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Sciatic Nerve Lipoprotein Lipase Is Reduced in Streptozotocin-Induced Diabetes and Corrected by Insulin

Ferreira, L. D. M. C.-B., Huey, P. U., Pulford, B. E., Ishii, D. N., Eckel, R. H.·2002·Endocrinology
DOI 10.1210/endo.143.4.8723
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Abstract

The metabolic abnormalities underlying the cause of diabetic neuropathy have been the subject of much debate. Lipoprotein lipase (LPL) is a 56-kDa enzyme produced by several tissues in the body and has recently been shown in vitro to be expressed in cultured Schwann cells, where it is important in phospholipid synthesis. This suggests a role for LPL in myelin biosynthesis in the peripheral nervous system. The aim of this study was to determine if acute streptozotocin (STZ)-induced diabetes reduces the expression and regulation of sciatic nerve LPL in vivo. Adult Sprague Dawley rats were rendered diabetic via an sc injection of STZ. A decrease in sciatic nerve LPL activity was observed in the STZ-treated rats after just 2 d of diabetes and remained significantly reduced for at least 35 d. The decrease in LPL activity coincided temporally with a drop in motor nerve conduction velocity. Treatment with insulin for 4 d showed a normalization of sciatic nerve LPL activity. These results show that STZ-induced diabetes causes a decrease in LPL activity in the sciatic nerve that, as in other tissues, is reversible with insulin treatment. These data may suggest a role for LPL in the pathophysiology of diabetic neuropathy.

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  • Diabetes status can affect LPL activity in the nervous system, as shown by STZ treatment inhibiting LPL activity in the sciatic nerve and insulin restoring it.

    “The notion that diabetes status can affect LPL activity in the nervous system is supported by Ferreira and colleagues, who showed that STZ treatment inhibits LPL activity in the sciatic nerve, and this could be restored by insulin treatment [36].”

    From Differential effects of angiopoietin-like 4 in brain and muscle on regulation of lipoprotein lipase activity (2015) · cites this paper as [36]

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Metadata

Authors
Ferreira, L. D. M. C.-B., Huey, P. U., Pulford, B. E., Ishii, D. N., & Eckel, R. H.
Affiliations
  • University of Colorado Health Sciences Center (L.D.M.C.-B.F., P.U.H., R.H.E.), Denver, Colorado 80262
  • Colorado State University (B.E.P., D.N.I.), Denver, Colorado 80262
Venue
Endocrinology
Publisher
The Endocrine Society
Published
2002-04-01
Volume
143
Issue
4
Pages
1213-1217
ISSN
  • 0013-7227
  • 1945-7170
DOI
10.1210/endo.143.4.8723
Cited by
8
References
1
Language
en

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