The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Oxidative Stress in the Pathogenesis of Diabetic Neuropathy
Abstract
Oxidative stress results from a cell or tissue failing to detoxify the free radicals that are produced during metabolic activity. Diabetes is characterized by chronic hyperglycemia that produces dysregulation of cellular metabolism. This review explores the concept that diabetes overloads glucose metabolic pathways, resulting in excess free radical production and oxidative stress. Evidence is presented to support the idea that both chronic and acute hyperglycemia cause oxidative stress in the peripheral nervous system that can promote the development of diabetic neuropathy. Proteins that are damaged by oxidative stress have decreased biological activity leading to loss of energy metabolism, cell signaling, transport, and, ultimately, to cell death. Examination of the data from animal and cell culture models of diabetes, as well as clinical trials of antioxidants, strongly implicates hyperglycemia-induced oxidative stress in diabetic neuropathy. We conclude that striving for superior antioxidative therapies remains essential for the prevention of neuropathy in diabetic patients.
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Cites
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Feldman, E. L., Callaghan, B. C., Pop-Busui, R., Zochodne, D. W., Wright, D. E., Bennett, D. L., Bril, V., Russell, J. W., & Viswanathan, V. (2019) · Nature Reviews Disease Primers · doi:10.1038/s41572-019-0092-1 · Cited by 1,697
Self-citationPathogenesis, diagnosis and clinical management of diabetic sensorimotor peripheral neuropathy
Sloan, G., Selvarajah, D., & Tesfaye, S. (2021) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00496-z · Cited by 534
How does diabetes accelerate Alzheimer disease pathology?
Sims-Robinson, C., Kim, B., Rosko, A., & Feldman, E. L. (2010) · Nature Reviews Neurology · doi:10.1038/nrneurol.2010.130 · Cited by 492
Self-citationMolecular mechanism of diabetic neuropathy and its pharmacotherapeutic targets
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Metadata
- Authors
- Vincent, A. M., Russell, J. W., Low, P., & Feldman, E. L.
- Venue
- Endocrine Reviews
- Publisher
- The Endocrine Society
- Published
- 2004-08-01
- Volume
- 25
- Issue
- 4
- Pages
- 612-628
- ISSN
- 0163-769X (ISSN-L)
- 1945-7189
- OpenAlex
- W2025958954
- Cited by
- 982
- References
- 9
- FWCI
- 12.16
- Type
- journal article
- Language
- en
- Open access
- closed
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