The DOI matches its Crossref record; 634 of the 638 references it cites were found in a registry or an index.
Praegnatio Perturbatio—Impact of Endocrine-Disrupting Chemicals
Open accessAbstract
The burden of adverse pregnancy outcomes such as preterm birth and low birth weight is considerable across the world. Several risk factors for adverse pregnancy outcomes have been identified. One risk factor for adverse pregnancy outcomes receiving considerable attention in recent years is gestational exposure to endocrine-disrupting chemicals (EDCs). Humans are exposed to a multitude of environmental chemicals with known endocrine-disrupting properties, and evidence suggests exposure to these EDCs have the potential to disrupt the maternal-fetal environment culminating in adverse pregnancy and birth outcomes. This review addresses the impact of maternal and fetal exposure to environmental EDCs of natural and man-made chemicals in disrupting the maternal-fetal milieu in human leading to adverse pregnancy and birth outcomes—a risk factor for adult-onset noncommunicable diseases, the role lifestyle and environmental factors play in mitigating or amplifying the effects of EDCs, the underlying mechanisms and mediators involved, and the research directions on which to focus future investigations to help alleviate the adverse effects of EDC exposure.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The most consistent evidence base relates to ambient air pollution, persistent pollutants such as per- and polyfluoroalkyl substances (PFAS), and selected endocrine-disrupting chemicals (EDCs), with diet and built-environment features functioning as modifiers and correlated determinants of risk across the life course [75,76,77].”
From Placental Pathophysiology and Developmental Programming of Adult Cardiometabolic Risk: A Narrative Review of Pregnancy Exposures (2026) · cites this paper as [75]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Baron, R. M., & Kenny, D. A. (1986) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.51.6.1173 · Cited by 91,532
Structure, function and diversity of the healthy human microbiome
The Human Microbiome Project Consortium (2012) · Nature · doi:10.1038/nature11234 · Cited by 11,726
Jenuwein, T., & Allis, C. D. (2001) · Science · doi:10.1126/science.1063127 · Cited by 9,756
Chen, X., Xiu, M., Xing, J., Yu, S., Min, D., & Guo, F. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479439 · Cited by 5,760
Buck, R. C., Franklin, J., Berger, U., Conder, J. M., Cousins, I. T., de Voogt, P., Jensen, A. A., Kannan, K., Mabury, S. A., & van Leeuwen, S. P. (2011) · Integrated Environmental Assessment and Management · doi:10.1002/ieam.258 · Cited by 4,641
Endocrine-Disrupting Chemicals: An Endocrine Society Scientific Statement
Diamanti-Kandarakis, E., Bourguignon, J.-P., Giudice, L. C., Hauser, R., Prins, G. S., Soto, A. M., Zoeller, R. T., & Gore, A. C. (2009) · Endocrine Reviews · doi:10.1210/er.2009-0002 · Cited by 4,585
Williams Textbook of Endocrinology
Melmed, S., & Polonsky, K. S. (2016) · Elsevier eBooks · doi:10.1016/c2013-0-15980-6 · Cited by 3,715
Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses
Vandenberg, L. N., Colborn, T., Hayes, T. B., Heindel, J. J., Jacobs, D. R., Lee, D.-H., Shioda, T., Soto, A. M., vom Saal, F. S., Welshons, W. V., et al. (2012) · Endocrine Reviews · doi:10.1210/er.2011-1050 · Cited by 3,209
DNA methylation: roles in mammalian development
Smith, Z. D., & Meissner, A. (2013) · Nature Reviews Genetics · doi:10.1038/nrg3354 · Cited by 3,045
Beyond diathesis stress: differential susceptibility to environmental influences
Belsky, J., & Pluess, M. (2009) · Psychological Bulletin · doi:10.1037/a0017376 · Cited by 3,039
Research works printed but not linked: 7
- United States Environmental Protection Agency, 2015, Endocrine Disruption.
- Harris, 2001, The endocrine disrupting potential of phthalates, 169
- Heindel, 2017, Metabolism disrupting chemicals and metabolic disorders, Reprod Toxicol., 68, 3, 10.1016/j.reprotox.2016.10.001 · DOI · Paper page
- Tal, 2000, Endotext
- Gingrich, 2020, The Effects of Endocrine Disrupting Chemicals on Placental Development and Function
- Gonzalez-Bulnes, Polyphenols: Mechanisms of Action in Human Health and Disease. 2nd ed., 249
- National Academies of Sciences, Engineering, and Medicine, 2019, Leveraging Artificial Intelligence and Machine Learning to Advance Environmental Health Research and Decisions: Proceedings of a Workshop—in Brief.
Cited by
Sorted by citations
Mishra, A., Goel, D., & Shankar, S. (2023) · Environmental Monitoring and Assessment · doi:10.1007/s10661-023-11977-1 · Cited by 81
Thyroid hormone system disrupting chemicals
Köhrle, J., & Frädrich, C. (2021) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2021.101562 · Cited by 72
Endocrine Disruptors and Thyroid Health
Pearce, E. N. (2023) · Endocrine Practice · doi:10.1016/j.eprac.2023.11.002 · Cited by 69
Wang, X., Ha, D., Yoshitake, R., Chan, Y. S., Sadava, D., & Chen, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168798 · Cited by 64
Hong, A.-B., Zhuang, L., Cui, W., Lu, Q., Yang, P., Su, S., Wang, B., Zhang, G., & Chen, D. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.156323 · Cited by 55
Metadata
- Authors
- Padmanabhan, V., Song, W., & Puttabyatappa, M.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Padmanabhan, Vasantha
- Song, Wenhui
- Venue
- Endocrine Reviews
- Publisher
- The Endocrine Society
- Published
- 2021-01-03
- Volume
- 42
- Issue
- 3
- Pages
- 295-353
- ISSN
- 0163-769X (ISSN-L)
- 1945-7189
- PMC
- PMC8152448
- OpenAlex
- W3120509918
- Cited by
- 103
- References
- 638
- Citations by year
- 2026: 17 · 2025: 24 · 2024: 19 · 2023: 29 · 2022: 10 · 2021: 4
- FWCI
- 1.50
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Endocrine Reviews (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Environmental Health Sciences (R01 ES 030374, UG3OD02325, UH3OD023)
- Children’s Environmental Health and Disease Prevention Center (P01 ES022844, RD 83543601)
- NIEHS Core Center (P30 ES017885)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Keywords
- endocrine disruptors, adverse pregnancy outcomes, preterm birth, low birth weight, prenatal exposure, non-communicable diseases, lifestyle factors, environmental chemicals
- MeSH terms
- Adult, Female, Humans, Infant, Newborn, Pregnancy, Maternal Exposure, Premature Birth, Endocrine Disruptors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
