The DOI matches its Crossref record; 235 of the 235 references it cites were found in a registry or an index.
Endocrine Regulation of HOX Genes
Abstract
Hox genes have a well-characterized role in embryonic development, where they determine identity along the anteroposterior body axis. Hox genes are expressed not only during embryogenesis but also in the adult, where they are necessary for functional differentiation. Despite the known function of these genes as transcription factors, few regulatory mechanisms that drive Hox expression are known. Recently, several hormones and their cognate receptors have been shown to regulate Hox gene expression and thereby mediate development in the embryo as well as functional differentiation in the adult organism. Estradiol, progesterone, testosterone, retinoic acid, and vitamin D have been shown to regulate Hox gene expression. In the embryo, the endocrine system directs axial Hox gene expression; aberrant Hox gene expression due to exposure to endocrine disruptors contributes to the teratogenicity of these compounds. In the adult, endocrine regulation of Hox genes is necessary to enable such diverse functions as hematopoiesis and reproduction; endocrinopathies can result in dysregulated HOX gene expression affecting physiology. By regulating HOX genes, hormonal signals utilize a conserved mechanism that allows generation of structural and functional diversity in both developing and adult tissues. This review discusses endocrine Hox regulation and its impact on physiology and human pathology.
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Self-citation
Metadata
- Authors
- Daftary, G. S., & Taylor, H. S.
- Venue
- Endocrine Reviews
- Publisher
- The Endocrine Society
- Published
- 2006-04-21
- Volume
- 27
- Issue
- 4
- Pages
- 331-355
- ISSN
- 0163-769X (ISSN-L)
- 1945-7189
- OpenAlex
- W2051150230
- Cited by
- 344
- References
- 235
- FWCI
- 7.12
- Type
- journal article
- Language
- en
- Open access
- closed
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