Cited by 103Effects and risks of endocrine disrupting chemicalsBirth, Development, and HealthToxic Organic Pollutants Impact

The DOI matches its Crossref record; 634 of the 638 references it cites were found in a registry or an index.

Praegnatio Perturbatio—Impact of Endocrine-Disrupting Chemicals

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Abstract

The burden of adverse pregnancy outcomes such as preterm birth and low birth weight is considerable across the world. Several risk factors for adverse pregnancy outcomes have been identified. One risk factor for adverse pregnancy outcomes receiving considerable attention in recent years is gestational exposure to endocrine-disrupting chemicals (EDCs). Humans are exposed to a multitude of environmental chemicals with known endocrine-disrupting properties, and evidence suggests exposure to these EDCs have the potential to disrupt the maternal-fetal environment culminating in adverse pregnancy and birth outcomes. This review addresses the impact of maternal and fetal exposure to environmental EDCs of natural and man-made chemicals in disrupting the maternal-fetal milieu in human leading to adverse pregnancy and birth outcomes—a risk factor for adult-onset noncommunicable diseases, the role lifestyle and environmental factors play in mitigating or amplifying the effects of EDCs, the underlying mechanisms and mediators involved, and the research directions on which to focus future investigations to help alleviate the adverse effects of EDC exposure.

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Cites

Research works printed but not linked: 7

  1. United States Environmental Protection Agency, 2015, Endocrine Disruption.
  2. Harris, 2001, The endocrine disrupting potential of phthalates, 169
  3. Heindel, 2017, Metabolism disrupting chemicals and metabolic disorders, Reprod Toxicol., 68, 3, 10.1016/j.reprotox.2016.10.001 · DOI · Paper page
  4. Tal, 2000, Endotext
  5. Gingrich, 2020, The Effects of Endocrine Disrupting Chemicals on Placental Development and Function
  6. Gonzalez-Bulnes, Polyphenols: Mechanisms of Action in Human Health and Disease. 2nd ed., 249
  7. National Academies of Sciences, Engineering, and Medicine, 2019, Leveraging Artificial Intelligence and Machine Learning to Advance Environmental Health Research and Decisions: Proceedings of a Workshop—in Brief.

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Metadata

Authors
Padmanabhan, V., Song, W., & Puttabyatappa, M.
Affiliations
University of Michigan (US)
Corresponding author
  • Padmanabhan, Vasantha
  • Song, Wenhui
Venue
Endocrine Reviews
Published
2021-01-03
Volume
42
Issue
3
Pages
295-353
ISSN
  • 0163-769X (ISSN-L)
  • 1945-7189
OpenAlex
W3120509918
Cited by
103
References
638
Citations by year
2026: 17 · 2025: 24 · 2024: 19 · 2023: 29 · 2022: 10 · 2021: 4
FWCI
1.50
Type
journal article
Language
en
Open access
Locations
  • Endocrine Reviews (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • National Institute of Environmental Health Sciences (R01 ES 030374, UG3OD02325, UH3OD023)
  • Children’s Environmental Health and Disease Prevention Center (P01 ES022844, RD 83543601)
  • NIEHS Core Center (P30 ES017885)
Topics
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
Keywords
endocrine disruptors, adverse pregnancy outcomes, preterm birth, low birth weight, prenatal exposure, non-communicable diseases, lifestyle factors, environmental chemicals
MeSH terms
Adult, Female, Humans, Infant, Newborn, Pregnancy, Maternal Exposure, Premature Birth, Endocrine Disruptors

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