Cited by 714Bone Metabolism and DiseasesTGF-β signaling in diseasesBone health and osteoporosis research

The DOI matches its Crossref record; 407 of the 408 references it cites were found in a registry or an index.

Transforming Growth Factor-β1 to the Bone

Janssens, Katrien, ten Dijke, Peter, Janssens, Sophie, Van Hul, Wim·2005·Endocrine Reviews

DOI 10.1210/er.2004-0001

Open this paper in CoChat — free account

Abstract

TGF-β1 is a ubiquitous growth factor that is implicated in the control of proliferation, migration, differentiation, and survival of many different cell types. It influences such diverse processes as embryogenesis, angiogenesis, inflammation, and wound healing. In skeletal tissue, TGF-β1 plays a major role in development and maintenance, affecting both cartilage and bone metabolism, the latter being the subject of this review. Because it affects both cells of the osteoblast and osteoclast lineage, TGF-β1 is one of the most important factors in the bone environment, helping to retain the balance between the dynamic processes of bone resorption and bone formation. Many seemingly contradictory reports have been published on the exact functioning of TGF-β1 in the bone milieu. This review provides an overall picture of the bone-specific actions of TGF-β1 and reconciles experimental discrepancies that have been reported for this multifunctional cytokine.

Integrity signals

Registry

Crossref · 10.1210/er.2004-0001

Cites

407 of 407 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

TGF-β SIGNAL TRANSDUCTION
Massagué, J. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.753 · Cited by 7,571
Osteoclast differentiation and activation
Boyle, W. J., Simonet, W. S., & Lacey, D. L. (2003) · Nature · doi:10.1038/nature01658 · Cited by 6,670 · cited 15×
“Runx2 binding sites are found in the promoters of several bone formation markers including collagen 1, ALP, osteopontin, RANKL, and osteocalcin (149).”
BackgroundInfluential
Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus
Shi, Y., & Massagué, J. (2003) · Cell · doi:10.1016/s0092-8674(03)00432-x · Cited by 5,860
Smad-dependent and Smad-independent pathways in TGF-β family signalling
Derynck, R., & Zhang, Y. E. (2003) · Nature · doi:10.1038/nature02006 · Cited by 5,498
Mitogen-Activated Protein Kinase Pathways Mediated by ERK, JNK, and p38 Protein Kinases
Johnson, G. L., & Lapadat, R. (2002) · Science · doi:10.1126/science.1072682 · Cited by 4,295
Osf2/Cbfa1: A Transcriptional Activator of Osteoblast Differentiation
Ducy, P., Zhang, R., Geoffroy, V., Ridall, A. L., & Karsenty, G. (1997) · Cell · doi:10.1016/s0092-8674(00)80257-3 · Cited by 4,246
Bone Resorption by Osteoclasts
Teitelbaum, S. L. (2000) · Science · doi:10.1126/science.289.5484.1504 · Cited by 3,962
The Novel Zinc Finger-Containing Transcription Factor Osterix Is Required for Osteoblast Differentiation and Bone Formation
Nakashima, K., Zhou, X., Kunkel, G., Zhang, Z., Deng, J. M., Behringer, R. R., & de Crombrugghe, B. (2002) · Cell · doi:10.1016/s0092-8674(01)00622-5 · Cited by 3,608
The Transforming Growth Factor-Beta Family
Massagué, J. (1990) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.06.110190.003121 · Cited by 3,041
Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease
Shull, M. M., Ormsby, I., Kier, A. B., Pawlowski, S., Diebold, R. J., Yin, M., Allen, R., Sidman, C., Proetzel, G., Calvin, D., et al. (1992) · Nature · doi:10.1038/359693a0 · Cited by 2,985

Flagged first, then by citations

Show all 408 references

1 of the 408 references couldn’t be matched to a known paper.

Research works printed but not linked: 6

Mumm, 2001, Camurati-Engelmann disease: new mutations in the latency-associated peptide of the transforming growth factor β-1 gene, J Bone Miner Res, 16, S223
Wells, 2001, Polymorphisms in the transforming growth factor-1 and bone mass and bone loss, Bone, 28, S131
Prince, 2002, Effect of the TGF-β T869C and the CYP119 TTTA repeat polymorphisms on bone mineral density and prevalent fracture in elderly women, J Bone Miner Res, 17, S422
Kim, 2000, T/C polymorphism of the TGF-β1 gene is not associated with quantitative ultrasound values of calcaneus in Korean postmenopausal women in Chung-Up district, J Bone Miner Res, 15, S362
Hong, 2003, Lack of association of transforming growth factor β 1 T29→C gene polymorphism with calcaneal quantitative ultrasound parameters and plasma TGF-β1 levels in postmenopausal Korean women., Calcif Tissue Int, 72, S418
Mundy, 1991, The effects of TGF-β on bone., Ciba Found Symp, 157, 137

Sorted by citations

TGF-β1–induced migration of bone mesenchymal stem cells couples bone resorption with formation
Tang, Y., Wu, X., Lei, W., Pang, L., Wan, C., Shi, Z., Zhao, L., Nagy, T. R., Peng, X., Hu, J., et al. (2009) · Nature Medicine · doi:10.1038/nm.1979 · Cited by 1,165
Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia
Raaijmakers, M. H. G. P., Mukherjee, S., Guo, S., Zhang, S., Kobayashi, T., Schoonmaker, J. A., Ebert, B. L., Al-Shahrour, F., Hasserjian, R. P., Scadden, E. O., et al. (2010) · Nature · doi:10.1038/nature08851 · Cited by 1,115
Exerkines in health, resilience and disease
Chow, L. S., Gerszten, R. E., Taylor, J. M., Pedersen, B. K., van Praag, H., Trappe, S., Febbraio, M. A., Galis, Z. S., Gao, Y., Haus, J. M., et al. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-022-00641-2 · Cited by 927
Role of transforming growth factor-β superfamily signaling pathways in human disease
Gordon, K. J., & Blobe, G. C. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2008.01.006 · Cited by 664
The Osteosarcoma Microenvironment: A Complex but Targetable Ecosystem
Corre, I., Verrecchia, F., Crenn, V., Rédiní, F., & Trichet, V. (2020) · Cells · doi:10.3390/cells9040976 · Cited by 494
The roles and regulatory mechanisms of TGF-β and BMP signaling in bone and cartilage development, homeostasis and disease
Wu, M., Wu, S., Chen, W., & Li, Y.-P. (2024) · Cell Research · doi:10.1038/s41422-023-00918-9 · Cited by 445
Molecular Biology of Bone Metastasis
Kingsley, L. A., Fournier, P. G. J., Chirgwin, J. M., & Guise, T. A. (2007) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-07-0234 · Cited by 456
Calcium/calmodulin signaling controls osteoblast growth and differentiation
Zayzafoon, M. (2005) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20675 · Cited by 438
“TGF-b1 is a growth factor implicated in the control of proliferation, migration, differentiation, and survival of many cells, including osteoblasts [Janssens et al., 2005].”
Background
Transforming growth factor‐β in stem cells and tissue homeostasis
Xu, X., Zheng, L., Yuan, Q., Zhen, G., Crane, J. L., Zhou, X., & Cao, X. (2018) · Bone Research · doi:10.1038/s41413-017-0005-4 · Cited by 414
Dimorphic effects of Notch signaling in bone homeostasis
Engin, F., Yao, Z., Yang, T., Zhou, G. D., Bertin, T., Jiang, M. M., Chen, Y., Wang, L. E., Zheng, H., Sutton, R. E., et al. (2008) · Nature Medicine · doi:10.1038/nm1712 · Cited by 425
“Activating mutations in transforming growth factor-β in humans is associated with increased bone formation and inhibition of bone resorptio”
Background
The dynamic roles of TGF‐β in cancer
Meulmeester, E., & ten Dijke, P. (2010) · The Journal of Pathology · doi:10.1002/path.2785 · Cited by 399
Cytokine expression pattern in compression and tension sides of the periodontal ligament during orthodontic tooth movement in humans
Garlet, T. P., Coelho, U., Silva, J. S., & Garlet, G. P. (2007) · European Journal Of Oral Sciences · doi:10.1111/j.1600-0722.2007.00469.x · Cited by 340
Paracrine Effect of Mesenchymal Stem Cells Derived from Human Adipose Tissue in Bone Regeneration
Linero, I., & Chaparro, O. (2014) · PLoS ONE · doi:10.1371/journal.pone.0107001 · Cited by 333
TGFβ2-Induced Changes in Human Trabecular Meshwork: Implications for Intraocular Pressure
Fleenor, D. L., Shepard, A. R., Hellberg, P. E., Jacobson, N., Pang, I.-H., & Clark, A. F. (2005) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.05-1060 · Cited by 322
Excessive transforming growth factor-β signaling is a common mechanism in osteogenesis imperfecta
Grafe, I., Yang, T., Alexander, S., Homan, E. P., Lietman, C., Jiang, M. M., Bertin, T., Munivez, E. M., Chen, Y., Dawson, B., et al. (2014) · Nature Medicine · doi:10.1038/nm.3544 · Cited by 307
Model structure and control of bone remodeling: A theoretical study
Pivonka, P., Zimak, J., Smith, D. W., Gardiner, B. S., Dunstan, C. R., Sims, N. A., Martin, T. J., & Mundy, G. R. (2008) · Bone · doi:10.1016/j.bone.2008.03.025 · Cited by 303
Local communication on and within bone controls bone remodeling
Henriksen, K., Neutzsky-Wulff, A. V., Bonewald, L. F., & Karsdal, M. A. (2009) · Bone · doi:10.1016/j.bone.2009.03.671 · Cited by 292
TGF-β Family Signaling in Mesenchymal DifferentiationPreprint
Grafe, I., Alexander, S., Peterson, J. R., Snider, T. N., Lévi, B., Lee, B., & Mishina, Y. M. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a022202 · Cited by 278
Elucidating the Secretion Proteome of Human Embryonic Stem Cell-derived Mesenchymal Stem Cells
Sze, S. K., de Kleijn, D. P. V., Lai, R. C., Tan, E. K. W., Zhao, H., Yeo, K. S., Low, T. Y., Lian, Q., Lee, C. N., Mitchell, W., et al. (2007) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m600393-mcp200 · Cited by 266
“For example, Jak-STAT signaling is associated with cardioprotection (35), hematopoiesis (36, 37), and skeletal repair and remodeling (38, 39); MAPK signaling plays a crucial role in many aspects of cardiovascular responses (40, 41), skeletal repair and remodeling (39, 42), and hematopoiesis (43); Toll-like receptor si…”
Background
The Role of Inflammatory Cytokines, the RANKL/OPG Axis, and the Immunoskeletal Interface in Physiological Bone Turnover and Osteoporosis
Weitzmann, M. N. (2013) · Scientifica · doi:10.1155/2013/125705 · Cited by 264
“…[86] and to blunt osteoclastic bone resorption and ameliorate bone loss induced by ovariectomy in mice [90], multiple myeloma induced osteoclast formation and activity in vitro [91], implant particle-induced osteoclastogenesis [92], and in a rheumatoid arthritis animal model in vivo [93].”
Background
Bone metastasis in prostate cancer: emerging therapeutic strategies
Sturge, J., Caley, M. P., & Waxman, J. (2011) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2011.67 · Cited by 262
Camurati-Engelmann disease: review of the clinical, radiological, and molecular data of 24 families and implications for diagnosis and treatment
Janssens, K., Vanhoenacker, F. M. H. M., Bonduelle, M., Verbruggen, L., Maldergem, L. V., Ralston, S. H., Guañabens, N., Migone, N., Wientroub, S., Divizia, M. T., et al. (2005) · Journal of Medical Genetics · doi:10.1136/jmg.2005.033522 · Cited by 244
Self-citation
The Effect of Inflammation on Bone
Epsley, S., Tadros, S., Farid, A., Kargilis, D., Mehta, S., & Rajapakse, C. S. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2020.511799 · Cited by 252
“Thus, the process of resorption and formation is closely coupled to maintain bone homeostasis (Janssens et al., 2005).”
Background
Osteoblasts in osteoporosis: Past, emerging, and future anabolic targets
Marie, P. J., & Kassem, M. (2011) · European Journal of Endocrinology · doi:10.1530/eje-11-0132 · Cited by 234
Effects of growth factors and cytokines on osteoblast differentiation
Hughes, F. J., Turner, W., Belibasakis, G. N., & Martuscelli, G. (2006) · Periodontology 2000 · doi:10.1111/j.1600-0757.2006.00161.x · Cited by 237
Osteoclast Activity and Subtypes as a Function of Physiology and Pathology—Implications for Future Treatments of Osteoporosis
Henriksen, K., Bollerslev, J., Everts, V. E., & Karsdal, M. A. (2011) · Endocrine Reviews · doi:10.1210/er.2010-0006 · Cited by 236
Accelerated orthodontic tooth movement: Molecular mechanisms
Huang, H., Williams, R. C., & Kyrkanides, S. (2014) · American Journal of Orthodontics and Dentofacial Orthopedics · doi:10.1016/j.ajodo.2014.07.007 · Cited by 239
Zinc stimulates osteoblastogenesis and suppresses osteoclastogenesis by antagonizing NF-κB activation
Yamaguchi, M., & Weitzmann, M. (2011) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-011-0852-z · Cited by 212
“These include transforming growth factor beta (TGFb), a potent early osteoblast commitment factor [ 10 ] and a potent recruiter of bone marrow stromal cells to sites of bone resorption [11].”
Primary cilium-dependent signaling mechanisms
Pala, R., Alomari, N., & Nauli, S. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18112272 · Cited by 205
“Transforming growth factor beta (TGF-β) plays major roles in bone development and maintenance metabolism by regulating cellular proliferation, differentiation, matrix deposition, and cell migration [96,97].”
Osteoimmunology and the influence of pro-inflammatory cytokines on osteoclasts
Zupan, J., Jeras, M., & Marc, J. (2013) · Biochemia Medica · doi:10.11613/bm.2013.007 · Cited by 205
A physiologically based mathematical model of integrated calcium homeostasis and bone remodeling
Peterson, M. C., & Riggs, M. M. (2010) · Bone · doi:10.1016/j.bone.2009.08.053 · Cited by 198
Growth factor delivery for oral and periodontal tissue engineering
Kaigler, D., Cirelli, J. A., & Giannobile, W. V. (2006) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.3.5.647 · Cited by 204
Effects of Bone Matrix Proteins on Fracture and Fragility in Osteoporosis
Sroga, G. E., & Vashishth, D. (2012) · Current Osteoporosis Reports · doi:10.1007/s11914-012-0103-6 · Cited by 192
The multiple facets of periostin in bone metabolism
Merle, B., & Garnero, P. (2012) · Osteoporosis International · doi:10.1007/s00198-011-1892-7 · Cited by 201
Microarray gene expression profiling of osteoarthritic bone suggests altered bone remodelling, WNT and transforming growth factor-β/bone morphogenic protein signalling
Hopwood, B., Tsykin, A., Findlay, D. M., & Fazzalari, N. L. (2007) · Arthritis Research & Therapy · doi:10.1186/ar2301 · Cited by 192
Design of 3D printed scaffolds for bone tissue engineering: A review
Kanwar, S., & Vijayavenkataraman, S. (2021) · Bioprinting · doi:10.1016/j.bprint.2021.e00167 · Cited by 180
Pharmacologic Inhibition of the TGF-β Type I Receptor Kinase Has Anabolic and Anti-Catabolic Effects on Bone
Mohammad, K. S., Chen, C. G., Balooch, G., Stebbins, E. G., McKenna, C. R., Davis, H., Niewolna, M., Peng, X., Nguyen, D. H., Ionova-Martin, S. S., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005275 · Cited by 181
Green tea and bone metabolism
Shen, C., Yeh, J. K., Cao, J., & Wang, J.-S. (2009) · Nutrition Research · doi:10.1016/j.nutres.2009.06.008 · Cited by 181
TGF-β coordinately activates TAK1/MEK/AKT/NFkB and SMAD pathways to promote osteoclast survival
Gingery, A., Bradley, E. W., Pederson, L. G., Ruan, M. M., Horwood, N. J., & Oursler, M. J. (2008) · Experimental Cell Research · doi:10.1016/j.yexcr.2008.06.006 · Cited by 175
The activin A‐follistatin system: potent regulator of human extracellular matrix mineralization
Eijken, M., Swagemakers, S. M. A., Koedam, M., Steenbergen, C., Derkx, P., Uitterlinden, A. G., van der Spek, P. J., Visser, J. A., de Jong, F. H., Pols, H. A. P., et al. (2007) · The FASEB Journal · doi:10.1096/fj.07-8080com · Cited by 175
Targeting pro-inflammatory cytokines following joint injury: acute intra-articular inhibition of interleukin-1 following knee injury prevents post-traumatic arthritis
Furman, B. D., Mangiapani, D., Zeitler, E. M., Bailey, K. N., Horne, P. H., Huebner, J. L., Kraus, V. B., Guilak, F., & Olson, S. A. (2014) · Arthritis Research & Therapy · doi:10.1186/ar4591 · Cited by 171
A Brief Review of Bone Cell Function and Importance
Šromová, V., Sobola, D. S., & Kaspar, P. (2023) · Cells · doi:10.3390/cells12212576 · Cited by 199
“They can be categorized into two main types [68]:”
Background
Human Urothelial Cells Isolation, In Vitro Expansion and Characterization for Evaluating Bio-Engineering Potentials
Muniswami, D. M., Devasia, A., Tharion, G., & Kumar, S. (2018) · doi:10.28967/jscrt.2018.01.18001 · Cited by 169
CD105 Protein Depletion Enhances Human Adipose-derived Stromal Cell Osteogenesis through Reduction of Transforming Growth Factor β1 (TGF-β1) Signaling
Lévi, B., Wan, D. C., Glotzbach, J. P., Hyun, J. S., Januszyk, M., Montoro, D. T., Sorkin, M., James, A. W., Nelson, E. R., Li, S., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.256529 · Cited by 169
Pulsed electromagnetic fields enhance BMP‐2 dependent osteoblastic differentiation of human mesenchymal stem cells
Schwartz, Z., Simon, B. J., Duran, M. A., Barabino, G. A., Chaudhri, R. A., & Boyan, B. D. (2008) · Journal of Orthopaedic Research® · doi:10.1002/jor.20591 · Cited by 166
Control of RANKL gene expression
O’Brien, C. A. (2009) · Bone · doi:10.1016/j.bone.2009.08.050 · Cited by 170
Cytokine-Mediated Bone Destruction in Rheumatoid Arthritis
Jung, S. M., Kim, K., Yang, C. W., Park, S., & Ju, J. H. (2014) · Journal of Immunology Research · doi:10.1155/2014/263625 · Cited by 165
Transforming Growth Factor-β and the Immune Response to Malignant Disease
Teicher, B. A. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-1654 · Cited by 161
TGF-β type II receptor phosphorylates PTH receptor to integrate bone remodelling signalling
Qiu, T., Wu, X., Zhang, F., Clemens, T. L., Wan, M., & Cao, X. (2010) · Nature Cell Biology · doi:10.1038/ncb2022 · Cited by 157
“Therefore, direct phosphorylation of the cytoplasmic domain of PTH1R by TβRII integrates PTH signalling for bone remodelling and TGF-β1 signalling for coupling bone resorption and formatio”
Background
Transforming Growth Factor β1 Induces Osteogenic Differentiation of Murine Bone Marrow Stromal Cells
Zhao, L., Jiang, S., & Hantash, B. M. (2009) · Tissue Engineering Part A · doi:10.1089/ten.tea.2009.0495 · Cited by 149
Transforming Growth Factor: β Signaling Is Essential for Limb Regeneration in Axolotls
Lévesque, M., Gatien, S., Finnson, K. W., Desmeules, S., Villiard, É., Pilote, M., Philip, A., & Roy, S. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001227 · Cited by 152
TGF-β in cancer and bone: Implications for treatment of bone metastases
Juárez, P., & Guise, T. A. (2010) · Bone · doi:10.1016/j.bone.2010.08.004 · Cited by 153
Secretomes from bone marrow–derived mesenchymal stromal cells enhance periodontal tissue regeneration
Kawai, T., Katagiri, W., Osugi, M., Sugimura, Y., Hibi, H., & Ueda, M. (2015) · Cytotherapy · doi:10.1016/j.jcyt.2014.11.009 · Cited by 141
Role of transforming growth factor-β in the progression of heart failure
Lim, H., & Zhu, Y. Z. (2006) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-006-6085-8 · Cited by 136
The role of TGF-β signaling in regulating chondrogenesis and osteogenesis during mandibular development
Oka, K., Oka, S., Sasaki, T., Ito, Y., Bringas, P., Nonaka, K., & Chai, Y. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.11.025 · Cited by 137
“TGF-β IIR is specifically expressed during the condensation, proliferation and differentiation stages of mandible bone development, suggesting that it has a crucial role in regulating osteogenesis (Janssens et al., 2005).”
Background
Effects on Proliferation and Differentiation of Multipotent Bone Marrow Stromal Cells Engineered to Express Growth Factors for Combined Cell and Gene Therapy
Fierro, F. A., Kalomoiris, S., Søndergaard, C. S., & Nolta, J. A. (2011) · Stem Cells · doi:10.1002/stem.720 · Cited by 135
TGF-β Signaling in Bone Remodeling and Osteosarcoma Progression
Lamora, A., Talbot, J., Mullard, M., Royer, B. B.-L., Rédiní, F., & Verrecchia, F. (2016) · Journal of Clinical Medicine · doi:10.3390/jcm5110096 · Cited by 141
Coupling systems biology with multiscale mechanics, for computer simulations of bone remodeling
Scheiner, S., Pivonka, P., & Hellmich, C. (2012) · Computer Methods in Applied Mechanics and Engineering · doi:10.1016/j.cma.2012.10.015 · Cited by 135
Transforming Growth Factor-β Signaling Plays a Pivotal Role in the Interplay Between Osteosarcoma Cells and Their Microenvironment
Verrecchia, F., & Rédiní, F. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00133 · Cited by 135
Lysyl Oxidase Binds Transforming Growth Factor-; and Regulates Its Signaling via Amine Oxidase Activity
Atsawasuwan, P., Mochida, Y., Katafuchi, M., Kaku, M., Fong, K. S. K., Csiszár, K., & Yamauchi, M. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m803142200 · Cited by 128
Rough titanium alloys regulate osteoblast production of angiogenic factors
Olivares‐Navarrete, R., Hyzy, S. L., Gittens, R. A., Schneider, J. M., Haithcock, D. A., Ullrich, P. F., Slosar, P. J., Schwartz, Z., & Boyan, B. D. (2013) · The Spine Journal · doi:10.1016/j.spinee.2013.03.047 · Cited by 127
Influence of the TGF-β Superfamily on Osteoclasts/Osteoblasts Balance in Physiological and Pathological Bone Conditions
Jann, J., Gascon, S., Roux, S., & Faucheux, N. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207597 · Cited by 133
Advances in osteoclast biology resulting from the study of osteopetrotic mutations
Segovia‐Silvestre, T., Neutzsky-Wulff, A. V., Sørensen, M. G., Christiansen, C., Bollerslev, J., Karsdal, M. A., & Henriksen, K. (2008) · Human Genetics · doi:10.1007/s00439-008-0583-8 · Cited by 128
Osteoblastogenesis regulation signals in bone remodeling
Zuo, C., Huang, Y., Bajis, R., Sahih, M., Li, Y., Dai, K., & Zhang, X. (2012) · Osteoporosis International · doi:10.1007/s00198-012-1909-x · Cited by 129
The Mechanosensory Role of Osteocytes and Implications for Bone Health and Disease States
Choi, J. U. A., Kijas, A. W., Lauko, J., & Rowan, A. E. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.770143 · Cited by 138
Growth Factor Interactions in Bone Regeneration
Kempen, D. H. R., Creemers, L. B., Alblas, J., Lu, L., Verbout, A. J., Yaszemski, M. J., & Dhert, W. J. A. (2010) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2010.0176 · Cited by 126
Role of carotenoid beta-cryptoxanthin in bone homeostasis
Yamaguchi, M. (2012) · Journal of Biomedical Science · doi:10.1186/1423-0127-19-36 · Cited by 124
“TGF-b1 has a potent activity on osteoblast-lineage commitment an event that is partly mediated through Smad transcription factors [38].”
Background
TGF‐β regulates β‐catenin signaling and osteoblast differentiation in human mesenchymal stem cells
Zhou, S. (2011) · Journal of Cellular Biochemistry · doi:10.1002/jcb.23079 · Cited by 135
“Many seemingly contradictory data have been reported on the exact functioning of TGF-b1 in the bone milieu [Janssens et al., 2005].”
Background
The pathophysiology of otosclerosis: Review of current research
Rudić, M., Keogh, I. J., Wagner, R. A., Wilkinson, E. P., Kiros, N., Ferrary, É., Sterkers, O., Grayeli, A. B., Žarković, K., & Žarković, N. (2015) · Hearing Research · doi:10.1016/j.heares.2015.07.014 · Cited by 122
Heparin enhances osteoclastic bone resorption by inhibiting osteoprotegerin activity.
Irie, A., Takami, M., Kubo, H., Sekino-Suzuki, N., Kasahara, K., & Sanai, Y. (2007) · Bone · doi:10.1016/j.bone.2007.04.190 · Cited by 116
Role of Osteoglycin in the Linkage between Muscle and Bone
Tanaka, K.-I., Matsumoto, E., Higashimaki, Y., Katagiri, T., Sugimoto, T., Seino, S., & Kaji, H. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.292193 · Cited by 121
“Previous studies suggest that MAP kinases are related to Smad-independent signaling of TGF- (13, 40).”
Background
High cholesterol diet increases osteoporosis risk via inhibiting bone formation in rats
Li, Y., Sheng, Z.-Y., Tang, C.-L., Chen, L., Pan, L., & Chen, J. (2011) · Acta Pharmacologica Sinica · doi:10.1038/aps.2011.135 · Cited by 118
The wonders of BMP9: From mesenchymal stem cell differentiation, angiogenesis, neurogenesis, tumorigenesis, and metabolism to regenerative medicine
Mostafa, S., Pakvasa, M., Coalson, E., Zhu, A. C., Alverdy, A., Castillo, H., Fan, J., Li, A., Feng, Y., Wu, D., et al. (2019) · Genes & Diseases · doi:10.1016/j.gendis.2019.07.003 · Cited by 122
Sulfated hyaluronan and chondroitin sulfate derivatives interact differently with human transforming growth factor-β1 (TGF-β1)
Hintze, V., Miron, A., Moeller, S. J., Schnabelrauch, M., Wiesmann, H., Worch, H., & Scharnweber, D. (2012) · Acta Biomaterialia · doi:10.1016/j.actbio.2012.03.021 · Cited by 116
Gene expression profile of the bone microenvironment in human fragility fracture bone
Hopwood, B., Tsykin, A., Findlay, D. M., & Fazzalari, N. L. (2008) · Bone · doi:10.1016/j.bone.2008.08.120 · Cited by 114
Age-associated callus senescent cells produce TGF-β1 that inhibits fracture healing in aged mice
Liu, J., Zhang, J., Lin, X., Boyce, B. F., Zhang, H., & Xing, L. (2022) · Journal of Clinical Investigation · doi:10.1172/jci148073 · Cited by 112
Novel application of stem cell-derived factors for periodontal regeneration
Inukai, T., Katagiri, W., Yoshimi, R., Osugi, M., Kawai, T., Hibi, H., & Ueda, M. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.11.074 · Cited by 114
Cthrc1 Is a Novel Inhibitor of Transforming Growth Factor-β Signaling and Neointimal Lesion Formation
LeClair, R. J., Durmus, T., Wang, Q., Pyagay, P., Terzic, A., & Lindner, V. (2007) · Circulation Research · doi:10.1161/01.res.0000260806.99307.72 · Cited by 110
Smad4 is required for maintaining normal murine postnatal bone homeostasis
Tan, X., Weng, T., Zhang, J., Jian, W., Li, W., Wan, H., Lan, Y., Cheng, X., Hou, N., Liu, H., et al. (2007) · Journal of Cell Science · doi:10.1242/jcs.03466 · Cited by 108
“Indeed, previous studies have shown that TGF 1 increases the cell population that will differentiate into osteoblasts by inducing chemotaxis and proliferation (Janssens et al., 2005).”
Background
Smad3 Prevents β-Catenin Degradation and Facilitates β-Catenin Nuclear Translocation in Chondrocytes
Zhang, M., Wang, M., Tan, X., Li, T.-F., Zhang, Y. E., & Chen, D. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.093526 · Cited by 105
MiRNA-10b Reciprocally Stimulates Osteogenesis and Inhibits Adipogenesis Partly through the TGF-β/SMAD2 Signaling Pathway
Li, H., Fan, J., Fan, L., Li, T., Yang, Y., Xu, H., Deng, L., Li, J., Li, T., Weng, X., et al. (2018) · Aging and Disease · doi:10.14336/ad.2018.0214 · Cited by 104
Antioxidant and bone repair properties of quercetin-functionalized hydroxyapatite: An in vitro osteoblast–osteoclast–endothelial cell co-culture study
Forte, L., Torricelli, P., Boanini, E., Gazzano, M., Rubini, K., Fini, M., & Bigi, A. (2015) · Acta Biomaterialia · doi:10.1016/j.actbio.2015.12.013 · Cited by 103
Genetic alterations in juvenile nasopharyngeal angiofibromas
Coutinho‐Camillo, C. M., Brentani, M. M., & Nagai, M. A. (2008) · Head & Neck · doi:10.1002/hed.20775 · Cited by 102
Melatonin delivery from PCL scaffold enhances glycosaminoglycans deposition in human chondrocytes – Bioactive scaffold model for cartilage regeneration
Kamath, S. M., Rao, S. K., Jaison, D., Sridhar, K. R., Natarajan, K., Gopinath, V., Sivaperumal, P., & Shantanu Patil, S. (2020) · Process Biochemistry · doi:10.1016/j.procbio.2020.08.015 · Cited by 100
HIV: Inflammation and Bone
Ofotokun, I., McIntosh, E. B., & Weitzmann, M. N. (2011) · Current HIV/AIDS Reports · doi:10.1007/s11904-011-0099-z · Cited by 99
The role of TGF-β in bone metastasis: novel therapeutic perspectives
Buijs, J. T., Stayrook, K. R., & Guise, T. A. (2012) · BoneKEy Reports · doi:10.1038/bonekey.2012.96 · Cited by 99
Inhibition of Insulin-like Growth Factor-1 (IGF-1) Expression by Prolonged Transforming Growth Factor-β1 (TGF-β1) Administration Suppresses Osteoblast Differentiation
Ochiai, H., Okada, S., Saito, A. M., Hoshi, K., Yamashita, H., Takato, T., & Azuma, T. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.279091 · Cited by 97
“It affects osteoblast differentiation and bone formation (10-14) and increases mRNA levels of osteoblast differentiation markers and alkaline phosphatase (ALP) activity in murine bone marrow stromal cells (12).”
Background
TGF-β-related mechanisms of bone destruction in multiple myeloma
Matsumoto, T., & Abe, M. (2010) · Bone · doi:10.1016/j.bone.2010.05.036 · Cited by 96
Post-traumatic osteoarthritis: A review of pathogenic mechanisms and novel targets for mitigation
Dilley, J. E., Bello, M., Natoli, R. M., McKinley, T. O., & Sankar, U. (2023) · Bone Reports · doi:10.1016/j.bonr.2023.101658 · Cited by 111
A mathematical multiscale model of bone remodeling, accounting for pore space-specific mechanosensation
Pastrama, M.-I., Scheiner, S., Pivonka, P., & Hellmich, C. (2017) · Bone · doi:10.1016/j.bone.2017.11.009 · Cited by 94
Transforming growth factor beta 1 induces CXCL16 and leukemia inhibitory factor expression in osteoclasts to modulate migration of osteoblast progenitors
Ota, K., Quint, P. S., Weivoda, M. M., Ruan, M. M., Pederson, L. G., Westendorf, J. J., Khosla, S., & Oursler, M. J. (2013) · Bone · doi:10.1016/j.bone.2013.07.023 · Cited by 92
The secret life of a megakaryocyte: emerging roles in bone marrow homeostasis control
Malara, A., Abbonante, V., Buduo, C. A. D., Tozzi, L., Currao, M., & Balduini, A. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1813-y · Cited by 92
Transforming growth factor‐β, matrix metalloproteinases, and urokinase‐type plasminogen activator interaction in the cancer epithelial to mesenchymal transition
Santibanez, J. F., Obradović, H., Кукољ, Т., & Krstić, J. (2017) · Developmental Dynamics · doi:10.1002/dvdy.24554 · Cited by 95
“The secreted LLC remains covalently associated to the ECM (Annes et al., 2003; Janssens et al., 2005).”
Background
Direct transcriptional targets of sex steroid hormones in bone
Krum, S. A. (2010) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22970 · Cited by 90
“TGF-b1 stimulates osteoblast proliferation of early osteoblastic precursor cells [Janssens et al., 2005], and thus androgens stimulate osteoblast proliferation, at least partly, through up-regulation of TGF-b.”
Background
Biphasic effects of transforming growth factor β on bone morphogenetic protein–induced osteoblast differentiation
de Gorter, D. J. J., van Dinther, M., Korchynskyi, O., & ten Dijke, P. (2010) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.313 · Cited by 89
KLF10 as a Tumor Suppressor Gene and Its TGF-β Signaling
Memon, A., & Lee, W. K. (2018) · Cancers · doi:10.3390/cancers10060161 · Cited by 90
Segmental bone defects: from cellular and molecular pathways to the development of novel biological treatments
Pneumaticos, S. G., Triantafyllopoulos, G. K., Basdra, E. K., & Papavassiliou, A. G. (2010) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2010.01062.x · Cited by 87
“TGF- 1 and TGF- 3 are found in chondrocytes of the proliferative and hypertrophic zone [13].”
Background
Mutations of TGFß signaling molecules in human disease
Harradine, K. A., & Akhurst, R. J. (2006) · Annals of Medicine · doi:10.1080/07853890600919911 · Cited by 87
TGF-β Induces Wnt10b in Osteoclasts From Female Mice to Enhance Coupling to Osteoblasts
Ota, K., Quint, P., Ruan, M., Pederson, L., Westendorf, J. J., Khosla, S., & Oursler, M. J. (2013) · Endocrinology · doi:10.1210/en.2013-1272 · Cited by 86
TGF-β1 Regulates Differentiation of Bone Marrow Mesenchymal Stem Cells
Zhao, L., & Hantash, B. M. (2011) · Vitamins and hormones · doi:10.1016/b978-0-12-386015-6.00042-1 · Cited by 86

Authors: Janssens, K., ten Dijke, P., Janssens, S., & Van Hul, W.
Affiliations: University of Antwerp (BE)
Department of Molecular Cell Biology (P.t.D.), Leids Universitair Medisch Centrum, 2333 AL Leiden, The Netherlands;
University of Lausanne (CH)
Department of Medical Genetics (K.J., W.V.H.), University of Antwerp, 2610 Antwerp, Belgium;
ORCID: Janssens, Katrien
Janssens, Sophie
Venue: Endocrine Reviews
Publisher: The Endocrine Society
Published: 2005-10-01
Volume: 26
Issue: 6
Pages: 743-774
ISSN: 0163-769X (ISSN-L)
1945-7189
DOI: 10.1210/er.2004-0001
OpenAlex: W2144206769
Cited by: 710
References: 408
Citations by year: 2026: 12 · 2025: 26 · 2024: 24 · 2023: 35 · 2022: 30 · 2021: 30 · 2020: 27 · 2019: 22 · 2018: 23 · 2017: 34 · 2016: 37 · 2015: 26 · 2014: 46 · 2013: 57 · 2012: 47
FWCI: 2.60
Type: journal article
Language: en
Open access: closed
Locations: Endocrine Reviews (publishedVersion)
PubMed (publishedVersion)
Ghent University Academic Bibliography (Ghent University) (submittedVersion)
Funders: Fonds Wetenschappelijk Onderzoek
Universiteit Antwerpen
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Keywords: TGF-β1, bone metabolism, osteoblasts, osteoclasts, bone remodeling, bone resorption, bone formation, cartilage, skeletal development, cytokine signaling
MeSH terms: Animals, Bone and Bones, Bone Development, Bone Resorption, Cells, Cultured, Humans, Osteoblasts, Osteoclasts, Phenotype, Stem Cells, Signal Transduction, Transforming Growth Factor beta, Protein Isoforms, Transforming Growth Factor beta1

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Transforming Growth Factor-β1 to the Bone

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks