HOXA10 expression is decreased in endometrium of women with adenomyosis
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HOXA10 gene expression is decreased in the secretory phase endometrium of women with adenomyosis. Diminished expression of HOXA10 is a potential mechanism explaining decreased implantation observed in women with adenomyosis.
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The endometrial transcriptome in women with endometriosis may have shared patterns of dysregulation with other inflammatory conditions such as hydrosalpinx or other estrogen dependent diseases such as leiomyomata, endometrial polyps, or adenomyosis.
“The endometrial transcriptome in women with endometriosis may have shared patterns of dysregulation with other inflammatory conditions such as hydrosalpinx [110] or other estrogen dependent diseases such as leiomyomata, endometrial polyps, or adenomyosis [111, 112].”
From Update on biomarkers for the detection of endometriosis (2015) · cites this paper as [112]
Gynecologic conditions other than endometriosis have been shown to influence eutopic endometrial gene and protein expression.
“In addition to menstrual cycle phase, gynecologic conditions other than endometriosis have been shown to influence eutopic endometrial gene and protein expression.”
From Update on biomarkers for the detection of endometriosis (2015) · cites this paper as [112]
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Cites
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“Decreased expression of HOXA10 during the midsecretory phase of themenstrual cycle is seen in other conditions associatedwith impaired implantation, such as PCOS, submucosal uterine leiomyomas, hydrosalphinx, and endometriosis (28, 29, 30, 31, 35).”
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Physiological and molecular determinants of embryo implantation
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“The same mechanisms may affect decidual/trophoblast invasion in women with adenomyosis, who showed increased expression of MMP-2 and MMP-9, E-cadherin, HOXA-10 and leukemia inhibitory factor (Fischer et al., 2011; Benagiano et al., 2012; Galliano et al., 2015; Fig.”
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“…implantation-associated factors, such as HOXA10, LIF, MMP2, IL-6, cytochrome P450 and RCAS1, in the eutopic endometrium in women with adenomyosis leads to reduced endometrial receptivity and impaired decidualization (Campo et al., 2012b; Fischer et al., 2011; Xishi et al., 2010; Zhou et al., 2012).”
Endometriosis-associated infertility: From pathophysiology to tailored treatment
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“Its expression is necessary for endometrial receptivity, and it is significantly lower in the endometrial stroma of women with adenomyosis compared with fertile controls.(93)”
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Benagiano, G., Brosens, I., & Habiba, M. (2014) · Human Reproduction Update · doi:10.1093/humupd/dmt052 · Cited by 246 · see citing works
“In a comparative study between women with adenomyosis and hypermenorrhoea or adnexal mass (whose fertility status is not stated) and a control group of fertile women with no adenomyosis who had hysterectomy for prolapse or adnexal mass, the expression of HOXA10 protein was shown to be down-regulated in endometrial str…”
BackgroundInfluentialUterine polyps, adenomyosis, leiomyomas, and endometrial receptivity
Munro, M. G. (2019) · Fertility and Sterility · doi:10.1016/j.fertnstert.2019.02.008 · Cited by 248 · see citing works
Assessment of endometrial receptivity.
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Pirtea, P., Cicinelli, E., Nola, R. D., de Ziegler, D., & Ayoubi, J. M. (2021) · Fertility and Sterility · doi:10.1016/j.fertnstert.2020.12.010 · Cited by 226 · see citing works
Update on biomarkers for the detection of endometriosis
Fassbender, A., Burney, R. O., F. O, D., D’Hooghe, T., & Giudice, L. (2015) · BioMed Research International · doi:10.1155/2015/130854 · Cited by 195 · see citing works
“The endometrial transcriptome in women with endometriosis may have shared patterns of dysregulation with other inflammatory conditions such as hydrosalpinx [110] or other estrogen dependent diseases such as leiomyomata, endometrial polyps, or adenomyosis [111, 112].”
Niu, Z., Chen, Q., Sun, Y., & Feng, Y. (2013) · Gynecological Endocrinology · doi:10.3109/09513590.2013.824960 · Cited by 167 · see citing works
“[33], expression of the HOXA10 gene, an established marker of endometrial receptivity, was shown to be decreased in the”
BackgroundCampo, S., Campo, V., & Benagiano, G. (2012) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2011.10.003 · Cited by 158 · see citing works
“, 1999) and recently it has been shown that in women with adenomyosis HOXA10 gene expression is significantly lower during the midsecretory phase compared with fertile controls and diminished expression of HOXA10 is therefore a potential mechanism to explain the decreased implantation observed in women with adenomyosi…”
BackgroundART and uterine pathology: how relevant is the maternal side for implantation?
Galliano, D., Bellver, J., Díaz‐García, C., Simón, C., & Pellicer, A. (2014) · Human Reproduction Update · doi:10.1093/humupd/dmu047 · Cited by 139 · see citing works
Park, C. W., Choi, M. H., Yang, K. M., & Song, I. O. (2016) · Daehan saengsik uihak hoeji/Clinical and experimental reproductive medicine · doi:10.5653/cerm.2016.43.3.169 · Cited by 137 · see citing works
“Adenomyosis is associated with several conditions that could interfere with natural conception [1-3].”
BackgroundThe eutopic endometrium in endometriosis: are the changes of clinical significance?
Brosens, I. A., Brosens, J. J., & Benagiano, G. (2012) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2012.01.022 · Cited by 124 · see citing works
“, 2010) as well as in adenomyosis (Fischer et al., 2010) and polycystic ovary syndrome (Cermik et al.”
BackgroundGlobal Transcriptome Abnormalities of the Eutopic Endometrium from Women with Adenomyosis
Herndon, C. N., Aghajanova, L., Balayan, S., Erikson, D., Barragan, F., Goldfien, G., Vo, K. C., Hawkins, S., & Giudice, L. C. (2016) · Reproductive Sciences · doi:10.1177/1933719116650758 · Cited by 106 · see citing works
“The implication of adenomyosis to fertility is contested but may impair implantation.(1,4) Previous data from several investigators have established that eutopic endometrium is abnormal in patients with endometriosis, another complex and multifactorial condition characterized by ectopic implants of endometrial glands…”
BackgroundEmbryo implantation in the laboratory: an update on current techniques
Ojosnegros, S., Seriola, A., Godeau, A. L., & Veiga, A. (2020) · Human Reproduction Update · doi:10.1093/humupd/dmaa054 · Cited by 107 · see citing works
Classification and Reporting Systems for Adenomyosis
Munro, M. G. (2019) · Journal of Minimally Invasive Gynecology · doi:10.1016/j.jmig.2019.11.013 · Cited by 103 · see citing works
“For example, HoxA-10 gene expression, a marker for endometrial receptivity, can be decreased both in the mouse model with experimental adenomyosis (29) and in the secretory phase endometrium of women with adenomyosis(30).”
BackgroundAdenomyosis and Infertility—Review of Medical and Surgical Approaches
Szubert, M., Koziróg, E., Olszak, O., Krygier-Kurz, K., Kaźmierczak, J., & Wilczyński, J. R. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18031235 · Cited by 99 · see citing works
“a deregulation of leukaemia inhibitory factors (LIF) in uterine flushing fluid during the implantation window has been reported in adenomyosis [5,26,27].”
BackgroundFabris, A. M., Pacheco, A., Cruz, M., Puente, J. M., Fatemi, H. M., & García-Velasco, J. A. (2014) · Fertility and Sterility · doi:10.1016/j.fertnstert.2014.08.030 · Cited by 90 · see citing works
“Defective HOXA10 expression has been shown in multiple pathologies correlated to infertility, such as endometriosis, adenomyosis, hydrosalpinx, polycystic ovarian syndrome, and endometriosis (22).”
BackgroundMyomas and Adenomyosis: Impact on Reproductive Outcome
Vlahos, N., Theodoridis, T. D., & Partsinevelos, G. A. (2017) · BioMed Research International · doi:10.1155/2017/5926470 · Cited by 85 · see citing works
“A significant decrease in the expression of HOXA-10 gene during the midluteal phase has been documented in women with adenomyosis [132].”
BackgroundYang, Y., Chen, X., Saravelos, S. H., Liu, Y., Huang, J. L., Zhang, J., & Li, T. C. (2016) · Fertility and Sterility · doi:10.1016/j.fertnstert.2016.09.016 · Cited by 83 · see citing works
Campo, S., Campo, V., & Benagiano, G. (2011) · Obstetrics and Gynecology International · doi:10.1155/2012/786132 · Cited by 83 · see citing works
“This means that proper expression of the maternal Hoxa10 gene is necessary to maintain viability of the preimplantation embryo, and, recently, it has been proven that in women with adenomyosis the expression of Hoxa10 gene is decreased during the secretory phase of the cycle, a possible explanation for the observed lo…”
BackgroundAn update on the pharmacological management of adenomyosis
Streuli, I., Dubuisson, J. B., Santulli, P., de Ziegler, D., Batteux, F., & Chapron, C. (2014) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2014.953055 · Cited by 75 · see citing works
“Studies have shown an over-expression of aromatase P450, a decrease of integrin b3, osteopontin and leukemia inhibiting factor and an impairment of HOXA-10 gene function during the implantation window suggesting an impaired receptivity and blastocyst--endometrium interaction in women with adenomyosis [26-30].”
BackgroundThe Endometrium in Adenomyosis
Benagiano, G., & Brosens, I. A. (2012) · Women s Health · doi:10.2217/whe.12.8 · Cited by 73 · see citing works
Pathogenesis of Human Adenomyosis: Current Understanding and Its Association with Infertility
Khan, K. N., Fujishita, A., & Mori, T. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11144057 · Cited by 74 · see citing works
“(iii) Impairment of implantation may result from inflammation, a lack of adequate expression of adhesion molecules (integrins), reduced expression of implantation markers, such as leukemia inhibitory factor (LIF), and altered function of the gene for embryonic development (HOXA10) [185].”
BackgroundZhu, L., Sun, L., Hu, Y., Jiang, Y., Liu, H., Shen, X., Jin, X., Zhen, X., Sun, H., & Yan, G. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-1429 · Cited by 65 · see citing works
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“HOXA10 gene expression is decreased in the secretory-phase endometrium of women with adenomyosis [7].”
BackgroundDecreased expression of NR4A nuclear receptors in adenomyosis impairs endometrial decidualization
Jiang, Y., Jiang, R., Cheng, X., Zhang, Q., Hu, Y., Zhang, H., Cao, Y., Zhang, M., Wang, J., Ding, L., et al. (2016) · Molecular Human Reproduction · doi:10.1093/molehr/gaw042 · Cited by 53 · see citing works
“Alterations in a number of implantation-associated factors (such as HOXA10, LIF, MMP2, Interleukin-6, Cytochrome P450, and RCAS1) in the eutopic endometrium in women with adenomyosis have been found to result in reduced endometrial receptivity and impaired decidualization (Xiao et al., 2010; Fischer et al., 2011; Camp…”
BackgroundNamiki, T., Ito, J., & Kashiwazaki, N. (2018) · Reproductive Medicine and Biology · doi:10.1002/rmb2.12103 · Cited by 52 · see citing works
Kulp, J. L., Mamillapalli, R., & Taylor, H. S. (2016) · Reproductive Sciences · doi:10.1177/1933719116630427 · Cited by 44 · see citing works
“The diseases studied are known to result in decreased expression of HOXA10 in the endometrium.(49) Our findings of increased methylation at certain CpG sites in the promoter of HOXA10 suggest that this methylation correlates with previous reports of decreased HOXA10 gene expression in these diseases.”
BackgroundResultSelf-citationHomeobox genes for embryo implantation: From mouse to human
He, B., Ni, Z., Kong, S., Lu, J., & Wang, H. (2018) · Animal Models and Experimental Medicine · doi:10.1002/ame2.12002 · Cited by 44 · see citing works
Integrative analysis reveals regulatory programs in endometriosis
Yang, H., Kang, K., Cheng, C., Mamillapalli, R., & Taylor, H. S. (2015) · Reproductive Sciences · doi:10.1177/1933719115592709 · Cited by 39 · see citing works
Self-citationSenturk, L. M., & İmamoğlu, M. (2015) · Women s Health · doi:10.2217/whe.15.60 · Cited by 37 · see citing works
Xue, P., Zhou, W., Fan, W., Jiang, J., Kong, C., Zhou, W., Zhou, J., Huang, X., Yang, H., Han, Q., et al. (2021) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-021-00872-4 · Cited by 36 · see citing works
“Abnormal expression of HOXA10 and its downstream target genes leading to decreased endometrial receptivity are closely related to female infertility in the patients with gynecological diseases, such as endometriosis [11, 20, 21], adenomyosis [39, 40], and hydrosalpinx [41].”
BackgroundRole of HOXA10 in pathologies of the endometrium
Mishra, A., & Modi, D. N. (2024) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-024-09923-8 · Cited by 35 · see citing works
“As compared to controls, there is low expression of HOXA10 in the endometrium of women with adenomyosis [84, 85].”
Juárez‐Barber, E., Segura-Benítez, M., Carbajo‐García, M. C., Bas-Rivas, A., Faus, A., Vidal, C., Gilés, J., Labarta, E., Pellicer, A., Cervelló, I., et al. (2022) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2022.12.008 · Cited by 34 · see citing works
Treatment options and reproductive outcome for adenomyosis-associated infertility
Soave, I., Wenger, J., Pluchino, N., & Marci, R. (2017) · Current Medical Research and Opinion · doi:10.1080/03007995.2017.1393404 · Cited by 33 · see citing works
Wu, Y., Huang, J., Zhong, G., Lan, J., Lin, H., & Zhang, Q. (2021) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2021.10.014 · Cited by 33 · see citing works
Expression of HOXA10 Gene in Women with Endometriosis: A Systematic Review
Lazim, N., Elias, M. H., Sutaji, Z., Karim, A., Abu, M. A., Ugusman, A., Syafruddin, S. E., Mokhtar, M. H., & Ahmad, M. F. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241612869 · Cited by 35 · see citing works
“The downregulation of HOXA10 in women with adenomyosis can also impact the rate of successful implantation [71].”
BackgroundImpaired decidualization of human endometrial stromal cells from women with adenomyosis†
Peng, Y., Jin, Z., Liu, H., & Xu, C. (2021) · Biology of Reproduction · doi:10.1093/biolre/ioab017 · Cited by 30 · see citing works
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Mahdavinezhad, F., Gharaei, R., Farmani, A. R., Hashemi, F., Kouhestani, M., & Amidi, F. (2021) · Reproductive Sciences · doi:10.1007/s43032-021-00520-7 · Cited by 27 · see citing works
Juárez‐Barber, E., Corachán, A., Carbajo‐García, M. C., Faus, A., Vidal, C., Gilés, J., Pellicer, A., Cervelló, I., & Ferrero, H. (2024) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-023-01182-7 · Cited by 26 · see citing works
Wang, M., Hao, C., Huang, X. Y., Bao, H., Qu, Q., Liu, Z., Dai, H., He, S., & Yan, W. (2017) · Reproductive Sciences · doi:10.1177/1933719117734320 · Cited by 26 · see citing works
Çelik, Ö., Acet, M., Küçük, T., Haberal, E. T., Acet, T., Bozkurt, M., Şahi̇n, L., Verit, F. F., & Çalışkan, E. (2016) · Reproductive Sciences · doi:10.1177/1933719116654993 · Cited by 23 · see citing works
“Some studies demonstrated that both HOXA10 and LIF gene expression are significantly decreased in women with adenomyosis.(131,132) In contrast, overexpression of IL-6 and cytochrome P450 have been reported in patients with adenomyosis suggesting dysfunctional endometrium.”
BackgroundPeng, Y., Liu, X., Jin, Z., Liu, H., & Xu, C. (2021) · Human Reproduction · doi:10.1093/humrep/deab234 · Cited by 22 · see citing works
Establishment of Adenomyosis Organoids as a Preclinical Model to Study Infertility
Juárez‐Barber, E., Francés‐Herrero, E., Corachán, A., Vidal, C., Gilés, J., Alamá, P., Faus, A., Pellicer, A., Cervelló, I., & Ferrero, H. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12020219 · Cited by 22 · see citing works
“Patients with adenomyosis experience defective decidualization [51], altered uterine peristaltic activity [52] and endometrial receptivity [53], impaired embryo-maternal communication [54], and delayed pinopode formation, resulting in unsuccessful embryo implantation [55].”
BackgroundGuan, X., Liu, D., Zhou, H., Dai, C., Wang, T., Fang, Y., Jia, Y., & Li, K. (2022) · Annals of Translational Medicine · doi:10.21037/atm-22-5493 · Cited by 22 · see citing works
“…(HoxA10/11) and leukemia inhibitory factor (LIF) were downregulated in both mice models (16) and the secretory phase endometrium of women with adenomyosis (17), and their dysregulation decreased downstream factors influencing endometrial receptivity by repressing the target gene integrin β 3 (18).”
Pier, B. D., Crellin, C., Katre, A. K., Conner, M., Novak, L., Young, S. L., & Arend, R. C. (2020) · Reproductive Sciences · doi:10.1007/s43032-019-00056-x · Cited by 22 · see citing works
Wu, H., Tsai, T.-C., Liu, S.-M., Pai, A. H.-Y., & Chen, L.-H. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25168937 · Cited by 21 · see citing works
“In addition, subendometrial myometrium (inner myometrium or junctional zone) presents with dysfunctional hyperperistalsis and increased intrauterine pressure in women with adenomyosis, amplified by local hyperestrogenism, leading to defective implantation and placentation and, in turn, miscarriages…”
BackgroundKay, N., Huang, C., Shiu, L., Yu, Y.-C., Chang, Y., Schatz, F., Suen, J., Tsai, E., & Huang, S.-T. J. (2020) · Reproductive Sciences · doi:10.1007/s43032-020-00308-1 · Cited by 20 · see citing works
Determining the Molecular Background of Endometrial Receptivity in Adenomyosis
Prašnikar, E., Kunej, T., Repnik, K., Potočnik, U., Knez, J., & Kovačič, B. (2020) · Biomolecules · doi:10.3390/biom10091311 · Cited by 19 · see citing works
Hiraoka, T., Hirota, Y., & Osuga, Y. (2022) · F&S Reviews · doi:10.1016/j.xfnr.2022.11.004 · Cited by 17 · see citing works
Stratopoulou, C. A., Rossi, M., Beaussart, C., Zipponi, M., Camboni, A., Donnez, J., & Dolmans, M. (2024) · Fertility and Sterility · doi:10.1016/j.fertnstert.2024.08.339 · Cited by 16 · see citing works
Schimpf, M. G., Milesi, M. M., Zanardi, M., & Varayoud, J. (2021) · Food and Chemical Toxicology · doi:10.1016/j.fct.2021.112695 · Cited by 17 · see citing works
Zou, Y., Liu, F., Wang, L., Guo, J.-B., Yang, B., Wan, X., Wang, F., He, M. L., & Huang, O. (2016) · Gene · doi:10.1016/j.gene.2016.12.011 · Cited by 16 · see citing works
Das, M., Mohanty, S. R., Minocha, T., Mishra, N. K., Yadav, S. K., & Haldar, C. (2022) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2022.112508 · Cited by 15 · see citing works
Juárez-Barber, E., Cozzolino, M., Corachán, A., Alecsandru, D., Pellicer, N., Pellicer, A., & Ferrero, H. (2023) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2022.09.007 · Cited by 16 · see citing works
Li, D., Jiang, W., Jiang, Y., Wang, S., Fang, J., Zhu, L., Zhu, Y., Yan, G., Sun, H., Chen, L., et al. (2019) · Systems Biology in Reproductive Medicine · doi:10.1080/19396368.2018.1563844 · Cited by 15 · see citing works
“…associated with subfertility in patients of reproductive age, with infertility being attributed to several factors, such as impaired endometrial receptivity, poor maternal immune status, a prethrombotic state, and other unexplained causes (Fischer et al. 2011; Campo et al. 2012; Zhou et al. 2012).”
BackgroundInfluentialHu, L., Li, H., Huang, C., Chen, H., Zhu, G., & Qian, K. X. (2014) · Fertility and Sterility · doi:10.1016/j.fertnstert.2014.05.036 · Cited by 13 · see citing works
Decreased intracellular IL-33 impairs endometrial receptivity in women with adenomyosis
He, B., Teng, X., Hao, F., Zhao, M., Chen, Z.-Q., Li, K., & Yan, Q. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.928024 · Cited by 12 · see citing works
Shi, B., Tu, H., Sha, L., Luo, X., Wu, W., Su, Y., Yang, S., & Wang, H. (2018) · Molecular Reproduction and Development · doi:10.1002/mrd.23099 · Cited by 12 · see citing works
Lai, T., Chang, F.-W., Lin, J., & Ling, Q. (2018) · Taiwanese Journal of Obstetrics and Gynecology · doi:10.1016/j.tjog.2018.06.005 · Cited by 12 · see citing works
Changaei, M., Javidan, M., Tehrani, F. R., Mosaffa, N., Noroozzadeh, M., Hosseinzadeh, R., & Rajaei, S. (2023) · American Journal of Reproductive Immunology · doi:10.1111/aji.13702 · Cited by 11 · see citing works
Jensen, A., Nielsen, M. L., Guleria, S., Kjær, S. K., Heitmann, B. L., & Kesmodel, U. S. (2019) · Fertility and Sterility · doi:10.1016/j.fertnstert.2019.09.017 · Cited by 11 · see citing works
“Supported by a grant to B.L.H. by the Danish Council for Strategic Research (11-116213) and by internal funding from the Danish Cancer Society.”
BackgroundZhang, M., Zhang, Q., Cao, Z., Cai, X., Liu, J., Jiang, Y., Zhu, Y., Zhou, J., Yu, L., Zhen, X., et al. (2022) · Cell Death Discovery · doi:10.1038/s41420-022-01203-1 · Cited by 10 · see citing works
Is adenomyosis a problem in reproduction and fertility?
Korzekwa, A. J., Łupicka, M., Socha, B. M., Mannelli, C., & Skarzynski, D. J. (2014) · Polish Journal of Veterinary Sciences · doi:10.2478/pjvs-2014-0028 · Cited by 11 · see citing works
Ismail, A., Agban, M. N., Hasanein, A. S., Rayan, A. A., & Abbas, A. M. (2017) · Middle East Fertility Society Journal · doi:10.1016/j.mefs.2017.05.004 · Cited by 9 · see citing works
Effects of pretreatment strategies on fertility outcomes in patients with adenomyosis
Moawad, G., Youssef, Y., Fruscalzo, A., Khedhri, S., Faysal, H., Pirtea, P., Guani, B., Vallée, A., Ayoubi, J. M., & Féki, A. (2024) · Frontiers in Reproductive Health · doi:10.3389/frph.2024.1484202 · Cited by 8 · see citing works
Receptivity-based uterine fibroid surgery: an updated systematic review of the evidence
Çelik, Ö., Koç, Ö., Yurci, A., Erşahin, A., Çelik, N., Çağiran, F. T., GÜRKAN, N., Özyurt, R., Özçil, M. D., Duran, B., et al. (2022) · Clinical and Experimental Obstetrics & Gynecology · doi:10.31083/j.ceog4905114 · Cited by 8 · see citing works
“Despite rare studies claiming the opposite view, it has been reported that the expression of some genes involved in re-ceptivity such as glycodelin, homeobox, leukemia inhibitor factor, has-miR-504-5p are impaired in the presence of fi-broid, endometriosis, adenomyosis, or hydrosalpinx [4–7].”
BackgroundÇelik, Ö., Çelik, N., GÜNGÖR, N. D., Çelik, S., Arslan, L., Morciano, A., & Tinelli, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232214201 · Cited by 8 · see citing works
Trinchant, R., Cruz, M., & Requena, A. (2022) · International Journal of Gynecology & Obstetrics · doi:10.1002/ijgo.14256 · Cited by 9 · see citing works
Chu, L.-H., Liao, C.-C., Liew, P., Chen, C.-W., Su, P., Wen, K., Lai, H.-C., Huang, R., & Chen, L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23115973 · Cited by 8 · see citing works
“The dysfunction of a group of implantation-associated factors, such as HOXA10 and LIF, was identified in the eutopic endometrium in adenomyosis and led to low endometrial receptivity and subsequent infertility [11,12].”
BackgroundEffect of adenomyosis on implantation
Vila-Vives, J. M., Martínez-Conejero, J. A., & Pellicer, A. (2012) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2012.02.005 · Cited by 8 · see citing works
The Art of Managing Infertile Patients with Adenomyosis
Pai, A. H.-Y., Chen, L.-H., Huang, S., Wu, H., Chang, C., Huang, H.-Y., Soong, Y., & Lee, C. (2024) · Gynecology and Minimally Invasive Therapy · doi:10.4103/gmit.gmit_53_24 · Cited by 7 · see citing works
“[10] In addition, current research has found reduced number of luminal microvilli, impaired steroid hormone metabolism, and increased oxidative stress in the endometrium of patients with adenomyosis.”
Trinchant, R., Cruz, M., Requena, A., & García-Velasco, J. A. (2024) · International Journal of Gynecology & Obstetrics · doi:10.1002/ijgo.16082 · Cited by 9 · see citing works
“27 These changes can undermine the embryo's ability to secure itself adequately, leading to potential implantation failure and affecting later stages of pregnancy.”
Alizadeh, Z., Faramarzi, S., Saidijam, M., Alizamir, T., Esna‐Ashari, F., Shabab, N., & Sanoee, M. F. (2013) · Europe PMC (PubMed Central) · Cited by 7 · see citing works
Zhang, S., He, H. R., Wang, J., Ma, L., Wei, X., Zhang, M., & Guo, Y. C. (2025) · Frontiers in Physiology · doi:10.3389/fphys.2025.1548737 · Cited by 6 · see citing works
mRNA and miRNA Biomarkers for Endometriosis
Aghajanova, L., Burney, R. O., Tran, N. D., & Giudice, L. C. (2017) · Springer eBooks · doi:10.1007/978-3-319-59856-7_9 · Cited by 6 · see citing works
Recent Advances and Current Perspectives on Endometrial Receptivity
Bakkensen, J. B., Agarwal, R., & Shapiro, M. (2021) · Current Obstetrics and Gynecology Reports · doi:10.1007/s13669-021-00313-4 · Cited by 6 · see citing works
The Mutation of the Ap3b1 Gene Causes Uterine Hypoplasia in Pearl Mice
Jing, R., Kong, Y., Han, G., Zhang, J., Li, K., Dong, X., Yan, J. R., Zhang, H., Han, J., & Feng, L. (2020) · Reproductive Sciences · doi:10.1007/s43032-019-00006-7 · Cited by 6 · see citing works
Kiani, M., Salehi, M., Mogheiseh, A., Mohammadi‐Yeganeh, S., & Shahidi, S. (2020) · Reproductive Sciences · doi:10.1007/s43032-020-00240-4 · Cited by 6 · see citing works
“TheHoxa10 gene is one of the miR16-1 target genes that may function in fertility, embryo viability, and regulation of hematopoietic lineage commitment [75, 76].”
BackgroundAberrant Hoxa10 gene methylation as a mechanism for endosulfan-induced implantation failures in rats
Milesi, M. M., Lorenz, V., & Varayoud, J. (2022) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2022.111576 · Cited by 6 · see citing works
Khan, K. N. (2024) · Journal of physiological investigation. · doi:10.4103/ejpi.ejpi-d-24-00032 · Cited by 4 · see citing works
Duan, J., Zhou, X., Zhu, H., Zhou, M., Liu, M., Zhou, Y., Li, W., Xu, B., & Zhang, A. (2025) · Molecular Medicine · doi:10.1186/s10020-024-01054-9 · Cited by 4 · see citing works
“Research indicates that patients with adenomyosis show no significant changes in the oocyte (Horton et al. 2019), suggesting that decreased endometrial receptivity is the primary cause of infertility in AM, as confirmed by multiple studies (Munro 2019; Pirtea et al. 2021; Fischer et al. 2011).”
Adénomyose et implantation : mise au point
Yazbeck, C. M., Falcone, S., Ballout, A., Gauché-Cazalis, C., Epelboin, S., Patrat, C., & Luton, D. (2015) · Gynécologie Obstétrique & Fertilité · doi:10.1016/j.gyobfe.2015.09.001 · Cited by 4 · see citing works
Apelin-13 modulates the endometrial transcriptome of the domestic pig during implantation
Dobrzyń, K., Kieżun, M., Kopij, G., Zarzecka, B., Gudelska, M., Kisielewska, K., Zaobidna, E. A., Makowczenko, K. G., Dall’Aglio, C., Kamiński, T., et al. (2024) · BMC Genomics · doi:10.1186/s12864-024-10417-9 · Cited by 4 · see citing works
“The drop of HOXA10 gene expression was also observed in women with adenomyosis and a decreased rate of proper implantation [45] The presence of this transcription factor was also confirmed in pigs, in both, the endometrium and conceptuses, and its expression raised during the peri-implantation…”
BackgroundChapron, C., Parpex, G., den Bosch, T. V., Hend, A. A., Gargiulo, A., Stockwell, E., Taylor, H., McCarus, S. D., & Petraglia, F. (2026) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2026.105642 · Cited by 4 · see citing works
Self-citationLópez-Luna, A., Hernández-Melchor, D., Ramírez-Martínez, L., & López‐Bayghen, E. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.80452 · Cited by 5 · see citing works
Tjahyadi, D., Pribadi, A., Ar, R. S. D., Shofiatun, N. A., & Djuwantono, T. (2022) · Annals of Medicine and Surgery · doi:10.1016/j.amsu.2022.104620 · Cited by 3 · see citing works
“There is a relationship between adenomyosis and disruption of the natural process of conception [4,5].”
BackgroundYu, R., Wei, C., Li, G., Ouyang, J., Liu, N., Gu, N.-H., Lin, Y., & Xu, H. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2024.167526 · Cited by 2 · see citing works
Etrusco, A., Riemma, G., Chiantera, V., Laganà, A. S., Agrifoglio, V., Donna, M. C. D., Pecorino, B., Scibilia, G., Tinelli, A., Malvası, A., et al. (2025) · Gynecologic and Obstetric Investigation · doi:10.1159/000543836 · Cited by 2 · see citing works
“Similar to the previous uterine conditions, patients with adenomyosis exhibit reduced levels of HOXA10 [144 – 146] and LIF [147, 148].”
Exome-Based Identification of Candidate Genes in Sporadic Adenomyosis Cases
Tuncer, F. N., Eser, N., Aydin, S., Selçuki, N. F. T., Özaydın, İ. Y., & Oral, E. (2025) · Diagnostics · doi:10.3390/diagnostics15233069 · Cited by 2 · see citing works
“Studies have observed that HOXA10 gene expression is significantly downregulated in the endometrium of women with both adenomyosis and endometriosis [19,20].”
Yang, Q., Zheng, X., Zhong, F., Chen, L., Hong, J., Liu, X., & Jiang, J. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2025.1488866 · Cited by 2 · see citing works
“Previous studies suggest that the downregulation of HOXA10, NR4A receptor, and FOXO1A appears to impaired implantation in women with AM (50, 51), and dysregulation of LIF has a similar effect (52).”
The Endometrium in Adenomyosis
Habiba, M. A., & Benagiano, G. (2015) · Springer eBooks · doi:10.1007/978-3-319-13012-5_6 · Cited by 2 · see citing works
- Authors
- Fischer, C. P., Kayisili, U., & Taylor, H. S.
- Affiliations
- Yale University (US)
- Corresponding author
- Taylor, Hugh S.
- ORCID
- Taylor, Hugh S.
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2011-03
- Volume
- 95
- Issue
- 3
- Pages
- 1133-1136
- ISSN
- 0015-0282 (ISSN-L)
- PMC
- PMC3053130
- OpenAlex
- W2165954066
- Cited by
- 133
- References
- 53
- Citations by year
- 2026: 8 · 2025: 8 · 2024: 18 · 2023: 6 · 2022: 17 · 2021: 11 · 2020: 8 · 2019: 9 · 2018: 6 · 2017: 8 · 2016: 8 · 2015: 6 · 2014: 8 · 2013: 5 · 2012: 4
- FWCI
- 4.55
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (U54HD052668, R01HD036887)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Keywords
- HOXA10, adenomyosis, endometrium, luteal phase, gene expression, implantation failure, endometrial receptivity
- MeSH terms
- Homeobox A10 Proteins, Adult, Biopsy, Endometriosis, Endometrium, Female, Humans, Immunohistochemistry, Infertility, Female, Middle Aged, Embryo Implantation, Case-Control Studies, Homeodomain Proteins
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