The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Hepatic Tumor Necrosis Factor Signaling and Nuclear Factor-κB: Effects on Liver Homeostasis and Beyond
Abstract
The proinflammatory cytokine TNF has a pivotal role in liver pathophysiology because it holds the capacity to induce both hepatocyte cell death and hepatocyte proliferation. This dual effect of TNF on hepatocytes reflects its ability to induce both nuclear factor kappaB (NF-kappaB)-dependent gene expression and cell death. Multiple studies have demonstrated the crucial role of the transcription factor NF-kappaB in the decision between life and death of a hepatocyte. Massive hepatocyte apoptosis preceding embryonic lethality in NF-kappaB-deficient mice constituted the first indication of an essential antiapoptotic function of NF-kappaB in the liver. Although many studies confirmed this crucial cytoprotective role of NF-kappaB in adult liver, a number of genetic studies recently obtained conflicting results on the exact role of NF-kappaB in different mouse models of TNF hepatotoxicity, demonstrating that caution should be taken when interpreting studies using different NF-kappaB-deficient mice in distinct models of liver injury. Recent reports showing a role for hepatic NF-kappaB activation in the proliferation of malignant cells during hepatocarcinogenesis, and in the progression of fatty liver diseases to insulin resistance and type 2 diabetes mellitus demonstrate that NF-kappaB can also have more detrimental effects in the liver. Moreover, its role in the development of the metabolic syndrome emphasizes that hepatic NF-kappaB activation might also have adverse effects on the endocrine system. Therefore, understanding the regulation of hepatic TNF signaling and NF-kappaB activation is of critical therapeutic importance. In this review, we summarize how studies on the role of NF-kappaB in different mouse models of liver pathologies have contributed to this understanding.
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Cites
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The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)
Buzzetti, E., Pinzani, M., & Tsochatzis, E. A. (2016) · Metabolism · doi:10.1016/j.metabol.2015.12.012 · Cited by 3,119
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Inflammatory Cytokine TNFα Promotes the Long-Term Expansion of Primary Hepatocytes in 3D Culture
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Macrophages and Inflammatory Mediators in Chemical Toxicity: A Battle of Forces
Laskin, D. L. (2009) · Chemical Research in Toxicology · doi:10.1021/tx900086v · Cited by 287
ABINs: A20 binding inhibitors of NF-κB and apoptosis signaling
Verstrepen, L., Carpentier, I., Verhelst, K., & Beyaert, R. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.02.009 · Cited by 180
Self-citation
Metadata
- Authors
- Wullaert, A., van Loo, G., Heyninck, K., & Beyaert, R.
- Venue
- Endocrine Reviews
- Publisher
- The Endocrine Society
- Published
- 2007-06-01
- Volume
- 28
- Issue
- 4
- Pages
- 365-386
- ISSN
- 0163-769X (ISSN-L)
- 1945-7189
- OpenAlex
- W2049498039
- Cited by
- 218
- References
- 35
- FWCI
- 5.57
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wullaert, A., van Loo, G., Heyninck, K., & Beyaert, R. (2007). Hepatic Tumor Necrosis Factor Signaling and Nuclear Factor-κB: Effects on Liver Homeostasis and Beyond. Endocrine Reviews. https://doi.org/10.1210/er.2006-0031
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