718001496 · Cited by 41
Angiotensin Regulation of Amygdala Response to Threat in High-Trait-Anxiety Individuals
Reinecke, A., Browning, M. D., Breteler, J. K., Kappelmann, N., Ressler, K. J., Harmer, C. J., & Craske, M. G. (2018) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2018.05.007 · Cited by 35
Angiotensin II AT1 and AT2 Receptor Types Regulate Basal and Stress‐Induced Adrenomedullary Catecholamine Production through Transcriptional Regulation of Tyrosine Hydroxylase
Armando, I., JEZOVA, M., Bregonzio, C., Baiardi, G., & Saavedra, J. M. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1296.036 · Cited by 38
Self-citation
Angiotensin Receptor Blockers Are Not Just for Hypertension Anymore
Saavedra, J. M. (2021) · Physiology · doi:10.1152/physiol.00036.2020 · Cited by 37
Self-citation
Normal Physiology of ACTH and GH Release in the Hypothalamus and Anterior Pituitary in Man
Lim, C. T., & Khoo, B. C. E. (2014) · Cited by 36
A peripherally administered, centrally acting angiotensin II AT2 antagonist selectively increases brain AT1 receptors and decreases brain tyrosine hydroxylase transcription, pituitary vasopressin and ACTH
Macova, M., Pavel, J., & Saavedra, J. M. (2008) · Brain Research · doi:10.1016/j.brainres.2008.11.006 · Cited by 36
Self-citation
Association between a functional polymorphism in the renin-angiotensin system and completed suicide
Hishimoto, A., Shirakawa, O., Nishiguchi, N., Hashimoto, T., Yanagi, M., Nushida, H., Ueno, Y., & Maeda, K. (2006) · Journal of Neural Transmission · doi:10.1007/s00702-006-0483-9 · Cited by 36
Secretin: Hypothalamic Distribution and Hypothesized Neuroregulatory Role in Autism
Welch, M. G., Keune, J. D., Welch-Horan, T. B., Anwar, N., Anwar, M., Ludwig, R. J., & Ruggiero, D. A. (2004) · Cellular and Molecular Neurobiology · doi:10.1023/b:cemn.0000018618.59015.a2 · Cited by 36
Increased Angiotensin II AT1 Receptor Expression in Paraventricular Nucleus and Hypothalamic-Pituitary-Adrenal Axis Stimulation in AT2 Receptor Gene Disrupted Mice
Armando, I., Terrón, J. A., Falcón‐Neri, A., Takeshi, I., Häuser, W., Inagami, T., & Saavedra, J. M. (2002) · Neuroendocrinology · doi:10.1159/000064525 · Cited by 35
Self-citation
Angiotensin II type 1 receptor blockade by telmisartan prevents stress-induced impairment of memory via HPA axis deactivation and up-regulation of brain-derived neurotrophic factor gene expression
Wincewicz, D., Juchniewicz, A., Waszkiewicz, N., & Braszko, J. J. (2016) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2016.06.010 · Cited by 34
Renin-angiotensin system: The underlying mechanisms and promising therapeutical target for depression and anxiety
Gong, S., & Deng, F. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1053136 · Cited by 41
Candesartan prevents impairment of recall caused by repeated stress in rats
Braszko, J. J., Wincewicz, D., & Jakubów, P. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2829-3 · Cited by 32
Transient hypertension and sustained tachycardia in mice housed individually in metabolism cages
Hoppe, C., Moritz, K. M., Fitzgerald, S. M., Bertram, J. F., & Evans, R. G. (2009) · Physiological Research · doi:10.33549/physiolres.931390 · Cited by 32
Effects of AT1 receptor antagonism on kainate-induced seizures and concomitant changes in hippocampal extracellular noradrenaline, serotonin, and dopamine levels in Wistar-Kyoto and spontaneously hypertensive rats
Tchekalarova, J. D., Loyens, E., & Smolders, I. J. (2015) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2015.03.021 · Cited by 31
Angiotensin II-triggered kinase signaling cascade in the central nervous system
Bali, A., & Jaggi, A. S. (2015) · Reviews in the Neurosciences · doi:10.1515/revneuro-2015-0041 · Cited by 30
Effects of acute stress on the day of proestrus on sexual behavior and ovulation in female rats: Participation of the angiotensinergic system
Donadio, M. V. F., Kunrath, A., Corezola, K. L., Franci, C. R., Anselmo-Franci, J. A., Lucion, A. B., & Sanvitto, G. L. (2007) · Physiology & Behavior · doi:10.1016/j.physbeh.2007.05.005 · Cited by 29
Involvement of the Renin-Angiotensin System in Stress: State of the Art and Research Perspectives
Correa, B. H. M., Becari, L., Fontes, M. A. P., Silva, A. C. S. E., & Kangussu, L. M. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666210719142300 · Cited by 31
Angiotensin II AT1 Receptor Blockade Prevents Gastric Ulcers during Cold‐Restraint Stress
Bregonzio, C., Armando, I., Ando, H., JEZOVA, M., Baiardi, G., & Saavedra, J. M. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1296.044 · Cited by 28
Self-citation
The association between the renin-angiotensin system and the hypothalamic-pituitary-adrenal axis in anxiety disorders: A systematic review of animal studies
Balthazar, L., Lages, Y., Romano, V. C., Landeira-Fernández, J., & Krahe, T. E. (2021) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2021.105354 · Cited by 26
Regulation of the hypothalamic-pituitary-adrenal axis by neuropeptides
Aguilera, G. (2011) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci.2011.123 · Cited by 29
Interaction of AT1 receptors and V1a receptors-mediated effects in the central cardiovascular control during the post-infarct state
Cudnoch‐Jędrzejewska, A., Dobruch, J. T., Puchalska, L., & Szczepanska‐Sadowska, E. K. (2007) · Regulatory Peptides · doi:10.1016/j.regpep.2007.01.010 · Cited by 26
Life‐Long Serotonin Reuptake Deficiency Results in Complex Alterations in Adrenomedullary Responses to Stress
Tjurmina, O., Armando, I., Saavedra, J. M., Li, Q., & Murphy, D. L. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1296.011 · Cited by 25
Self-citation
Targeting brain angiotensin and corticotrophin-releasing hormone systems interaction for the treatment of mood and alcohol use disorders
Sommer, W. H., & Saavedra, J. M. (2008) · Journal of Molecular Medicine · doi:10.1007/s00109-008-0333-3 · Cited by 26
Self-citation
Multiple Aspects of Inappropriate Action of Renin–Angiotensin, Vasopressin, and Oxytocin Systems in Neuropsychiatric and Neurodegenerative Diseases
Szczepanska‐Sadowska, E. K., Wsół, A., Cudnoch‐Jędrzejewska, A., Czarzasta, K., & Żera, T. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11040908 · Cited by 26
Brain angiotensin AT1receptors as specific regulators of cardiovascular reactivity to acute psychoemotional stress
Mayorov, D. N. (2010) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2010.05469.x · Cited by 25
Angiotensin II AT1 Receptor Blockade Prolongs the Lifespan of Spontaneously Hypertensive Rats and Reduces Stress‐Induced Release of Catecholamines, Glucocorticoids, and Vasopressin
Baiardi, G., Bregonzio, C., JEZOVA, M., Armando, I., & Saavedra, J. M. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1296.015 · Cited by 24
Self-citation
Angiotensin II AT1 Receptor Blockade Decreases Brain Artery Inflammation in a Stress‐Prone Rat Strain
Ando, H., JEZOVA, M., Zhou, J., & Saavedra, J. M. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1296.043 · Cited by 22
Self-citation
The Serotonin Transporter is Required for Stress-Evoked Increases in Adrenal Catecholamine Synthesis and Angiotensin II AT2 Receptor Expression
Armando, I., Tjurmina, O., Li, Q., Murphy, D. L., & Saavedra, J. M. (2003) · Neuroendocrinology · doi:10.1159/000073705 · Cited by 22
Self-citation
Angiotensin II AT2 Receptors Contribute to Regulate the Sympathoadrenal and Hormonal Reaction to Stress Stimuli
Saavedra, J. M., & Armando, I. (2017) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-017-0533-x · Cited by 21
Self-citation
Short-term Heat Exposure Promotes Hippocampal Neurogenesis via Activation of Angiotensin II Type 1 Receptor in Adult Rats
Koyama, Y., Mukuda, T., Hamasaki, S., Nakane, H., & Kaidoh, T. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.05.045 · Cited by 22
Effects of life-long caloric restriction and voluntary exercise on age-related changes in levels of catecholamine biosynthetic enzymes and angiotensin II receptors in the rat adrenal medulla and hypothalamus
Erdös, B., Broxson, C. S., Landa, T., Scarpace, P. J., Leeuwenburgh, C., Zhang, Y., & Tümer, N. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2007.04.007 · Cited by 21
Angiotensin Antagonist Inhibits Preferential Negative Memory Encoding via Decreasing Hippocampus Activation and Its Coupling With the Amygdala
Xu, T., Zhou, X., Jiao, G., Zeng, Y., Zhao, W., Li, J., Yu, F., Zhou, F., Yao, S., & Becker, B. (2022) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2022.05.007 · Cited by 16
Angiotensin II AT1 receptor blocker candesartan prevents the fast up-regulation of cerebrocortical benzodiazepine-1 receptors induced by acute inflammatory and restraint stress
Sánchez-Lemus, E., Honda, M., & Saavedra, J. M. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.03.041 · Cited by 20
Self-citation
Stress sensitivity is increased in transgenic rats with low brain angiotensinogen
Müller‐Fielitz, H., Kröger, J., Jöhren, O., Szymczak, S., Bäder, M., Dominiak, P., & Raasch, W. (2009) · Journal of Endocrinology · doi:10.1677/joe-09-0363 · Cited by 20
Systemic angiotensin II and exercise-induced neurogenesis in adult rat hippocampus
Mukuda, T., Koyama, Y., Hamasaki, S., Kaidoh, T., & Furukawa, Y. (2014) · Brain Research · doi:10.1016/j.brainres.2014.09.019 · Cited by 18
Chronic AT1 blockade improves glucose homeostasis in obese OLETF rats
Rodríguez, R., Minas, J. N., Vázquez‐Medina, J. P., Nakano, D., Parkes, D. G., Nishiyama, A., & Ortiz, R. M. (2018) · Journal of Endocrinology · doi:10.1530/joe-17-0678 · Cited by 20
Interaction between irbesartan, peroxisome proliferator-activated receptor (PPAR-γ), and adiponectin in the regulation of blood pressure and renal function in spontaneously hypertensive rats
Afzal, S., Sattar, M. Z. A., Johns, E. J., Abdulla, M. H., Akhtar, S., Hashmi, F., & Abdullah, N. A. (2016) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-016-0497-1 · Cited by 16
Angiotensin II AT1 receptor antagonists inhibit the angiotensin‐CRF‐AVP axis and are potentially useful for the treatment of stress‐related and mood disorders
Saavedra, J. M., & Pavel, J. (2005) · Drug Development Research · doi:10.1002/ddr.20027 · Cited by 16
Self-citation
Anti-stress and nootropic activity of drugs affecting the renin-angiotensin system in rats based on indirect biochemical evidence
Kumar, K. A., Nagwar, S., Thyloor, R., & Satyanarayana, S. (2014) · Journal of the Renin-Angiotensin-Aldosterone System · doi:10.1177/1470320313516173 · Cited by 16
Validation of Brain Angiotensin System Blockade as a Novel Drug Target in Pharmacological Treatment of Neuropsychiatric Disorders
Wincewicz, D., & Braszko, J. J. (2017) · Pharmacopsychiatry · doi:10.1055/s-0043-112345 · Cited by 16
Predicted role of secretin and oxytocin in the treatment of behavioral and developmental disorders: implications for autism
Welch, M. G., & Ruggiero, D. A. (2005) · International review of neurobiology · doi:10.1016/s0074-7742(05)71012-6 · Cited by 16
Involvement of hippocampal angiotensin 1 receptors in anxiety-like behaviour of olfactory bulbectomized rats
Tashev, R. E., & Velikova, M. (2018) · Pharmacological Reports · doi:10.1016/j.pharep.2018.03.001 · Cited by 15
Altered urinary excretion of aquaporin 2 in IgA nephropathy
Rocchetti, M. T., Tamma, G., Lasorsa, D. R., Suriano, I. V., d’Apollo, A. M., Papale, M., Mastrofrancesco, L., Grandaliano, G., Svelto, M., Valenti, G., et al. (2011) · European Journal of Endocrinology · doi:10.1530/eje-11-0512 · Cited by 15
Novel mechanism within the paraventricular nucleus reduces both blood pressure and hypothalamic pituitary-adrenal axis responses to acute stress
Erdös, B., Clifton, R. R., Liu, M., Li, H., McCowan, M. L., Sumners, C., & Scheuer, D. A. (2015) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00207.2015 · Cited by 16
QTL mapping for traits associated with stress neuroendocrine reactivity in rats
Llamas, B., Contesse, V., Guyonnet‐Dupérat, V., Vaudry, H., Mormède, P., & Moisan, M. (2005) · Mammalian Genome · doi:10.1007/s00335-005-0022-2 · Cited by 14
Effect of acute stress on sexual behavior in female rats: Participation of the central angiotensinergic system
Cecconello, A. L., Raineki, C., Sebben, V., Lucion, A. B., & Sanvitto, G. L. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.10.026 · Cited by 13
Regulation of angiotensin II type 2 receptor gene expression in the adrenal medulla by acute and repeated immobilization stress
Nostramo, R., Tillinger, A., Saavedra, J. M., Kumar, A., Pandey, V. G., Serova, L. I., Květňanský, R., & Sabban, E. L. (2012) · Journal of Endocrinology · doi:10.1530/joe-12-0181 · Cited by 12
Self-citation
AT1 and AT2 Receptors in the Prelimbic Cortex Modulate the Cardiovascular Response Evoked by Acute Exposure to Restraint Stress in Rats
Brasil, T. F. S., Fassini, A., & Corrêa, F. M. D. A. (2017) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-017-0518-9 · Cited by 12
Angiotensin-converting enzyme 2 activator, DIZE in the basolateral amygdala attenuates the tachycardic response to acute stress by modulating glutamatergic tone
Silva, C. C., Correa, A. M., Kushmerick, C., Sharma, N. M., Patel, K. P., Almeida, J. F., Moreira, F. A., Ferreira, A. J., & Fontes, M. A. P. (2020) · Neuropeptides · doi:10.1016/j.npep.2020.102076 · Cited by 12
The effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on ischemic stroke and the possible underlying mechanisms
Song, Y., Fan, H., Tang, X., Luo, Y., Liu, P., & Chen, Y. (2021) · International Journal of Neuroscience · doi:10.1080/00207454.2021.1897588 · Cited by 12
Living alone and activation of the renin-angiotensin-aldosterone-system: Differential effects depending on alexithymic personality features
Terock, J., Hannemann, A., Janowitz, D., Völzke, H., Nauck, M. A., Freyberger, H.-J., Wallaschofski, H., & Grabe, H. J. (2017) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2017.03.007 · Cited by 12
Renoprotective and haemodynamic effects of adiponectin and peroxisome proliferator-activated receptor agonist, pioglitazone, in renal vasculature of diabetic Spontaneously hypertensive rats
Afzal, S., Sattar, M. Z. A., Johns, E. J., & Eseyin, O. A. (2020) · PLoS ONE · doi:10.1371/journal.pone.0229803 · Cited by 11
Aldosterone Action on Brain and Behavior
Murck, H. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803592-4.00052-3 · Cited by 10

Authors: Armando, I., Carranza, A., Nishimura, Y., Hoe, K.-L., Barontini, M., Terrón, J. A., Falcón-Neri, A., Ito, T., Juorio, A. V., & Saavedra, J. M.
Affiliations: Centro de Investigaciones Endocrinologicas, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Buenos Aires (I.A., A.C., M.B.), Buenos Aires 1013, Argentina
Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
National Institutes of Health (US)
Section on Pharmacology, National Institute of Mental Health, National Institutes of Health (I.A., Y.N., K.-L.H., J.A.T., A.F.-N., T.I., A.V.J., J.M.S.), Bethesda, Maryland 20814
ORCID: Carranza, Andrea
Hoe, Kwang-Lae
Ito, Takeshi
Saavedra, Juan M.
Venue: Endocrinology
Publisher: The Endocrine Society
Published: 2001-09-01
Volume: 142
Issue: 9
Pages: 3880-3889
ISSN: 0013-7227 (ISSN-L)
1945-7170
DOI: 10.1210/endo.142.9.8366
OpenAlex: W1985671788
Cited by: 148
References: 50
Citations by year: 2026: 3 · 2024: 1 · 2023: 2 · 2022: 6 · 2021: 9 · 2020: 3 · 2019: 4 · 2018: 7 · 2017: 7 · 2016: 5 · 2015: 8 · 2014: 3 · 2013: 6 · 2012: 7
FWCI: 5.12
Type: journal article
Language: en
Open access: closed
Locations: Endocrinology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: angiotensin II, AT1 receptor antagonists, candesartan, isolation stress, hypothalamic-pituitary-adrenal axis, paraventricular nucleus, ACTH, vasopressin, aldosterone, corticosterone, adrenal catecholamines, angiotensin II type 2 receptor, zona glomerulosa, stress response
MeSH terms: Adrenal Cortex Hormones, Adrenal Glands, Animals, Benzimidazoles, Biphenyl Compounds, Brain, Catecholamines, Hormones, Hypothalamo-Hypophyseal System, Infusion Pumps, Injections, Subcutaneous, Male, Pituitary Hormones, Pituitary-Adrenal System, Receptors, Angiotensin, RNA, Messenger, Social Isolation, Stress, Psychological, Tetrazoles, Tyrosine 3-Monooxygenase, Rats, Wistar, Receptor, Angiotensin, Type 2, Receptor, Angiotensin, Type 1, Rats, Angiotensin Receptor Antagonists

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Peripheral Administration of an Angiotensin II AT1 Receptor Antagonist Decreases the Hypothalamic-Pituitary-Adrenal Response to Isolation Stress

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks