The DOI matches its Crossref record; 213 of the 213 references it cites were found in a registry or an index.
Relaxin’s Physiological Roles and Other Diverse Actions
Abstract
Relaxin has vital physiological roles in pregnant rats, mice, and pigs. Relaxin promotes growth and softening of the cervix, thus facilitating rapid delivery of live young. Relaxin also promotes development of the mammary apparatus, thus enabling normal lactational performance. The actions of relaxin on the mammary apparatus vary among species. Whereas relaxin is required for development of the mammary nipples in rats and mice, it is essential for prepartum development of glandular parenchyma in pregnant pigs. During pregnancy relaxin also inhibits uterine contractility and promotes the osmoregulatory changes of pregnancy in rats. Recent studies with male and nonpregnant female rodents revealed diverse therapeutic actions of relaxin on nonreproductive tissues that have clinical implications. Relaxin has been reported to reduce fibrosis in the kidney, heart, lung, and liver and to promote wound healing. Also, probably through its vasodilatory actions, relaxin protects the heart from ischemia-induced injury. Finally, relaxin counteracts allergic reactions. Knowledge of the diverse physiological and therapeutic actions of relaxin, coupled with the recent identification of relaxin receptors, opens numerous avenues of investigation that will likely sustain a high level of research interest in relaxin for the foreseeable future.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Serial study of factors influencing changes in cardiac output during human pregnancy
Robson, S. C., Hunter, S., Boys, R. J., & Dunlop, W. (1989) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1989.256.4.h1060 · Cited by 839
Activation of Orphan Receptors by the Hormone Relaxin
Hsu, S. Y., Nakabayashi, K., Nishi, S., Kumagai, J., Kudo, M., Sherwood, O. D., & Hsueh, A. J. W. (2002) · Science · doi:10.1126/science.1065654 · Cited by 786
Self-citationCryptorchidism in mice mutant for Insl3
Nef, S., & Parada, L. F. (1999) · Nature Genetics · doi:10.1038/10364 · Cited by 738
Targeted Disruption of the Insl3 Gene Causes Bilateral Cryptorchidism
Zimmermann, S., Steding, G., Emmen, J. M. A., Brinkmann, A. O., Nayernia, K., Holstein, A. F., Engel, W., & Adham, I. M. (1999) · Molecular Endocrinology · doi:10.1210/me.13.5.681 · Cited by 714
Plasma estrone, estradiol, estriol, progesterone, and 17-hydroxyprogesterone in human pregnancy
Tulchinsky, D., Hobel, C. J., Yeager, E., & Marshall, J. R. (1972) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(72)90185-8 · Cited by 564 · cited 1×
“: Am J Obstet Gynecol 112:1095–1100, 1972 (91)].”
INSL3/Leydig Insulin-like Peptide Activates the LGR8 Receptor Important in Testis Descent
Kumagai, J., Hsu, S. Y., Matsumi, H., Roh, J.-S., Fu, P., Wade, J. D., Bathgate, R. A. D., & Hsueh, A. J. W. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c200398200 · Cited by 407
Experimental relaxation of the pubic ligament of the guinea pig.
Hisaw, F. L. (1926) · Experimental Biology and Medicine · doi:10.3181/00379727-23-3107 · Cited by 407
Anatomical and Functional Aspects of Testicular Descent and Cryptorchidism*
Hutson, J. M., Hasthorpe, S., & Heyns, C. F. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.2.0298 · Cited by 400
Human Relaxin Gene 3 (H3) and the Equivalent Mouse Relaxin (M3) Gene
Bathgate, R. A. D., Samuel, C. S., Burazin, T. C. D., Layfield, S., Claasz, A. A., Reytomas, I. G. T., Dawson, N. F., Zhao, C., Bond, C., Summers, R. J., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m107882200 · Cited by 378
Hsueh, A. J. W., 工藤, 正., Chen, T., Nakabayashi, K., Bhalla, A., van der Spek, P. J., van Duin, M., & Hsueh, A. J. W. (2000) · Molecular Endocrinology · doi:10.1210/me.14.8.1257 · Cited by 358
Cited by
Tan, Y., Zhang, Z., Zheng, C., Wintergerst, K. A., Keller, B. B., & Cai, L. (2020) · Nature Reviews Cardiology · doi:10.1038/s41569-020-0339-2 · Cited by 835
Relaxin family peptides and their receptors
Bathgate, R. A. D., Halls, M. L., van der Westhuizen, E. T., Callander, G. E., Kocan, M., & Summers, R. J. (2013) · Physiological Reviews · doi:10.1152/physrev.00001.2012 · Cited by 534
Cardiovascular effects of relaxin: from basic science to clinical therapy
Du, X.-J., Bathgate, R. A. D., Samuel, C. S., Dart, A. M., & Summers, R. J. (2010) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2009.198 · Cited by 188
Endocrinology of human parturition
Vannuccini, S., Bocchi, C., Severi, F. M., Challis, J. R., & Petraglia, F. (2016) · Annales d'Endocrinologie · doi:10.1016/j.ando.2016.04.025 · Cited by 173
Mercado-Evans, V., Mejia, M. E., Zulk, J. J., Ottinger, S., Hameed, Z. A., Serchejian, C., Marunde, M. G., Robertson, C. M., Ballard, M. B., Ruano, S. H., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-45336-6 · Cited by 40
Metadata
- Authors
- Sherwood, O. D.
- Venue
- Endocrine Reviews
- Publisher
- The Endocrine Society
- Published
- 2004-04-01
- Volume
- 25
- Issue
- 2
- Pages
- 205-234
- ISSN
- 0163-769X (ISSN-L)
- 1945-7189
- OpenAlex
- W2117607600
- Cited by
- 543
- References
- 213
- FWCI
- 35.11
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Relaxin’s Physiological Roles and Other Diverse Actions. https://app.cochat.ai/papers/10.1210/er.2003-0013
- The paper
- Sherwood, O. D. (2004). Relaxin’s Physiological Roles and Other Diverse Actions. Endocrine Reviews. https://doi.org/10.1210/er.2003-0013
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
