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Cited by 714Bone Metabolism and DiseasesTGF-β signaling in diseasesBone health and osteoporosis research

The DOI matches its Crossref record; 407 of the 408 references it cites were found in a registry or an index.

Transforming Growth Factor-β1 to the Bone

Janssens, Katrien, ten Dijke, Peter, Janssens, Sophie, Van Hul, Wim·2005·Endocrine Reviews
DOI 10.1210/er.2004-0001
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Abstract

TGF-β1 is a ubiquitous growth factor that is implicated in the control of proliferation, migration, differentiation, and survival of many different cell types. It influences such diverse processes as embryogenesis, angiogenesis, inflammation, and wound healing. In skeletal tissue, TGF-β1 plays a major role in development and maintenance, affecting both cartilage and bone metabolism, the latter being the subject of this review. Because it affects both cells of the osteoblast and osteoclast lineage, TGF-β1 is one of the most important factors in the bone environment, helping to retain the balance between the dynamic processes of bone resorption and bone formation. Many seemingly contradictory reports have been published on the exact functioning of TGF-β1 in the bone milieu. This review provides an overall picture of the bone-specific actions of TGF-β1 and reconciles experimental discrepancies that have been reported for this multifunctional cytokine.

Overview

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Crossref · 10.1210/er.2004-0001

Cites

407 of 407 references verified0 citation errors · 0 not checkable

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Citations

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1 of the 408 references couldn’t be matched to a known paper.

Research works printed but not linked: 6

  1. Mumm, 2001, Camurati-Engelmann disease: new mutations in the latency-associated peptide of the transforming growth factor β-1 gene, J Bone Miner Res, 16, S223
  2. Wells, 2001, Polymorphisms in the transforming growth factor-1 and bone mass and bone loss, Bone, 28, S131
  3. Prince, 2002, Effect of the TGF-β T869C and the CYP119 TTTA repeat polymorphisms on bone mineral density and prevalent fracture in elderly women, J Bone Miner Res, 17, S422
  4. Kim, 2000, T/C polymorphism of the TGF-β1 gene is not associated with quantitative ultrasound values of calcaneus in Korean postmenopausal women in Chung-Up district, J Bone Miner Res, 15, S362
  5. Hong, 2003, Lack of association of transforming growth factor β 1 T29→C gene polymorphism with calcaneal quantitative ultrasound parameters and plasma TGF-β1 levels in postmenopausal Korean women., Calcif Tissue Int, 72, S418
  6. Mundy, 1991, The effects of TGF-β on bone., Ciba Found Symp, 157, 137

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Metadata

Authors
Janssens, K., ten Dijke, P., Janssens, S., & Van Hul, W.
Affiliations
  • University of Antwerp (BE)
  • Department of Molecular Cell Biology (P.t.D.), Leids Universitair Medisch Centrum, 2333 AL Leiden, The Netherlands;
  • University of Lausanne (CH)
  • Department of Medical Genetics (K.J., W.V.H.), University of Antwerp, 2610 Antwerp, Belgium;
ORCID
Venue
Endocrine Reviews
Publisher
The Endocrine Society
Published
2005-10-01
Volume
26
Issue
6
Pages
743-774
ISSN
  • 0163-769X (ISSN-L)
  • 1945-7189
DOI
10.1210/er.2004-0001
OpenAlex
W2144206769
Cited by
710
References
408
Citations by year
2026: 12 · 2025: 26 · 2024: 24 · 2023: 35 · 2022: 30 · 2021: 30 · 2020: 27 · 2019: 22 · 2018: 23 · 2017: 34 · 2016: 37 · 2015: 26 · 2014: 46 · 2013: 57 · 2012: 47
FWCI
2.60
Type
journal article
Language
en
Open access
closed
Locations
  • Endocrine Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • Ghent University Academic Bibliography (Ghent University) (submittedVersion)
Funders
  • Fonds Wetenschappelijk Onderzoek
  • Universiteit Antwerpen
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Keywords
TGF-β1, bone metabolism, osteoblasts, osteoclasts, bone remodeling, bone resorption, bone formation, cartilage, skeletal development, cytokine signaling
MeSH terms
Animals, Bone and Bones, Bone Development, Bone Resorption, Cells, Cultured, Humans, Osteoblasts, Osteoclasts, Phenotype, Stem Cells, Signal Transduction, Transforming Growth Factor beta, Protein Isoforms, Transforming Growth Factor beta1

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